2010waterswallcalendar

[ 2010 Calendar ]

In the world of generic pharmaceuticals, there’s a simple saying: He who reaches the market first gets the biggest return. Little wonder Apotex wanted to decrease their overall cycle time from inception through to product launch. Naturally, they called Waters.

First order of business was talk, not about solutions, but about Apotex. Waters goes beyond the norm in order to truly understand a client’s key issues. The meetings were frequent and in-depth.

Waters quickly realized their global capabilities would come into play. For example, both companies had major operations in the same city in India, making it easier to deploy Waters Informatics Solutions into the facility, while ensuring consistency and smooth integration. Efficiency improved. Deliverables increased.

And with its ACQUITY UPLC® System, Waters also helped put Apotex on the fast track to success. You see, the ACQUITY UPLC System does the work of about three traditional HPLC systems, and it helped Apotex conduct mandatory bio-equivalent studies in less time. For yet another generic drug, Waters helped Apotex complete a critical U.S. FDA filing in a mere three months, reducing chemistry time from 88 to 30 days.

Because of Waters, Apotex today is better able to launch their generic drugs in the fast-paced way that leads to success. And because of Apotex’s generic medications, patients everywhere have the opportunity to be properly treated in an affordable manner.

First to market. T he ultimate pain reliever for a generic pharmaceutical company.

[ january 2010 ]

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Engineering students are not chemists. But at the University of Massachusetts, Amherst, engineering majors participate in an analytical experience normally reserved for chemists – conducting research on water contaminants.

The engineers of tomorrow collect and analyze sensitive data using the latest in high performance technology and equipment. A bit overwhelming, perhaps? Not really. Because the instruments in the laboratories at UMass-Amherst are Waters instruments. So easy to use even that wide-eyed underclassmen quickly grow comfortable operating the most sophisticated pieces of technology, like the ACQUITY UPLC® System.

And with Waters equipment comes Waters professionals. When the students were recently faced with a challenging study, a team from Waters arrived on campus to help. Patiently, they walked the students through the methodologies, even suggesting alternatives in case of problems. In the end, an analytical perplexity that would have been a brain-bender for a laboratory full of highly-trained chemists was completed by a classroom of student engineers.

T he hope of UMass-Amherst and Waters Corporation is that by involving students in this unique experience they become more attuned to the importance of water quality as both an environmental and public health issue. And armed with that knowledge, be they civil or environmental engineers, the projects they develop in the future reflect what they learned in the classroom normally reserved for chemists.

Chemist discovered inside engineering student.

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[ February 2010 ]

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Pharmavite is the company behind Nature Made,® the #1 selling broadline vitamin, mineral, and supplement brand in America. A real stickler for quality, Pharmavite won’t release a single lot of product until confirming it meets FDA requirements. As their sales keep growing, their LC systems need to keep up.

So for more speed and better performance, Pharmavite switched to Waters instrumentation: eight LCs and three ACQUITY UPLC® Systems. What a difference! The biotin assay that used to take 45 minutes is now done in 10. The Gingko Biloba report that used to take all night is now finished in a single shift. Echinacea now flies out the door in a couple of days.

The uniformity of having all Waters equipment further boosted productivity. Shared parts. Same training. Chemists can go from one system to another without confusion.

The end result for Pharmavite: greater speed, greater performance, dramatically improved productivity.

For a nutritional supplement brand about to go global, that is an easy pill to swallow.

Waters brings a healthy dose of productivity to nutritional supplement company.

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[ MarCh 2010 ]

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Skipping across the playground. Trotting off to school. Flying kites in the park. The researchers at the Centre Hospital Universitaire de Sherbrooke (CHUS) in Quebec need not look far to see reminders of why their work is so important.

The children of this French-Canadian province are the reason for a voluntary screening program to detect metabolic disorders in newborns. Parents collect urine samples from their babies at 21 days of age and bring them in for analysis: 500 samples a day, over 2.6 million samples to date.

Results have revealed over 1,800 cases of inborn errors of metabolism. Early detection offers a better chance for preventing serious conditions, such as mental retardation, metabolic acidosis, even death. It also offers the opportunity for an improved quality of life by beginning proper treatments early.

Critical to the proper diagnosis of sick patients is the analytical instrumentation. It provides the high quality results needed to put patients on the right course of treatment. It can, has, and will continue to help Quebec’s newest citizens lead healthier and longer lives.

Metabolic disorder: Find it early, save a child.

