acne vulgaris and rosacea dr. lyn guenther university of western ontario
TRANSCRIPT
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Acne Vulgaris and
Rosacea
Dr. Lyn Guenther
University of Western Ontario
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Objectives
• State the incidence of acne • Discuss the psychosocial impact of acne & scarring • Discuss the pathophysiology of acne • Differentiate acne vulgaris from rosacea • Elicit a history and perform a relevant examination • Give an approach to acne and rosacea treatment from mild to severe
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Acne vulgaris
• Incidence: 95%
• Scarring - In 95% seeing a dermatologist for the first
time
- Increased with: • Squeezing
• Inflammatory lesions
• Longer disease duration
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Psychological Scarring
• QOL studies: - Social, psychological & emotional deficits
comparable to: • Asthma
• Epilepsy
• Diabetes Mellitus
• Back Pain
• Arthritis
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Pilosebaceous Unit
• Sebaceous Gland
• Sebum
• Follicle
• Arrector Pili Muscle
900 glands/cm2 on face, back, chest <100 glands/cm2 on rest of body
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Pathogenesis of Acne
• Abnormal Keratinization (genes)
• Androgens cause increased sebum production
• Propionibacterium acnes
• Inflammation
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Acne Vulgaris Pathophysiology
Microcomedones Accumulation of Sebum
Closed/Open Comedones(non-inflammatory acne)
Proliferation of P. acnes Infiltration of neutrophils
Ruptured comedones
Papules, Pustules, Cysts (inflammatory acne)
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Acne vulgaris - History
• Age of onset • Family history of acne • Location and severity of lesions • Scarring • Psychosocial impact • Menses/Contraceptive use • Moisturizer and foundation • Medications & Drug Allergies • Current and Past treatment including response and A/E’s
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Physical Examination:
Scarring and Pigmentary Changes Scarring: depressed / ice pick / saucer / keloid
Excoriations Hyper / hypo-pigmentation
Lesion Morphology
Non-inflammatory Comedonal
Inflammatory Papules / pustules
Nodules / cysts
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Acne Lesions
Comedones Papules & Pustules Cysts
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Acne vulgaris - Why treat?
• Improve appearance • Minimize scarring • Eliminate discomfort of inflammatory lesions • Reduce psychological consequences
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Acne vulgaris - Dispel myths
• Acne is NOT caused by: - Chocolate
- Fried or fatty food
- Too much or too little sex
- Dirt
- Wrong kind of soap
• Not contagious
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Acne vulgaris - Aggravating Factors
• Stress
• Lack of sleep
• Tight headbands/helmets
• Grease-filled environments
• Heavy makeup while exercising
• Premenstrual in some
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Acne vulgaris - Cleansing
• Wash BID
• Lukewarm water
• Mild cleanser
• No abrasives
• No scrubbing
• Don’t squeeze
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Acne vulgaris Moisturizers and Foundation
• Non-comedogenic
• Non-acnegenic
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Treatment Guidelines
Non-scarring acne
* Comedones: Retinoid * Tretinoin cream .01-.05% daily or * Tazarotene cream/gel or * Differin cream/gel
* Papules/Pustules * Topical antibiotic B.I.D. * Benzoyl peroxide 5% daily * Antibiotic/benzoyl peroxide * Oral antibiotics * Hormonal agents for women
desiring oral contraception
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ANTIBIOTIC DOSE Tetracyclines
Tetracycline 500 mg B.I.D.
Minocycline 100 mg/day
Doxycycline 100 mg/day
Erythromycin 500 mg B.I.D.
Trimethoprim 100 - 200 mg/day
NOTES
*Avoid in pregnancy or children < 8 years *Take on empty stomach *G.I. irritation *May be taken with food *Dizziness may develop at higher dos es *Pigmentary changes *May be taken with food *Phototoxicity a potential problem *Safe in pregnancy and for children *May caus e G.I. Ups et *Useful in those resistant to other antibiotics
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Hormonal Therapies for Acne
Diane-35® cyproterone acetate/ ethinyl estradiol
Ortho -Tricyclen® norgestimate/ ethinyl estradiol
Alesse® levonorgestral/ ethinyl estradiol
Yasmin ® drospirenone-ethinyl estradiol
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Treatment Guidelines
Severe or
Scarring acne
Isotretinoin:
* 0.5mg/kg/day for the first 2-4 weeks
* 1 mg/kg /day for the next 4-5 months to a total cumulative dose of 120-150 mg/kg * 80% have long-term drug free remission
* 20% require a second course
* patients unable to take isotretinoin should be given topical therapy combined with systemic antibiotics or hormonal agents
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Isotretinoin
Sebaceous follicles
• Decreases sebum production within 2 weeks
• Corrects follicular hyperkeratinization
• Decreases growth of P. acnes • Decreases inflammation
Pre-Accutane On Accutane
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Isotretinoin Contraindication:
Absolute: • Pregnancy (see Pregnancy Prevention Program™)
Relative:
• History of pre-morbid depression
• History of hypertriglyceridemia/ hypercholesterolemia
• Pre-existing liver disease
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Accutane use and pregnancy
• Isotretinoin is a potent teratogen - >25% risk of fetal malformation.
