MPHARM PART 2 RECENT SEMINAR

UV CURABLE GEL FORMULATIONS as

drug carriers

PRESENTED BY

SUBODH S SATHEESH2ND MPHARMECPS

.

Hello!

I am SubodhHearty welcome to my presentation

UV CURABLE GELS

Let’s start with the first set of slides

“Nail diseasesAffects the quality of lifeTopical and oral antifungalsAdverse effects and

contraindications

TOPICAL AGENTS

×Overcomes the disadvantages×Needs to be frequently applied×Poor patient complaince

Currently used as cosmetics

Glossy cosmetically acceptable film

Topical drug carriers Increases drug

residence Increases patient

complaince

UV curable gels

Materials

×Drug×Base Resins

eg…urethene methaacrylate×Photoinitiators

eg….alpha hydroxy ketone×Additives

eg…pyromellitic glycerol×Rheology Modifiers

eg…bentonite

……….

×Drug used amorolfine HCl and terbinafine HCl×Base resin..dimethyl acrylate×Solvent inclusion for effective drug loading×Ethanol and NMP(n methyl 2 pyrollidine)

Proportion ofexcipients

Concentration of photoinitiators and base resins were used as similar as cosmetic gels

Formulation with ethanol in 25 to 50%

Increased water sensitivity and decreased drug residence

Inclusion of ethanol at 25% produced 3%AF and 4% TF and NMP Produced 1% of each

Preaparation of formulations

×Three types of formulation

Drug free solvent

containing formulations

Drug free solvent free formulation

Drug and

solvent

UV curing of formulations

× Formulation was applied to a microscope glass slide using pipette tip× Placed under a UV nail lamp× Curing of formulation and formation of film× Surface wiped with propanol× Glossy film× Mass conversion percentage

Wt/W0*100

Characterisation of uv cured film

ThicknessAK9635D 0–25 mm Digital External Micrometer

Maximum drug loadXRD and polarised light microscopy

DSCQ2000TA

SEMFEI Quanta 200F.

TGADiscovery TGA model

DMAQ800DMA

…

× Uv cured films adhesivity× Sensitivity to water× Drug release from films× Invitro drug permeation studies× Analytical methods × .

RESULTS

...

THICKNESS

..Solvent-free and drug-free gel 211.1 _ 6.0

Drug-free gel containing ethanol 161.1 _ 7.8

Gel containing ethanol and 3% w/v Amorolfine HCl 163.3 _ 8.7

Gel containing ethanol and 4% w/v Terbinafine HCl 164.4 _ 7.3

Drug-free gel containing NMP 165.6 _ 7.3

Gel containing NMP and 1% w/v Amorolfine HCl 167.8 _ 8.3

Gel containing NMP and 1% w/v Terbinafine HCl 166.7 _ 7.1

Drug-free gel containing ethanol 161.1 _ 7.8

Percentage of conversion

.. Solvent-free and drug-free gel 51.3

Drug-free gel containing ethanol 61.1

Gel containing ethanol and 3% w/v Amorolfine HCl

61.4

Gel containing ethanol and 4% w/v Terbinafine HCl

59.9

Drug-free gel containing NMP 62.7

Gel containing NMP and 1% w/v Amorolfine HCl

63.7

Gel containing NMP and 1% w/v Terbinafine HCl

60.9

Drug-free gel containing ethanol 59.4

SEM RESULTS

…

Mass after UV curing

× Mass yield and drug yield

FTIR

× No interactions× NMP’s incorporation

into polymer has produced C=O strech

× Ethanol have no effect

DMA Results

. × Two transitions represent two polymer chains

× Reaction of monomers× In NMP more residual

solvent has produced plasticizing effect on UV cured film

× Low Tg value

Film adhesion to substrate

.. × High scores shows low adhesion

× Ethanol dont make much change

× NMP reduces adhesivity× More NMP on curing

Water sensitivity values

. × NMP formulations are extremely water sensitive

× Incorporation of NMP in the polymer

× Low water sensitivity of ethanol

× Low water sensitivity ensures longer residence on nail

Stability

× Accelerated stability studies

× 3months× No changes for

uv films× Polymer films

produced crystals

Drug release

× Curanail is commercially available nail lacquer

× Curanail produced complete drug release by day 10

× Uv curable produced slow release which indicates greater affinity to films.

CONCLUSIONS

× Promising topical drug carriers× Ethanol containing formulations have high stability

and water resistance× Improves topical therapy of nail diseases

× .

REFERENCES

Stephen Hilton, laxmi R, Sudaxshina Murdan. UV-curable gel formulations: Potential drug carriers for the topical treatment of nail diseases. Intl J pharmacy, 2015, 177˗190

Thomas B, Chemistry and Formulation of UV curable gel formulations. Esstech.In 2014 page 234to240

Marjo K Uv curable gel formulations. Tamper J of App Sci. 2011:1(3) 1˗28

Kentaro T, Effects of Curing Conditions and Formulations on Residual Monomer Contents and Temperature Increase of a Model UV Gel Nail Formulation. Journal of Cosmetics, Dermatological Sciences and Applications, 2011, 1, 111-118

Mianz K Uv curable gels in cosmetics. J of cosmetics. 2013,13˗21×.

Thanks!.