the 3 h’s of pediatric plastic surgery h's of... · 2019. 5. 10. · new trends for...
TRANSCRIPT
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The 3 H’s of Pediatric Plastic Surgery
Hemangiomas
Hidradenitis Supprativa
Head Shapes
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New Trends for Treatment in 2019
Eric Stelnicki MD
Pediatric Plastic and Craniofacial Surgeon
Atlantic Center for Reconstructive surgery
Palms West Children’s Hospital
Palm Beach Children’s Hospital
Cleveland Clinic Florida
Nova Southeastern University
Barry University
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Disclosures:
• The authors have no financial disclosures to
report in relationship to this topic and
research.
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IRB Appoval
All Studies have been IRB approved by the
Cleveland Clinic Florida IRB committee.
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Hemangiomas
Todays Treatment
Modalities
Myths and Methods
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Multiple treatment strategies
• Observation
• Steroids
• LASER
• Vincristine/Bleomycin
• Interferon alpha
• Surgical excision
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New England Journal of Medicine
• Propranolol for
Severe
Hemangiomas of
Infancy
Leaute-Labreze C, et. al. Propranolol for severe
hemangiomas of infancy. N Engl J Med 2008; 358:2649-2651
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Pulse Dye Laser Therapy
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Intralesional Steroid Injection
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Surgical Excision
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New Concept
Combination Therapy
Propranolol followed by
Laser and Intralesional Injection
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Results: last 8 patients with combined therapy
Case Age Dose Location Outcome Complications
JC 5 M 2mg/kg/D Lower Lip 7 treatment in
OR
none
JM 3M 2mg/kg/D Nose 3 treatments in
the OR/ surgical
excision
none
LN 4M 2mg/kg/D L upper eye 5 treatments in
the OR
none
KP* 3M 2mg/kg/D eye 4 treatments none
VQ 5M 2mg/kg/D Lip, chin, face,
ear
2 treatments in
the OR
none
LG 3M 2mg/kg/D Lower Lip 4 treatments in
the OR/surgical
excision
none
JG* 5M 2mg/kg/D nose 5 treatments none
OP* 3M 2mg/kg/D ear 4 Treatments none
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Case Report JG: 3 treatments in the OR, Propranolol 2mg/kg/D
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Case Report LN: 5 treatments in the OR, Propranolol 2mg/kg/D
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Results
• 3.5 % of the total patients treated with Infantile
Hemangioma were referred to a cardiologist for
consultation regarding Propranolol treatment
• 0% major complications
• 2 patients stopped propranolol treatment secondary
to loss of appetite and failure to thrive
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Infantile Hemangioma
Simple IH,
Inconspicuous
Simple IH,
Large size Complex IH *
Observation1st line: LASER and Intra-
Lesional Steroids
Or 2nd Line: Propranolol
Triple modality
therapy**
WorseWorse
Continue
Therapy,
Stop
When
Healed
Better
Explore
Alternative
Therapies
Better
Continue
Therapy,
Stop
When
Healed
*Complex IH=Obstruction of critical organs, very large IH, >10 IH, lesions that fail to respond to other treatments
** Triple Modality Therapy= LASER, Intra-Lesional Steroids, and Propranolol
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Clinical Significance
• Our treatment algorithm offers a safe and
effective treatment plan IH
• Propranolol is reserved for complex IH
• Triple therapy works well for IH resistant to
single modality therapy
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Primary Treatment of Hidradenitis Suppurativa
Using Nd:YAG Laser
Eric Stelnicki, MD
Cleveland ClinicFlorida
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Hidradenitis Suppurativa
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Hidradenitis Suppurativa
Common Locations
– Axilla
– Under Breasts
– Inner Thighs
Hurley Staging
– Groin
– Buttocks
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Treatment
Lifestyle Modification– Weight loss
– Smoking cessation
Medical Treatment– Topical/oral antibiotics
– Corticosteroids
– Hormone therapy
– Retinoids
