xxxv sunbelt conference connect with spru … · • science and technology policy! ... innovation...

The Emergence of Molecular Biology in the Diagnosis of Cervical Cancer: A Network Perspective !

Rotolo Daniele (SPRU, University of Sussex, [email protected], www.danielerotolo.com, @danielerotolo),!Michael M. Hopkins (SPRU, University of Sussex), Ismael Rafols (INGENIO, Universitat Politecnica de Valencia),!

Stuart Hogarth (Dept. of Social Science, Health and Medicine, King's College London)!

Tie formation (dyad)!

•  How do different institutional groups of actors shape technological emergence through inter-organisational networks? !

•  How does the role of institutional groups in inter-organisational networks evolve over the emergence process?!

Research questions!

Brokerage roles (triad)!

Co-

auth

orsh

ip n

etw

ork!

log2 number of !publications!

Research and Higher Education (RHE) !Universities, university hospitals, medical centres (involved in teaching activities), colleges and schools, research centres/institutes!

co-authorship!

Industry (IND) !Pharmaceutical and biotechnology firms, consultants, laboratories (when independent from other organisations) !

Governmental (GOV) !Nat./pub. agencies/bureaus, health boards, nat. institutes, registries, nat. labs, pub. dept., councils, nat. programmes/initiatives, ministries, regional centres, international organisations supported by governments !

Non-governmental (NGO) !Societies, associations, other non-profit organisations, charities, foundations !

Hospitals and Care (HC) !Medical centres, clinics, infirmaries, cancer centres, medical groups/associates, healthcare providers !

Other (OT) !Organisations not in the previous categories !

•  4,721 publications from 1980 to 2011 –MEDLINE/PubMed data matched with Scopus (Rotolo & Leydesdorff, 2015)!

•  Query based on MeSH (Medical Subject Headings): descriptors (uterine cervical neoplasms, uterine cervical dysplasia, cervical intraepithelial neoplasia) and !qualifier (diagnosis)!

•  3,072 affiliations (harmonisation of 9,806 variations of affiliation names)!

•  Science and Technology Policy!Emerging technologies as technology capable of changing the the status quo (e.g. Rotolo et al. 2015RP, Small et al. 2014RP)!

•  (Evolutionary) Economics !Technological trajectories/paradigms (e.g. Dosi 1982RP), lock-in and path dependence (e.g. David 1985AER) !

•  Science and Technology Studies (STS) Socio-technical regimes, visions, expectations and directionality of technological developments (e.g. Geels 2002RP, Stirling and Scoones 2009ES)!

•  The role of inter-organisational networks!Inter-organisational relationships as enabling actors to engage with the ‘problematisations’ of an emerging technology (Blume 1992)!!Innovation is “commonly found in the interstices between firms, universities, research laboratories, suppliers, and customer” (Powell 1990: 118) !!Ties provide actors with access to knowledge and resources, whereas the configurations of these relationships may affect power distribution (e.g. Brass 1992)!

Conceptual framework!

Data!

Findings!•  Ties with HC in the early phase of emergence are

important for most groups, especially for RHE, IND!

•  All institutional groups form predominantly inter-group ties, except RHE!

•  All groups perform the full variety of (‘intra’ and ‘between’ groups) brokering roles to some extent!

•  The predominant forms of brokering roles played by different institutional groups are relatively stable during the emergence process, although the intensity of brokerage activity varies over time!

•  NGOs and IND actors play a similar role as !liaison-type brokers!

Funded by

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Project: RES-360-25-0076

RHE!

GOV!

HC!

IND!

NGO!

•  Cervical cancer: one of the most common cancers among women – about 528,000 new cases and 266,000 deaths each year (WHO 2012)!

•  Human Papilloma Virus (HPV) as its association with cervical cancer!!

•  The emergence of diagnosis: !Pap vs. HPV test!

Year

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pathologydiagnosisradiotherapyprevention & controlsurgeryvirologyepidemiologytherapydrug therapygenetics

1992

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2007

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2011

RHE−NGORHE−INDRHE−HCRHE−GOVRHE−RHE

Year (end of the time window)

Num

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f tie

s

0

500

1000

1500

2000

2500

1992

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1996

1997

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2004

2005

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Prop

ortio

n of

ties

0

20

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100

1992

1993

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1995

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2001

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GOV−NGOGOV−INDGOV−HCGOV−RHEGOV−GOV


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HC−NGOHC−INDHC−GOVHC−RHEHC−HC


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IND−NGOIND−HCIND−GOVIND−RHEIND−IND


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1992

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NGO−INDNGO−HCNGO−GOVNGO−RHENGO−NGO

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1.0


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Prob

abilit

y to

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1996 1998 2000 2002 2004 2006 2008 2010

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0.4

0.6

0.8

1.0


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Prob

abilit

y to

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ker

1996 1998 2000 2002 2004 2006 2008 2010

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1.0


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Prob

abilit

y to

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ker

1996 1998 2000 2002 2004 2006 2008 2010

0.0

0.2

0.4

0.6

0.8

1.0


XXXV SUNBELT Conference!Brighton (UK), 23-29 June 2015!

xxxv sunbelt conference connect with spru … · • science and technology policy! ... innovation...

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