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Nanomedicine and Nanobiology Research and CBET
Nanomedicine WorkshopAugust 27, 2007
Judy RaperDivision Director, Chemical, Bioengineering, Environmental & Transport Systems
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OUTLINE
NSF, ENG and External ForcesCBET Organization Budget and TrendsNanomedicine and Nanobiology ResearchFunding OpportunitiesQuestions
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NSF Twenty Year Budget by Accountin Millions of Current Dollars
0
500
1,000
1,500
2,000
2,500
3,000
3,500
4,000
4,500
5,000
5,500
6,000
6,500
88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07Req
08Req
Fiscal Year
Millions of Current Dollars
Research & Related Activities Education & Human ResourcesAcademic Research Infrastructure Major Research Equipment & Facilities ConstructionAgency Operations and Award Management Office of Inspector GeneralNational Science Board
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American Competitiveness Initiative The centerpiece of American
Competitiveness Initiative (ACI) is to double the federal investment in key agencies that support basic research in physical sciences and engineering.
Over the next 10 years, the Federal agencies impacted are NSF, DOE Science, and NIST.
ACI includes three broad components: Research in physical sciences and engineering
(including 12 specific goals with 7 related to NSF) Research and Development tax incentives Education and workforce
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CBET Vision and Mission VISION
CBET will be a global leader in identifying and enabling the most innovative research and education at the frontiers of engineering; inspiring the integration of physical, mathematical and/or life sciences with engineering; and cultivating a vibrant, diverse community in key, emerging and core areas benefiting society.
MISSION CBET will promote and support transformative research and education in
engineering areas based on the physical, life and/or mathematical sciences; advance scientific and engineering knowledge; and develop a diverse, globally engaged workforce enhancing the economy of the United States.
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Chemical, Biochemical, and Biotechnology
Systems
Chemical, Biochemical, and Biotechnology
Systems
Biomedical Engineering and
EngineeringHealthcare
Biomedical Engineering and
EngineeringHealthcare
Transport andThermal FluidsTransport andThermal Fluids
Process and Reaction Engineering
Maria Burka
Process and Reaction Engineering
Maria Burka
Catalysis andBiocatalysis
John Regalbuto
Catalysis andBiocatalysis
John Regalbuto
EnvironmentalEngineering and
Sustainability
EnvironmentalEngineering and
Sustainability
Chemical, Bioengineering, Environmental, and Transport Systems
Biotechnology, Biochemical
& Biomass EngFred Heineken
Biotechnology, Biochemical
& Biomass EngFred Heineken
Chemical andBiological Separations
Rose Wesson
Chemical andBiological Separations
Rose Wesson
Thermal Transport Processes
Pat Phelan
Thermal Transport Processes
Pat Phelan
Interfacial Processes And Thermodynamics
Bob Wellek
Interfacial Processes And Thermodynamics
Bob Wellek
Particulate andMultiphase Processes
Marc Ingber
Particulate andMultiphase Processes
Marc Ingber
Fluid Dynamics Bill Schultz
Fluid Dynamics Bill Schultz
Combustion, Fire, andPlasma SystemsPhil Westmoreland
Combustion, Fire, andPlasma SystemsPhil Westmoreland
Research to Aid Persons
With DisabilitiesBob Jaeger
Research to Aid Persons
With DisabilitiesBob Jaeger
Biomedical Engineering
Semahat Demir
Biomedical Engineering
Semahat Demir
Biophotonics, Imaging & Sensing for Healthcare
Leon Esterowitz
Biophotonics, Imaging & Sensing for Healthcare
Leon Esterowitz
EnvironmentalEngineeringMarshall Lih
EnvironmentalEngineeringMarshall Lih
EnvironmentalTechnologyCindy Ekstein
EnvironmentalTechnologyCindy Ekstein
Energy forSustainability
Trung Van Nguyen
Energy forSustainability
Trung Van Nguyen
EnvironmentalSustainability
Bruce Hamilton
EnvironmentalSustainability
Bruce Hamilton
Division DirectorJudy Raper
Division DirectorJudy Raper
Deputy Division DirectorBob Wellek
Deputy Division DirectorBob Wellek
Senior AdvisorMarshall Lih
Senior AdvisorMarshall Lih
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Engineering FY 2008 Budget RequestDollars in Millions
Change over
FY 2006 FY 2007 FY 2008 FY 2007Request
Actual Request Request Amt %
CBET $125.09 $124.44 $144.97 $20.53 16.5%
CMMI 148.82 152.16 174.08 21.92 14.4%
ECCS 77.91 80.90 93.96 13.06 16.1%
IIP 109.65 120.08 128.39 8.31 6.9%
Small Business Innovation Research (SBIR) 99.45 108.88 116.41 7.53 6.9%
EEC 123.99 125.97 116.90 -9.07 -7.2%
EFRI
- 25.00 25.00 - -
Total, ENG $585.46 $628.55 $683.30 $54.75 8.7%
(Totals may not add due to rounding.)
