the martin b. leon, md johnson

The Martin B. Leon, MD Johnson & Johnson/Cordis Corporation Research Fellowship in Interventional Cardiology Application Deadline: March 16, 2009 For Award Activation: July 1, 2009

Objective To advance the science of interventional cardiology through a significant basic science or clinical research project. This could include projects on the spectrum from basic vascular biology to clinical outcomes following interventional cardiology procedures. Target Market Supports physicians-in-training with M.D. or D.O. degrees, or junior faculty who have not achieved an academic rank higher than an assistant professor or equivalent. Eligibility criteria includes but is not limited to physicians before, during or following interventional cardiology fellowship training. The award is designed to carry out research in this field at an institution or laboratory in the region served by the AHA Founders Affiliate.

Citizenship At application: US citizen, permanent resident, exchange visitor (J-1), temporary worker in a specialty occupation (H-1B), Canadian or Mexican citizen engaging in professional activities (TN), temporary worker with extraordinary abilities in the sciences (O-1) or student visa (F-1). Exception: Postdoctoral applicants who are outside the United States at time of application must provide visa documentation prior to award activation. Budget Items Trainee stipend. Fringe benefits up to 15% of stipend. Project/travel support: Up to $17,500 per year. No dependent allowances. No indirect costs.

Annual Award Amount

For two years: $50,000 per year for stipend plus 15% of stipend ($7,500) for fringe benefits. Additional $17,500 per year for project support, supplies and travel. Maximum award amount not to exceed $150,000 for a two year-period.

Award Duration Two years NEW Peer Review Criteria

Criterion #1 – EVALUATION OF THE INVESTIGATOR Assessment of the applicant should account for 1/3 of the overall score.

1. Does the trainee have potential for a research career? 2. Are the trainee’s career plans specified in the application? 3. Is this supported by the trainee’s academic record and the assessment provided by the 3 letters of

reference? 4. Does the trainee have prior research experience and/or publications? 5. Is there a clear rationale supporting the need for the proposed training? 6. What is the sponsor’s assessment of the applicant?

Criterion #2 – SPONSOR/TRAINING PLAN AND ENVIRONMENT Assessment of the sponsor/training plan and environment should account for 1/3 of the overall score.

Sponsor/Training Plan

American Heart Association, Founders Affiliate Martin B. Leon/Johnson & Johnson Cordis Corporation Interventional Cardiology Award PROJECT SUMMARY 1. Applicant : First Middle Last Jr/Sr/etc Degree(s) 2. Institution where work will be done: 3.Sponsor(if applicable) : First Middle Last Jr/Sr/etc. Degree(s) 4.Department Head: : First Middle Last Jr/Sr/etc. 5. Applying to: Founders Affiliate 6. Award program: Leon/Johnson & Johnson Cordis Corp. Interventional Cardiology Award 7. Resubmission? Yes No Previous Application ID #:

8. Dates of proposed award: Start: End: mm/dd/yyyy mm/dd/yyyy 9. Project title (limit to 50 characters or less): 10. Project summary (must be completed on this page):

11. Amount Requested: Year 1 Year 2 Year 3 Year 4 Year 5

PROJECT PERSONNEL/SIGNATURES 1. Other professional personal associated with the project: (List name, degree and position of each professional associated with the project, with indication of capacity, e.g., Consultant, Collaborating Investigator, Other Professional, Technician, etc. See instructions for definitions of roles.)

Name & Degree Institution Position Title Role in Project % of Time

First: Last: Degree:







2. Signatures The undersigned have reviewed this application for an American Heart Association clinically applied research award and are familiar with the conditions, policies and objectives of the AHA concerning research support and accept the obligation to comply with all such conditions, policies and objectives of the supporting Heart Association. Applicant (Please Type) Signature Date Sponsor (If Applicable) Signature Date Department Head (Please Type) Institution which assumes fiscal responsibility Official signing for applicant institution Signature Date

Applicant’s Name (Please Type)

APPLICANT INFORMATION Current Address 1. Applicant: First Middle Last Degree(s) 2. E-mail address: 3. Department: 4. Division: 5. Institution: 6. Address: 7. Address: 8. City: 9. State: Zip code: Country: 10. Phone Number: Fax: Institution where work will be done Place an X here and do not complete if same as current address 11. Department: 12. Division: 13. Institution: 14. Address: 15. Address: 16. City: 17. State: Zip code: Country: 18. Phone Number: Fax: Effective Date: 19. Applicant’s present title: 20. Applicant’s present academic position: 21. Applicant’s title at award activation: 22. Applicant’s academic position at award activation: Intern 23. Career stage:

APPLICANT INFORMATION (continued) 24. First full-time faculty/staff appointment: mm/yyyy 25. First full-time faculty/staff appointment at assistant professor (or equivalent) level: mm/yyyy 26.1st doctoral degree: Date earned: mm/yyyy 27. Specialty ( 1st degree): mm/yyyy 28. 2nd doctoral degree: Date earned: mm/yyyy 29. Specialty (2nd degree): 30. If you have not received a doctoral degree, please indicate:

Date (mm/yyyy)

Date of actual or expected completion of required course work:

Date of actual or expected admission to doctoral degree candidacy:

31. For Postdoctoral Fellowship applicants only, indicate length of postdoctoral research training or experience (exclusive of clinical training) as of award activation date: yrs mos 32. Indicate total annual grant support available to the applicant, exclusive of salary /fringe and indirect costs: 33. Please indicate any of the following awards you have received or currently hold:

ACS Clinical Research Training Grant for Junior Faculty Leukemia & Lymphoma Society Special Fellow

ACS Research Scholar Grant for Beginning Investigator NIH Career Transition Award (K22)

AHA Scientist Development Grant NIH Independent Scientist Award (K02)

Alzheimer’s Assoc. New Investigator Research Grant NIH Sponsored Clinical Scientist Dev Award (K08)

American Lung Assoc. Career Investigator NIH Research Project Grant (R01)

Arthritis Foundation Investigator Award NIH Senior Scientist Award (K05)

Arthritis Foundation Physician Scientist Dev Award Pfizer Scholar Grant for New Faculty

Burroughs Wellcome Fund Award United Cerebral Palsy Hausman Clinical Scholar Award

Howard Hughes Award Veterans Administration Award

Leukemia & Lymphoma Society Scholar Whitaker Foundation Biomedical Engineering Research Grant Other Specify

ACS - American Cancer Society AHA – American Heart Assoc. NIH – National Institutes of Health 34.Country of citizenship: 35. Immigration (Status/Visa):

ADMINISTRATIVE INFORMATION Sponsor Name/Address (complete Sponsor information only if your program requires a Sponsor) 1. Sponsor: First Middle Last Jr/Sr/etc Degree(s) 2. Department: 3. Division: 4. Institution: 5. Address: 6. Address: 7. City: 8. State: Zip code: Country: 9. Phone Number: Fax: 10. E-mail address: Grants Officer Name/Address (Pre-Award) 11. Grants Officer: First Middle Last Jr/Sr/etc 12. Department: 13. Institution: 14. Address: 15. Address: 16. City: 17. State: Zip code: Country: 18. Phone Number: Fax: 19. E-mail address: Fiscal Officer Name/Address (Post-Award) 20. Fiscal Officer: First Middle Last Jr/Sr/etc 21. Department: 22. Institution: 23. Phone Number: Fax: 24. E-mail address: Applicant’s Name (Please type)

ADMINISTRATIVE INFORMATION (continued) Percent Time 25. Percent of applicant’s total effort devoted to this project: 26. Indicate percent of time applicant spends on: Project Endorsements 27.Research involves: Yes No

a) Recombinant DNA?

b) Biohazards (other than recombinant DNA)?

c) Human subjects?

d) Adult human stem cells?

e) Human embryonic or fetal stem cells?

f) Human fetal tissue?

g) Cloning?

h) Animal subjects?

Date Approved

i) If using animals, is your institution accredited by AAALAC?

Effective date:

j) If using animals, does your institution have a current PHS Animal Welfare Assurance?

ID number:

a) b) and g) -No documentation required c) and d) -IRB documentation required prior to award activation. e) and f) -If yes, you are not eligible to apply to the American Heart Association. h) -IACUC documentation required prior to award activation. (See Application Instructions for details.)

Applicant’s Name (please type)

A. Administration % E. Coursework %

B. Patient care % F. Other %

C. Research %

D. Teaching % G. Total 0%

BIOGRAPHICAL SKETCH (PI) Do not exceed 5 pages for the complete Biographical Sketch, including bibliography Name: First Middle Last Jr/Sr/etc Degree(s) Position/Title: Education/Training: (Begin with entry into college and include postdoctoral training.)

Institution and Location Dates Attended

Degree (if applicable)

Conferred (mm/yyyy)

Field of Study

For Principal Investigator Only: Address personal variances from ordinary career progression, including part-time work, if applicable. Positions, Publications and Research Support (create these pages as PDFs) 1) Positions/Employment, Memberships and Honors – List in chronological order previous positions, concluding with your present position. Include star/end dates, position title, name of organization and department. Also list other experience and professional memberships, and academic/professional honors received. If necessary senior applicants may list previous employment for the past 15 years and should be very selective regarding memberships/honors. 2) Peer-reviewed Publications – List, in chronological order, selected peer-reviewed publications. Do not include publications submitted or in preparation. 3) Research Support – List selected ongoing or completed (during the last three years) research projects. Give project number, agency, title of project, and dates of award. Then briefly indicate the overall goals of the projects and your role (e.g., PL, Co-Investigator, Consultant) in the research project. Do not list award amounts or percent effort in projects. Applicant’s Name (please type)

CO-AUTHORS/REFERENCES Co-Authors: Please list each co-author (at assistant professor level or above) with whom you have published an article or abstract within the past 3 years. Last name First initial Last name First initial Last name First initial

Current Supervisor: First Middle Last Degree(s) References (if applicable): List names and addresses of persons familiar with your scientific interests and abilities and who have been requested to submit a Reference Report for Applicant. (See application instructions for number of Reference Reports needed and further requirements.) Name (last name, first name) Title Department Institution First: Last:

First: Last:

First: Last:


Johnson (SAMPLE) M

RESEARCH PROJECT ENVIRONMENT FACILITIES: specify the facilities to be used for the conduct of the proposed research. Indicate the performance sites and describe capacities, pertinent capabilities, relative proximity, and extent of availability to the project. Under “Other, “ identify support services and specify the extent to which they will be available to the project. Use continuation pages if necessary. Location(s):

Computer Support:

Office:

Other:

MAJOR EQUIPMENT: List the most important items already available for this project, noting the location and pertinent capabilities of each.


PROJECT BUDGET Proposed Project Budget Year 1 Year 2 $ Amount $ Amount

1. Salary & Fringe Benefits (Salary) of Investigators/team (Fringe)

2. Project Costs (if allowed for program)

3. Subtotal (lines 1 & 2) $0.00 $0.00

4. Indirect Costs (if allowed by AHA funding component)

5. Total Costs $0.00 $0.00


OTHER SUPPORT There is no form page for other support. Information on other support should be provided in the format shown below, using blank pages. Include the Principal Investigator’s name at the bottom (right-hand side) and number consecutively with the rest of the application. The sample is intended to provide guidance regarding the type and extent of information requested, If you have no active or pending support, complete an Other Support page with the PI’s name and state “None” Format

NAME OF INDIVIDUAL ACTIVE/PENDING

Dates of Approved/Proposed Project Annual Direct Costs

Percent Effort

Project number (Principal Investigator) Source

Title of Project (or Subproject) The major goals of this project are…

OVERLAP/ALTERNATIVE (scientific and/or budgetary, summarized for each individual)

ANDERSON, R.R.

ACTIVE 2 RO1 HL 00000-13 (Anderson) 3/1/99-2/28/02 30% NIH/NHLBI $186,529 Chloride and Sodium Transport in Airway Epithelial Cells The major goals of this project are to define the biochemistry of chloride and sodium Transport in airway epithelial cells and clone the gene(s) involved in transport. 5ROI HL 00000-07 (Baker) 4/1/97-3/31/02 10% NIH/NHLBI $122,717 lon Transport in Fetal Lung The major goal of this project is to study chloride and sodium transport in normal and cystic fibrosis fetal lung. PENDING 5 RO1 HL 00000-22 (Anderson) 12/01/99-11/30/01 20% NIH/NHLBI $82,163 Liposome Membrane Composition and Function The major goals of this project are to define biochemical properties of liposome membrane components and maximize liposome uptake into cells. ALTERNATIVE There is scientific overlap between aim 2 of NIH HL 00000-22 and aims 3 and 4 of the application under consideration. This application is alternative to the AHA proposal.

FUNDS AVAILABLE (1) - APPLICANT List active or approved awards first, and then list all pending awards.

1. Funding agency: 2. Award name/ID number:

3. Project title:

4. Principal Investigator: 5. Applicant’s role:

6. Beginning date of award: 7. Ending date of award:

8. Award status: Active Approved Pending

9. Total award: 10. Total amt available to applicant:

11. Annual amt available to applicant*: * Do not include applicant’s salary/fringes or intramural support dollars

12a. Is this project overlapping* (current award) or alternative* (pending award) to this AHA proposed project? *scientific or budgetary

Yes No

12b. Whether you answer yes or no, please describe relationship to this AHA project. (See Application Instructions, Funds Available section, for AHA’s definitions and policies regarding Alternative and Overlapping applications. Note: 100% duplication between applications is not a requirement for an application to be deemed alternative or overlapping. The Research Committee may deem an application as alternative or overlapping if there is any duplication of scientific aims or budget.)

(Remember to submit summary/abstract, specific project aims, budget, and budget justification pages for this project with paper sets. See Application Instructions, Enclosures from Applicant section for details.)


