Kansas Regen Med

Welcome to the KRMC. You probably arrived at this site because your or a loved one are searching for new therapeutic options. Those options may be found with Regenerative Medicine.1What is REGENERATIVE MEDICINE?The regeneration or replacement of cells, tissues or organs to restore or establish normal function.

The goal is to help you live a more normal life.

Under investigational protocols, the physicians of the KRMC offer the latest in PRP and Adult Stem Cell treatments.

These new modalities may be the answer you are looking for

What is PRP?PRP is made from a patients bloodCentrifugation removes the red cells leaving behind plasma with a concentration of plateletsThese products contain growth factors special proteins that aide wound healing

What are Stem Cells?Stem cells are found throughout your bodyThey have 3 main jobs:Keeping the immune system in checkReplacing tissues that are lost in day-to-day lifeCoordinating repair of injuries

What conditions are being treated?Orthopedic conditionsArthritis, osteonecrosis, non-healing fractures etc.

Immune-mediated diseases Multiple Sclerosis (MS), chronic-obstructive pulmonary disease (COPD) etc.

Critical limb ischemia

Many other diseases are being investigated

Evidence for OsteoarthritisNathan et al, Tis Eng, 2003, 9(4)

Biomechanically, the repair tissue approximated intact cartilage

Evidence for OsteoarthritisAdipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function.

All clinical results significantly improved at 2-year follow-up

Koh et al, Knee Surg Sports Traumatol Arthrosc, 2013 Dec (epub)

Evidence for OsteonecrosisAdipose stem cells AND PRP injected into femoral head of patients with severe osteonecrosis

presence of sustained,regenerated medullary bone-like tissue in 2 severely necrotic femoral heads.

Pak, J. Pain Physician, 2012; 15

Clinical Study - Fractures

J Bone Joint Sx (1998) 80:985-996

10This is a fracture repair model. A section from a long bone was removed then a bone plate was inserted. After 4 months, the fracture has not closed. In the next group of this study they inserted a cell-free scaffold.Case Study - FracturesJ Bone Joint Sx (1998) 80:985-996

Comparison in Fracture Implant without Stem Cells

11No reparative callous formed around the implant and bone formation did not occur throughout the implant

In the final group they used this scaffold but coated it in with stem cells.Case Study - FracturesJ Bone Joint Sx (1998) 80:985-996

Comparison in Fracture Implant with Stem Cells

12new-bone formation can be elicited by the implantation of autologous mesenchymal stem cells.Critical Limb Ischemia #1 Cause of AmputationMiranville et al, Circulation 2004;110; 349-355

185,000 amputations in the US every yearCritical limb ischemia (diabetes, peripheral artery disease) is the number one cause13Ischemic Limb - #1 Cause of AmputationDas et al, World J Surgery, 2013; 37(4)All were confirmed as no-option patients by a vascular surgeonAfter a single injection of stem cells, 86% of the limbs treated with stem cells were saved!

Mesenchymal stem cells for critical limb ischemia are safe and efficacious

Safety Stem cells are collected by liposuction 1000s are performed daily in the US

For PRP all that is required is blood

Both these products come from your own body, there is no chance for rejection

Safety MSCs [stem cells] have been used in clinical trials since 1995; currently, more than 80 trials are registered with ClinicalTrials.gov and no significant adverse events have been reported.

Sensebe et al, Mesenchymal stem cells for clinical applications, Vox Sanguinis, 2010; 98

Safety this study with 100 joint injections of ADSCs,in the form of SVF, with PRP shows that ADSCs/PRP treatment is safe and provides long-term pain improvement

Pak et al, Safety reporting on implantation of autologous adipose tissue-derived stem cells with platelet-rich plasma into human articular joints, BMC Musculoskeletal Disorders, 2013; 14

Think you may be a candidate?www.kansasRMC.com 785-320-4700