• Reported pregnancy rate on Accutane<1%
- Average age: 26 years.
• Reasons for these pregnancies: - abstinence unsuccessful
- use of ineffective method of contraception
- contraceptive used inconsistently
- unexpected sexual activity
- failure of contraceptive method
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Pregnancy Prevention Program™
• Two negative pregnancy tests required before starting Accutane
- Initial visit & day 2-3 of next period
• Two effective forms of birth control
- one primary and one secondary
• Begin therapy on 2nd or 3rd day of next menses
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Pregnancy Prevention Program™
• One month prescription only
• Monthly pregnancy testing
• Monthly contraceptive counseling
• Initial Consent form
• Patient Information booklet
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Effective Forms of Contraception
Primary
• Tubal ligation
• Partner’s vasectomy
• Birth control pills
• Injectable/implanted hormones
• IUD
Secondary
• Diaphragms with spermicide
• Latex condoms with spermicide
• Cervical caps with spermicide
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Isotretinoin Adverse Events
• Cheilitis 96%
• Dermatitis 55%
• Dry nose 51%
• Eye irritation 11%
• Joint pain 13%
• Depression rare
• Elevated TG (25%) & cholesterol (7%)
• Elevated liver enzymes (15%)
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Isotretinoin and Psychiatric Events
Depression Suicide/attempt
Isotretinoin Use
(1982-2000)
USA General Pop’n
(CDC 1980-92)
10-13 per 100,000 patients
20,000 per 100,000 patients
1-1.7 per 100,000 patients
20 per
100,000 patients
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Isotretinoin
Mucutaneous adverse events: • Chapstick • Lubricants
Lab monitoring: • CBC, liver function and fasting lipids
• Pregnancy test
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Case studies
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Case 1
• Washes with apricot scrub
• Has tried numerous other cleansers
• Has stopped eating chocolate
• No other treatment
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• Case 2
• Won’t socialize • Regular menses • Not sexually active • No prior treatment
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Case 3
• Oily skin
• Seborrheic dermatitis
• Plucks facial hair
• Irregular menses
• Proactive-No help
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Case 4
• Acne lesions hurt
• Tetracycline 500 mg BID for 6 months, then
• Minocycline 100 mg BID for 8 months
• Differin gel x14 months
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Rosacea
• ~10% of Canadians affected
• Women: Men=2:1, but men more prone to rhinophyma
• Celtic descent - Uncommon in Africans & Asians
• Onset usually after age 30 - Peak: 4th to 7th decade
- Rarely in children
Konshik PC et al. Dermatol Clin 1992;10(3):533-47
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Rosacea Pathophysiology • Genetic
• Abnormalities of cutaneous vasculature - Dysregulation of thermal mechanisms
• Dermal matrix degeneration - Poor connective tissue support for cutaneous vessels
• Infectious organisms - Demodex
- Helicobacter pylori
• Excess of canthelicidins and protease stratum corneum tryptic enzyme (STCE) in facial skin
Yamaski K et al. Nat Med 2007;13:975-80
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Rosacea Pathophysiology
• Murine model: - Injection of cathelicidins found in rosacea or addition of SCTE → skin inflammation - Deletion of the serine protease inhibitor gene Spink5 →
protease activity → skin inflammation - TCN + Minocycline indirectly inhibit serine proteases and work even in the face of bacterial resistance Hypothesis: Increase in local antimicrobial peptide expression may change the normal skin microflora in
rosacea
Yamaski K et al. Nat Med 2007;13:975-80
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Rosacea affects QOL
• Recent Canadian Survey (n=1271): - Social life affected in 36%
• 16% of all respondents declined a social invitation due to rosacea symptoms
• Lower self esteem
• Affects professional interactions
