thermodiynamic principlesbunshi4.bio.nagoya-u.ac.jp/~bunshi4/class/09kisoseika/... · 2009. 7....
TRANSCRIPT
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Thermodiynamic Principles
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Figure 22-1 The sites of electron transfer that form
NADH and FADH2 in glycolysis and the citric acid cycle.
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NAD+ as an
electron
shuttle (fig9-4)
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Oxidation
Reduction
2[H]
(from food)
NADH
H+
NAD+
(nichotinamide adenine dinucleotide)
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Dehydrogenase
E0'=-0.320 V
coenzyme
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iron-sulfur protein (Fe!S)
ubiquinone (Q)
cytochromes (cyt)
electron transport
chain
Chemiosmosis: How the mitochondrial membrane couples
electron transport to oxidative phosphorylation (fig9-15)
Chemiosmosis PMF
Figure 22-2a Mitochondria. (a) An electron
micrograph of an animal mitochondrion.
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Figure 22-2b Mitochondria. (b) Cutaway diagram
of a mitochondrion.
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Figure 22-3 Freeze-fracture and freeze-etch electron
micrographs of the inner and outer mitochondrial membranes.
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Figure 22-4 Electron microscopy–based three-dimensional
image reconstruction of a rat liver mitochondrion.
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The glycerophosphate shuttle. The mitochondrial electron-transport chain.!
Voet Biochemistry 3e
© 2004 John Wiley &
Sons, Inc.
The oxygen electrode.
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Effect of inhibitors on electron transport.
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Electron micrographs of mouse liver mitochondria.
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(a) In the actively respiring state.! (b) In the resting state.!
The mitochondrial electron-transport chain.