3. Project title:







Yes No 12b. Whether you answer yes or no, please describe relationship to this AHA project.

(See Application Instructions, Funds Available section, for AHA’s definitions and policies regarding Alternative and Overlapping applications. Note: 100% duplication between applications is not a requirement for an application to be deemed alternative or overlapping. The Research Committee may deem an application as alternative or overlapping if there is any duplication of scientific aims or budget.)


Applicant’s Name:



3. Project title:







Yes No




3. Project title:










Applicant’s Name:

RESEARCH CLASSIFICATION (1)

The American Heart Association is frequently asked to categorize the research it is funding by a number of different categories. These requests can originate with our donors, the general public or our many volunteers. Please complete each of the following classifications as they relate to your research. The classifications are independent of each other and the classification of your research will not affect the peer review of your application.

CVD/Stroke Classification (select only one)

CVD – related

CVD and closely stroke-related CVD and broadly

stroke-related Closely stroke-related (see list below)

Broadly stroke-related (see list below)

Current Areas of Interest (If applicable to your project, select one or both. Otherwise leave blank)

To improve population and/or behavioral methods or develop novel methods to advance primary and/or secondary prevention goals of the American Heart Association

To improve the effectiveness of therapy, quality of care and systems of healthcare delivery goals of the American Heart Association.

As a general rule, AHA considers closely related to stroke to include projects involving brain blood vessels, brain tissue, or cerebral ischemia. Projects broadly related to stroke include those involving vascular biology in other vascular beds and coagulation control systems. The following list of stroke terms may assist you:

Closely Related to Stroke Broadly Related to Stroke Cerebellum Cerebral infarction Blood pressure control Cerebrovascular disorders Cerebral ischemia Blood vessel growth & development

Carotid artery diseases Cerebral ischemia, transient Hypertension Carotid artery atherosclerosis Subclavian steal syndrome HypoxiaCarotid artery thrombosis Leukomalacia, periventricular Ion channels and blockers Carotid stenos is Vascular headache Intracellular motility Moyamoya disease Cluster headache Micro-circulation

Cerebral amyloid angiopathy Migraine Platelets & platelet activation Cerebral aneurysm Vertebrobasilar insufficiency Smooth muscle Cerebral anoxia Dura Thrombosis Cerebral arteriosclerosis Echoencephalography Transmitter Cerebral arteriovenous malformations Hypothalamus ControlCerebral artery diseases Mid-Brain ReleaseCerebral circulation Neuroglia Synthesis Cerebral embolism and thrombosis Neurons Vascular biology

Carotid artery thrombosis Pia Mater; Pia Vein Vascular endothelium Sinus thrombosis Ventricle Vascular injury Wallenberg's syndrome Vascular intema

Cerebral hemorrhage Vascular reactivities Hematoma, epidural Vascular tone Hematoma, subdural Subarachnoid hemorrhage


RESEARCH CLASSIFICATION (2)

Types of Research (select only one)

Basic Biomedical Research is conducted to increase understanding of fundamental life processes.

Clinical Research addresses important questions of normal function and disease using human subjects.

Population Health Research is the science and art of studying the distribution and determinants of health status as influenced by social, economic, and physical environments, human biology, health policy and services and of preventing disease, prolonging life and promoting health at the population level.

Research Categories (select all that apply)

African Americans Imaging

Aging/elderly Medications

Angiogenesis Native Americans

Angioplasty Nutrition

Asian Americans Obesity

Behavioral research Outcomes research

Cholesterol Pediatric research

Diabetes Physical activity/inactivity

Emergency cardiac care/defibrillation/ chain of survival

Rehabilitation

Epidemiological research Smoking/tobacco

Gene therapy Stroke

Heart attack Surgical techniques

Heart failure Transplantation

Heart valves Treatment/patient care

High blood pressure Women

Hispanic/Latino American


SCIENCE CLASSIFICATION (1)

Assignment to a peer review group is based largely upon the Major Science Categories that you choose below (not the sub-categories).

1. Choose two Major Science Categories from those listed below.

2. For each Major Science Category, choose up to six (6) sub -category terms most relevant to your proposal.

NOTE: If you have checked Resubmission on page 1 of your application and the Major Science Classification choices you make are different from your previous submission, your application might not be reviewed by the same scientific peer review committee. With any choice, prior critiques and scores are provided to the new reviewers.

If you make an error or wish to start again, click on the "Reset" button(s) to clear the fields within each group.

Major Science Classification (1)

Sub Classification(s)

Major Science Classification (2)

Sub Classification(s)

2060 - BASIC CELL & MOLECULAR BIOLOGY

2078 Cell Adhesion/Extracellular Matrix 3001 Cell Proliferation/Cell Cycle 1217 Chromatin, Nuclear Matrix & Mitosis 1294 Cytoskeletal Signaling 1057 Cytoskeleton & Motility 1506 Intracellular Targeting 2161 Intracellular Trafficking 1815 Muscle Cell Contractility 1720 Physical Biochemistry 2162 Post Translational Protein Modifications 1761 Protein Structure-function Relationships 1762 Protein/DNA Interactions 1763 Protein/Protein Interactions Including

Contractile Proteins 3002 Proteomics 1820 Regulation of Gene Expression 3003 Stem Cell Biology 2064 Structural Biology 1814 Structural Studies of Contractile & Other Proteins

1205 - BEHAVIORAL SCIENCE, EPIDEMIOLOGY & PREVENTION

1090 Biomedical Ethics 1115 Cardiac Rehabilitation 1405 Cost Effectiveness 1340 Epidemiology of CVD 1355 Exercise/Physical Activity 1375 Genetic Epidemiology 1400 Health Promotion/Prevention 1445 Nutrition 2163 Prevention & Management of Diabetes &

Multiple Metabolic Syndrome 3004 Prevention & management of Hypertension

1205 - BEHAVIORAL SCIENCE, EPIDEMIOLOGY & PREVENTION

2164 Prevention & Management of Obesity 1760 Preventive Cardiology 2165 Psycho/Social Factors 1795 Quality of Life

2050 - BIOENGINEERING & BIOTECHNOLOGY 2054 Bioelectrics 2056 Bioinformatics 2057 Biomaterials 2058 Biomechanics 2166 Biotransport Processes 2065 Chemistry & Chemical Synthesis 2066 Computation, Modeling & Simulation 2167 Computational Systems Biology 2067 Defibrillators & Pacemakers 2168 Pacing & Devices 2059 Drug Delivery 2169 Electrophysiology Modeling 2060 Image Methods, Analysis & Processing 2170 Mechanical Cardiac Assistance &

Replacement Technology 2062 Molecular/Cellular Tissue Engineering & Technologies 2068 Nanotechnology 2069 Non-linear Dynamics (Chaos & Fractals) 3026 Rehabilitation Engineering 2063 Sensors and Devices 2070 Signal Processing & Analysis


1100- BRAIN 3005 Astrocytes 1095 Blood-Brain Barrier 3006 Brain Immunology & Inflammation 3013 CNS Autonomic Control 3014 CNS Electrophysiology 3007 Cell Therapies in Stroke 1195 Cerebral Blood Flow and Metabolism 1200 Cerebral Edema and Intracranial Pressure 3011 Cerebral Hemorrhage & Hematoma 3008 Cerebral Hypoxia 3009 Cerebral Ischemic Pre-conditioning 3010 Cerebral Plasticity & Repair 1206 Cerebral Vascular Biology 3012 Clinical Stroke & Cerebrovascular Disease 3015 Epidemiology of Stroke 3016 Genetics/Genomics in Brain 3017 Mechanisms of Cerebral Ischemic Cell Death 3018 Neurodevelopment 3019 Neuroprotection: Focal Cerebral Ischemia 3020 Neuroprotection: Global Cerebral Ischemia &

Cardiac Arrest 3021 Perinatal Brain Injury 3003 Stem Cell Biology 3022 Stroke Rehabilitation: Clinical & Experimental 3023 Technologies in Stroke: MRI, CT, PET, TCD 3024 Thrombosis in Cerebrovascular Disease 3025 Traumatic Brain Injury

3000 - CARDIAC BIOLOGY/REGULATION 1006 Aging 1707 Autonomic Neurophysiology 1120 Cardiomyopathies 1142 Congestive Heart Failure 1276 Coronary Artery Disease 1280 Coronary Circulation 3033 Developmental Programming of Adult CVD 1297 Exercise Physiology 1360 Experimental & Clinical Hypertension 3031 Gender Differences 1415 Hemodynamics 1653 Hypertrophy 3049 Inflammation 1026 Myocardial Apoptosis 1625 Myocardial Ischemia 3050 Myocardial Regeneration 1024 Myocarditis 1828 Neurohumoral Control 1661 Nitric Oxide in Myocardial Biology 3029 Obesity & Metabolic Syndrome 1696 Oxidant Stress 1298 Pharmacology 2172 Physiological Genomics 3032 Pregnancy & Hypertension 1826 Remodeling 3003 Stem Cell Biology 3030 Steroid Hormones 1962 Valvular Disease 2020 Ventricular Function

3100 - CARDIAC ELECTROPHYSIOLOGY & ARRHYTHMIAS/REGULATION

2173 Ablation 2174 Arrhythmia 1707 Autonomic Neurophysiology 1190 Cellular Electrophysiology, Voltage-Sensitive Ion Channels 2175 Electrophysiologic Testing 3040 Heart failure, Cardiomyopathy & Arrythmias 2176 Mechanisms of Arrhythmias 3039 Non-invasive Risk Stratification 2178 Pacing & Devices 1298 Pharmacology 2177 Physiological Genomics 3041 Resuscitation Arrhythmias 3003 Stem Cell Biology

1125 - CARDIORENAL 1005 Acid-Base Balance, pH Regulation 1006 Aging 1707 Autonomic Neurophysiology 1171 Cellular & Immunological Mechanisms of Injury 3027 Complications of Chronic Kidney Disease 1296 Cytokines, Chemokines & Other Mediators 3033 Developmental Programming of Adult CVD 1248 Diabetic & Hypertensive Vascular Renal Disease 1133 Divalent Ion Metabolism & Function 1387 Functional Genomics & Proteomics in Renal Disease 3031 Gender Differenc es 1396 Growth Factors, Peptide Hormones & Autocoids 1571 Mechanisms of Renal Progression & Salvage 1596 Molecular Genetics of Renal Disease & Development 3029 Obesity & Metabolic Syndrome 3032 Pregnancy & Hypertension 1841 Renal Growth, Differentiation & Angiogenesis 3028 Renal Hemodynamics 1905 Signal Transduction 3003 Stem Cell Biology 2073 Steroid & Peptide Natriuretic Factors 3030 Steroid Hormones 1932 Structural & Matrix Biology 1934 Structure Function Correlations in the Kidney 1951 Transcriptional & Post-transcriptional Regulation 1959 Transporters & Ion Channels

1135 - CARDIOVASCULAR DEVELOPMENT 1150 Cardiovascular Morphogenesis/Teratology 1165 Cell Differentiation, Myocyte & Other Lineages 1167 Congenital Cardiovascular Disease 1285 Coronary/Vascular Development 1460 Developing Myocardium - Physiology, Pharmacology,

Metabolism & Disease 1300 Developmental Electrophysiology 1461 Developmental Molecular Biology 1305 Developmental Physiology/Pharmacology/Metabolism 3034 Developmental/Morphogenic Signaling 1380 Fetal and Perinatal Circulation 2072 Genetic Mapping 1435 Human Genetics of Congenital CV Malformations 1600 Molecular Models of Congenital Cardiovascular Malformations 1705 Pediatric Cardiovascular Disease 1706 Pulmonary Embryology 3003 Stem Cell Biology


1175 - CELL TRANSPORT, PHYSIOLOGY & METABOLISM 3038 Biophysics of Ion Channels 1110 Calcium & Magnesium Transport & Regulation 1169 Cell Biochemistry & Metabolism 2202 Cell Membranes 1168 Cell Volume Regulation 2071 Cellular & Molecular Physiology of Ion Channels 1166 Cellular & Molecular Physiology of Ion Transporters 1185 Cellular Cardiac Physiology & Pharmacology 2201 Cellular Fluorescence Imaging 3035 Cellular Vascular Physiology & Pharmacology 3036 Epithelial Transport 2203 Excitation Cessation Coupling 1350 Excitation Contraction Coupling in Muscle Cells 2076 Intracellular pH Regulation 1585 Mitochondria, Bioenergetics 3037 TRP and Store-Ope rated Channels

1475 - IMMUNOLOGY AND MICROBIOLOGY 2186 Autoimmune Diseases 2187 Bacteria, Protozoa, Fungi & Viruses 1315 Cardiovascular Diseases of Immunogenic Origin 1393 Cytokines 2188 Endocarditis & Myocarditis 1365 Experimental Organ & Tissue Transplantation 1465 Immunochemistry & Immunopathology 2189 Immunologic Mechanisms in Cardiovascular Diseases 1011 Infectious Diseases of the CV System 3043 Inflammatory Molecules (Markers & Mediators) 3042 Innate Immunity 1575 Microbial Chemistry 1576 Microbial Genetics 1577 Microbial Pathogenesis 3003 Stem Cell Biology

1530 - LIPOPROTEINS, LIPID METABOLISM & NUTRITION 2190 Animal Models of Lipoprotein Metabolism 2191 Atherosclerosis, Lipoprotein-Related Mechanisms 3058 Biology of Adipose Tissue 3057 Biology of Body Weight Regulation & Obesity 3052 Intracellular Cholesterol & Lipid Trafficking 3055 Lipid & Lipoprotein Metabolism 3056 Lipid & Lipoprotein Oxidation 3051 Lipid Efflux & Reverse Cholesterol Transport 1515 Lipolytic Enzymes & Lipid Transfer 1520 Lipoprotein Receptors and Lipoprotein - Cell