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Rosacea: Skin changes
• Symmetric over convexities of central face - nose, cheeks, chin, central
forehead • Occ. on neck, scalp, chest • Very rarely on back and limbs
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Rosacea: Skin changes
• Primary features: - Flushing:
• Usually lasts > 10 minutes • Sparing of periocular skin • Often assoc. with burning, stinging
- Persistent Erythema - Telangiectasia - Papules, pustules (follicular and non-
follicular) ……..NO COMEDONES
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Rosacea: Skin changes
• Secondary features: - Burning or stinging - Lowered threshold for irritation from topical substances - Plaques - Dry appearance - Edema (e.g. periorbital, glabellar, malar)
• Acute, chronic recurrent, chronic persistent • Pitting or non-pitting
- Ocular - Peripheral location (neck, chest, scalp, ears, back)
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Subtypes of Rosacea
1. Erythematotelangiectatic
2. Papulopustular
3. Phymatous
4. Ocular
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Phymatous Variant
• Men • Erythematous, irregularly swollen, bulbous, dilated pores, telangiectasia
- Rhinophyma (nose) - Metophyma (forehead) - Gnathophyma (chin) - Blepharophyma (eyelids) - Otophyma (ears)
Aloi F et al. JAAD 2000;42:468-72
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Rosacea-Ocular
• 50% of patients• 6th-7th decade (later than skin)
• Women=Men • Onset with skin:2
- 53% skin first - 20% eyes first - 27% together
• Strong correlation with flushing3
1. Barankin B, Guenther L. Can Fam Physician. 2002;48:721-4. 2. Borrie P. Br J Ophthalmol 1953:65:458. 3. Wilkin JK. Int J Dermatol 1983;22:393-400.
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Rosacea-Ocular
• Dry, gritty eyes, itching, burning, tearing, blurry vision, photophobia
• Blepharitis (93%), conjunctival hyperemia (86%), conjunctivitis, keratitis, superficial punctate keratopathy (41%), keratoconjunctivitis sicca (up to 40%)
corneal vascularization ulceration and perforation, iritis (20%), chalazion (22%)
• ~ 60% of patients with chalasion have rosacea
Barankin B, Guenther L. Can Fam Physician. 2002;48:721-4.
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Rosacea Triggers
• Food: - Hot food - Spicy food - Tomatoes - Chocolate - Yogurt, sour cream,cheese
• Alcohol • Hot and cold temperatures • Wind • Exercise • Stress
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Rosacea Triggers
• Drugs:1
- Corticosteroids
- Amiodarone • Rosacea + multiple chalazia2
- Epidermal growth factor receptor inhibitors
- High dose vitamin B6 and B12
1. Crawford GH et al. JAAD 2004;51:327-412. Reifler DM et al. Am J Ophthalmol 1987;103:594-5
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Rosacea Treatment
• Avoid triggers • Flushing:
- Clonidine 0.05 mg OD→BID - Green moisturizers
• Telangiectasia - Vascular lasers (e.g. pulsed dye, KTP, 532 and 810 light-emitting diode (LED), Alexandrite, Nd-TAG, IPL
alone or with PDT)
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Rosacea Treatment: Topical
• Mild cleansers • Sunscreen: titanium dioxide & zinc oxide well tolerated
• Topical - Metronidazole - Azelaic acid 15% (Finacea) - Sodium sulfacetamide 10%/sulfur 5% - Clindamycin - Dapsone - Pimecrolimus/Tacrolimus - +/- BP, VAA (phymatous rosacea; may irritate)
• Eye: - Warm soaks, dilute baby shampoo - Topical steroids (ophthalmologist) - Artificial tears:
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Rosacea Treatment: Oral
• Oral antibiotics (skin + eye) - Tetracyclines:
• Tetracycline • Minocycline • Doxycycline
- Others: • Erythromycin • Clarithromycin • Azithrmycin • Metronidazole • Dapsone
• Isotretinoin (skin including phymas + eye)
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Rosacea Treatment: Rhynophyma
• Medical: Isotretinoin
• Surgical: - Ablative lasers
- Shave excision
- Cryosurgery
- Electrosurgical loops to shave off excessive
tissue, then fine tune with dermabrasion
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www.rosaceainfo.com