bio lab case 2
TRANSCRIPT
Case #2
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Patient Information
Female, 55 years old No history of health problems Marriage problems Recently won the lottery
Symptoms
Fatigue Headaches Excessive salivation Nausea / Vomiting
Diarrhea Vertigo Abdominal pain Weight loss
Physical Examination
Swelling of eyelids Partial limb paralysis Hyperkeratosis of skin on palms & soles White banding on fingernails Muscle weakness
Lab Results
Low levels of ATP production Unusually high levels of arsenic Abnormal levels of cell death
Due to lack of energy
Our Theory – Arsenic Poisoning!
Patient's Symptoms vs. Arsenic Poisoning Symptoms
High levels of arsenic
headache dizziness
Falling body temperature
White banding on fingernails
diarrhea
vomiting
Abdominal pain
Muscle weakness
fatigue
vertigo
Excessive salivation
Hyperkeratosis of skin on palms & soles
Eyelid swellingLimb paralysis
Weight loss
Low levels of atp production
Abnormal amount of cell death
Garlic odor on breath
Kidney failure
Progressive blindness
dementia
Arsenic Poisoning
Organelle affected: mitochondria Inhibits pyruvate dehydrogenase Conversion of pyruvate to acetyl CoA
decreased Citric acid cycle activity decreased Production of ATP decreased Inhibits cellular glucose uptake and fatty
acid oxidation
How (we're guessing) It Happened
Husband hated her as it was She won the lottery He wanted her money He poisoned her.
ALL MEN ARE EVIL