Interactions 1519 Lipoprotein, Structural Biology, Biochemistry &

Biophysics 2194 Metabolic Syndrome, Diabetic & other Dyslipidemias 1680 Nutrition, Physical Activity, Lipids & Atherosclerosis 3053 Transcription Factors & Regulation of Lipid &

Lipoprotein Metabolism 1540 - LUNG, RESPIRATION & RESUSCITATION

1045 ARDS Acute Respiratory Distress Syndromes & Acute Lung Injury 1015 Alveolar

& Airway Function 3059 Alveolar Fluid Clearance 1290 CPR (Cardiopulmonary Resuscitation) 1490 Cardiopulmonary Function & Disease 2077 Control of Ventilation 1415 Hemodynamics 1654 Hypoxia & Ischemia 3061 Inflammation & Fibrosis 1535 Lung Cell & Molecular Biology 1580 Microcirculation 1597 Molecular Genetics of Lung Disease 3060 Neonatal lung 1697 Oxidant Metabolism & Signaling

1540 - LUNG, RESPIRATION & RESUSCITATION 1666 Oxygen Transport & Tissue Respiratory Processes 1779 Pathophysiology, Cell & Molecular Biology of

Pulmonary Edema 2195 Pulmonary Endothelium & Nitric Oxide 1780 Pulmonary Hypertension 1876 Pulmonary Physiology Pharmacology & Therapeutics 1790 Pulmonary Vascular Biology 1826 Remodeling 2196 Respiratory Genomics & Proteomics 1905 Signal Transduction 3003 Stem Cell Biology 1951 Transcriptional & Post-transcriptional Regulation

1605 - MOLECULAR SIGNALING 2200 Apoptotic Signaling 3066 Calcium Signaling 3070 Caveolae Microdomains 1394 Cytokine Signaling 3064 G Protein Coupled Receptors 1396 Growth Factors, Peptide Hormones & Autocoids 3068 Heterotrimeric G Proteins 3067 Junctional Signaling 2197 Kinase & Phosphatase Signaling Cascades 2198 Nitric Oxide 3065 Nuclear Receptors 3062 Reactive Oxygen Species 3063 Receptor Tyrosine Kinases 3069 Rho Family 2199 Second Messengers 1905 Signal Transduction 3003 Stem Cell Biology

1805 - RADIOLOGY & IMAGING 1156 Cardiovascular Ultrasound 1806 Computed Tomography 2171 Coronary Angiography & Coronary Interventions 2074 Echocardiography 1455 Imaging Technology 1546 MRI, MRA 1456 Magnetic Resonance Spectroscopy 1457 Myocardial Imaging 1671 Nuclear Cardiology 1800 Radiology 1801 Radionuclide Imaging (PET, SPECT & Others) 1807 Vascular Angioplasty & Interventions 1994 Vascular Imaging

1940- SURGERY 1025 Anesthesiology 1569 Interventions/Surgeries 1572 Mechanical Surgical Assistance & Replacement 1635 Myocardial Preservation 1755 Postoperative Care (Critical Care) 1900 Shock 3071 Surgery, Cell Therapies 1941 Surgery, Congenital Heart Disease 1942 Surgery, Ischemic Heart Disease 1943 Surgery, Valvular Disease 2205 Surgical Outcomes 1956 Transplantation, Cardiac 1958 Transplantation, Non-Cardiac 1975 Vascular Disease


1945- THROMBOSIS 1240 Clotting Factors & Clotting Inhibitors 1241 Coagulation 1385 Fibrinogen 1386 Fibrinolysis 1410 Hematology 1420 Hemostasis 1740 Plasminogen 1750 Platelets

3200 - VASCULAR BIOLOGY & BLOOD PRESSURE/REGULATION 1006 Aging 3075 Angiogenesis 2179 Apoptosis 1707 Autonomic Neurophysiology 1032 Baroreflex Chemoreflex 2017 CNS Control of Cardiovascular Function 1276 Coronary Artery Disease 1280 Coronary Circulation 3033 Developmental Programming of Adult CVD 2180 Endothelial Function 1297 Exercise Physiology 1360 Experimental & Clinical Hypertension 3031 Gender Differences 1415 Hemodynamics 1653 Hypertrophy 3049 Inflammation 1580 Microcirculation 1828 Neurohumoral Control 2182 Nitric Oxide 3029 Obesity & Metabolic Syndrome 1696 Oxidant Stress 1298 Pharmacology 2184 Physiological Genomics 3032 Pregnancy & Hypertension 1826 Remodeling 1905 Signal Transduction 3003 Stem Cell Biology 3030 Steroid Hormones 2185 Vascular Smooth Muscle Function 2010 Vasoactive Agents & Hormones

2000 - VASCULAR WALL BIOLOGY 1035 Angiogenesis & Vasculogenesis 1031 Animal Models of Atherosclerosis & Arterial Injury 1066 Atherosclerosis, Pathogenesis 1056 Cell - Cell Interactions 2206 Diabetes/Atherogenic Mechanisms 1330 Endothelium Structure and Function 1550 Macrophage Biology 1910 Smooth Muscle Cells 3003 Stem Cell Biology 1991 Vascular Cell Apoptosis 1970 Vascular Cytokines 1980 Vascular Extracellular Matrix & Cell Adhesion 1981 Vascular Growth Factors 1662 Vascular Reactivity 3080 Vascular Wall Developmental 2005 Vascular Wall Mechanics

PERSONAL DATA The American Heart Association (AHA) is committed to monitoring the operation of its review and award processes to detect, and the deal with appropriately, any instances of real or apparent inequities with respect to age, gender, race or ethnicity of its applicants. The following information will enable us to honor this commitment. Upon receipt of the application by the AHA, this form will be separated from the application. The form will not be duplicated, and will not be a part of the review process. Data will be confidential. All analyses conducted on the data will report aggregate statistical findings only and will not identify individuals. If you decline to provide this information, it will in no way affect consideration of your application. Your cooperation will be greatly appreciated. 1. Applicant: First Middle Last Jr, III, etc 2. Social Security Number: 3. Date of birth: mm/dd/yyyy 4. Gender: Male Female 5. Race and/or ethnic origin (place an X in the most appropriate box):

(Note: For purposes of reporting mixed racial and/or ethnic origins, the category that most closely reflects the individual’s recognition in the community should be used.)

Alaskan Native

American Indian

A person having origins in any of the original people of North America, and who maintains cultural identification through tribal affiliation or community recognition.

Asian

A person having origins in any of the original peoples of the Far East, Southeast Asia or the Indian Subcontinent. This area includes, for example, China, India, Japan, Korea, etc.

Pacific Islander A person having origins in any of the original peoples of the islands of the Pacific. This

includes people of Polynesian, Samoan or Micronesian heritage.

Black, not of Hispanic Origin A person having origins in any of the black racial groups of Africa.

Hispanic A person of Mexican, Puerto Rican, Cuban, Central or South American or other

Spanish culture or origin, regardless of race.

White, not of Hispanic Origin A person having origins in any of the original peoples of Europe, North Africa, or the

Middle East.

The following information is requested for program evaluation purposes. Data will be reported in aggregate statistical form only. 6. Do you have tenure? Yes No Not Applicable Tenure Year:

The American Heart Association’s Founders Affiliate Research Committee would like to bring to your attention the annual call for applications to the Martin B. Leon, M.D./Johnson & Johnson Cordis Corporation Research Fellowship in Interventional Cardiology. This program began a few years ago with the intention of providing interventional cardiology fellows and junior faculty with funds to pursue research on a majority time basis. The applicant criteria have been broadened to all those physician-scientists performing research related to interventional cardiology. The awards are up to two years in duration, $150,000 in amount, and for a minimum of 25% research-directed effort. This is a terrific opportunity. Applications are due March 16, 2009 with a July 1, 2009 activation date. This is a terrific opportunity for appropriate fellows and junior faculty to apply.

• Martin B. Leon/J&J Cordis Corporation Interventional Cardiology Fellowship Grant

The purpose of this grant is to advance the science of interventional cardiology through a significant basic science or clinical research project. This could include projects on the spectrum from basic vascular biology to clinical outcomes following interventional cardiology procedures. Target Market Supports physicians-in-training with M.D. or D.O. degrees, including junior faculty who are within two years of achieving faculty status, and who have not achieved an academic rank higher than an assistant professor or equivalent. Eligibility criteria includes but is not limited to physicians before, during or following interventional cardiology fellowship training. The award is designed to carry out research in this field at an institution or laboratory in the region served by the AHA Founders Affiliate.

Application deadline: March 16, 2009 Award activation: July 1, 2009

For more information, attached are the instructions and forms needed to apply for this program. You can also visit: Founders Affiliate local research opportunities to obtain information and forms

Please email or call me if you have any questions.

Thank you for your support and cooperation. Mary Gonzalez Research Coordinator

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http://www.americanheart.org/presenter.jhtml?identifier=3015642

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American Heart Association Founders Affiliate 122 East 42nd Street New York, NY 10168 ----------------------------- Phone: 212-878-5912 [email protected]

mailto:[email protected]

American Heart Association Martin B. Leon / Johnson & Johnson Cordis Corporation Research

Fellowship in Interventional Cardiology

Application Instruction and Guidelines

Founders Affiliate Includes: Connecticut, Maine, Massachusetts, New Hampshire, New Jersey, New York, Rhode Island and Vermont Application deadline: March 16, 2009 Award activation: July 1, 2009

Table of Contents General Information Peer Review Criteria for Fellowships Streamlined Review (Triage) .............................................................................................. 3 Process ...................................................................................................................... 4

Email Application Deadline ........................................................................................ 5 Supplementary Materials ........................................................................................... 5 Administrative Withdrawal Procedures................................................................................................................. 5 Timeline (Submission to Activation) ........................................................................... 6

Tips for Fellowship Applicants ............................................................................................ 7 Application Checklist........................................................................................................... 8 Assembly of Paper Sets...................................................................................................... 11 Font and Characters per Inch Requirements...................................................................................................................... 12 Body of Application

Project Summary form ............................................................................................... 13 Definition of a Resubmission...................................................................................... 13 Project Personnel/Signatures form ............................................................................ 14 Applicant Information form ......................................................................................... 16 Administrative Information form ................................................................................. 19 Biographical Sketch (PI) form .................................................................................... 21 Co-Authors/References form ..................................................................................... 21

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Reference Reports for Applicant form............................................................................................................................ 22 Academic Record of Applicant ................................................................................... 23 Research Project Environment form .......................................................................... 24 Project Budget form ................................................................................................... 24 Funds Available form(s) (to be completed by Fellow) ................................................................................................. 25 Sponsor Packet.......................................................................................................... 26 Co-Sponsor Packet .................................................................................................... 27 Proposed Research Plan ........................................................................................... 28 Vertebrate Animal Subjects........................................................................................ 30 Literature Cited........................................................................................................... 31 Biographical Sketch (Collaborating Investigator, if applicable) .......................................................................................... 31 Research Classification forms.................................................................................... 31 Science Classification forms ...................................................................................... 31 Personal Data form .................................................................................................... 31

Enclosures from Applicant Letter from Collaborating Investigator (if applicable) .......................................................................................... 32 Letter from Consultant (if applicable).................................................................................................................. 32 Reprints of Applicant’s Publications ........................................................................... 33

Submission of Your Application .......................................................................................... 33

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GENERAL INFORMATION

The American Heart Association has approved new peer review criteria for the fellowship programs. Make sure that you and your Sponsor are fully addressing the new peer review criteria given below. Criterion #1 – EVALUATION OF THE INVESTIGATOR Assessment of the applicant should account for 1/3 of the overall score.

1. Does the trainee have potential for a research career? 2. Are the trainee’s career plans specified in the application? 3. Is this supported by the trainee’s academic record and the assessment provided by the

3 letters of reference? 4. Does the trainee have prior research experience and/or publications? 5. Is there a clear rationale supporting the need for the proposed training? 6. What is the sponsor’s assessment of the applicant?

Criterion #2 – SPONSOR/TRAINING PLAN AND ENVIRONMENT Assessment of the sponsor/training plan and environment should account for 1/3 of the overall score.

Sponsor/Training Plan 1. Is the mentor an independent investigator? 2. Does the mentor have the experience to direct the proposed research training, as

evidenced by their track record regarding productivity, funding and prior trainees? 3. Does the mentor have adequate current funding to support the fellow’s project? 4. Does the mentor provide a comprehensive training plan that will facilitate the

applicant’s progress towards his/her research career goals? Environment 1. Does the scientific environment in which the work will be done contribute to the

probability of success for the training experience? 2. Is there evidence of institutional commitment?

Criterion #3 – EVALUATION OF THE PROPOSAL Together, assessment of these three criteria should account for 1/3 of the overall Proposal score.

1. Significance: Does this study address an important problem broadly related to interventional cardiology? What will be the effect of these studies on the concepts, methods, and technologies that drive this field?

2. Approach: It is recognized that a new fellow may not have had adequate time to generate preliminary data. It is acceptable for applicants to present preliminary data generated by the sponsor. The assessment of preliminary data, whether generated by the sponsor or the applicant, should be put into perspective such that bold new ideas and risk taking on the part of the beginning investigators are encouraged rather than stymied.

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Are the conceptual framework, design, methods, and analyses adequately developed, well integrated, well reasoned, feasible (as determined by preliminary data or the expertise available in the mentor’s and/or collaborator’s laboratories) and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics?

