workshop: dressing selection - rcsi.ie · •also called ‘biologic debridement’ •most...
TRANSCRIPT
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WORKSHOP: DRESSING SELECTION - BIOLOGICAL DRESSINGS - PAIN ASSESSMENTMr. Steven Smet, University Hospital Ghent, Belgium Ms. Emer Shanley, RGN in Community care, Co. Cork, Ireland
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Speaker Name: Steven Smet
I have no financial interests or relationships to disclose with regard to the subject matter of this presentation.
Declaration of
Financial Interests or Relationships
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Learning objectives
• At the end of this lecture, students will be able to: – Differentiate between the different debridement options
– describe best practices for dressing selection
– Distinguish between the most common available wound dressing groups
– Make a correct choice in wound dressing, based on the general principles of wound healing and the characteristics of the wound dressing
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TIME principles
• T: Tissue– Based on following references:
• Anghel EL et. al. Current concepts in Debridement: Science and strategies. American Society of Plastic Surgeons. 2016; 138(3S): 82S-93S
• EWMA Document: Debridement. An updated overview and clarification of the principle role of debridement. Journal of Wound Care. 2013; 22(1): 1-49
• National Pressure Ulcer Advisory Panel, European Pressure Ulcer Advisory Panel and Pan Pacific Pressure Injury Alliance. Prevention and Treatment of Pressure Ulcers: Quick Reference Guide. Emily Haesler (Ed.). Cambridge Media: Osborne Park, Australia; 2014.
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TIME principles: Tissue
• Recommendations?– Debride devitalized tissue within the wound bed
or edge of pressure ulcers• Only when there’s adequate perfusion to the wound!
– Debride the wound bed when the presence of biofilm is suspected orconfirmed
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TIME principles: Tissue
• Recommendations?– Select the debridement method(s) most
appropriate to the individual, the wound bed and the clinical setting• A variety of surgical and non-surgical strategies
available but non have proven completely effective in a certain setting…
• Multimodal approach to remove necrotic (infected) tissue, biofilm and/or senescent cells
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TIME principles: Tissue
Anghel E et. al., 2016
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TIME principles: Tissue
Anghel E et. al., 2016
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TIME principles: Tissue
• Painfull and traumatic solution
• Insufficient for adequate wound bed preparation
• Outlayer: Gentle mechanicaldebridement (Debrisoft®)
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TIME principles: Tissue
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TIME principles: Tissue
• Also called ‘biologic debridement’
• Most important groups:
– Autolytic debridement
• Hydrogels, hydrocolloids, foam dressings
• Stimulation of endogenous proteolytic enzymes– Digestion of necrotic tissue
– Stimulation of granulation tissue
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TIME principles: Tissue
• Also called ‘biologic debridement’
• Most important groups:
– Autolytic debridement
• Some evidence of hydrogel on dry, non infected cat 3-4 pressure ulcers
• Some evidence of hydrocolloïd dressing on cat 2 pressure ulcers…
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TIME principles: Tissue
• Also called ‘biologic debridement’
• Most important groups:
– Autolytic debridement
• Some evidence of advantage of foam dressings abovehydrocolloids in exudate management of cat 2 PU
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TIME principles: T
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TIME principles: Tissue
• Also called ‘biologic debridement’
• Most important groups:– Enzymatic debridement
• Ointments with collagenases and proteases
• No specific literature of usage on pressureulcers
• Exudating wound is necessary
• Protect the wound edges
• Ex. Iruxol®, Hyalo® 4 start
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TIME principles: Tissue
• Also called ‘biologic debridement’
• Most important groups:
– Osmotic debridement
• Medicinal honey (FDA approved as wound dressing, notas debriding or antimicrobial agent…)
• Alginates / hydrofibers
• Dextranomer / cadexomer Iodine dressings
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TIME principles: Tissue
• Cost-effective alternative for treating drug-resistant chronically infected wounds
• Patients who are poor operative candidates
• Most studies in patients with diabetic footulcers
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TIME principles: Tissue
• Standard of care withnecrotic infected(pressure ulcer) wounds
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Case
14/01
After bedside sharp debridement
After first sharp debridement -> flap surgery
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TIME principles: Moisture
• Recent new consensus document
– World Union of Wound Healing Societies (WUWHS) Consensus Document. Wound exudate: effective assessment and management
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TIME principles: Moisture• Definition exudate:
– Exuded matter; especially the material composed of serum, fibrin, and white blood cells that escapes into a superficial lesion or area of inflammation” (Merriam-Webster Dictionary, 2018).
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TIME principles: Moisture• exudate production is highest during the inflammatory
phase and decreases as healing progresses (Schultz et al, 2011).
