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Nanomedicine and Nanobiology Research and CBET

Nanomedicine WorkshopAugust 27, 2007

Judy RaperDivision Director, Chemical, Bioengineering, Environmental & Transport Systems

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OUTLINE

NSF, ENG and External ForcesCBET Organization Budget and TrendsNanomedicine and Nanobiology ResearchFunding OpportunitiesQuestions

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NSF, ENG & EXTERNAL FORCES

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National Research Funding

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NSF Twenty Year Budget by Accountin Millions of Current Dollars

0

500

1,000

1,500

2,000

2,500

3,000

3,500

4,000

4,500

5,000

5,500

6,000

6,500

88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07Req

08Req

Fiscal Year

Millions of Current Dollars

Research & Related Activities Education & Human ResourcesAcademic Research Infrastructure Major Research Equipment & Facilities ConstructionAgency Operations and Award Management Office of Inspector GeneralNational Science Board

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American Competitiveness Initiative The centerpiece of American

Competitiveness Initiative (ACI) is to double the federal investment in key agencies that support basic research in physical sciences and engineering.

Over the next 10 years, the Federal agencies impacted are NSF, DOE Science, and NIST.

ACI includes three broad components: Research in physical sciences and engineering

(including 12 specific goals with 7 related to NSF) Research and Development tax incentives Education and workforce

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American Competitiveness InitiativeFY 2007 – FY 2016

Source: OSTP, Feb. 2006

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CBET Organization

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CBET Vision and Mission VISION

CBET will be a global leader in identifying and enabling the most innovative research and education at the frontiers of engineering; inspiring the integration of physical, mathematical and/or life sciences with engineering; and cultivating a vibrant, diverse community in key, emerging and core areas benefiting society.

MISSION CBET will promote and support transformative research and education in

engineering areas based on the physical, life and/or mathematical sciences; advance scientific and engineering knowledge; and develop a diverse, globally engaged workforce enhancing the economy of the United States.

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Chemical, Biochemical, and Biotechnology

Systems

Chemical, Biochemical, and Biotechnology

Systems

Biomedical Engineering and

EngineeringHealthcare

Biomedical Engineering and

EngineeringHealthcare

Transport andThermal FluidsTransport andThermal Fluids

Process and Reaction Engineering

Maria Burka

Process and Reaction Engineering

Maria Burka

Catalysis andBiocatalysis

John Regalbuto

Catalysis andBiocatalysis

John Regalbuto

EnvironmentalEngineering and

Sustainability

EnvironmentalEngineering and

Sustainability

Chemical, Bioengineering, Environmental, and Transport Systems

Biotechnology, Biochemical

& Biomass EngFred Heineken

Biotechnology, Biochemical

& Biomass EngFred Heineken

Chemical andBiological Separations

Rose Wesson

Chemical andBiological Separations

Rose Wesson

Thermal Transport Processes

Pat Phelan

Thermal Transport Processes

Pat Phelan

Interfacial Processes And Thermodynamics

Bob Wellek

Interfacial Processes And Thermodynamics

Bob Wellek

Particulate andMultiphase Processes

Marc Ingber

Particulate andMultiphase Processes

Marc Ingber

Fluid Dynamics Bill Schultz

Fluid Dynamics Bill Schultz

Combustion, Fire, andPlasma SystemsPhil Westmoreland

Combustion, Fire, andPlasma SystemsPhil Westmoreland

Research to Aid Persons

With DisabilitiesBob Jaeger

Research to Aid Persons

With DisabilitiesBob Jaeger

Biomedical Engineering

Semahat Demir

Biomedical Engineering

Semahat Demir

Biophotonics, Imaging & Sensing for Healthcare

Leon Esterowitz

Biophotonics, Imaging & Sensing for Healthcare

Leon Esterowitz

EnvironmentalEngineeringMarshall Lih

EnvironmentalEngineeringMarshall Lih

EnvironmentalTechnologyCindy Ekstein

EnvironmentalTechnologyCindy Ekstein

Energy forSustainability

Trung Van Nguyen

Energy forSustainability

Trung Van Nguyen

EnvironmentalSustainability

Bruce Hamilton

EnvironmentalSustainability

Bruce Hamilton

Division DirectorJudy Raper

Division DirectorJudy Raper

Deputy Division DirectorBob Wellek

Deputy Division DirectorBob Wellek

Senior AdvisorMarshall Lih

Senior AdvisorMarshall Lih

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Budget and Trends

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Engineering FY 2008 Budget RequestDollars in Millions