– Immunosuppressive/biologic therapy
Surgical Treatment
– Incision and drainage
– Debridement/wide excision
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Treatment
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Hypothesis
• Since HS now considered disease of follicular occlusion…
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Purpose
• To determine effectiveness of Nd:YAG laser therapy as primary treatment for HS
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Materials and Methods
• Surgical database queried
– All pts with HS treated with Nd:YAG laser in last 3 years
Datapoints
– Age – Hurley stage
– Gender – Duration of symptoms
– Skin type (Fitzpatrick) – # of laser treatments
– Operative site – Post-treatment flare-ups
• Pathology results and photographs obtained
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Materials and Methods
• Telephone survey
– “Do you feel that your laser therapy was successful?” (yes, no)
– “How satisfied are you with your results?” (1-5)
– “How satisfied are you with your laser hair removal?” (1-5)
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ResultsPatient Skin Type
(Fitzpatrick)Operative Site Hurley
StageDuration of Symptoms(in years)
# of LaserTreatments
Success of Treatment
Patient Satisfaction
(1-5)
Satisfaction with Hair Removal
17 F 6 B axilla 2 2 8 yes 5 5
17 F 3 B axilla 2 3 8 yes 5 5
22 F 2 B inguinal 2 2 7 yes 5 5
19 F 6 B axilla 2 4 1 yes 4 4
18 F 6 B axilla 2 3 2 yes 5 5
15 F 6 B axilla 3 3 7 yes 5 5
12 F 6 B axilla, gluteal 2 1 3 yes 5 5
17 F 2 B axilla 2 1 1 yes 4 4
Average Age = 17All Female
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Results
Type 112%
Type 212%
Type 313%
Type 40%Type 5
13%
Type 650%
Skin Type (Fitzpatrick)
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Results
B inguinal12% B axilla,
gluteal13%
B axilla75%
Operative Site
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Results
Stage 10%
Stage 287%
Stage 313%
Hurley Stage
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ResultsPatient Skin Type
(Fitzpatrick)Operative Site Hurley
StageDuration of Symptoms(in years)
# of LaserTreatments
Success of Treatment
Patient Satisfaction
(1-5)
Satisfaction with Hair Removal
17 F 6 B axilla 2 2 8 yes 5 5
17 F 3 B axilla 2 3 8 yes 5 5
22 F 2 B inguinal 2 2 7 yes 5 5
19 F 6 B axilla 2 4 1 yes 4 4
18 F 6 B axilla 2 3 2 yes 5 5
15 F 6 B axilla 3 3 7 yes 5 5
12 F 6 B axilla, gluteal 2 1 3 yes 5 5
17 F 2 B axilla 2 1 1 yes 4 4
Average Duration of Symptoms = 2.4 years
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ResultsPatient Skin Type
(Fitzpatrick)Operative Site Hurley
StageDuration of Symptoms(in years)
# of LaserTreatments
Success of Treatment
Patient Satisfaction
(1-5)
Satisfaction with Hair Removal
17 F 6 B axilla 2 2 8 yes 5 5
17 F 3 B axilla 2 3 8 yes 5 5
22 F 2 B inguinal 2 2 7 yes 5 5
19 F 6 B axilla 2 4 1 yes 4 4
18 F 6 B axilla 2 3 2 yes 5 5
15 F 6 B axilla 3 3 7 yes 5 5
12 F 6 B axilla, gluteal 2 1 3 yes 5 5
17 F 2 B axilla 2 1 1 yes 4 4
Average # of Laser Treatments = 4.6
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ResultsPatient Skin Type
(Fitzpatrick)Operative Site Hurley
StageDuration of Symptoms(in years)
# of LaserTreatments
Success of Treatment
Patient Satisfaction
(1-5)
Satisfaction with Hair Removal
17 F 6 B axilla 2 2 8 yes 5 5
17 F 3 B axilla 2 3 8 yes 5 5
22 F 2 B inguinal 2 2 7 yes 5 5
19 F 6 B axilla 2 4 1 yes 4 4
18 F 6 B axilla 2 3 2 yes 5 5
15 F 6 B axilla 3 3 7 yes 5 5
12 F 6 B axilla, gluteal 2 1 3 yes 5 5
17 F 2 B axilla 2 1 1 yes 4 4
Success of Treatment = 100%
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ResultsPatient Skin Type
(Fitzpatrick)Operative Site Hurley
StageDuration of Symptoms(in years)
# of LaserTreatments
Success of Treatment
Patient Satisfaction
(1-5)
Satisfaction with Hair Removal
17 F 6 B axilla 2 2 8 yes 5 5
17 F 3 B axilla 2 3 8 yes 5 5
22 F 2 B inguinal 2 2 7 yes 5 5
19 F 6 B axilla 2 4 1 yes 4 4
18 F 6 B axilla 2 3 2 yes 5 5
15 F 6 B axilla 3 3 7 yes 5 5
12 F 6 B axilla, gluteal 2 1 3 yes 5 5
17 F 2 B axilla 2 1 1 yes 4 4
Patient Satisfaction = 4.75/5
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ResultsPatient Skin Type
(Fitzpatrick)Operative Site Hurley
StageDuration of Symptoms(in years)
# of LaserTreatments
Success of Treatment
Patient Satisfaction
(1-5)
Satisfaction with Hair Removal