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TIME principles: Moisture• Although it is clear too much or insufficient exudate
delays healing, there is no internationally accepted standard method for measuring the rate of exudate production nor is there an accepted ‘normal’ rate
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TIME principles: Moisture• Definition
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TIME principles: Moisture• Definition
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TIME principles: Moisture
• Local management of wound exudate
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TIME principles: Moisture
• Ideal situation: moist environment– No exudate: Hydrogels
– Moderate exuding: Foam dressings, alginogels, honey, dextranomer / cadexomer, alginates, fibredressings
– Heavy exuding: Superabsorbers, honey, dextranomer / cadexomer, alginates, fibredressings, NPWT
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TIME principles: Moisture
• Ideal situation: moist environment
– Adapted bandages for ‘thick’ exudate (ex. Mepilex® XT)
– Be careful with hydrocolloids…
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Wound barrier protection
• Working mechanism– Transparent barrier film at the wound edges and
wound environment– Film stays in place for more or less 72 hours– Repeat every 24-48h
• Points of attention?– Apply on dry skin– Don’t apply to frequent– Apply on all the affected zones
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Wound barrier protection
• Werking– Protective barrier with zinc oxide
– Light repair effect, additional antimycotic effect withDaktozin
• Points of attention– No observation possible.
– Agressive removal
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TIME principles: Tissue and Moisture
• Negative Pressure Wound Therapy (withinstillation)
– Recommendation: Consider NPWT as an earlyadjuvant for the treatment of deep cat 3 or 4 pressure ulcers
• Not on necrotic wounds and/or dry wounds
• Only applied by professionals
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TIME principles: Tissue and Moisture• Negative Pressure Wound Therapy (with
instillation)
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TIME principles: Tissue and Moisture
• Negative Pressure Wound Therapy (withinstillation)
– Often as wound bed preparation beforereconstructive surgery
• Increased local blood flow and granulation
• Decrease of oedema
• Exudate control / control of bacterial proliferation
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TIME principles: Tissue and Moisture
• Negative Pressure Wound Therapy withinstillation– Can significantly reduce the wound bioburden– Not clear yet which solution to instill
– With PU reconstructive surgery?• High tension incisions• Repetitive incisions• AND high risk patient
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TIME principles: Tissue and Moisture• Negative Pressure
Wound Therapy forsurgical incisionmanagement
World Union of Wound Healing Societies (WUWHS) Consensus Document. Closed surgical incisionmanagement: understanding the role of NPWT. Wounds International, 2016
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TIME principles: Tissue and Moisture• Negative Pressure Wound Therapy for surgical incision
management– WHO recommendations for surgical site prevention 2016
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Prevena®?
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TIME: Epithelialization
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Non-migrating or underminedepidermal edge• Absence of
– necrosis, – infection and – excessive exsudate
but yet no progression in wound healing (insufficient granulation and epithelialisation)
• R/ need for– revision of the diagnosis– active stimulation of (granulation and) epithelialisation
=> surgery=> biological wound dressings=> biophysical agents
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Epidermal edges
6/12 13/12
29/11
20/12
easily epithelialising wound
difficultly epithelialising wound
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Non-migrating or underminedepidermal edge• Absence of
– necrosis,
– infection and
– excessive exsudate
but yet no progression in wound healing (insufficient granulation and epithelialisation)
• R/ need for– active stimulation of (granulation and) epithelialisation
=> biological wound dressings
=> biophysical agents
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High tech biological dressings• Products which inactivate proteinases (MMP’s)
– Eg. Dermax®, Promogran®
• Products that contain ECM components
– Collagen dressings
• Eg. Hyalo regen®, Promogran®,
– Hyaluronic acid dressings
• Eg. Hyalo skin®
• Isolated growth factors (eg. Recombinant PDGF (Regranex®)
• Amniotic membrane
• Skin cell cultures
• Skin equivalents (tissue engineered skin)
• Eg. Apligraf®, Dermagraft®
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Need for more than conventional treatment
• Large wounds: conventional treatment is not feasable
– extensive burn wounds
– epidermolysis bullosa
• Hard to heal chronic wounds:conventional treatment is not effective
– Pressure ulcers
– Diabetic ulcers
– vascular ulcers...
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Need for more than conventional treatment
• Wound dressing– insufficient because of depth or extension of the injury
• Need for replacement of diseased or injured tissue– autologous skin graft = gold standard
• not always available in sufficient amount
• sometimes deficient due to underlying disease
– allogeneic skin graft (donor tissue)
• severe and growing shortage of human organs and tissues => not alwaysavailable in sufficient amount
– Cultured keratinocytes and tissue engineered skin
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Epithelial grafts or“keratinocyte sheet grafts”
• source:
– Autologous grafts:
• Biopsy or burn patient
– Allografts:
• Seologically tested donors in good health
• Neonatal foreskin or elevtive surgery specimen
• culture technique
– Modified Rheinwald and Green technique
– Alternatives for xenogeneic material:
• Fibrin coated culture dishes
• Medium without bovine serum
– multilayered sheets, mounted on vaseline gauze
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Allogeneic cultured keratinocytes
• Cell cultures, prepared in clean room, starting from autologous or allogeneic skin
• direct application on the wound: basal cell layer immediately on the wound bed
• vaselin gauze dressing and dry sterile dressing
• dressing can remain on the wound for 5 to 7 days
• repeated application if necessary
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Spray grafts
• spray grafting: carriers:• fibrine
• Hyaluronic acid
• comparison– multilayered confluent sheets (conventional “sheet” grafts)
versus
– subconfluent cell transplantation (“spray” grafts)
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Composite multilayered dermo-epidermal skin equivalents
• Dermagraft
• Apligraf
• Hyaff + Laserskin
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Dermal substitutes• Example
– Integra® products
• Expensive!