3. Innovation: Is the project original?

Because the fellow receives primarily stipend support from these awards, additional research support for the proposed project MUST come from the Sponsor’s lab. Therefore, the proposed project will likely be related to the Sponsor’s funded research. The Sponsor should clarify the role that the applicant played in the development of the proposal, the relationship of the proposed project to ongoing research in the Sponsor’s laboratory, and how the project will contribute toward the training and career development of the applicant. However, keep in mind that the submission of applications to AHA with identical or significantly similar content from a Sponsor (for project support) and a postdoctoral fellowship is prohibited. If submitted, the peer review committee will recommend a “disapproval” for both applications. If a grant application is submitted by a Sponsor of a fellowship application, both applications may be funded if there is no duplication of aims. The AHA Research Committee approved the use of streamlined review (or “triage”) for all Association peer review groups. All programs (both fellowship and grant programs) are eligible for streamlined review. This process has been implemented to ensure that committee meeting discussion is focused upon applications that may be competitive. For applications that receive a streamlined review, applicants will receive critiques and notices without scores. For assistance with program and eligibility criteria, instructions or form content contact:

Phone 212-878-5912, 5900 Fax 212-878-5960 E-mail [email protected]

Print these Instructions and Forms -- You are advised to print these instructions for reference before completing your application. It is also recommended that you print all of the forms so you can see the pagination that you will need to maintain on your final application. Only the items listed with an “X” on the Application Checklist (pages 8-10) should be completed. Refer to the Checklist for number of copies needed for all enclosures. To complete the application form on your computer, you must have Word 3.0 for Windows (for PC) or a later version. If you have this capability, you should download the appropriate format to your computer’s hard drive from the web site in order to complete the application form. If you do not have this software capability or are having problems accessing the main application form, you may contact Mary Gonzalez at 212-878-5912 or [email protected] and the necessary documents will be sent to you via email.



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Application Deadline -- Applications for this program must be submitted via email at: [email protected] on later than Monday, March 16, 2009 at 5:00 p.m. Eastern Standard Time. Applicants are strongly advised to complete their required email submission early on the deadline day or preferably several days before, in case technical difficulties are encountered. Applicants who encounter technical difficulties with the email submission must contact the AHA office at the numbers above prior to the deadline (5:00 p.m. Eastern Standard Time) to resolve the situation. Otherwise, their applications will be rejected. Email submission is mandatory. A complete submission requires forms and body of application in separate word document file(s) submitted to [email protected] by the deadline. For instructions on how to submit via email go to our web site at http://www.americanheart.org/presenter.jhtml?identifier=3015642

Late applications will not be accepted.

You will receive an acknowledgment via the e-mail address provided. After submitting the application via email, the original with all signatures plus 3 paper sets must arrive at the Founders Affiliate NYC Research Office on Monday, March 23, 2009 by 5 p.m. Eastern Standard Time. For instructions on how to assemble your paper copies, refer to page 11. DO NOT MAKE ANY CHANGES TO YOUR PAPER COPIES AFTER THE EMAIL SUBMISSION. The application sent by email may be compared with the paper application; these applications must match word-for-word in the Project Summary and Proposed Research Plan. If changes to the text of the Project Summary or Proposed Research Plan occur, the application will be administratively withdrawn. If minor administrative changes are needed after email electronic submission (such as an incorrect zip code, budget miscalculations, incorrect administrative addresses, etc.), these changes must be addressed in writing by the Principal Investigator. The PI must notify the AHA in writing; send this letter to the same address given at the end of this document. No supplementary material (additional preliminary data, new publications, etc.) will be accepted after the application deadline (with the exception of missing documentation requested by AHA staff). Your application will be administratively withdrawn if you: • modify the Project Summary or Research Plan of the application after the email submission • submit the same or similar application for the fourth time • fail to comply with format requirements (type size/characters per inch, lines per page, and

page limitations)




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An applicant may submit only one Affiliate application per deadline. An applicant may simultaneously submit applications for an Affiliate award and for a National award. If both are funded, the applicant must choose one award. An individual may not hold more than one Association award concurrently. Applicants should never contact reviewers regarding their applications since discussion of the scientific content of an application or an attempt to influence review outcome will constitute a conflict of interest in the review. Reviewers are directed to notify the AHA if an applicant contacts them. The timeline, from application submission to award activation, is given below for your information. March 16, 2009 Email submission deadline March 23, 2009 Paper deadline April, 2009 Applications assigned to peer review

committee and reviewers April 2009 Applications sent to peer review committee April or May 2009 Peer review committee meet May 2009 Founders Affiliate Research Committee meet

and determine funding levels June 2009 Awardees receive funding notifications July 1, 2009 New awards activate

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TIPS FOR MARTIN B. LEON, MD, JOHNSON & JOHNSON CORDIS CORPORATION

INTERVENTIONAL CARDIOLOGY FELLOWSHIP APPLICANTS Before beginning an application, please review the specific award descriptions provided on the AHA local web site, (http://www.americanheart.org/presenter.jhtml?identifier=3015642) noting especially the qualifications and any restrictions for the program to which you will be applying. To apply for the Martin B. Leon, MD, Johnson & Johnson / Cordis Corporation Interventional Cardiology Fellowship the following forms found on the AHA web site must be completed:

• Main Form • Sponsor Packet • Reference Report for Applicant

Note: You will need to create some word-processed documents, and insert them into the Main Form or send them in separate word-processed documents. Also, a form is not provided for the Proposed Research Plan; refer to Instructions on pages 29-31 for Proposed Research Plan requirements. Because the fellow receives primarily stipend support from these awards, additional research support for the proposed project MUST come from the Sponsor’s lab. Therefore, the proposed project will likely be related to the Sponsor’s funded research. The Sponsor should clarify the role that the applicant played in the development of the proposal, the relationship of the proposed project to ongoing research in the Sponsor’s laboratory, and how the project will contribute toward the training and career development of the applicant. However, keep in mind that the submission of applications to AHA with identical or significantly similar content from a Sponsor (for project support) and a fellowship is prohibited. If submitted, the peer review committee will recommend a “disapproval” for both applications. If a grant application is submitted by a Sponsor of a fellowship application, both applications may be funded if there is no duplication of aims. Reference Reports are critical to the Fellowship application. Check with your referents near the deadline to ensure that your Reference Reports have been sent to the American Heart Association. Reference Reports cannot be from your Sponsor. The applicant and Sponsor should provide information regarding project funds available for the fellow. The absence of listed support indicates that the applicant has no funds available for research; it is expected that candidates applying for fellowships will receive support from their Sponsor or from institutional funds. A stipend for a fellowship cannot be awarded in the absence of adequate support for research expenses. A Department Head letter is not part of a Fellowship application: the Sponsor’s information is critical for the application.


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Please refer to the Application Checklist below to determine which forms to complete and how to assemble your application.

MARTIN B. LEON, MD, JOHNSON & JOHNSON / CORDIS CORPORATION INTERVENTIONAL CARDIOLOGY FELLOWSHIP

APPLICATION CHECKLIST X = Required for program The email submission and paper application should be assembled in the same sequence given below. Email submission includes all items listed under Body of Application including the Research and Science Classification Forms and Personal Data form. The single-sided original application and each of the duplicated paper sets should be assembled in the sequence listed below. AHA prefers that sets be duplexed (printed on both sides of the sheet) but will accept single-sided sets. Each set must be put in a manila folder. Items may be clipped or rubber banded. Do not staple. Mark the folder with the original application “original.”

BODY OF APPLICATION (original and 3 duplicated sets) The body begins with form page 1 and ends with the Personal Data form.

Source Leon/Cordis

Project Summary, page 1 Main Form X Project Personnel/Signatures, page 2 Main Form X Applicant Information, page 3 Main Form X Applicant Information (continued), page 4 Main Form X Administrative Information, page 5 Main Form X Administrative Information (continued), page 6 Main Form X Biographical Sketch (PI) for applicant, pages 7 – 11 (create Positions, Publications and Research Support section as PDF, number pages consecutively, and insert into main form; no more than 5 pages for the entire AHA Biographical Sketch)

Main Form- pg. 7 Create Microsoft word processed document pgs. 8-11

X

Co-Authors/References, number page consecutively following Biographical Sketch (PI)

Main Form X

Academic Record of Applicant (create as word processed document and insert following Co-Authors/References form) Insert pages into main form

Create Microsoft word processed document

X

Research Project Environment form Fellowship applicants should leave blank this form page; the Sponsor Packet includes the Research Project Environment form

Leave Blank

Project Budget, number page consecutively following Academic Record of Applicant

Main Form X

Budget Justification Fellowship applicants should leave blank this form page and the Budget Justification Sample form.

Leave Blank

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BODY OF APPLICATION (continued) Source Leon/Cordis

Funds Available (1) form (by applicant), number pages consecutively following Project Budget. All applicants must complete a Funds Available form; type in “none” if you have no funds available. Delete other Funds Available forms (2-4) if not needed

Main Form X

Sponsor Packet - number consecutively following Funds Available (by applicant) page Includes Sponsor Information – Part I and Part II, Research Project Environment, and Biographical Sketch (Sponsor) Insert pages completed by Sponsor into main form. This form is not a part of the main form, but is located in a separate file at http://www.americanheart.org/presenter.jhtml?identifier=3025391

Sponsor Packet Form

X

Co-Sponsor Packet (if Co-Sponsor designated) - number consecutively following Sponsor Packet forms Includes Co-Sponsor Information – Part I and Part II, Research Project Environment, and Biographical Sketch (Co-Sponsor). Insert pages completed by Co-Sponsor into main form. This form is not a part of the main form, but is located in a separate file at http://www.americanheart.org/presenter.jhtml?identifier=3025393

Co-Sponsor Packet form

X

Proposed Research Plan (no more than 12 consecutively numbered pages), create as PDF and insert following Sponsor Packet as appropriate


X

Vertebrate Animal Subjects (to be addressed separately from the 12 pages of the Research Plan) Create as a word file at end of Proposed Research Plan


X

Literature Cited (no limit on number of literature references cited) Create as PDF at end of Proposed Research Plan (or at end of Vertebrate Animal Subjects if using animals)


X

Biographical Sketch for Collaborating Investigator(s) (Use NIH Biographical Sketch for Collaborating Investigators; number pages consecutively) Insert into main form

Create Microsoft word processed

document

X

Research Classification Forms (1,2) Do not delete this form from your electronic submission.

Main Form X

Science Classification Forms (1,2,3,4) Do not delete this form from your electronic submission.

Main Form X

Personal Data form Do not delete this form from your electronic submission. Exception: Do not submit any paper copies of this form; it should be submitted only in the electronic file.

Main Form X



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REQUIRED ENCLOSURES (to accompany mailed application) Limited number of paper copies needed; number noted beside each item below. Do not submit electronically. These items are to be submitted with your original and 3 paper copies. (See Assembly of Paper Sets.)

Leon/Cordis

Letter from Collaborating Investigator(s), if applicable (original and 3 copies) X Letter from Consultant(s), if applicable (original and 3 copies) X 4 reprints each (or duplicated copies) of 3 pertinent (or most representative) publications by applicant (abstracts are acceptable for fellowship applicants)

X

4 copies of your American Heart Association Progress Report (if you currently hold or have held an AHA research award which has terminated within the past two years)

Note: The Reference Report for Applicant – Part I and Part II forms are in a separate file on the AHA web site (http://www.americanheart.org/presenter.jhtml?identifier=3025344). These should come from the referent directly to AHA. DO NOT INCLUDE THEM IN THE APPLICATION PACKAGE. The Reference Reports are considered confidential communications and will not be disclosed to the applicant.


Assembly of Paper Sets Assemble your paper copies in the following sequence, collating all materials into an original and 3 sets of like materials. Use staples, clips or rubber bands. Top to bottom:

• Application (see Checklist for items included in Body of Application) • Letter from each Collaborating Investigator, if applicable • Letter from each Consultant, if applicable • One each of 3 different reprints • Copy of AHA Progress Report, if applicable

Original Set – in a manila folder labeled “original”

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3 Duplicated Sets of Same Materials – each set placed in a manila folder

Do not include in original or sets: Personal Data form Visa documentation IRB or IACUC approvals The following items should not be sent; if sent with paper sets, these pages will be counted toward the page limit, resulting in administrative withdrawal.

• Enlarged or original set of images (photographs or color images of gels, micrographs, etc.)

• Surveys, questionnaires, data collection instruments, clinical protocols, informed consent documents, etc.

• Any additional printed materials not specifically requested in Instructions. The information will not be sent to reviewers.

1 copy of

each Reprint

Original

Consultant

Letters (signed)

Original

Application

(with original signatures)

Original

Coll. Invest.

Letters (signed)

1 copy of Progress Report (if

applicable)

Cover Letter (only if

required by institution)

1 copy of each

Reprint

1 copy of

Consultant

Letters

1 copy of

Application

1 copy of

Coll. Invest.

Letters

1 copy of Progress Report (if

applicable)

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INSTRUCTIONS FOR PREPARING

MARTIN B. LEON/ JOHNSON & JOHNSON CORDIS CORPORATION INTERVENTIONAL CARDIOLOGY FELLOWSHIP APPLICATIONS

Your application will be strengthened by the conciseness and clarity of its presentation. Page restrictions are noted throughout the instructions; these page restrictions must be observed by the applicant. If late or excessive in length, the application will be returned. It is the responsibility of the applicant to make all necessary arrangements for conducting the proposed research work, both with the work institution and with the investigator (sponsor) under whom the work will be performed. A sponsor is the awardee's administrative link with the institution. The sponsor and the department head are responsible for determining the awardee's institutional rank and offering whatever supervisory or collaborative assistance is necessary for the progress of the awardee's research program. A sponsor must be familiar with an awardee's area of research. Applications will be presented for review as received. Applications may not be modified after email submission. The forms are password protected and default to a font style of Helvetica. Font size within the forms is controlled and cannot be altered by the applicant. For your research plan (and resubmission modifications and animal subjects text, if applicable) the following are AHA requirements:

• no more than 15 characters per inch (cpi) or an average of no more than 15 cpi (cpi includes symbols, punctuation and spaces)

• ¾” margins should be used • 60 lines per page are the maximum allowed (The average number of lines per page

using the font and point size below will be approximately 50-55 lines.) • Windows Arial font style 12 point* • Macintosh Helvetica 12 point *

*Figures, charts, tables, graphics and legends may be smaller in size but must be clear and legible.