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[ april 2010 ]

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Clutching his cell phone, a farmer called his wife from the animal barn. “Help me,” was all he said. By the time anyone got to him, it was too late. The tragedy of his unexpected death was compounded by the mystery of what caused it. No signs of a crime. No clues to an accident. No previous health concerns. The sheriff was stumped.

Blood samples were sent to one of the most highly regarded forensic laboratories in the country, AIT Laboratories. Using Waters ACQUITY UPLC® System and time-of-flight Mass Spectrometry, the forensic scientists detected a compound they had never seen before. Additional research identified it as a powerful veterinary antibiotic. Safe for animals, deadly to humans.

It was later learned that the farmer had been treating animals in the barn with this drug. Somehow he lost his footing and fell to the ground, accidently injecting himself. After yanking out the syringe, he tossed it aside, before grabbing his cell phone to call his wife. For the farmer’s widow, law enforcement, and the coroner, there was finally closure. The cause of death had been identified with absolute certainty by Waters ACQUITY UPLC/MS System.

Had AIT Laboratories not been using the latest analytical equipment, the drug would not have been discovered. Another example of how Waters technology elevates testing to levels never seen before.

Farmer dies mysteriously. Only witnesses are the livestock.

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[ May 2010 ]

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The United Kingdom had a pepper problem of prodigious proportions. A 40,000-pound shipment of chili peppers was brought in from a foreign country, converted into food products, and distributed far and wide. That’s when the government discovered that the peppers contained Sudan Red, a dye that’s okay in furniture wax and floor polish, but hardly in food. The resulting food recall was one of the largest in history.

The challenge of making sure unsafe chemicals, like Sudan Red, never took another ride on a pack of peppers again fell to Certified Laboratories, a leader in food safety. They relied on Waters equipment. The low levels of detection required as well as the wide variety of products undergoing tests could not have been accomplished without Waters ACQUITY UPLC®/MS/MS System.

Aided by the American Spice Trade Council, Certified Laboratories has been able to utilize Waters technology and analytical science to detect Sudan Red in chili peppers before they enter the country.

Much of what we eat today comes from all over the world. Waters technology is helping companies like Certified Laboratories ensure the foods we import are safe for human consumption.

Problem peppers put UK in a pickle. Waters helps prevent a repeat.

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[ june 2010 ]

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Protecting the citizens of the United Kingdom from dangerous food contaminants is the job of the scientists at the Central Science Laboratory (CSL). In a single year, they will test tens of thousands of samples, running their equipment hard, 24/7.

With that kind of volume and with so much riding on the accuracy of the results, is it any wonder CSL uses Waters instrumentation? The tandem quadrupole MS system along with Waters AutoSpec Premier™ GC/MS Detector monitor for a myriad of contaminants including pesticides, veterinary drugs, and even packaging chemicals. The equipment provides extremely sensitive analysis at very high speeds.

An important combination when dealing with perishable imports like fish from the Far East. Typically, the fish are held at port while samples are taken to CSL to look for prohibited antibiotics or their residues. Since the cargo is perishable, test results are needed very quickly.

Waters high quality, speedy analysis allows the laboratory to respond rapidly and either reject the fish right there on the dock or approve it for import. Swift, accurate results like these are what continues to earn the UK a reputation for food safety vigilance.

Protecting The Empire from unseen invaders.

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[ july 2010 ]

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Members of the Drug Control Center at King’s College London are already gearing up for the 2012 Olympics. They won’t be running in any events; they’ll be running drug tests on the Olympic competitors.

Every year, more and more forbidden substances enter the athletic arena. The challenge is to detect the new drugs and to do it as quickly as possible. For the Olympics, testing results must be back in 24 hours, which means the analysis needs to be completed in about 8 hours, allowing the remaining time for possible re-testing, confirming results, gathering results, etc.

With so much at stake and the whole world watching, the toxicology team at King’s College London made a big decision – they decided to convert their analytical equipment from gas chromatography/mass spectrometry to Waters ACQUITY UPLC®/tandem MS. Why? Three reasons: 1. The analysis is significantly faster2. Prep time is significantly shorter3. Sensitivity is significantly higher because of the lower flow rates

The 2012 Olympic Games may still be years away, but the scientists at King’s College London are already off and running.

Separating record breakers from rule breakers in record time.

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[ auGuST 2010 ]

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How does a doctor determine whether a drug will work if he doesn’t know what other drugs the patient is taking? This perplexing question challenged Dominion Diagnostics, a laboratory specializing in urine drug testing and medication monitoring.