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Non-migrating or underminedepidermal edge• Absence of
– necrosis,
– infection and
– excessive exsudate
but yet no progression in wound healing (insufficient granulation and epithelialisation)
• R/ need for– active stimulation of (granulation and) epithelialisation
=> biological wound dressings
=> biophysical agents
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Biophysical agents
• Electrical stimulation
• Electromagnetic agents
• Pulsed radio fraquency energy
• Phototherapy (laser/infrared and ultraviolet)
• Acoustic energy (ultrasound)
• Hydrotherapy (whirlpool and pulsed lavage)
• Oxygen (hyperbaric oxygen/ topical oxygen
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Pain and pressure wounds
do not forget to ask the patient if she/he has pain!
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Pain and wounds
• Anamnesis ( and clinical examination)
• Diagnosis => type of pain
• Treatment of pain
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Assessment of pain
• Necessary to assess pain in each pressure wound• Use a valid and reliable scale (eg. Adapted to
age)• Ask the patient to describe the pain (cave
neuropathic pain)• Ask for changes in pain• Combine with QoL and assess the impact of
pressure wounds on QoL
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Anamnesis
• Is the pain constant?• Intermittent vs. constant
• When?• During dressing change? At night? After exercise?
• Severity of the pain?• Pain scale (VAS or comparable scale)
• Influencing factors? • Aggravation? Amelioration?
• Type of pain? Description of pain?• Dull / shooting / burning / nagging
• Impact of the pain? • Awake at night? Decreased appetite?
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Nocireceptive pain vs. neuropathicpain
-Physiological response of pain on stimulus
-In zone that has been hurted/ affected
-Well-known pain sensation
-Good response to traditional pain killers
-Abnormal response due to dysfunction or damage of nerve tissue
-According to the nerve
-New type of pain sensation
-Not responding well to traditional pain relief
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Prevention of pain
• E.g. The use of a lift or transfer sheet canreduce friction and shear
• E.g. Positioning off the pressure ulcer canreduce pain
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Management of pain
• Adequate topical dressings
• Topical analgetics
• Systemic analgetics
• Non-medicinal pain reduction
• Multidisciplinary pain reduction
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Management of pain
• Adequate topical dressings
• Topical analgetics
• Systemic analgetics
• Non-medicinal pain reduction
• Multidisciplinary pain reduction
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Adequate topical dressings
• Moist, non adherent dressing
• Dressing that can remain on the wound for a long time (less bandage changes)
• Ibuprofen impregnated dressing with topicalanalgetics
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Systemictreatmentof pain
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Literature
– Reddy M. Pressure ulcers: treatment. BMJ Clin Evid. 2015
– Jugun K et al. Factors associated with treatmentfailure of infected pressure sores. AnnSurg. 2016
– Norman G et al. Antibiotics and antiseptics forpressure ulcers. Cochrane Database Syst Rev. 2016
– Gould L et al. Wound Healing Society 2015 update onguidelines for pressure ulcers. Wound Rep Reg. 2016
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Literature
• Anghel EL et. al. Current concepts in Debridement: Science and strategies. American Society of Plastic Surgeons. 2016; 138(3S): 82S-93S
• EWMA Document: Debridement. An updated overview and clarification of the principle role of debridement. Journal of Wound Care. 2013; 22(1): 1-49
• National Pressure Ulcer Advisory Panel, European Pressure Ulcer Advisory Panel and Pan Pacific Pressure Injury Alliance. Prevention and Treatment of Pressure Ulcers: Quick Reference Guide. Emily Haesler (Ed.). Cambridge Media: Osborne Park, Australia; 2014
• Westby MJ, Dumville JC, Soares MO, Stubbs N, Norman G. Dressings and topical agents for treating pressure ulcers. Cochrane Database of Systematic Reviews 2017, Issue 6. Art. No.: CD011947. DOI: 10.1002/14651858.CD011947.pub2.– Consequently we are unable to determine which dressings or topical agents are the most likely to heal pressure
ulcers, and it is generally unclear whether the treatments examined are more effective than saline gauze…
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