17 F 6 B axilla 2 2 8 yes 5 5
17 F 3 B axilla 2 3 8 yes 5 5
22 F 2 B inguinal 2 2 7 yes 5 5
19 F 6 B axilla 2 4 1 yes 4 4
18 F 6 B axilla 2 3 2 yes 5 5
15 F 6 B axilla 3 3 7 yes 5 5
12 F 6 B axilla, gluteal 2 1 3 yes 5 5
17 F 2 B axilla 2 1 1 yes 4 4
Satisfaction with Hair Removal = 4.75/5
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Results
A: Baseline – Perifollicular and deep inflammation with follicular plugging
B: 1 month after treatment – Mild perifollicular inflammation with no hair shaft seen
C: 2 months after treatment– Follicular fibrosis; minimal perivascular inflammation
Pathology (R axilla)
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Results
baseline s/p 8 laser treatments
• 17 yo F with B axillary hidradenitis suppurativa (Hurley stage 2)
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Results• 15 yo F with B axillary hidradenitis suppurativa (Hurley stage 3)
baseline s/p 7 laser treatments
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Results• 12 yo F with B axillary hidradenitis suppurativa (Hurley stage 2)
baseline s/p 3 laser treatments
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Conclusion
• Successful primary treatment of hidradenitissuppurativa with Nd:YAG laser therapy in 100% of patients
• Patient satisfaction extremely high with average satisfaction rating of 4.75/5
• Further prospective studies needed to validate results
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Retrospective Review of over 4000 Patients with Head Shape AnomaliesThe Truth About Cranial Molding Band Use
and the Effectiveness of “Helmet” Therapy
Eric Stelnicki, MD
Associate Professor Plastic Surgery, Cleveland Clinic Florida, Weston Florida
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Incidence of Plagiocephaly
• Reports vary between 3.1-61.0% of the newborn
population
• Recent article in Pediatrics found it to be 46.6%-
Basically half of all the children born today have
this problem
• World wide problem since the initiation of the
“Back to Sleep Campaign” started in 1992
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Causes of Abnormal Head Shape
• Craniosynostosis
• Positional Molding
• In Utero Positioning
• Torticollis
• Other
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Characteristics of Plagiocephaly
• Right to left Skull Asymmetry
• Occipital Flattening
• Ipsilateral Frontal Bossing
• Anterior ear Shift
• Diagonal Difference > 6 mm
• Cranial Asymmetry Index > 6.0
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Congenital Muscular Torticollis
• Shortening or tightening of the SCM
• Leads to Head Tilt
• Contralateral Head Turning
• Increases amount of time spent on one side of the
head
• Adds to Plagiocephaly
• Creates “Torticocephaly”
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Characteristics of Brachycephaly
• Short-Wide head form
• Elevated Cephalic Ratio >.91
• Flat Occiput
• Frontal Bossing
• Squamosal Bulging
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Treatments of Abnormal Head Shape
• Surgery
• Repositioning of Child
• Skull Massage
• Torticollis Therapy
• New Born Repositioning Devices
• Cranial Molding Orthosis- Star Band and others
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In USA, CMO use is Common
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Many Articles have Shown CMO’s are Effective
• Graham, JM., et al J. Peds 2005- Treated roughly 150 kids with and
without helmets and showed helmets normalized position more
than repositioning
• Teichgraeber, JF J Craniofac Surg 2004- Looked at 488 pts..
comparing helmet therapy with repositioning and found helmets
normalized head shape, where as repositioning did not
• Kluba, S et al PRS 2011 showed early helmet therapy is more
effective in younger patients than late therapy (>6 months) in
small study of 24 pts.
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Then came along the BJM Study
• Renske, MW et al in BJM 2014 - one of few long term,
prospective randomized trials from the Netherlands
• Showed no long term difference between between
helmet and non-helmet arms at 2 years
• Showing only full recovery of approximately 25% of
both groups at 2 years
• Cast doubt on effectiveness of the CMO
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Problem- We Don’t Believe This Study!
