Plus an optional half-day Short Course onWork Up and Product Isolation

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Early BirdSAVE €350if registered before

30/04/2017

Register for this course by using our fast online booking system or form on page 4 or call +44 (0)1435 873062

27-29 SEPTEMBER 2017

Media Sponsors

The 38th International Conference and Exhibition

Organic Process Research& Development

The Leading Process Chemistry Conference

Stockholm, SwedenWorld Trade Center

Platinum Sponsor

Gold Sponsor

“Scientific Update provides

excellent conferences with an eye on the overall quality

(venue, location, timing, etc.), aside from the high

quality of speakers.”F.I.S. SpA

Organic Process Research& Development

The 38th International Conference and Exhibition

27-29 September 2017 Stockholm, Sweden, World Trade Center

Why Attend? Benefits of attending this conference?> Invest in yourself: keeping up to date on

current developments and future trends could mean greater job security.

> Learn from a wide range of industrial case studies given by hand-picked industrial speakers.

> Take home relevant ideas and information that are directly applicable to your own work with the full proceedings in colour and a USB of the talks.

> Save time. Our intensive, commercial-free programme means less time away from work.

> Meet and network with the key people in the industry in a relaxed and informal atmosphere.

Who should attend?> Process Research & Development

Chemists

> Chemical Engineers in Industry

> Heads of Departments & Team Leaders

What’s included?> Attendance at all the conference

sessions

> Set of colour conference proceedings

> Lunch & refreshments daily

> Access to the exhibition

> Place at the Networking Reception

> FREE Poster Board (by request)

Conference FeesEarly Bird €1550Regular Delegate €1900Exhibitor Package €2750 (includes one exhibitor attending)

Additional Exhibitors €1080Academic rate €600 Please contact us to obtain this special rate

Optional Short Course fee €360

Conference TimingsWednesday 27 September08.15 am Registration8.55am-5.45pm Conference in Session2.00pm-5.45pm Welcome Reception - sponsored by Rise2.00pm-5.45pm Sightseeing Boat Trip plus dinner - sponsored by Evonik

Thursday 28 September8.55am – 12.45pm Conference in session2.00pm – 5.30pm Optional Short Course / Site Visit to Rise

Friday 29 September 8.55am – 12.45pm Conference in session1.30pm –4.30pm Work Shop - C-Tech Innovation

Cancellation Policy Please complete and return the form overleaf with full payment details. Cancellation must be sent in writing. If notice of a cancellation is received more than thirty days prior to the event, the registration fee will be refunded less a €300 cancellation fee. If notice is received less than thirty days before the event, all fees are forfeited. Substitutions are permitted at any time. Scientific Update reserves the right to alter the arrangements as described in unforeseen circumstances. For the full terms and conditions, please see our website.

EXHIBITION OPPORTUNITIESWhy not Exhibit at this prestigious conference. There will be plenty of opportunities to network with key decision makers in a relaxed an informal environment. For more details on what the Exhibition package includes, visit our website www.scientificupdate.co.uk

Follow us on twitter#OPRDEU17

The efficient conversion of a chemical process into a process for manufacture on tonnage scale has always been of importance in the chemical and pharmaceutical industries. However, in the current economic and regulatory climate, it has become increasingly vital and challenging to do so efficiently. Indeed, it has never been so important to keep up to date with the latest developments in this dynamic field.

At our Organic Process Research & Development Conference, you will hear detailed presentations and case studies from top international chemists. Our hand-picked programme of speakers has been put together specifically for an industrial audience. They will discuss the latest issues relating to synthetic route design, development and optimisation in the pharmaceutical, fine chemical and allied fields. Unlike other conferences, practically all our speakers are experts from industry, which means the ideas and information you take home will be directly applicable to your own work.

The smaller numbers at our conferences create a more intimate atmosphere. You will enjoy plenty of opportunities to meet and network with speakers and fellow attendees during the reception, sit-down lunches and extended coffee breaks in a relaxed and informal environment. Together, you can explore the different strategies and tactics evolving to meet today’s challenges.

Book your place today at the leading process R&D conference.

Do you want to improve efficiency and innovation in your synthetic route design, development and optimisation?

Tutor: Dr Will Watson, Scientific Update

Thursday 28 September 2.00pm - 5.30pm

VENUEWorld Trade Conference CenterWorld Trade Center StockholmKlarabergsviadukten 70Stockholm SE-111 64, Sweden+46 8 700 45 00www.wtc.se/en

World Trade Center Stockholm is in the middle of Stockholm and is only 20 minutes away from the airport. The building is easily accessible via public transportation and has 16 meeting rooms of various sizes as well as nearby expo surfaces.

Accommodation: Comfort Hotel Stockholm is an affordable alternative, and you will be hard pressed to find a room closer to your conference.Alternative accommodation will also be listed on confirmation.