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ENG and NSF Funding RatesResearch Grants
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G P
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ate Percen
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FY 2000 FY 2001 FY 2002 FY 2003 FY 2004 FY 2005 FY 2006 FY 2007Request
FY 2008Projection
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10%
15%
20%
25%
30%
35%
ENG Proposals ENG Awards ENG Funding Rate NSF Funding Rate
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CBET Success Rates
Proposals Received
0
500
1000
1500
2000
2500
2002 2003 2004 2005 2006 2007
Year
Number of proposals
Unsolicited proposals
All actions
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CBET Research Thematic Areas Energy, Water and Sustainability
closely aligns with the ACI goals of hydrogen and solar energy, and research critical to alternative energy.
Nanoscience and Engineering encourage utilization of research results in
active nanosystems and devices
Systems and Multi-scale Approaches overcoming barriers to quantum information
processing
Integration of Life Sciences in Engineering Research Gain advantages of “Genomic” revolution by
application of engineering way of thinking
VLP (Virus-Like Particle) with attached vaccine activators produced by the cell-free process
Swartz, Stanford
Structure of Virus used for Cancer Therapy Young, Montana State University
Freeman, Texas
Des Jardin,
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Exploitation of Self-Organization in Virus-like Particles (VLPs)
Protein-protein interactions lead to the formation of a regular capsid (protein shell of a virus)
B. DragneaIndiana University
VLP Assembly Mechanism
Electrostatic interaction leads to the formation of disordered protein-silver complexes
Symmetric protein shells (blue) assembled around functionalized metallic cores (yellow) provide for crystallization of 3D structures
Biotechnology, Biochemical and Biomass Engineering (BBB)
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Darrell J. Irvine, MIT
CAREER: Colloidal micelles as multifunctional vaccines
Chemoattracting microspheres:• Chemoattractants released from hydrogel ‘carrier’ microspheres draw
immune cells (dendritic cells) to nanoparticles for delivery of multiple drug signals
• Nanoparticles containing drug are sequestered inside carrier microsphere until phagocytosed by attracted dendritic cell
Biomedical Engineering (BME)
Darrell Irvine, MIT
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ARTIFICIAL RETINA SYSTEMMark Humayan - USC
Array of tiny electrodes attached to inner surface of retina Currently uses an external camera Miniature intraocular camera fits within lens sac Allows natural movement of the eye to scan the environment
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Chemical, Biochemical and Biotechnology Systems
Suzie Pun, U. of Washington
A Synthetic Delivery
Vehicle for Gene Transfer - “hitchhike” gene delivery nanoparticles
onto motor protein complexes
- convert chemical energy to mechanical work
- carry nanoparticle cargo toward cell nuclei
Bloodless Biosensing with Carbon Nanotubes- implantable capillary devices- filled with carbon nanotubes- monitor glucose levels - without drawing blood- for diabetes and other biosensors
Michael Strano, UIUC
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Opportunities for Engineering at NSF Disciplinary Research Programs
Investigator initiated awards (unsolicited) February 1 – March 1 August 15 – September 15
CAREER awards July 18
SGER awards Supplements Workshops, Conferences
Engineering Education and Centers (EEC) Engineering Research Centers (ERC) Research Experiences for Undergraduates (REU) Sites Research Experiences for Teachers (RET) Sites Unsolicited Education awards
Industrial Innovation and Partnerships (IIP) Partnership for Innovation Industry/University Cooperative Research Centers SBIR/STTR Programs GOALI Awards
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Opportunities for Engineering at NSF (cont’d)
Office of Integrative Affairs (IA) Science and Technology Centers (STC)
Directorate of Computer Information Science and Engineering (CISE) Division of Experimental & Integrative Affairs Combined Research Curriculum Development & Educational
Innovation Program (CRCD)
Directorate of Education and Human Resources (EHR) Division of Undergraduate Education (DUE)
Course, Curriculum, and Laboratory Improvement (CCLI) Division of Graduate Education (DGE)
Integrative Graduate Education and Research Training (IGERT)
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Cyber-Enabled Discovery & Innovation (CDI) “Broaden the Nation’s capability for innovation by developing a new
generation of computationally based discovery concepts and tools to deal with complex, data-rich, and interacting systems.”