• Flawed Results
• Improper Measurements
• Improper Band manufacturing or Adjustments
• Small Patient Number
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European Study Excluded Torticollis!
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Our Hypothesis
• We hypothesize that a properly made and
adjusted CMO will normalize Skull form
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Study
• Retrospective Review of all patients referred
to our center and treated by a single
Craniofacial Surgeon and Cranial Molding
Orthosis Provider
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Methods
• Characteristic of the Skull Shape
Deformity was verified by a Star Scan
• All Babies where evaluated by a Star
Scan on Initial intake, during
Treatment, and at the end of
Treatment
• Only plagiocephaly, brachycephaly,
and combined Brachycephaly and
Plagiocephaly patients were included
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Methods
• Presence or Absence of Torticollis recorded
• Patients were seen throughout treatment
• Patients were all direct referrals from Pediatricians who had
already attempted repositioning and conservative therapy, but this
had failed – This means we are seeing the worst of the worst! (or
babies belonging to really “particular” Moms and/or Dads)
• Exclusion criteria included: incomplete records or follow-up, kids
not treated with STAR BAND, craniosynostosis
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Treatment Protocol
• Star Scan at initial visit, interim scan when child’s head
is showing significant progress, at end of treatment
• Patients were typically treated conservatively for a
minimum of 2-3 months
– Conservative Therapy continued until patient has
normalized or until no progress towards normalization
was noted for at least 2-3 consecutive months and
documented on the Star Scan
– In some cases 6 months of documented conservative care
is required by insurance companies
• Torticollis Therapy was prescribed for all infants with
any degree of torticollis
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Treatment Flow ChartPlagio/Brachyce
phaly
Rule out Craniosynostosis
Surgery if Craniosynostosis
Present
Conservative Care on initial
referral if no CS
Normalization of Head Shape
Stop treatment and Follow
No Normalization
Refer for Star Band
Normalization
Stop Band and Follow
No Normalization
Confirm effective use of the band
Refer for second band
Rule out delayed onset
craniosynostosis
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End Points for CMO Exit
• Oblique diagonal difference < 6
• End posterior symmetry ratio > 90%
• Cephalic index 0.75-0.91
• Cranial Vault Asymmetry index < 6
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Results- Patient Stats
• Mean Age of deformity noticed by parents- 2 months
(range: birth- 7 months)
• Mean age at beginning of treatment– 7.2 months
(range:3-12 months)
• Male 672(63%) : Female 390(37%)- 2:1 Male to Female
• 92% had associated Torticollis for which they were
receiving therapy.
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ResultsDelivery type and Gestational Age
• 2/3 (653/980) of the patients were born via SVD
• Average Gestational age: 38 weeks (range: 31-41 weeks)
• 22% born at or before 37 weeks gestation – Therefore most
of the patients treated were not “Premees”
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Average Measurements prior to CMO Fabrication
• Oblique Difference: 9.7 (range: 1-20.3)
• Posterior symmetry: 0.84 (range: 0.708-0.973)
• Cephalic Ratio: 0.831 (range: 0.714-1.014)
• Cranial Vault Asymmetry index: 6.5 (range: 0.5-13.1)
– This data has not separated out the plagiocephaly patient
from the brachycepahly patient from the combined
plagio/brachy patient
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ResultsMost Patients Normalize and Do
Not “Need” a “Helmet”
• 3186/4248, i.e. 75% patients normalized over the course of
the Study without a CMO
• This corresponds with the findings of the Netherlands Study
• Our patient population is biased. We see the patients that
did not self correct under the watchful eye of the
Pediatrician- Therefore this number would be even higher if we
included this population!