It is essential that the text of your research plan complies exactly with the Association’s type specifications and page limits. Failure to comply will result in the administrative withdrawal of the application. Users of other word processing programs must adjust settings appropriately and should measure text after saving. Type requirements should be checked using a standard measuring device (such as a ruler), rather than relying on the font selected for a particular word processing/printer combination. Type size specifications must be observed in the text of your research plan (and animal subject’s text, if applicable) or the application will not be reviewed and will be withdrawn. Adherence to font and margin requirements is necessary. No applicant should have an advantage over other applicants by providing more content in his/her application by using smaller, denser type.

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The AHA has the responsibility to make the final determination of conformance to format requirements and the authority to withdraw applications. This decision is final and not subject to appeal.

BODY OF APPLICATION The completed application must contain page numbers in sequential order. It is important that you add a footer containing the page number and name of the applicant to your word-processed document. It is advisable to first complete all of the required documents, insert page numbers and applicant’s name, and then insert into the main form. PROJECT SUMMARY FORM 1. Type first name, middle name, last name, lineage, and degree(s). 2. Type in institution where research project will be performed. 3. Type name of Sponsor and degree(s). 4. Type name of Department Head and degree(s). 5. Affiliate name is already populated. 6. Award program is already populated. Leon/Johnson & Johnson Cordis Corp.

Interventional Cardiology Award. 7. An applicant who is unsuccessful in a competition may resubmit the same or similar

application three times (the original plus two resubmissions)*. If you are submitting a modified proposal to the AHA (whether it was submitted to National or an Affiliate previously), check Yes. If not, check No. If the “Yes” box is checked, the applicant must:

a) Provide 1-2 pages of additional text which address modifications made to the application due to suggestions/criticisms from the previous review; b) Display changes to the research plan in the revised proposal; c) Use the same project title as used for the original application, to facilitate tracking by AHA. If major changes are made to the application or if this is an entirely different/new project, it

should not be checked as a resubmission. (Resubmissions are not applicable to the Martin B. Leon, MD, Johnson & Johnson /

Cordis Corporation Interventional Cardiology Fellowship Award)

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8. Founders Affiliate applications submitted for Martin B. Leon, Johnson & Johnson Cordis

Corporation Interventional Cardiology Fellowship will be activated on July 1, 2009 and end on June 30, 2011.

9. Title may not exceed 100 letters and spaces; any titles exceeding this length will be

automatically truncated and appear incomplete. Do not use abbreviations unless absolutely necessary.

10. The project summary should be a brief synopsis of the proposed project. The summary

must be completed in the space provided. Include the following: • a statement of specific aims • the methods or techniques to be used, including the model to be used (animal, tissue

culture, etc.) • the end points or objectives to be achieved

Note: You cannot enter special characters and formatting (such as super or subscripts, special characters, Greek symbols, italics, underlining, bolding, etc.) into this form field. This is a known limitation of Adobe Acrobat. You may enter text characters only in the Project Summary field.

11. These fields are read-only and cannot be completed. These fields will be automatically

populated after completion of the Project Budget form.

PROJECT PERSONNEL/SIGNATURES FORM 1. List other personnel who will be involved with the research project in a significant role (i.e.,

will have impact on project content, data collection, data interpretation, etc.). Be certain to state name of institution if different from the Principal Investigator’s.

All personnel listed here must be classified based upon the following roles and definitions

of roles in the project, regardless of whether a salary is requested. For each individual, select from the drop down list for the Role in Project. The Principal Investigator is not to be listed here, but the definition is given below for information.

Principal Investigator – the one person responsible to the applicant organization for the

scientific and technical direction of the project (for the Fellowship program, this is the Leon, Johnson & Johnson / Cordis Corporation Interventional Cardiology Fellowship applicant)

Note: The concept of Co-Principal Investigators is not recognized. The American Heart Association recognizes only one Principal Investigator. If two investigators are listed (each as Co-Principal Investigator), the first name listed will have primary responsibility for the project and the second name will automatically be listed as a Collaborating Investigator.

Sponsor – a senior investigator under whom the research project of a Leon, Johnson & Johnson / Cordis Corporation Interventional Cardiology Fellowship will be performed. A sponsor is the administrative link with the institution. The sponsor offers whatever supervisory or collaborative assistance is necessary for the progress of the research program. A sponsor must be familiar with an applicant’s area of research. (The Sponsor must complete a Sponsor Packet; see page 1, Table of Contents.)

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Co-Sponsor – a joint Sponsor of a Postdoctoral Fellowship applicant, having the same

responsibilities described above for the Sponsor. Inclusion of a Co-Sponsor is considered an exceptional circumstance. (A Co-Sponsor must complete a Co-Sponsor Packet; see page 1, Table of Contents.)

Note: In the case of fellowship awards, the services of a collaborator or consultant are not routine and should only be listed in cases where the collaborator or consultant is absolutely essential to the proposed research training experience. Please do not list all members of the department or all collaborators of your Sponsor. Also, it is a very unusual situation in which a fellowship applicant needs to include a technician on the project.

Collaborating Investigator – an individual who contributes in a substantive way to the

scientific development or execution of the project; typically, these individuals have doctoral or other professional degrees; these individuals would devote a specific percent of effort to the project; by American Heart Association policy, a Collaborating Investigator may not be paid. (Each Collaborating Investigator must provide a letter; see page 2, Table of Contents.)

Consultant – an individual who contributes to the scientific development or execution of

the project in a discrete way; typically, these individuals have doctoral or other professional degrees. Consultants may provide discrete services which are performed in a limited window of time or occasionally contribute a specific method/technique/analysis or materials for the project. (Each Consultant must provide a letter; see page 2, Table of Contents.)

2. Signatures required in this section are not expected for email submission. They are required on the original and paper copies only.

Type applicant’s name as used in signature. Applicant to sign original and date.

Type Sponsor’s name as used in signature. Sponsor to sign original and date. Type Department Head’s name as used in signature. Department Head to sign original and date. If it is necessary for an acting Department Head to sign the application, indicate the name of the regular Department Head in order that future correspondence may be directed to the proper individual. (Not applicable to the Leon, Johnson & Johnson / Cordis Corporation Interventional Cardiology Fellowship) Name the institution that will be financially responsible for the activities supported by the award. Type Institutional Officer’s name as used in signature. Institutional Officer to sign original and date. Note: The Association expects that an applicant will have institutional approval before submitting an application via email, just as he/she would if submitting via paper only. If the Grants Office/Sponsored Programs Office discovers minor administrative changes which are needed after the email submission occurs (such as an incorrect address, budget miscalculations, wrong Fiscal Officer’s name, etc.), these modifications should be submitted in writing by the Principal Investigator (and Grants Officer, if needed). It is the Association’s practice that applications are final upon submission; any modifications to the text of the Project Summary, Proposed Research Plan or animal subjects text (if

16

applicable) are not allowed. A letter addressing minor administrative changes should be sent to AHA. Assurances The applicant and institution are responsible for compliance with all American Heart Association research award policies and guidelines for the duration of any awards they may receive. The institution assures that it is in compliance with current guidelines of the U.S. Department of Health and Human Services regarding recombinant DNA and Financial Conflict of Interest by the signature of the institutional official. Go to Policies Governing All Research Awards to review AHA policies at http://www.americanheart.org/presenter.jhtml?identifier=12150

APPLICANT INFORMATION FORM 1. Type applicant’s name and degree(s). Enter doctoral degrees with no periods; e.g., MD,

PhD, DVM, etc. 2. Type applicant’s e-mail address. Note: This e-mail address will be used to communicate

with the applicant in several ways. You will receive information regarding funded status via this address. Due to the confidential nature of the award notification, please give an accurate e-mail address. If your e-mail address changes after submission of your application, notify the Founders Affiliate Research Office via e-mail at [email protected].

Address lines 3, 4, 6, and 7 cannot exceed 50 characters and spaces. 3. Self-explanatory. 4. Self-explanatory. 5. Type in name of institution where research project will be performed. 6,7. Use exact delivery address of institution, e.g., building and street number, P.O. box

number, etc. 8. Self-explanatory. 9. Always use standard 2-letter abbreviation for the state. Provide at minimum your 5-digit

zip code. Select country from drop-down list or type in name of country if not in drop-down list.

10. Type in contact numbers for applicant. 11- 18. If institution where research will be performed is same as the current address, check box

and do not complete.

If institution is different (such as Columbia University [current] and Albert Einstein College



17

of Medicine [where research will be performed] or a university [current] and a VA hospital [where research will be performed]) give work institution address in same sequence as current address. Or if you are currently at one institution and will be relocating to another, give the new address where work will be done.

Type in your institution’s name where research project will be performed. Grants Office/Sponsored Programs Office should not be listed here. This address/location should be the physical location where the actual research will be conducted, if different from current address. Type in contact numbers for applicant. Specify the effective date of this address.

19. Provide present title; e.g., postdoctoral fellow, graduate student, etc. 20. Enter your current academic position at time of application from drop-down list. (Items 19

and 20 may be the same.) 21. Provide anticipated title at time of award activation, July 1, 2008 (title may remain the

same as in item 19). 22. Enter anticipated academic position at time of award activation from drop-down list

(position may remain the same as in item 20). 23. Review the descriptions of career stage below and select most appropriate current career

stage from drop-down list. These descriptions are requested for aggregate program evaluation purposes only.

Career Stage

Gaining Credentials Doctoral candidate PhD, MD, MD/PhD, DO/PhD, or DVM/PhD or equivalent students

Attaining graduate credentials.

Directed Step Postdoctoral fellow PhD, MD/PhD or DO/PhD, MD, DO, DVM or equivalent

Building a career in research.

First Independent Step Instructor or other first academic appointment

Establishing independent status. Acquiring preliminary results as a basis for developing grant application.

Intermediate Level Assistant professor or equivalent Entry not more than 8 years after PhD or subspecialty board eligibility (MD or DO)

Strengthening independent status. Acquiring new knowledge through research.

Recognized Investigator Associate professor or equivalent Professor or equivalent

Acquiring new knowledge through research. Establishing new research direction. Acquiring preliminary results as a basis for developing grant application.

Research Group Leader Professor or equivalent

Stimulating newly emerging areas of research. Strengthening research.

Other

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24. Give month and year of first faculty or equivalent staff appointment at an institution (such

as Instructor; for these purposes, Postdoctoral Fellowships are not considered as first appointments). (June 2008 should be listed as 06/2008). Leave blank if not appropriate.

25. Type in month and year of first faculty/staff appointment at Assistant Professor (or

equivalent) level. Leave blank if not appropriate. 26. Type name of degree with no periods. List the month and year for first doctoral degree.

(June 2008 should be listed as 06/2008.) 27. Type in the specialty for your first doctoral degree that from the drop-down list. Enter the

specialty that most closely coincides with your field of degree. 28 & 29. If appropriate, complete additional doctoral degree information in same manner as items

26 and 27 above. 30. If you have not received a doctoral degree, complete. 31. Martin B. Leon, MD, Johnson & Johnson/Cordis Corporation Interventional Cardiology

fellowship applicants should complete as of award activation date (July 1, 2009). If you have a medical degree, be sure to complete postdoctoral clinical training years and months.

32. Fellowship applicants should leave this item blank. 33. Check any of the awards that you have held or currently hold. Under “Other” list any other

national funding agency/association award that you have held or currently hold. Specify agency and name of award.

34. If a United States citizen, type in United States. If you are not a U.S. citizen, type in the

name of your country of citizenship. 35. Be very specific as to the immigration status you have. If you are not a U.S. citizen but

currently in the U.S. with a visa, select the appropriate status from the drop-down list (such as F1). (U.S. citizens should leave blank.)

Applicants who have been lawfully admitted for permanent residence, i.e., are in

possession of a Permanent Resident Card (formerly known as Alien Registration Card) or other legal verification of such status (such as I-551 stamp in passport), should choose Permanent Resident.

Applicants who have applied for permanent residency should choose Permanent Resident/Pending from the drop-down list. Only applicants who have filed form I-485 with the U.S. Citizenship and Immigration Services and who have received authorization to legally remain in the U.S. (having filed an Application for Employment form I-765) should choose Permanent Resident/Pending.

Awardees must meet AHA citizenship criteria throughout the duration of their awards.

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ADMINISTRATIVE INFORMATION FORM 1- 10. Complete information for Sponsor. 11- 19. Complete information for Grants/Sponsored Programs Officer. Type the institution

where research project will be performed. 20- 24. Complete information for Fiscal Officer for institution that will be financially responsible for

the activities supported by the award. Type the institution where research project will be performed.

25. Indicate percent of applicant's total effort which will be devoted to this project. The time

refers only to the period you expect to receive support from this award, not to any time which previously may have been spent on this project.

26. Total should equal 100%.

Effort to Research: Interventional Cardiology fellows will be expected to devote 25% FTE to research or activities directly related to their development into independent researchers, as opposed to administrative, patient care, or teaching responsibilities.