ENG broadly supports research in advanced cyber-enabled engineering throughout all its divisions.
CDI investments areas include: Complex interactions Computational experimentation Knowledge extraction Virtual environments Education in computational discovery
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CAREER
The Faculty Early Career Development (CAREER) Program: a Foundation-wide activity that offers the NSF’s most prestigious awards for new faculty members.
Recognizes and supports the early career-development activities of those teacher-scholars who are most likely to become the academic leaders of the 21st century.
Awardees selected on the basis of creative, career-development plans that integrate research and education.
Full Proposal Deadline Date: July 17/18/19, 2008
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Grant Opportunities for Academic Liaison with Industry (GOALI)
Improve the nation’s capacity for intellectual and economic growth by serving as a catalyst for university and industry partnerships Effective mechanism for transfer of knowledge between academe and
industry Promotes fundamental research topics not undertaken by industry Supports industry-university educational programs
Aims to synergize industry-university partnerships by enabling linkages: Interdisciplinary university-industry collaborative projects (up to 3 years) Faculty, postdoctoral fellows and students in industry (up to 1 year) Industry engineers and scientists in academe (up to 1 year)
Supported by all NSF Directorates
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Small Grants for Exploratory Research (SGER)
High-risk research in the fields of science, engineering and education
Preliminary work on untested and novel ideas Ventures into emerging research areas Application of new expertise or new approaches to research
topics Quick-response research on unanticipated events Efforts to catalyze rapid and innovative advances
submit to individual programs only after discussion with Program Manager
two-to-five pages; the maximum award amount is $200,000 for 2 year $20-50k much more common – PD is limited in total amount he/she can
award as SGERs
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Emerging Frontiers in Research and Innovation (EFRI)
~$25 million each year Topics change each year Pre-proposal required PI plus two co-PIs from at least three disciplines $500,000/year for 4 years FY 2008 Topics
Resilient and Sustainable Infrastructure Design, renew, expand, monitor, and control critical interdependent infrastructures to
be both resilient and sustainable
Cognitive Optimization and Prediction through Reverse Engineering
Understanding subsymbolic intelligence can lead to development of new designs and algorithms for optimal decision making and prediction in engineered systems
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COGNITIVE OPTIMIZATION AND PREDICTION: FROM NEURAL SYSTEMS TO NEUROTECHNOLOGY (COPN)
to understand how massively parallel circuits in brains and the associated system identification circuits address complex tasks in adaptive optimal decision-making and prediction.
to develop cognitive engineered designs or algorithms for optimal dynamic decision-making and/or prediction.
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Important Information (NSF 07-579)
Proposal Information Team Proposals Only:
3 or more PIs 3 or more disciplines
Award size will depend on the type of research program proposed Up to 4 years in duration Up to $500K/year (direct and indirect cost)
FY08 Dates Sep 5, 2007 Information Webcast Sep 25, 2007 Letters of Intent Due (required) Oct 26, 2007 Preliminary Proposals Deadline Apr 30, 2008 Full Proposals Deadline
(by invitation)
www.nsf.gov/eng/efri