PLATINUM SPONSORRISE Process and Pharmaceutical Development (RISE PPD) is a research institute focusing on chemical process- and pharmaceutical development. As a partner to industrial organizations and academic research groups we lead projects from idea to proof of concept for commercial application. Our activities range from research, development and concept testing e.g. small scale manufacture. The majority of the current personnel have a

background from industrial pharmaceutical R&D with profound experience of drug substance and drug product development throughout the preclinical and clinical program to launch. Our current main business areas are within Life Science, Specialty & Fine Chemistry, BioEconomy and Material Science. The innovation infrastructure at RISE PPD includes expertise and state of the art research laboratories as well as very flexible facilities for process demonstration and

testing of new concepts, scale up of technical new materials, as well as small scale GMP-manufacture of drug substance (APIs) and drug product (IMPs) for clinical trials. We are a fully owned subsidiary of RISE, Research Institutes of Sweden.Come and meet us at the site visit provided on Thursday 28 September as part of the OPRD conference program!

SHORT COURSE: Work Up and Product Isolation

This short course will discuss the importance of designing simple, practical reaction quenches, work-ups and product isolations for a range of reaction and product types eg highly exothermic quenches, products with poor stability, removal of reagent by-products, consideration of impurities and meeting the needs of process intermediates

as well as final products. The focus of this short course will be to design processes suitable for large scale operation and the importance of laboratory experimental design and execution to adequately model the large–scale process.

Short Course Fee: €360

For details on how to book this conference, please visit our website: www.scientificupdate.co.uk

International Presentations, to include:

Anna Minidis, RISE Process and Pharmaceutical Development, Sweden Direct facile methods for catalytic enantioselective reductive amination of prochiral ketones using hydrogen

Damian Grainger, Johnson Matthey, UK

David Maillard, Merck, Germany Examples of useful PAT-Application (Process Analytical Technology) during chemical process development

Francesco Fontana, F.I.S. - Fabbrica Italiana Sintetici S.p.A, Italy Process Development and Scale Up of API Intermediates: cross-couplings & friends

Fridtjof Schroeder,Givaudan, Switzerland Fragrances through Cyclopropyl carbinyl Rearrangement

Gabriele Menges-Flanagan, Fraunhofer ICT-IMM, Germany

Hansjoerg Lehmann, Novartis Pharma AG, Switzerland Diazomethane, Hazardous Intermediates and Continuous Flow: How to make risky reactions attractive again

Lars Eklund, Cambrex, Sweden Medetomidine, a simple difficult substance to make

Michael Depierro, Dow Corning Corp, USA Process Development for Organosilicon-Based Flame Retardants

Pablo Garcia-Losada, Eli Lilly & Co, Spain Alternative Synthetic Technologies transforming traditional synthetic activities in discovery chemistry: Impact on scale-up for GLP material supply

Simone Tortoioli, Acetelion, Switzerland

Steve Han, Boehringer Ingelheim, USA Research toward Practical Methods for the Synthesis of P-Stereogenic Chiral Phosphine Ligands and Applications to Asymmetric Synthesis of Drug Substances

Xianglin Shi, Biogen, USA Three-Reaction-Cycle Solid-Phase Synthesis Process for Phosphorothioate Oligonucleotide Manufacture

Includes Workshop by C-Tech Developing a validated technology platform for the application of oxygen dependent enzymes in synthesis and transformation of alcohols

GOLD SPONSORA chemical process and pharmaceutical development research institute. Comprehensive Innovation infrastructure with expertise and state of the art experimental facilities constitute Your Innovation partner. We run challenging projects and solve complex problems from idea to scaleup demonstration.

Synthesis & Chemical Engineering, Formulation & Drug Design, Preformulation, Analytical Development, Crystallization & Solid State, Continuous Processing, and Catalysis including high temperature and pressure chemistry.

No. Delegates Early Bird rate Regular Delegate Exhibitor Package Additional Exhibitors Academic rate

€1550 per person (if you book before 30/04/2017)

€1900 €2750(includes one exhibitor attending)

€1080 €600Please contact us to obtain this special rate

Optional short course I would like to attend (Course Fee €360)

Please complete this form and fax to +44 (0)1435 872734You can also download the PDF from www.scientificupdate.co.uk, complete the form online and email back

Scientific Update, Maycroft Place, Stone Cross, Mayfield, E. Sussex TN20 6EW, UK Tel +44 (0)1435 873062 sciup@scientificupdate.co.uk

The organisers reserve the right to change the published programme of events and course content as circumstances dictate 8511

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Organic Process Research& Development

27-29 September 2017, Stockholm, Sweden

For full terms of business and payment details please see our website

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* Currency Payments If you select to pay in GBP or Dollars, the amount charged will be based on the exchange rate at the time of preparing the invoice.Discounts Complete the details for either two or three delegates and your discount will automatically be applied. This offer only applies where all delegates are booked simultaneously and at the same billing address.Cancellations Should you be unable to attend and cancel in writing no later than 1 month before the start of the course, Scientific Update will refund your registration fee less £300 (or equivalent in €/$) processing fee. Unfortunately refunds are not possible within 1 month of the course date. Substitutions can be made at any time.Data Protection The personal information on this form may be used by Scientific Update for marketing purposes. If you do NOT wish this information to be disclosed to any third parties, please tick this box.