        Change over

FY 2006 FY 2007 FY 2008 FY 2007Request

  Actual Request Request Amt %

CBET $125.09 $124.44 $144.97 $20.53 16.5%

CMMI 148.82 152.16 174.08 21.92 14.4%

ECCS 77.91 80.90 93.96 13.06 16.1%

IIP 109.65 120.08 128.39 8.31 6.9%

Small Business Innovation Research (SBIR) 99.45 108.88 116.41 7.53 6.9%

EEC 123.99 125.97 116.90 -9.07 -7.2%

EFRI

- 25.00 25.00 - -

Total, ENG $585.46 $628.55 $683.30 $54.75 8.7%

(Totals may not add due to rounding.)

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ENG and NSF Funding RatesResearch Grants

EN

G P

rop

os a

l s a

nd

Aw

ard

sF

un

din

g R

ate Percen

t

0

1000

2000

3000

4000

5000

6000

7000

FY 2000 FY 2001 FY 2002 FY 2003 FY 2004 FY 2005 FY 2006 FY 2007Request

FY 2008Projection

0%

5%

10%

15%

20%

25%

30%

35%

ENG Proposals ENG Awards ENG Funding Rate NSF Funding Rate

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CBET Success Rates

Proposals Received

0

500

1000

1500

2000

2500

2002 2003 2004 2005 2006 2007

Year

Number of proposals

Unsolicited proposals

All actions

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CBET Research ThemesFY 2008

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CBET Research Thematic Areas Energy, Water and Sustainability

closely aligns with the ACI goals of hydrogen and solar energy, and research critical to alternative energy.

Nanoscience and Engineering encourage utilization of research results in

active nanosystems and devices

Systems and Multi-scale Approaches overcoming barriers to quantum information

processing

Integration of Life Sciences in Engineering Research Gain advantages of “Genomic” revolution by

application of engineering way of thinking

VLP (Virus-Like Particle) with attached vaccine activators produced by the cell-free process

Swartz, Stanford

Structure of Virus used for Cancer Therapy Young, Montana State University

Freeman, Texas

Des Jardin,

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Exploitation of Self-Organization in Virus-like Particles (VLPs)

Protein-protein interactions lead to the formation of a regular capsid (protein shell of a virus)

B. DragneaIndiana University

VLP Assembly Mechanism

Electrostatic interaction leads to the formation of disordered protein-silver complexes

Symmetric protein shells (blue) assembled around functionalized metallic cores (yellow) provide for crystallization of 3D structures

Biotechnology, Biochemical and Biomass Engineering (BBB)

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Darrell J. Irvine, MIT

CAREER: Colloidal micelles as multifunctional vaccines

Chemoattracting microspheres:• Chemoattractants released from hydrogel ‘carrier’ microspheres draw

immune cells (dendritic cells) to nanoparticles for delivery of multiple drug signals

• Nanoparticles containing drug are sequestered inside carrier microsphere until phagocytosed by attracted dendritic cell

Biomedical Engineering (BME)

Darrell Irvine, MIT

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ARTIFICIAL RETINA SYSTEMMark Humayan - USC

Array of tiny electrodes attached to inner surface of retina Currently uses an external camera Miniature intraocular camera fits within lens sac Allows natural movement of the eye to scan the environment

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Chemical, Biochemical and Biotechnology Systems

Suzie Pun, U. of Washington

A Synthetic Delivery

Vehicle for Gene Transfer - “hitchhike” gene delivery nanoparticles

onto motor protein complexes

- convert chemical energy to mechanical work

- carry nanoparticle cargo toward cell nuclei

Bloodless Biosensing with Carbon Nanotubes- implantable capillary devices- filled with carbon nanotubes- monitor glucose levels - without drawing blood- for diabetes and other biosensors

Michael Strano, UIUC

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FUNDING OPPORTUNITIES

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Opportunities for Engineering at NSF Disciplinary Research Programs

Investigator initiated awards (unsolicited) February 1 – March 1 August 15 – September 15