27. For this project: Check the appropriate blanks relating to experimentation. (a) Self-explanatory. (b) Self-explanatory. (c) Human subjects

The AHA has adopted just-in-time IRB/Privacy Board assurances for human subjects. Each applicant is strongly encouraged to submit his/her project to the appropriate human subjects Institutional Review Board/Privacy Board at the time of application. Funded applicants will have a maximum time of three months following the original activation date to submit the IRB human subjects approval and approved patient consent form for their projects to the AHA. (For example, if the activation date is July 1, IRB approval and approved patient consent form must be received prior to September 30.) If the IRB approval and approved patient consent form are not provided to the AHA within three months of the originally-posted activation date, the award must be relinquished; there are no exceptions.

Any significant change in the scientific research plan or scope/aims of the project subsequent to AHA submission must be reported to the AHA when submitting the just-in-time IRB/Privacy Board approval.

NOTE: If the proposed research project involves human subjects, the population sampled shall be inclusive of the general population, of relevance to the scientific question posed, without restriction in regard to gender, race, age, and socioeconomic status. Proposals that intentionally restrict the population sampled must include a compelling scientific rationale for such research design.

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(d) Adult human stem cells The American Heart Association funds human adult stem cell research.

This research is governed by the standards described in “Ethical Aspects of Research with Human Subjects and Animals.” These standards shall be applied by the AHA in funding any research involving human adult stem cells. Applications involving human adult stem cells fall under the just-in-time IRB/Privacy Board assurance policy described above under human subjects.

(e) Human embryonic stem cells or fetal stem cells

If your answer is “Yes”, you are not eligible to apply. Research applications involving the creation of human embryos or the derivation or use of human stem cells from in vitro fertilization (IVF) treatment embryos or fetal sources will not be accepted.

(f) Human fetal tissue

The AHA does not fund scientific research that involves the use of human fetal tissue.

(g) Cloning

The AHA funds cloning research including human DNA sequences, cell lines and animals subject to ethical principles and restrictions to prevent abuse.

Acceptable research

Acceptable research involves cloning to generate animal models (such as transgenic animals) which express human disease for research use: • to develop specific treatments for persons suffering from diseases, and • to produce tissue or organs for transplantation to replace or augment damaged

or diseased tissues or organs in humans

Areas ineligible for AHA funding Cloning of humans as asexual reproduction or cloning of humans intended as sources of tissue or organs to harvest are not acceptable. However, the Association will fund research using human cell lines and DNA sequences for purposes of producing tissue or organs for transplantation to replace or augment damaged or diseased tissues or organs in humans.

(h) Animal subjects

If your proposal involves animals and your institution does not have unqualified accreditation from the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC) or does not hold a current Public Health Service (PHS) Animal Welfare Assurance, you are not eligible to apply. The AHA has adopted just-in-time IACUC assurances for animal subjects. Each applicant is strongly encouraged to submit his/her project to the appropriate animal care and use committee at the time of application; it is not a requirement that IACUC approval be deferred. Funded applicants will have a maximum time of three months following the original activation date to submit the IACUC approval for their projects to the AHA. (For example, if the activation date is July 1, IACUC approval must be received prior to September 30.) If the IACUC approval is not provided to the AHA within three months of the originally-posted activation date, the award must be relinquished; there are no exceptions.

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Any significant change in the scientific research plan and scope/aims of the project subsequent to AHA submission must be reported to the AHA when submitting the just-in-time IACUC approval.

(i) Self-explanatory. (j) Self-explanatory. BIOGRAPHICAL SKETCH (PI) FORM To be completed by Principal Investigator (fellowship applicant). Complete the AHA Biographical Sketch form page (which includes personal variances from ordinary career progression). This page is similar in format to the PHS 398 Biographical Sketch used by the NIH. Under Education/Training, begin with entry into college and include postdoctoral training. Under Variances from Ordinary Career Progression: Complete if applicable. Each award program has specific eligibility criteria or qualifications. Please review these qualifications or career stage requirements. If you have any extenuating circumstances that affect your eligibility for this particular program, please explain these circumstances. Explain personal variances from ordinary career progression (for example, child-rearing years, military service, unusual circumstances that led to gaps in research experience). It is incumbent upon the applicant to make a convincing justification of eligibility. Also, if you have had a name change (changed your name for any reason) and your name does not match the name on your publications, please address this briefly here. (For instance, your publication history reflects your maiden name and you have recently married and begun publishing under your married name.) Next, if you have a current NIH Biographical Sketch you may insert it. Otherwise, create a Positions, Publications and Research Support section in your word processor and insert the word document after the Biographical Sketch form page. See the bottom of the Biographical Sketch (PI) form page for information to be included in these pages. For Peer-reviewed Publications, fellowship applicants should list all significant earlier publications even if they are not relevant to the proposed project (unless the page limit will be exceeded). Articles accepted for publication and abstracts may be listed. If you have no publications, under “Publications” indicate NONE. Do not exceed 5 pages for the entire AHA Biographical Sketch. CO-AUTHORS/REFERENCES FORM Co-Authors All applicants are to list all co-authors (at assistant professor level or above) with whom you have published an article or abstract within the past 3 years. If you cannot determine co-authors’ academic positions, list all co-authors within the past 3 years. If no publications, complete this area indicating NONE. Current Supervisor Give the name of your current, immediate Supervisor and his/her degree(s).

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REFERENCE REPORTS FOR APPLICANT FORM This form is located in a separate file of additional required forms http://www.americanheart.org/presenter.jhtml?identifier=3025344 References List names and addresses for three persons who have been requested to submit a Reference Report for Applicant (Part I and Part II). If possible select one referent who is not from your current department or organization. Reference Reports should be from individuals familiar with the applicant’s scientific interests and abilities (excluding Sponsor). Since reference reports are critical for your application, request reports only from individuals who will be able to return them by the application deadline date of March 16, 2009. It is the responsibility of the Fellowship applicant to have 3 Reference Report for Applicant forms (Part I and Part II) sent to the American Heart Association. Duplicate the Reference Report for Applicant (Parts I and II), complete with applicant’s name, and provide to referents. Reference Reports may also be e-mailed by the applicant to referents for their completion and submission to the American Heart Association. An electronic Reference Report is not required. The Reference Report may be typed on the form, typed on a separate letterhead and attached, etc. If providing a paper copy to the referent, it is recommended that the applicant provide the respondent with a pre-addressed, postage-paid envelope for returning directly and confidentially to the address below. Reference Reports should not be faxed or e-mailed to the American Heart Association. Due to the confidentiality and the signature required, original Reference Reports must be received. Reference Reports should be received by March 16, 2009. Three Reference Reports should be sent directly and confidentially to: American Heart Association, Founders Affiliate Research Department attn: Mary Gonzalez 122 East 42nd Street, 18th Floor. New York, NY 10168 Reference Reports are critical to your application. Check with your referents near the deadline to ensure that your Reference Reports have been sent to AHA. DO NOT INCLUDE REFERENCE REPORTS IN YOUR APPLICATION PACKAGE.


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Postdoctoral Fellowship Applicants Please create the Academic Record as a new document using a blank page. After creating this word-processed document, place applicant’s name in the lower right corner of each page. Insert this form after the Co-Authors/References form. Note: If you received your education outside of the U.S., please provide this information as completely as possible. Translate the course names into English, if needed, and explain the grading or evaluation system.

Academic Record of Postdoctoral Applicant

Grade Point Average for Undergraduate Courses: Explain grading system. Show level required for passing. Grade Point Average for Graduate Courses: Explain grading system. Show level required for passing. State performance on Graduate Record Examination: Give MCAT scores if appropriate: Page ___ ___________________________ Applicant’s Name

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RESEARCH PROJECT ENVIRONMENT FORM The applicant should delete this form from the main application. This form is part of the Sponsor Packet, which is sent to the Sponsor to complete and is returned to the applicant for submission. PROJECT BUDGET FORM This page should be completed by all Fellowship applicants. Give costs to nearest dollar only. Note: The totals will automatically calculate throughout the form. An annual total which exceeds the maximum allowed for any year will be automatically adjusted by AHA staff. Complete the Year 1 – Year 2 portion of the form at the top as appropriate. 1. Complete each year with salary and fringe benefits amount for the Principal Investigator. Martin B. Leon, MD, Johnson & Johnson / Cordis Corporation Interventional Cardiology

Fellowship stipend should be given here. If fringe benefits are allowed (such as health insurance, etc.), enter amount in fringe line.

2. Complete the total amount requested in each year for project support costs (see Project Support amount allowed in grid which follows).

3. The form will calculate subtotals on this line. 4. No overhead or indirect costs are allowed for fellowships. 5. The form will automatically calculate total costs. Once completed, these totals will

populate the Amounts Requested on the bottom of page 1, Project Summary page.

Summary of Information for Reference

Founders Affiliate

Stipend for Leon / Johnson & Johnson Cordis Corporation Fellow Fringe Benefits Allowed? Project Support Given?

Indirect/ Overhead Costs?

2 years; $50,000 per year for PI stipend plus 15% of stipend ($7,500) for fringe benefits. Additional $17,500 per year for supplies and travel. Maximum annual amount not to exceed $75,000.

No indirect costs; no dependent allowances

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FUNDS AVAILABLE (1-4) - APPLICANT Fellow Support (exclusive of funds available from Sponsor) The Fellow should complete the Funds Available form only with currently active or pending fellowships. Include the Principal Investigator's (Fellow’s) name at the bottom right-hand side and number consecutively with the rest of the application. List all active fellowship awards first, then all pending fellowship awards (which have been submitted to any granting agency). If you have applied to another agency for fellowship/training support and the period of support overlaps with that of this proposed American Heart Association fellowship, list that award status as Pending and check Yes, designating it as Alternative. Since this is considered an alternative proposal, the applicant can accept only one fellowship award if more than one is funded. If the fellow has no active or pending support in his/her own name, complete Funds Available (1) form and place None in item 1. Delete Funds Available forms that are not needed. 1-8. Self-explanatory. 9. Type total award amount (total award dollars, stipend/project dollars/tuition and fees paid

as part of award/institutional allowance that is part of award/training costs/etc., for all years of award).

10. Type total amount available to the applicant (all award dollars for all years of award.)

This amount may be the same as item 9. 11. Type annual amount available to the applicant (minus salary and fringes). If annual

amount is staggered, give an average annual amount. (For some awards that are stipend only, this might be $0.)

Examples for Items 9-11: Example 1: Applicant is the recipient of a 3-year NRSA. Item 9: Total award amount = $138,768 (stipend plus institutional allowance of $7,000

per year for supplies, equipment, travel to meetings and health insurance costs [considered a fringe benefit] x 3 years)

Item 10: Total amount available to applicant = $138,768 (same as item 9) Item 11: Annual award amount available to applicant ($46,256 average annual amount)

minus salary/fringes ($41, 256) = $5,000 Example 2: Applicant is the recipient of a 2-year fellowship from an institutional training

grant. Item 9: Total award amount = $0 (institutional total award amount is not required) Item 10: Total amount available to applicant = $70,000 ($35,000 x 2 years) Item 11: Annual award amount available to applicant ($35,000) minus salary/fringes

($31,000) = $4,000

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Procedural Policies and Standards An application MUST be identified as ALTERNATIVE if submitted to more than one granting agency. Fellowship applicants must include information regarding Fellowship applications pending with any other granting agency. After the application is reviewed by the Association the alternative designation of the project or the budget cannot be changed in order to accommodate any partial alternative funding. The applicant can accept only one fellowship award if more than one is funded. An AHA fellowship awardee may hold only one named fellowship award. SPONSOR PACKET The complete Sponsor packet includes 3 items: 1 - Sponsor Information - Part I and Part II 2 - Research Project Environment 3 - Biographical Sketch-Sponsor The Sponsor must address all the areas covered by the Peer Review criteria (see pages 3-4) within the Sponsor Packet materials. These forms are located in a separate file of additional required forms, named Sponsor Packet (http://www.americanheart.org/presenter.jhtml?identifier=3025391). The Sponsor Information, Research Project Environment, and a Biographical Sketch must be completed by the Sponsor, returned to the applicant and inserted into the application. The Sponsor may provide the information to the applicant in a word-processed format and the applicant may cut and paste the appropriate information into the forms and then insert them into the application. The Sponsor Information, Research Project Environment, and Biographical Sketch are inserted in that order following the Funds Available (by applicant) and prior to the Proposed Research Plan. Give or e-mail these forms to the Sponsor for completion. Also, give or e-mail the peer review criteria to your Sponsor and make sure that he/she is fully covering the criteria as part of the application and Sponsor Packet. Provide the Sponsor with a printed copy of this text in order to ensure proper completion of all forms. 1 - Sponsor Information – Part I and Part II The Sponsor may add an additional one or two pages to each Part I and an additional three pages to Part II, if needed. The Sponsor should be certain to address all 7 items listed on the top of Part II. The Sponsor’s signature is required at the bottom of the original Part II (paper copy).


