therapeutic approaches to hypopigmentation disorder dr. oussama al haj-hussein, syria
Post on 21-Dec-2015
216 views
TRANSCRIPT
Hipopigmentation is a lake of pigment in the skin
It can be DefinitiveAlbinism
or TemporaryAfter Kriotherapy
The colour of skin
Normal skin colour is dependent on hemoglobin, carotenoids and melanin pigment. the major colour
determinant is melanin.
Most of these disorders are related to the function of Melanocyte, the cell responsible of
producing melanin, the major colour determinant .
Melanocyte is very sensitive towards a lot of effects
Medicaments (phenobarbital)Detergent (Phenol)Chemicals (Monobenzyl)Physical effects (Temperature)
Treatment
Treatment depends first on removing the effective agent when possible.
(Medicaments, Detergent, Chemicals)..
Treatment of Vitiligo
The treatment of vitiligo is unsatisfactoryand in most cases the patient is advised toSeek effective cosmetic camouflage for the lesions on exposed skin.
Photoprotection by Sunscreens
Benzylidine campherDibenzoyl methanBenzophenonesBenzimidazoles
CinnamatesPABA
PUVA Therapy
Treatment with Systemic Psoralens combined with exposure to sunlight or
to UVA light is effective in some cases Therapy is continued for at least 6 months, and in some for several years.
Topical Psoralens
The use of topical applications of Psoralens is hazardous and mayresult in untoward blistering of the skin
Topical corticosteroid
In some patient, the more potent topical corticosteroid preparations are effective but often at the price of some atrophy.
Skin-bleaching creams
In those patients with extensiveVitiligo and Only a few areas of hyperpigmentation skin–bleachingcreams, such as hydroquinone are
of use, under the risk of skin cancer!
Grafting
The use of grafting techniques minigrafts and autologous cultured melanocytes is interesting
New therapy )Vitix)
Vitix is a new, innovative topical treatment for Vitiligo with results ranging among the most effective, and without any reported
side-effects, It is a combination of Catalase and Superoxide Dismutase.