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ResultsNearly All Patients Using the Star
Band Normalized • 1062/4248 patients were placed in a Star Band. 95% of patients who were compliant
with a single Star Band Normalized
• 4% normalized with a second CMO with less than 1% needing a third CMO to normalize
• Complete records with proper follow-up was available for 980 (92%) of the patients
• 49(5%) patients either required or parents requested a second helmet for further head
shape correction, with less than 0.1% (8/980) requiring or requesting a third helmet for
correction
• Rate of normalization ranged from 2-7 months with a mean treatment time of 3.5
months
• This radically differs from the findings of the Netherlands study at showed only 75% of
their helmet patients normalized
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Plagiocephaly Treatment
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Tortico-cephaly Treatment
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ResultsThe presence of persistent Torticollis was the #1
Factor in Persistent Head Shape Anomalies
• Torticocephaly is harder to treat due to direct
muscle action on the base of the growing skull
• Give predisposition to laying on contralateral
occiput
• Must treat torticollis to maximize effectiveness
of treatment and limit risk of relapse
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ResultsThe Star Band Effectively Corrects Head
Shape
• 83% (809/980) of patients were age 6 months or older at beginning of
treatment and therefore you do not have to start treatment prior to 6
months of age as some advocate
• Star band was 100% effective in treating these patients to normal, some
patients requiring multiple helmets
• Kids over 12 months required longer Star Band use with average
treatment time 4.75 months (2-7 months)
• We had no kids over 18 months of age placed into Star Band, but we
hypothesize they would show limited or very slow response to the helmet
therapy as has been published
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Results at Exit of first CMO
• Oblique Diagonal Difference: 2.8 (range:0.1-
9.4)
• Posterior symmetry: 0.93 (range: 0.847-0.989)
• Cephalic Ratio: 0.76 (range: 0.758-0.981)
• Cranial vault asymmetry index: 1.9 (range:
0.2-5.9)
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Results at Exit after Second or Third CMO
• Oblique Diagonal Difference: 3.41(range: 0.2-
8.5)
• Posterior Symmetry: 0.975 (range 0.951-1)
• Cephalic Ratio: 0.841(range: 0.774-0.947)
• Cranial vault asymmetry index: 2.1 (range: 0.1-
3.4)
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ResultsPlagiocephaly = Brachycephaly in
Terms of Results
• No difference in the effectiveness of Treatment
regardless of diagnosis
• Different helmet used for each which is equally
effective
• This differs from Netherlands study- seems there one
Helmet type fit all
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Severity of Deformity Dictates Length of Treatment
• More Deformity = Longer Treatment
• More Deformity increases the likelihood of
the need for subsequent Star Bands
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Long Term Results2-5 year Follow Up
• Relapse rate is 0.3 percent – 1 of which
resulted in re-Helmeting
• No reported recurrence in 99.7% of patients
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Conclusions
• We agree with the Netherlands Study that 25% of untreated
children with abnormal head shapes will Not Self Correct
• We agree that over 75% of children with deformational skull
deformities do not need a CMO
• We disagree with Netherland Study about the effectiveness of the
CMO.
– We find 100% of our Star Band patients achieve normal skull form
with the use of the CMO
– This is statistically greater than the Netherland’s non-helmet group
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Largest Study Reported
• This is the largest study ever reported with:
1. A single craniofacial surgeon
2. A single helmet manufacturer
3. A single orthotist performing adjustments
4. With use of objective data for pre CMO and
exit data
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Netherlands ProvesBad Helmet =
Bad Result
• Netherlands Band is similar
to the “Other” Bands in the
USA which receive very few
adjustments.
• Our own internal review
shows little change in head
shape with this product
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This Study ProvesGood Helmet = Good Result
• Properly made and adjusted Star Bands will
normalize the head shape
• This normalization is far greater than that
seen in the untreated general population
• This improvement is long lasting and
produces a normal head for the long term
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Type of Cranial Molding Orthosis
• Star Band
• Doc Band
• C.A.P.
• Michigan Cranial Orthosis
• Hanger band
• Finneston Band
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Type of CMO Really Does Matter
• D.E. Couture et al. tx 1050 pts. in
Danmar helmets- 2 sizes and 2 colors
for all patients
Conclusions:
1. More severe plagio=longer tx
2. Overall correction rate 81.6% for all
severity types
3. Argenta Type IV- 73.2% (194/265)
normalized
4. Argenta Type V- 47.9% (23/48)
normalized
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Use of CMO with Surgery
Endoscopic Craniosynostosis Repair
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Surgery Technique- Endoscopic
• Endoscopic
– 2 V-shaped scalp
incisions
– Sub-galeal
dissection
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Results Endoscopic Repair
Pre-op Immediate Post op 12 months Post op
Cranial Index = 65 Cranial index = 77
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Endoscopic Results- Sample Case 2
Pre-op Immediate Post op 12 months Post op
Cranial index = 66 Cranial index = 78
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Thank You