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2 - Research Project Environment This page is similar in format to the PHS 398 Resources form used by the NIH. This allows the Sponsor to use information from a current Resources form already prepared for an NIH application. Information from the NIH Resources form can be copied and pasted into the Research Project Environment form. If a more extensive description is needed, one additional page may be added behind this form. 3 - Biographical Sketch (Sponsor) Complete the AHA Biographical Sketch (Sponsor) form page. This page is similar in format to the PHS 398 Biographical Sketch used by the NIH. Under Education/Training, begin with entry into college and include postdoctoral training. Next, if you have a current NIH Biographical Sketch you may insert it. Otherwise, create a Positions, Publications and Research Support section in your word processor, and insert it after the AHA Biographical Sketch (Sponsor) form page. See the bottom of the AHA Biographical Sketch (Sponsor) form page for information to be included in these pages. If you have no publications, under “Publications” indicate NONE. Do not exceed 5 pages for the entire AHA Biographical Sketch. CO-SPONSOR PACKET The inclusion of a Co-Sponsor is considered an exceptional circumstance. The complete Co-Sponsor packet includes 3 items: 1 - Co-Sponsor Information - Part I and Part II 2 - Research Project Environment 3 - Biographical Sketch-Co-Sponsor The Co-Sponsor must address all the areas covered by the Peer Review criteria (see pages 2) within the Co-Sponsor Packet materials. If you have designated a Co-Sponsor, this individual must provide the Co-Sponsor packet. These forms are located in a separate file of additional required forms, named Co-Sponsor Packet (http://www.americanheart.org/presenter.jhtml?identifier=3025393). The Co-Sponsor Information, Research Project Environment, and a Biographical Sketch must be completed by the Co-Sponsor, returned to the applicant and inserted into the application. The Co-Sponsor may provide the information to the applicant in a word-processed format and the applicant may cut and paste the appropriate information into the forms and then insert them into the application. The Co-Sponsor Information, Research Project Environment, and Biographical Sketch are inserted in that order following the Sponsor packet and prior to the Proposed Research Plan. Give or e-mail these forms to the Co-Sponsor for completion. Also, give or e-mail the peer review criteria to your Co-Sponsor and make sure that he/she is fully covering the criteria as part of the application and Co-Sponsor Packet. Provide the Co-Sponsor with a printed copy of this text in order to ensure proper completion of all forms.


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1 - Co-Sponsor Information – Part I and Part II The Co-Sponsor may add an additional one or two pages to each Part I and an additional three pages to Part II, if needed. The Co-Sponsor should be certain to address all 5 items listed on the top of Part II. The Co-Sponsor’s signature is required at the bottom of the original Part II (paper copy). 2 - Research Project Environment This page is similar in format to the PHS 398 Resources form used by the NIH. This allows the Co-Sponsor to use information from a current Resources form already prepared for an NIH application. Information from the NIH Resources form can be copied and pasted into the Research Project Environment form. If a more extensive description is needed, one additional page may be added behind this form. 3 - Biographical Sketch (Co-Sponsor) Complete the AHA Biographical Sketch (Co-Sponsor) form page. This page is similar in format to the PHS 398 Biographical Sketch used by the NIH. Under Education/Training, begin with entry into college and include postdoctoral training. Next, if you have a current NIH Biographical Sketch you may insert it. Otherwise, create a Positions, Publications and Research Support section in your word processor and insert it after the AHA Biographical Sketch (Co-Sponsor) form page. See the bottom of the AHA Biographical Sketch (Co-Sponsor) form page for information to be included in these pages. If you have no publications, under “Publications” indicate NONE. Do not exceed 5 pages for the entire AHA Biographical Sketch. PROPOSED RESEARCH PLAN (no more than 12 pages; if page limit is exceeded, application will be administratively withdrawn) A form is not provided for your proposed research plan. For your research plan (and animal subjects sections, if applicable) the following are AHA requirements:

• no more than 15 characters per inch (cpi) or an average of no more than 15 cpi (cpi includes symbols, punctuation and spaces)

• ¾” margins should be used • 60 lines per page are the maximum allowed (The average number of lines per page

using the font and point size below will be approximately 50-55 lines.) • Windows Arial font style 12 point* • Macintosh Helvetica 12 point *

*Figures, charts, tables, graphics and legends may be smaller in size but must be clear and legible.

It is essential that the text of your research plan complies exactly with the Association’s type specifications and page limits. Failure to comply will result in the administrative withdrawal of the application.

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Word processing programs must adjust settings appropriately and should measure text after saving. Type requirements should be checked using a standard measuring device (such as a ruler), rather than relying on the font selected for a particular word processing/printer combination. Type size specifications must be observed in the text of your research plan or the application will be returned without review. Create the Proposed Research Plan and after creating this word-processed document, number these pages consecutively; the applicant's name should appear in the lower right corner of each page. Insert the pages after the fellow’s Sponsor packet pages, as appropriate. No more than 12 consecutively numbered pages (including any diagrams, tables, graphics/images, etc.) will be accepted. (Appendices or enlarged sets of images should not be sent; if sent with paper sets, these pages will be counted toward the 12-page limit, usually resulting in administrative withdrawal.) Applications with greater than 12 consecutive pages in the Proposed Research Plan (items 1-4 below) and/or not adhering to format requirements (characters per inch, etc.) will be administratively withdrawn. Type the proposed research plan single-spaced, specifically following the outline given. All items should be addressed. Please indicate N/A or None if not applicable to this application. The Research Plan should be written in such a way as to address all of the Peer Review criteria (see pages 3 for new criteria). Suggested lengths are guidelines only but must not exceed 12 pages. 1) Specific Aims (1 page) Provide a clear, concise summary of the aims of the work proposed and the hypothesis

to be tested. 2) Background and Significance ( 3 pages) Sketch briefly the background to the proposal; preliminary studies may be addressed

here. State concisely the importance of the research described in this application by relating the specific aims to broad, long-term objectives.

State concisely the relevance of the research to cardiovascular function or disease,

stroke, or to related fundamental problems. 3) Research Design and Methods (7-1/2 pages) Provide the following information: a) research design and the procedures to be used to accomplish the specific aims; b) tentative sequence for the investigation; c) statistical procedures by which the data will be analyzed; d) discussion of potential experimental difficulties and alternative approaches to achieve the aims

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Note: Except as provided below, if a proposed research project involves human

subjects, the population sampled shall be inclusive of the general population, of relevance to the scientific question posed, without restriction in regard to gender, race, age, and socioeconomic status. Proposals that intentionally restrict the population sampled must include a compelling scientific rationale for such research design. Be sure to address this topic.

4) Ethical aspects of the proposed research (1/2 page) Describe any special consideration you have given to all ethical issues involved in your

proposed investigations (biohazards, human subjects, etc.), identifying risks and management. Be sure to address this topic. If using animals, see instructions below.

End of text (not to exceed 12 pages in the Proposed Research Plan). VERTEBRATE ANIMAL SUBJECTS (to be addressed separately from the 12 pages of the research plan) Format requirements are the same as those given for the Proposed Research Plan (characters per inch, font, etc.) If using vertebrate animal subjects, address the following five points. In addition, when research involving vertebrate animals will take place at collaborating site(s) or other performance site(s), provide this information before discussing the five points.

1) Provide a detailed description of the proposed use of the animals in the work outlined in the Research Design and Methods section. Identify the species, strains, ages, sex, and numbers of animals to be used in the proposed work.

2) Justify the use of animals, the choice of species, and the numbers to be used. If animals are in short supply, costly, or to be used in large numbers, provide an additional rationale for their selection and numbers.

3) Provide information on the veterinary care of the animals involved.

4) Describe the procedures for ensuring that discomfort, distress, pain, and injury will be limited to that which is unavoidable in the conduct of scientifically sound research. Describe the use of analgesic, anesthetic, and tranquilizing drugs and/or comfortable restraining devices, where appropriate, to minimize discomfort, distress, pain, and injury.

5) Describe any method of euthanasia to be used and the reasons for its selection. State whether this method is consistent with the recommendations of the Panel on Euthanasia of the American Veterinary Medical Association. If not, present a justification for not following the recommendations.

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LITERATURE CITED There is no page limitation. List all literature references. Each reference must list the authors in the same order as they appear on the paper, the title, the name of the book or journal, volume number, page numbers, and year of publication. References should be limited to relevant and current literature; be concise and select only those references pertinent to the proposed research. BIOGRAPHICAL SKETCH (of Collaborating Investigator, if applicable) AHA considers it highly unusual for a postdoctoral fellow to designate a Collaborating Investigator. If you have a Collaborating Investigator, insert his/her NIH Biographical Sketch into your application. Provide a separate Biographical Sketch for each Collaborating Investigator named in your application. A word-processed document should be created, saved and inserted into your application. The Collaborating Investigator’s Biographical Sketch should not exceed 5 pages.) Insert and consecutively number these Biographical Sketches here. RESEARCH CLASSIFICATION FORMS (1, 2) Follow instructions on the form to categorize terms that best apply to your project. SCIENCE CLASSIFICATION FORMS (1, 2, 3, 4) Follow instructions on the form to identify scientific terms that best apply to your project. PERSONAL DATA FORM Review and complete if desired. (This is a confidential document and should not be included with each paper copy of the application.) Provision of the 4-digits of the Social Security Number is voluntary. The American Heart Association requests it for the purpose of accurate identification and for efficient management of the Association’s research programs. Please note: The Research Classification, Science Classification and Personal Data form are part of the email submission application. They are the last forms in the Main Form. Complete these forms based upon the instructions on the form.

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ENCLOSURES FROM APPLICANT (to be included with paper application materials

received one week after email submission deadline) LETTER FROM COLLABORATING INVESTIGATOR (if applicable) If a Collaborating Investigator is named on the Project Personnel/Signatures page, a letter must be provided confirming participation and amount of time to be devoted to the project. The original letter and three copies should be provided. LETTER FROM CONSULTANT (if applicable) If a Consultant is named on the Project Personnel/Signatures page, a letter must be provided describing specific services for the project. The original letter and three copies should be provided. REPRINTS OF APPLICANT’S PUBLICATIONS Submit 4 reprints each (or duplicated copies) of the 3 most pertinent publications by the applicant. (If none are considered pertinent to the project, submit 3 other publications which best represent your work.) Preprints and articles recently submitted may be used. Abstracts are acceptable for Fellowship applicants. (Publications which do not list the applicant as an author are unacceptable.) FELLOWSHIP APPLICATION CHECKLIST Refer to the Application Checklist at the beginning of these Instructions for appropriate number of copies needed and assembly of application.

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SUBMISSION OF APPLICATION After submitting the application via email, the original and 3 duplicated sets are required. The completed email application submission is due by March 16, 2009, 5 p.m. Eastern Standard Time. Submit your application via email to: [email protected]. The original plus 3 paper sets must arrive at the New York City Research Office by 5 p.m. Eastern Standard Time, March 23, 2009 (one week later). Mail materials to:

American Heart Association, Founders Affiliate Research Department

attn: Mary Gonzalez 122 East 42nd Street, 18th Floor. New York, NY 10168

For assistance with program and eligibility criteria, instructions or form content contact: Phone 212-878-5912, 5900 E-mail [email protected]



REFERENCE REPORT FOR APPLICANT – PART I Privileged Communication, to be completed by person providing reference. Please mail directly to the American Heart Association. It is recommended that the applicant provide the respondent with a preaddressed, postage-paid envelope (see instructions). 1. Applicant’s name: 2. Sponsoring institution: 3. Name (with doctoral degrees): 4. Department: Division: 5. Institution: Phone Number: 6. Dates associated with applicant: From: To: 7. Capacity at that time (teacher, supervisor, etc.): 8. Position of applicant at that time (undergraduate, teaching asst., etc.): 9. Please rate the applicant relative to other individuals of similar training and experience with whom you have been associated. Mark every line.

Outstanding (upper 5%)

Excellent

(upper 6-20%)

Very Good

(upper 21-40%)

Good Average (mid 41-60%)

Fair/Below Avg

(lower 40%)

Insufficient Knowledge

Research ability and potential Knowledge in chosen field, familiarity with literature Written and verbal communication skills Self-reliance and independence Motivation and perseverance in pursuing goals Ability to plan and conduct research, organize data Ability to work as a member of a research team Imagination, originality, creativity

Accuracy Laboratory skills and techniques, if relevant

Clinical proficiency, if relevant

Overall scientific ability Award program Applicant’s Name (Please type)

RERENCE REPORT FOR APPLICANT- PART II Comment specifically on the applicant’s strengths and limitations as they relate to his/her potential in the chosen field of study. Descriptions of significant accomplishments and personal qualities related to scholarly achievement (including major academic strengths and weaknesses) are particularly helpful, if appropriate. Describe any qualifications and traits you consider of special significance in judging the applicant’s fitness for a research career in the biomedical sciences, emphasizing research aspects.

Respondent’s Name: Signature: Date: Award program name Applicant’s Name (Please type)

SPONSOR INFORMATION – PART I (To be completed by SPONSOR) 1. Applicant:

First Middle Last Jr/Sr/etc Degree(s) 2. Sponsor Name/Address: 3. Sponsor: First Middle Last Jr/Sr 4. Institution: List trainees under you supervision (within past five years, current and pending) and indicate the source of stipend support for all current and pending trainees. For past trainees, also give the name of their present employer (institution) and position title or occupation.

SPONSOR INFORMATION – PART II Describe your detailed plan for the proposed research training of this applicant (use no more than two (2) additional blank pages if needed). The narrative should include the following items: 1) A description of research in progress in the Sponsor’s establishment with which the applicant will be involved. 2) The Sponsor’s plan to develop the applicant’s research capabilities including a statement as to the sequence in which the applicant will be given increasing personal responsibility for the conduct of research. 3) An indication of other related training or course work which will be required for specific technical skills or methods the applicant will expect to master. (Include the names, degrees and titles of other individuals who will be involved in training the applicant.) 4) The relationship of the research training plan to the applicant’s career goals.

Indicate the approximate percentage of time the SPONSOR will spend on the trainee’s research program: % Signature: Date: Applicant’s Name (Please type)

RESEARCH PROJECT ENVIRONMENT FACILITIES: Specify the facilities to be used for the conduct of the proposed research. Indicate the performance sites and describe capacities, pertinent capabilities, relative proximity, and extent of availability to the project. Under “Other,” identify support services and specify the extent to which they will be available to the project. Use continuation pages if necessary. Laboratory:

Clinical:

Animal:

Computer:

Office:

Other:

MAJOR EQUIPMENT: List the most important items already available for this project, noting the location and pertinent capabilities of each.


