bio lab case 2

Case #2

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...Robert and Lauren!

Patient Information

Female, 55 years old No history of health problems Marriage problems Recently won the lottery

Symptoms

Fatigue Headaches Excessive salivation Nausea / Vomiting

Diarrhea Vertigo Abdominal pain Weight loss

Physical Examination

Swelling of eyelids Partial limb paralysis Hyperkeratosis of skin on palms & soles White banding on fingernails Muscle weakness

Lab Results

Low levels of ATP production Unusually high levels of arsenic Abnormal levels of cell death

Due to lack of energy

Our Theory – Arsenic Poisoning!

Patient's Symptoms vs. Arsenic Poisoning Symptoms

High levels of arsenic

headache dizziness

Falling body temperature

White banding on fingernails

diarrhea

vomiting

Abdominal pain

Muscle weakness

fatigue

vertigo

Excessive salivation

Hyperkeratosis of skin on palms & soles

Eyelid swellingLimb paralysis

Weight loss

Low levels of atp production

Abnormal amount of cell death

Garlic odor on breath

Kidney failure

Progressive blindness

dementia

Arsenic Poisoning

Organelle affected: mitochondria Inhibits pyruvate dehydrogenase Conversion of pyruvate to acetyl CoA

decreased Citric acid cycle activity decreased Production of ATP decreased Inhibits cellular glucose uptake and fatty

acid oxidation

How (we're guessing) It Happened

Husband hated her as it was She won the lottery He wanted her money He poisoned her.

ALL MEN ARE EVIL