regenerative medicine initiatives in osaka · regenerative medicine industryin osaka ? n the...
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Regenerative Medicine Initiativesin Osaka
Nov 8, 2016Bio Europe 2016Cologne, Germany
1Senri Life Science Foundation/Osaka Bio Head Quarters
OSAKA at a glancen Area: 1,899 km2
n Population: 8.8 millionn Population density: 4,660/km2
n GDP:443.5 billion dollars (2012)
n Number of establishment: 449,766(7.4% of the nation)
n Share of SMEs: 99.6%
2Senri Life Science Foundation/Osaka Bio Head Quarters
Competitive advantages in OSAKA
n Industry gatheringp Pharmaceutical companiesp Medical device manufacturers
n knowledge accumulationp Renowned universities and research institutesp Abundant expertise pool p Saito life science park
n Established government, industry and academia business networksp Osaka Bio Headquartersp Protein-Mall Kansai
3Senri Life Science Foundation/Osaka Bio Head Quarters
Scientific Expertisen Focused technology areasp Immunology ü Basic research, imaging, informatics
p Vaccineü Adjuvant, new vaccine technology
p Regenerative medicinep Pre-emptive medicineü Life-style related diseases
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Ongoing clinical Studies using human stem cells in Japan
Source: http://www.skip.med.keio.ac.jp/frontline/hub/
Tohoku UniversityYamagata UniversityAomori Prefectural Central Hospital
Keio UniversityToranomon HospitalTokyo Medical and Dental UniversityToho UniversityTokyo Women’s Medical UniversityJikei University School of MedicineNational Center for Global health and MedicineNational center for Child Health and DevelopmentChiba-East-Hospital
Yamaguchi UniversityTottori UniversityShimane UniversityNagasaki University
Shin Koga Hospital
Kochi UniversityEhime UniversityTokushima Red Cross Hospital;
Hiroshima UniversityOkayama University
Nagoya UniversityAichi Gakuin UniversityNational Center for Geriatrics and GerontologyTokai University School of MedicineShonan Kamakura General Hospital
Shinshu UniversityMatsumoto Dental University
Osaka UniversityOsaka City UniversityNational cerebral and Cardiovascular CenterKinki UniversityKitano HospitalSumitomo Hospital
Foundation for Biomedical Research and InnovationHyogo College of MedicineRiken Kobe Branch
Kyoto UniversityKyoto Prefectural University of Medicine
Nara Medical University
Sapporo Higashi Tokushukai HospitalSAPPORO HOKUYU HOSPITALHospital Hakodate Hokkaido
Kanazawa UniversityNiigata University
5Senri Life Science Foundation/Osaka Bio Head Quarters
Map of the medical institutes engaged in the clinical researches of advanced medicine and regenerative medicine in Osaka area
Osaka Bay
KIX
ITM
age-related macular degeneration
iPS cell
Spinal cord injury
6Senri Life Science Foundation/Osaka Bio Head Quarters
Number of clinical researches related to regenerative medicine in Japan(as of Nov. 2014).
Source: ヒト幹指針への適合性が承認され我が国で実施されているヒト幹細胞臨床研究
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Num
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Osaka Kobe Kyoto Nara Tokyo Kanagawa Nagoya
Osaka University, National Cerebral and Cardiovascular Center, etc. Tokyo University, Keio University, etc.
RIKEN, etc.
KYOTO University, etc.
NAGOYA University, etc.
The pursuit of clinical studies related regenerative medicine in Osaka area has been increasing year by year and the number of clinical studies in Osaka University and National Cerebral and Cardiovascular Center is higher than other regions.