BIOGRAPHICAL SKETCH (SPONSOR) Name:

First Middle Last Jr/Sr/etc Degree(s) Position/Title:

Education/Training: (Begin with entry into college and include postdoctoral training.)

Institution and Location Dates Attended

Degree (if applicable)

Conferred (mm/yyyy) Field of Study

Positions, Publications and Research Support (create these pages as word files) 1) Positions/Employment, Memberships and Honors – List in chronological order previous positions, concluding with your present position. Include start/end dates, position title, name of organization and department. Also list other experience and professional memberships, and academic/professional honors received. If necessary, senior applicants may list previous employment for the past 15 years and should be very selective regarding memberships/honors. 2) Peer-reviewed Publications – List, in chronological order, selected peer-reviewed publications. Do not include publications submitted or in preparation. 3) Research Support – List selected ongoing or completed (during the last three years) research projects. Give project number, agency, title of project, and dates of award. Then briefly indicate the overall goals of the projects and your role (e.g., Pl, Co-Investigator, Consultant) in the research project. Do not list award amounts of percent effort in projects.


OTHER SUPPORT There is no form page for other support. Information on other support should be provided in the format shown below, using blank pages. Include the Principal Investigator’s name at the bottom (right-hand side) and number consecutively with the rest of the application. The sample is intended to provide guidance regarding the type and extent of information requested. If you have no active or pending support, complete an Other Support page with the PI’s name and sate “None”. Format NAME OF INDIVIDUAL ACTIVE/PENDING

Dates of Approved/Proposed Project Annual Direct Costs

Percent Effort Project number (Principal Investigator) Source Title of Project (or Subproject) The major goals of this project are…

OVERLAP/ALTERNATIVE (Scientific and/or budgetary, summarized for each individual)

ANDERSON, R.R. ACTIVE 2 RO1 HL 00000-13 (Anderson) 3/1/99-2/28/02 30% NIH/NHLBI $186,529 Chloride and Sodium Transport in Airway Epithelial Cells The major goals of this project are to define the biochemistry of chloride and sodium Transport in airway epithelial cells and clone the gene(s) involved in transport. 5ROI HL 00000-07 (Baker) 4/1/97-3/31/02 10% NIH/NHLBI $122,717 lon Transport in Fetal Lung The major goal of this project is to study chloride and sodium transport in normal and cystic fibrosis fetal lung. PENDING 5 RO1 HL 00000-22 (Anderson) 12/01/99-11/30/01 20% NIH/NHLBI $82,163 Liposome Membrane Composition and Function The major goals of this project are to define biochemical properties of liposome membrane components and maximize liposome uptake into cells. ALTERNATIVE There is scientific overlap between aim 2 of NIH HL 00000-22 and aims 3 and 4 of the application under consideration. This application is alternative to the AHA proposal

Email Application Submission

Email submission is mandatory for the Martin B. Leon, MD/Johnson & Johnson Cordis Corporation Research Fellowship in Interventional Cardiology

• To download the forms for this program please go to: http://www.americanheart.org/presenter.jhtml?identifier=3015642

• To complete the main application and all other forms on your computer, you must have Word 3.0 for

Windows (for PC) or a later version. If you have this capability, you should download the appropriate format to your computer’s hard drive from the web site in order to complete the forms. If you do not have this software capability or are having problems accessing the form, you may contact Mary Gonzalez at 212-878-5912 or [email protected] and the necessary documents will be sent to you via email.

• Submit the Main Application Form, proposed research plan and all other required forms in one combined word document file or separate word document files. Your email submission will not have signatures. • Scanned documents will not be accepted.

• Your email submission and paper copies must match word-for-word. If changes occur the application may be withdrawn. For minor administrative changes, contact AHA research office at the contact information listed above.

• After submitting the application via email, paper copies are required. See application instructions for details about number of copies and mailing address.

Applications for the Leon/Johnson & Johnson Cordis Interventional Cardiology Award must be submitted by email at: [email protected] no later than Monday, March 16, 2009 at 5:00 p.m. Eastern Standard Time. The original with all signatures plus 3 paper sets must arrive at the Founders Affiliate NYC Research Office on Monday, March 23, 2009 by 5 p.m. Eastern Standard Time.

If you have questions about this research award, please contact Mary Gonzalez at 212-878-5912 or via e-mail at: [email protected]




Weekly NIH Funding Opportunities and Notices NIH Guide for Grants and Contracts

January 30, 2009 Table of Contents (TOC)

Web Version

Notices

• Expiration of Several Research Career Development Award (K Award) Funding Opportunity Announcements (NOT-OD-09-039) National Institutes of Health http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-039.html

• Findings of Scientific Misconduct (NOT-OD-09-040) Department of Health and Human Services http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-040.html

• Renumbered NIH Guide Funding Opportunity Announcement: RFA-OD-09-002 to PAR-09-091 for Pre-Application for Dietary Supplement Research Centers: Botanicals (X02) (NOT-OD-09-041) National Institutes of Health http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-041.html

• Delays in Grant Application Submission due to Winter Ice Storms January 2009 (NOT-OD-09-042) National Institutes of Health http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-042.html

• Adobe-Based Grant Application Forms Now Available for All NIH Funding Opportunity Announcements Requiring Electronic Submission (NOT-OD-09-043) National Institutes of Health http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-043.html

• Announcing a Delay in Transition to Electronic Submission of Applications for Individual National Research Service Awards (Fs) and Confirming Plans to Transition Individual Research Career Development Awards (Ks) (NOT-OD-09-044) National Institutes of Health Agency for Healthcare Research and Quality Food and Drug Administration National Institute for Occupational Safety and Health http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-044.html

• Error-Correction Window Extended for All Electronic Applications with Submission Deadlines through the End of February, 2009 (NOT-OD-09-045) National Institutes of Health Agency for Healthcare Research and Quality Food and Drug Administration National Institute for Occupational Safety and Health http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-045.html

• 2009 NIH Regional Seminar on Program Funding & Grants Administration: Register now for Atlanta, Ga (NOT-OD-09-046) National Institutes of Health http://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-046.html

• Second Notice to Extend Expiration Date for PAR-06-536 (NOT-AR-09-005) National Institute of Arthritis and Musculoskeletal and Skin Diseases http://grants.nih.gov/grants/guide/notice-files/NOT-AR-09-005.html

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http://grants.nih.gov/grants/guide/notice-files/NOT-AR-09-005.html

• Request for Information (RFI): Public Comment on Development of a Funding Opportunity Announcement on Translational Research on Minimizing Risks of Managing Pain with Opioids in General and Specialty Medical Settings (NOT-DA-09-006) National Institute on Drug Abuse http://grants.nih.gov/grants/guide/notice-files/NOT-DA-09-006.html

• Notice of Intent to Publish a Request for Applications for Nutrition Obesity Research Centers (P30) (NOT-DK-09-002) National Institute of Diabetes and Digestive and Kidney Diseases http://grants.nih.gov/grants/guide/notice-files/NOT-DK-09-002.html

• Change in Application and Submission Guidelines for RFA-DK-08-011: Type 1 Diabetes TrialNet: Clinical Centers (U01) (NOT-DK-09-003) National Institute of Diabetes and Digestive and Kidney Diseases http://grants.nih.gov/grants/guide/notice-files/NOT-DK-09-003.html

• Participation of NIH Intramural Research Program (IRP) Investigators in RFA-DK-09-004:Multi-Ethnic Study of Type 2 Diabetes Genes (U01) (NOT-DK-09-004) National Institute of Diabetes and Digestive and Kidney Diseases http://grants.nih.gov/grants/guide/notice-files/NOT-DK-09-004.html

• Extension of the AHRQ Grants for Health Services Research Dissertation Program (R36) Funding Opportunity Announcement (PAR-06-118) (NOT-HS-09-005) Agency for Healthcare Research and Quality http://grants.nih.gov/grants/guide/notice-files/NOT-HS-09-005.html

• Notice of Clarification for PAR-08-070 (NOT-OH-09-002) National Institute for Occupational Safety and Health http://grants.nih.gov/grants/guide/notice-files/NOT-OH-09-002.html

• Notice Regarding PAR-06-484 Occupational Safety and Health Training Project Grants (T01, T02, T03, T15) (NOT-OH-09-005) National Institute for Occupational Safety and Health http://grants.nih.gov/grants/guide/notice-files/NOT-OH-09-005.html

Requests for Applications

• Pharmacogenomics Research Network (U01/U19) (RFA-GM-10-001) National Institute of General Medical Sciences National Cancer Institute National Heart, Lung, and Blood Institute Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institute on Drug Abuse National Institute of Mental Health Application Receipt Date(s): June 02, 2009 http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-10-001.html

• NHLBI Progenitor Cell Biology Consortium Research Hubs (U01) (RFA-HL-09-004) National Heart, Lung, and Blood Institute Application Receipt Date(s): May 01, 2009 http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-09-004.html

• NHLBI Progenitor Cell Biology Consortium Administrative Coordinating Center (U01) (RFA-HL-09-005) National Heart, Lung, and Blood Institute Application Receipt Date(s): May 01, 2009 http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-09-005.html

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http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-09-004.html

http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-09-005.html

• NCMHD Endowment Program for Increasing Research and Institutional Resources Capacity in Section 736 Health Professions Schools (NCMHD Research Endowment Fund) (S21) (RFA-MD-09-002) National Center for Minority Health and Health Disparities Application Receipt Date(s): March 23, 2009 http://grants.nih.gov/grants/guide/rfa-files/RFA-MD-09-002.html

• NCMHD Research Infrastructure in Minority Institutions (P20) (RFA-MD-09-003) National Center for Minority Health and Health Disparities Application Receipt Date(s): March 31, 2009 http://grants.nih.gov/grants/guide/rfa-files/RFA-MD-09-003.html

Program Announcements

• Pre-Application for Dietary Supplement Research Centers: Botanicals (X02) (PAR-09-091) National Institutes of Health National Center for Complementary and Alternative Medicine National Cancer Institute Application Receipt/Submission Date(s): April 30, 2009 http://grants.nih.gov/grants/guide/pa-files/PAR-09-091.html

• Academic-Community Partnership Conference Series (U13) (PAR-09-092) Eunice Kennedy Shriver National Institute of Child Health and Human Development Application Receipt/Submission Date(s): March 31, 2009, March 2, 2010, March 2, 2011 http://grants.nih.gov/grants/guide/pa-files/PAR-09-092.html

NIH Funding Opportunities now available in RSS (Really Simple News Syndication) format - see http://grants.nih.gov/grants/guide/rss_info.htm for details.

To Unsubscribe to the NIH Guide Weekly TOC LISTSERV, follow the instructions at http://grants.nih.gov/grants/guide/listserv.htm.

This weekly list can be found at: http://grants.nih.gov/grants/guide/WeeklyIndex.cfm?WeekEnding=01-30-2009

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1. Is the mentor an independent investigator? 2. Does the mentor have the experience to direct the proposed research training, as evidenced by their track

record regarding productivity, funding and prior trainees? 3. Does the mentor have adequate current funding to support the fellow’s project? 4. Does the mentor provide a comprehensive training plan that will facilitate the applicant’s progress towards

his/her research career goals? Environment 1. Does the scientific environment in which the work will be done contribute to the probability of success for the

training experience? 2. Is there evidence of institutional commitment?

Criterion #3 – EVALUATION OF THE PROPOSAL Together, assessment of these three criteria should account for 1/3 of the overall Proposal score.

1. Significance: Does this study address an important problem broadly related to interventional cardiology? What will be the effect of these studies on the concepts, methods, and technologies that drive this field?

2. Approach: It is recognized that a new fellow may not have had adequate time to generate preliminary data. It is acceptable for applicants to present preliminary data

generated by the sponsor. The assessment of preliminary data, whether generated by the sponsor or the applicant, should be put into perspective such that bold new ideas and risk taking on the part of the beginning investigators are encouraged rather than stymied. Are the conceptual framework, design, methods, and analyses adequately developed, well integrated, well reasoned, feasible (as determined by preliminary data or the expertise available in the mentor’s and/or collaborator’s laboratories) and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics?

3. Innovation: Is the project original? Restrictions

• Not intended for individuals above the faculty rank of Assistant Professor

• Awardee will be expected to devote at least 25% FTE to research or to activities directly related to research

• Must be broadly related to a problem in interventional cardiology including vascular biology, thrombosis or coronary physiology, clinical trials including pilot studies, and studies of epidemiology and outcomes.

• May apply for another Association grant during the year and may apply for a second Cordis Award

• Awardee may not hold another Association award concurrently

• Limitation of one Association-funded fellow per sponsor at any time

• No restriction or limit on prior years of postgraduate research experience

• Institution may supplement stipend

• An applicant may submit only one Affiliate application per deadline

Location of Work Awards are limited to nonprofit institutions such as medical schools, universities and colleges, public and voluntary hospitals and other nonprofit institutions that can demonstrate the ability to conduct the proposed research in the Founders Affiliate. Applications will not be accepted for work with funding to be administered through any federal institution or work to be performed by a federal employee with the exception of Veterans Administration employees Interim Reporting Assessment of mid progress and final reports from fellow and sponsor, including research and training accomplishments, abstracts, and publications. Evaluation Publications, citations by others, ability to attract ongoing research funding, faculty advancement, and contribution of Association support to career advancement. Contact: Mary Gonzalez at (212) 878-5912 or via email at: [email protected]

the martin b. leon, md johnson

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