CAREER awards July 18

SGER awards Supplements Workshops, Conferences

Engineering Education and Centers (EEC) Engineering Research Centers (ERC) Research Experiences for Undergraduates (REU) Sites Research Experiences for Teachers (RET) Sites Unsolicited Education awards

Industrial Innovation and Partnerships (IIP) Partnership for Innovation Industry/University Cooperative Research Centers SBIR/STTR Programs GOALI Awards

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Opportunities for Engineering at NSF (cont’d)

Office of Integrative Affairs (IA) Science and Technology Centers (STC)

Directorate of Computer Information Science and Engineering (CISE) Division of Experimental & Integrative Affairs Combined Research Curriculum Development & Educational

Innovation Program (CRCD)

Directorate of Education and Human Resources (EHR) Division of Undergraduate Education (DUE)

Course, Curriculum, and Laboratory Improvement (CCLI) Division of Graduate Education (DGE)

Integrative Graduate Education and Research Training (IGERT)

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Cyber-Enabled Discovery & Innovation (CDI) “Broaden the Nation’s capability for innovation by developing a new

generation of computationally based discovery concepts and tools to deal with complex, data-rich, and interacting systems.”

ENG broadly supports research in advanced cyber-enabled engineering throughout all its divisions.

CDI investments areas include: Complex interactions Computational experimentation Knowledge extraction Virtual environments Education in computational discovery

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CAREER

The Faculty Early Career Development (CAREER) Program: a Foundation-wide activity that offers the NSF’s most prestigious awards for new faculty members.

Recognizes and supports the early career-development activities of those teacher-scholars who are most likely to become the academic leaders of the 21st century.

Awardees selected on the basis of creative, career-development plans that integrate research and education.

Full Proposal Deadline Date: July 17/18/19, 2008

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Grant Opportunities for Academic Liaison with Industry (GOALI)

Improve the nation’s capacity for intellectual and economic growth by serving as a catalyst for university and industry partnerships Effective mechanism for transfer of knowledge between academe and

industry Promotes fundamental research topics not undertaken by industry Supports industry-university educational programs

Aims to synergize industry-university partnerships by enabling linkages: Interdisciplinary university-industry collaborative projects (up to 3 years) Faculty, postdoctoral fellows and students in industry (up to 1 year) Industry engineers and scientists in academe (up to 1 year)

Supported by all NSF Directorates

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Small Grants for Exploratory Research (SGER)

High-risk research in the fields of science, engineering and education

Preliminary work on untested and novel ideas Ventures into emerging research areas Application of new expertise or new approaches to research

topics Quick-response research on unanticipated events Efforts to catalyze rapid and innovative advances

submit to individual programs only after discussion with Program Manager

two-to-five pages; the maximum award amount is $200,000 for 2 year $20-50k much more common – PD is limited in total amount he/she can

award as SGERs

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Emerging Frontiers in Research and Innovation (EFRI)

~$25 million each year Topics change each year Pre-proposal required PI plus two co-PIs from at least three disciplines $500,000/year for 4 years FY 2008 Topics

Resilient and Sustainable Infrastructure Design, renew, expand, monitor, and control critical interdependent infrastructures to

be both resilient and sustainable

Cognitive Optimization and Prediction through Reverse Engineering

Understanding subsymbolic intelligence can lead to development of new designs and algorithms for optimal decision making and prediction in engineered systems

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COGNITIVE OPTIMIZATION AND PREDICTION: FROM NEURAL SYSTEMS TO NEUROTECHNOLOGY (COPN)

to understand how massively parallel circuits in brains and the associated system identification circuits address complex tasks in adaptive optimal decision-making and prediction.

to develop cognitive engineered designs or algorithms for optimal dynamic decision-making and/or prediction.

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Important Information (NSF 07-579)

Proposal Information Team Proposals Only:

3 or more PIs 3 or more disciplines

Award size will depend on the type of research program proposed Up to 4 years in duration Up to $500K/year (direct and indirect cost)

FY08 Dates Sep 5, 2007 Information Webcast Sep 25, 2007 Letters of Intent Due (required) Oct 26, 2007 Preliminary Proposals Deadline Apr 30, 2008 Full Proposals Deadline

(by invitation)

www.nsf.gov/eng/efri

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Thank You

Questions