7Senri Life Science Foundation/Osaka Bio Head Quarters
Promising regenerative medicine in Osaka
preoperative Postoperative 1 year
In the case of Stevens-Johnson syndrome
Autologous oral mucosal epithelium cell sheet transplantation
Corneal reconstructionOsaka University (Prof. Nishida)
Severe cardiac failureOsaka University (Prof. Sawa)
skeletal myoblast sheets Grafting the sheet to patients with dilated cardiomyopathy
Femoral musclemyoblast cell culture
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TERUMO have received the conditional approval by Ministry of Health, Labour and Welfare (MHLW) on Sep 18, 2015
Companies engaged in regenerative medicine and its products in Osaka area
Osaka Bay
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Heart Sheet®
n Autologous skeletal myoblast sheetsp Time to prepare: 7 weeksp Necessary sheet for treatment: 5 sheets
n Target disease: severe heart failure caused by ischemic heart disease
n Official insurance pricep Kit A (collect muscle tissue, culture myoblast cells) ¥6,360,000p Kit B(preparation of sheet): ¥ 1,680,000/sheet
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Calculated cost for heart failure treatment: ¥14,760,000(¥ 6,360,000 + ¥1,680,000 X 5)
TERUMO
Issues we need to consider
n Cost-benefit performancen National Health Insurance (NHI) coveragen Necessity of regenerative medicine treatmentn Standardization of technologiesn Overseas regenerative medicine supporting
materials
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What should we do for progress of regenerative medicine industry in Osaka ?
n The regenerative medicine industry require not only regenerative medicine products but also various type of supporting materials and tools.p Transportation, Equipment and apparatus, Cell Processing and Storage,
Plasticware, Consumables, Reagent and culture media, automated culture apparatus and so on.
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n Boost SMEs entering to regenerative medicine supporting business because the highest potential SMEs with state of the art technology are gathering in Osaka region and they are eager to expand their business.
In summary
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n State of the art regenerative medicine and cell therapy
n Research and clinical studies
High accumulation of SMEs having high quality of technologies in Osaka region and they are eager to expand their business to new frontier fields. But they don’t have budget, knowledge on regenerative medicine and talents.
AcademiaMedical Institute
Global Players
n Clinical trialn Industrialization
Regenerative MedicineCell Therapy
SMEs
Active Osaka Promotion Fundn Objective
p To develop a new business by taking advantage of local resources (technology, manpower, etc.) and to contribute to promotion and revitalization of Osaka industries and local community
p Set up under the cooperation between the public and private sectors.
n Supporting fieldsp Medicine, iPS cell related R&D, and medical devicesp Managed scientifically by Senri Life Science Foundation
n R&D Subsidies for SMEs in Osakap ¥5,000,000 (approx. €37,000)/yearp 2-3 Years
New SMEs engaging in regenerative medicine and their products (2016, OSAKA)
15Senri Life Science Foundation/Osaka Bio Head Quarters
Osaka Active
Promotion Fund
2015-2016
Refrigerated stored bag for living tissue & Packaging
Thermo-controlled transportation
Automatic Cell Processing System
REIMEI Inc. Ophthalmology
Dermatology
In Vitro 3D Culturing Platform with Hybrid Gel Cubes for Multidirectional Observations
Hub for international regenerative medicine
n The smart city is still at the design stagen Central part of Osaka city
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Protein-Mall Kansai
The 2nd Generation
Objectiven In collaboration with northern Osaka bio medical
cluster, Protein Mall Kansai aim to encourage the Osaka area’s SMEs engaging in the field of life science and to acquire the international competiveness.
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ProteinBiomarker
SMEsin Life Science
The 1st Generation2009-2016
The 2nd generation2016-XXXX ?
We offer services to members for fostering the realization through major daily activities
ProteinMall
KANSAI
Share of Information among members• Business & Academic Seminar
Share of Information among members• Business & Academic Seminar
Partnering & Alliance Activities• One to One Partnering
Partnering & Alliance Activities• One to One Partnering
19Senri Life Science Foundation/Osaka Bio Head Quarters
European Biotech & Pharma Partnering Conference, Osaka
n Date: Oct. 11, 2016n Hosted by bioXclusters plus, Osaka Bio
Headquarters, Senri Life science Foundationn Co-hosted with EU Japan Centren 181 participants, 103 companies n 288 meetings
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Attractive place for regenerative medicine business !
n Osaka is attractive place to start for regenerative medicine business.
n We are pleasure to support you to find productive business partners in Osaka.
21Senri Life Science Foundation/Osaka Bio Head Quarters
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Thank you for your attention!n Contact:n Mayuko Naganon Osaka Bio Headquartersn [email protected]
n Tamio Sugawaran Senri Life Science Foundationn [email protected]