therapeutic approaches to hypopigmentation disorder dr. oussama al haj-hussein, syria
DESCRIPTION
Therapeutic approaches to hypopigmentation disorder Dr. Oussama Al Haj-Hussein, Syria. Hipopigmentation is a lake of pigment in the skin It can be Definitive Albinism or Temporary After Kriotherapy. Hypopigmentation could be acquired Vitiligo. Or congenetal Piebaldism. - PowerPoint PPT PresentationTRANSCRIPT
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Therapeutic approaches to
hypopigmentation disorder
Dr. Oussama Al Haj-Hussein, Syria
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Hipopigmentation is a lake of pigment in the skin
It can be DefinitiveAlbinism
or TemporaryAfter Kriotherapy
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Hypopigmentation could be acquired
Vitiligo
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Or congenetal
Piebaldism
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Hipopigmentation can be generalized
Albinism
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Or localized
Vitiligo
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The colour of skin
Normal skin colour is dependent on hemoglobin, carotenoids and melanin pigment. the major colour
determinant is melanin.
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Most of these disorders are related to the function of Melanocyte, the cell responsible of
producing melanin, the major colour determinant .
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Melanocyte is very sensitive towards a lot of effects
Medicaments (phenobarbital)Detergent (Phenol)Chemicals (Monobenzyl)Physical effects (Temperature)
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Hypomelanotic areas occur following the resolution of (T cell Lymphoma)
Pityriasis Lichenoide
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It may occur in the superficial fungal infection (mistaken for Vitiligo)
Pityriasis versicolor
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In inflammatory disorders of the skin there are areas of Hypomelanosis
Scleroderma
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Hypopigmentation is seen in
Sarcoidosis
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Hypopigmentation is seen in
Leprosy
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Hypopigmentation is seen in
Syphilis
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Amelanosis is when there is a total lack of melanin in the skin
Albinism
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Leukoderma is a white skin and can be due to a variety of etiological factors
Keratoderma
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Both allergic and irritant dermatitis can produce secondary Leucoderma
Atopic Dermatitis
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Treatment
Treatment depends first on removing the effective agent when possible.
(Medicaments, Detergent, Chemicals)..
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No treatment is possible other than prescribing photoprotective creams
Treatment of Albinism
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Treatment of Vitiligo
The treatment of vitiligo is unsatisfactoryand in most cases the patient is advised toSeek effective cosmetic camouflage for the lesions on exposed skin.
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Sunscreens
In sunny climates, the prescription of sunscreens is often necessary
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Photoprotection by Sunscreens
Benzylidine campherDibenzoyl methanBenzophenonesBenzimidazoles
CinnamatesPABA
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PUVA Therapy
Treatment with Systemic Psoralens combined with exposure to sunlight or
to UVA light is effective in some cases Therapy is continued for at least 6 months, and in some for several years.
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Narrow band UVB
It is more effective than PUVA Therapy
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Topical Psoralens
The use of topical applications of Psoralens is hazardous and mayresult in untoward blistering of the skin
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Topical corticosteroid
In some patient, the more potent topical corticosteroid preparations are effective but often at the price of some atrophy.
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Skin-bleaching creams
In those patients with extensiveVitiligo and Only a few areas of hyperpigmentation skin–bleachingcreams, such as hydroquinone are
of use, under the risk of skin cancer!
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Grafting
The use of grafting techniques minigrafts and autologous cultured melanocytes is interesting
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New therapy )Vitix)
Vitix is a new, innovative topical treatment for Vitiligo with results ranging among the most effective, and without any reported
side-effects, It is a combination of Catalase and Superoxide Dismutase.
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The Syrian Society of Vitiligo
Arabic English Reviews
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Syria
Ugarit (The first alphabet in the world)
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Thank you