The Novartis Malaria Initiative Der Weg zur Eliminierung von Malaria

Silvio Gabriel, BASAID

April 2012

Malaria is an African tragedy!More than 90% of malaria deaths occur in Africa2/60a

Malaria is preventable and treatable, yet nearly 655,000 lives are lost to the disease every year2/73a

Children under 5 years old and pregnant women are most at risk1/2a

Most of the older treatments (e.g. chloroquine) are not effective anymore because of resistance3/14a

Artemisinin-based Combination Therapies (ACTs) have transformed the treatment of malaria in the past decade

Estimated incidence of malaria per 1,000 population in 20102/221-2

Source: WHO Malaria Report 2011

0-4 5-49 50-100 100-150 >150Data not available

2 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only

The Novartis Malaria Initiative A holistic approach to best serve patients needs

Capacity building – patient-focused education and information Best practice sharing workshops for public health officials responsible for malaria control

State-of-the-art packaging and patient information developed specifically for not yet literate populations

Training material made available free of charge in several local languages

Access – affordability and availability are keyTreatment provided without profit to governments and NGOs

A 25-fold production increase since 200413

SMS for life: using mobile technology to help avoid stock-outs at health facility level14/3a

R&D – leading the path to malaria eliminationMass screening and targeted treatment of asymptomatic carriers10/ 1a; 11/1a

Next generation of malaria treatments12/1179a/22

Treatment – Coartem®,a story of firstsFirst fixed-dose ACT brought to market in 1999 and > 95% cure rate* with demonstrated safety profile4/940a,b; 5/547a,b; 6/251a,254b; 7/246a; 8/1824a

First ACT pre-qualified by the WHO for its efficacy, safetyand quality9/1a

First dispersible sweet- tasting ACT specifically developed for infants and children8/1820a

* 28-day PCR-corrected in evaluable population

3 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only

500 million Coartem® treatments deliveredImpacting more than 1 million lives20

4.01.30.10.29

62

66

74

Treatmentsin millions

84

Funding uncertainGlobal policy uncertain

125%

580%

7%

12%

14%

Erraticorders

Supply challenges

ACT policy

adoption

ACT roll-out in public

sector

82

- 2%

Increase in production capacity (2001–2011)

Deliveries

100 100 100 100 100

Success in patient impact results in mortality reduction

Available production capacity

Novartis Malaria Initiative | April 20124

10022%

Together with our partners, and with our continued patient-centric approach…

5 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only

6 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only

The Novartis Malaria Initiative Four pillars of activities

7 | BASAID | Silvio Gabriel | April 2012 | Der Weg zur Eliminierung von Malaria | Business Use Only

No one should die of malaria.