Dr Shafiq Khan LabTransforming Growth Factor beta (TGF-) signaling•How TGF- promotes tumor progression •The role of the different TGF- isoforms

Dr Jaideep Chaudhary LabInhibitors of Differentiation (Id)•Promotes tumor progression

Viruses causing prostate cancer•Pathway of action

Dr Valerie Odero-Marah LabSnail transcription factor•Promotes tumor progression via reactive oxygen species•Promotes metastasis to bone

Dr. Cimona V. Hinton LabPTEN and CXCR4•Studying how loss of tumor suppressors permits metastasis enhancing genes.

PTEN usually lost early in cancer progression

CXCR4 associatedwith metastasis

Dr Godwin Ananaba LabRole of Sterols in prostate cancer•How high cholesterol and low phytosterol can promote prostate cancer•Using cyclodextran compounds as a delivery system

Sources of Funding

National Institute of Health (NIH): RCMI, P20

National Cancer Institute (NCI): RO1 Department of Defense (DOD): Idea, New

Investigator, Pca Training Grant Georgia Research Alliance (GRA):

equipment and personnel

Publications and Presentations

May 2009-April 2010: 11 journal articles 50 presentations in national meetings

Research Facilities

Molecular Biology Cell Biology Structural Biology Histology Bioinformatics and Biostatistics Analytical

Collaborative Center for Cancer Genomics (CCGC)

Collaborative effort between Clark Atlanta University and Ovarian Cancer Institute at Georgia Tech

Gene expression analysis of individual patients

Prostate Cancer Tissue Bank

Collaboration between Saint Joseph’s hospital and Georgia Tech

Intend to acquire prostate cancer patient samples for analysis at the Genomics center

Intend to establish a prostate cancer tissue bank