Without knowing exactly what the medications are, the number of possible drug interactions is mind-numbing. Questioning the patient is no guarantee of accuracy. With herbal remedies and nutritional supplements readily available, even patients don’t know what’s bouncing around their insides.

So what did Dominion Diagnostics do when faced with this challenge? They called Waters.

Because of the ACQUITY UPLC® MS/MS System, Dominion Diagnostics can quickly and accurately produce a metabolic profile for the patient and then deliver – in real-time – a comprehensive report and interpretation. Now able to determine the possible drug interactions on the spot, the clinician can make an immediate and fully-informed decision as to which medications are working and which are not.

Thanks to Waters, clinicians now know exactly what’s in a patient’s body, even if the patient doesn’t.

Want to know what drugs are in a patient’s body? Doctors know not to ask the patient.

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[ SepTeMber 2010 ]

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There’s a lot of pressure in the quality control lab of a fast-paced company like Alexza Pharmaceuticals. New products have to get to market as quickly as possible. The lab has to provide quick results. The faster the data turn around, the better for production and profitability. But speed is not enough. The data must also be ultra reliable and compliant with FDA regulations. If that’s not pressure enough, factor in multiple projects with tight time lines, and you can see why every test is a stress test.

Fortunately, it didn’t take long for Alexza Pharmaceuticals, a company known for their innovative products, to realize it needed an instrument equally as innovative to do the job.

Into the quality control lab rolled the ACQUITY UPLC® System from Waters.

The lab completed testing on a migraine medication in one week instead of two. Seventeen minutes instead of 90 minutes for another test. And on another drug, testing time fell from 30 minutes all the way down to 1 minute!

That’s the ACQUITY UPLC story: shorter run time, higher quality data.

And a load of pressure off the shoulders of quality control.

From a 30-minute stress test to a 1-minute waltz.

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[ oCTober 2010 ]

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At the Jaume I University in Castellon, Spain, you’ll find the Research Institute of Pesticides and Water. Scientists here focus on identifying contaminants in the environment and in food.

Recently the laboratory scientists were asked to analyze popcorn for mycotoxins. Using two new ACQUITY UPLC® Systems coupled to two Waters mass spectrometers, they quickly located the mycotoxins. Best of all, the results confirmed there was no reason to panic. The mycotoxins were well below regulated levels. Waters equipment allowed them to work much faster, as well as detect compounds at the lowest levels.

In the future, a much more daunting challenge awaits these scientists – identifying the dangerous mega-contaminants sometimes found in food today. Unregulated, these are the compounds nobody knows to search for. A classic example is melamine. It was found in baby formula and other milk products, but only after it had caused the death of four Chinese children and severe illness in hundreds of thousands.

The scientists at Jaume I University hope that by using the latest advances, like Waters ACQUITY UPLC/MS/MS Systems, they can find the unexpected contaminant and help prevent such tragic events in the future.

Some see milk. Others see mega-contaminants.

[ noveMber 2010 ]

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When the scientists at the University of Warwick (UK) are in need, they call Waters.

From the latest in analytical instrumentation and software, to just needing an ear to listen to their ideas and plans for the future. In one particular case, the necessity involved instrumentation that was only dreamt about. The scientists were studying misfolded proteins, the ones that are thought to create diseases such as Alzheimer’s and Parkinson’s. But traditional instrumentation wasn’t enough to get the job done. The university asked Waters if they could build a shape-selective mass spectrometer. It was a necessity.

As luck would have it, Waters had already been working along similar lines. So with input from the scientists, a new mass spectrometer was created. It became known as SYNAPT™ High Definition Mass Spectrometry,™ or HDMS™ for short, the first commercial shape-selective mass spectrometry instrument. Originally purchased to study misfolded proteins, it also allows the scientists at the University of Warwick to collect 200 high- quality mass spectra in 18 milliseconds.

And that’s how necessity led to a new form of mass spectrometry.

Necessity is the mother of mass spectrometry.

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[ deCeMber 2010 ]

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www.waters.comWaters and ACQUITY UPLC are registered trademarks of Waters Corporation. AutoSpec Premier, SYNAPT, High Definition Mass Spectrometry, HDMS, and The Science of What’s Possible are trademarks of Waters Corporation. All other trademarks are the property of their respective owners.

©2009 Waters Corporation. Printed in the U.S.A.October 2009 720001963EN LB-CP

2010waterswallcalendar

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