the revelation of jean-claude bradley
DESCRIPTION
Abstract: Jean-Claude Bradley blazed a trail that many of us have followed. A true visionary, a dreamer of dreams, but what was his motivation? What was the goal he was striving towards? What was his vision of the future and why was Open Notebook Science a part of that vision? I will present Jean-Claude's work, from coining the phrase 'Open Notebook Science' to his latest project 'Chemical Rediscovery,' through the lens of defining the future for Open Notebook Science.TRANSCRIPT
The Revelation of Jean-Claude Bradley
for the Jean-Claude Bradley Memorial SymposiumCambridge University - Monday July 14, 2014
Why?
Q: Why did you decide to adopt an open approach?
A: In thinking about what has meaning for me as a scientist, I realized that the work I was doing wasn’t having the kind of impact that I would like it to have, and it was not benefitting mankind in the way I would have hoped. I concluded that this was partly a consequence of secrecy. However, I couldn’t be open with the project I was then working on, because I was collaborating with someone who didn’t feel the same way as me.My decision to do open science meant cutting ties with my previous collaborators. Having done that in 2005, I started the project UsefulChem.
http://www.infotoday.com/it/sep10/Poynder.shtml
Interview With Jean-Claude BradleyThe Impact of Open Notebook Science
by Richard Poynder
Open Source Science
Open Source Science >>
Open Notebook ScienceInfluenced by: Peter Murray-Rust & Beth Ritter-Guth
http://drexel-coas-elearning.blogspot.com/2006/09/open-notebook-science.html
Open Notebook Science
Jean-Claude Bradley
Dec 11, 2008
NIST
Associate Professor of ChemistryDrexel University
Open and Closed Science TraditionalLab Notebook(unpublished)
TraditionalJournal Article
Open Access Journal Article
Open Notebook Science (full transparency)
CLOSED OPEN
TraditionalPaper TextbookF2F lectures
Lectures Notes public
Assigned problems public
Archived Lectures Public and free online textbooks
RESEARCH
TEACHING
Motivation: Faster Science, Better Science
Where is Science headed?
WE ARE HERE
There are NO FACTS, only measurements embedded
within assumptions
Open Notebook Science maintains the integrity of data
provenance by making assumptions explicit
TRUST
PROOF
Open Notebook Science ChallengeCo-conceived with Cameron Neylon
https://www.flickr.com/photos/24801682@N08/2824469941/http://usefulchem.blogspot.com/2008/09/open-notebook-science-challenge.html
359 ONS Experiments4,640 CC0 non-aqueous solubilities
28,645 CC0 melting points
http://figshare.com/articles/Jean_Claude_Bradley_Open_Melting_Point_Datset/1031637
Where is Science headed?
WE ARE HERE
There are NO FACTS, only measurements embedded
within assumptions
Open Notebook Science maintains the integrity of data
provenance by making assumptions explicit
Dibenzalacetone First recrystallized in ethyl acetate in 1906. Straus and Ecker, Ber. 39, 2988 (1906) Recrystallized in ethyl acetate in Organic Syntheses
Organic Teaching Labs Recommended recrystallization solvent: ethyl acetate.
(http://classes.kvcc.edu/chm230/mixed%20aldol%20condensation.pdf
(http://www.xula.edu/chemistry/documents/orgleclab/Aldol_notes.pdf)
Recrystallization AppEnter compound identification and desired parameters
ResultsLists solvents and their predicted recrystallization yield.Prediction is generated by the temperature dependent solubility curves.
The Chemical Rediscovery Survey
and the role of Openness in Chemistry
Jean-Claude Bradley
March 6, 2014
Research Mini-Symposia
Associate Professor of ChemistryDrexel University
Drexel University Department of Chemistry
The current paradigm of doing and sharing science in
chemistry1. Design experiments based on established or potentially new theories.
2. Execute and record experimental outcomes in private notebooks.
3. When a sufficient narrative emerges selective experimental data are combined to publish, with a limited amount of “supplementary supporting data”
What kind of (chemical) worldview has this approach
created?1. Selective bias towards which experiment are even attempted.
2. Overconfidence in our understanding since deviant or ambiguous results are rarely reported.
Filling in the blind spots with the Chemical Rediscovery Survey
(chemrs.wikispaces.com)1. Randomize the mixture of chemicals
with certain criteria*2. Identify “what happens” after
convenient* periods of time.3. Follow up on unexpected behavior with
the traditional scientific method.4. Openly share the entire process,
including all raw data and preliminary hypotheses and discoveries as it happens.
Open Notebook Science >>
Intelligent System Open Notebook Science