The Next-generation Dengue diagnostics technology

Marco Donolato, PhDCSO

The next-generation of Point-of-care blood testing (POCT)

Consumables cartridge testsDevice

One compact device for multiple diagnostics tests with a single drop of blood

Single use cartridges, Nespresso-like business model

Designed for minimally-trained operators

Perfect match between clinical accuracy and consumer design

Integrated cloud services for real-time 3G data reporting

Diagnostics of Dengue fever

Dengue is growing worldwide and has huge need of better diagnostics tools

Mosquito-born disease with 4 virus forms, dengue affects 120 countries and 390M people/year

Spread of Dengue fever worldwide

Dengue fever has increased 30-fold over the past 4 decades

Outside Africa, dengue’s impact on society is already larger than malaria

UrbanizationClimate change Movement of people

Dengue fever vaccine just released from Sanofi-Pasteur

Introduction of vaccines completely change the diagnostics landscape, making

current rapid testing tools obsolete

Dec 8th 2015 – Approved in MexicoDec 22nd 2015 – Approved in BrazilJan 8th 2016 – Approved in Philippines

2016-2017 – Expected approval in Malaysia, Indonesia, Thailand, Vietnam, Singapore, Colombia, Peru

Dengvaxia vaccine

Outbreaks expected to grow demand for better diagnostics tools

http://www.economist.com/blogs/graphicdetail/2016/01/daily-chart-19

http://www.theguardian.com/world/2016/jan/25/zika-virus-likely-spread-throughout-americas-says-who

http://www.reuters.com/article/us-health-zika-obama-idUSKCN0V50DM

https://www.safetravel.govt.nz/news/dengue-fever-chikungunya-and-zika-virus-pacific-islands

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Dengue blood testing market forecast

Diagnostics of clinical cases

Post-vaccination monitoring

Increase in dengue cases and introduction of vaccines will drive dengue testing market growth until 2030

Dengue fever blood testing market forecast

TrackDengue – Next-generation Dengue diagnostics device

Quantitative diagnostics of dengue fever

TrackDengue products: portable device, multiple cartridges and real-time cloud services.

Market leader vs. BluSense’s TrackDengue

A new generation of better dengue diagnostics instruments

Integrating multiple mosquito-borne diseases diagnostics

Enabling critical diagnosis of severe mosquito-borne diseases

Aedes Aegypti is carrier for three different virus:

Dengue

Chikungunya

Zika virus

3 tests in one drop of blood

• Dengue IgG• Chikungunya IgG• Zika IgG

The three diseases are often confused by symptoms

Clinical decision requires identification of infection

Mapping virus is imperative to contain outbreaks

Endorsement from key stakeholders

http://www.breakdengue.org/rapid-new-test-could-transform-dengue-diagnostics/

Endorsement from government organizations and NGOs

http://www.nature.com/articles/srep16145

BluSense market focus

BluSense focuses its products distribution in South East Asian region

South East Asia has the largest dengue burden

Grants(€1M)

Round A (€3M) Round B (€4M) Round C

From concept to prototype

From product to revenue

From prototype to product

From revenue to profitability

EXIT

2012 2014 2016 2018 2020

Financing timeline

Trade sale or IPO Target > EUR 300MROI > 10

5-years Exit Strategy

TaiwanDenmark

Driven by visionaries, powered by scientists

Thank you!