Terapia Neoadiuvante nella malattia HER-2 positiva:Trasferibilità nella pratica clinica

Vincenzo Adamo Vincenzo Adamo

UOC Terapie Integrate in OncologiaAOU Policlinico ”G.Martino” MessinaUOC Terapie Integrate in OncologiaAOU Policlinico ”G.Martino” Messina

Sequence of Treatment for Primary Breast Cancer

Diagnosis and Staging

Surgical Resection

Adjuvant systemic treatment

Diagnosis and Staging

Neoadjuvant systemic therapy

Surgical Resection

Adjuvant therapy

The Rational for Neoadjuvant Therapy in Breast Cancer: Which Patients?

Traditionally: Neoadjuvant systemic therapy should be considered for patients inoperable at onset: T4, clinical N2-N3

New data: supporting preoperative or neoadjuvant systemic therapy in primary operable breast cancer patients

NCCN Guidelines 2011:neoadjuvant chemotherapy or trastuzumab plus chemotherapy should be considered for HER2+ patients

Goals of Neoadjuvant Theapy in Breast Cancer

Make tumours more operable, increase the rate of breast conserving surgeries

Improve prognosis of certain disease subtypes (i.e. HER2+)

Have a better idea of prognosis based on response to neoadjuvant treatment

Allow patients to start treatment earlier

Reduce the extent of surgery required in breast and axylla

Improve DFS and OS using pathological response rate for selection of subsequent treatment in individual patients

Parametres to assessed in clinical practice

pCR and Treatment Outcomes

Status lymph node (sentinel node biopsy)

Instrumental evaluation with MRI and PET

Toxicity

Definition of pCR

Different definition of pCR are in use:

- Absence of invasive cancer in the breast

- Absence of invasive cancer in the breast and in the axillary lymph nodes.

- Absence of invasive and in situ cancer cells in the breast and in the axillary nodes

There is high degree of concordance between the different definition

With very definition pCR identifies cases with favorable disease

Marchiò C. & Sapino A. JNCI Monogr 2011;43:86–90

Putative Predictive Factors of pCR

Tumor size & Tumor grade

Histological type

ER/PgR

Her2/neu

Proliferative markers ( Ki-67/MIB-1, PCNA)

Treatment & MDR-1/pgp

There was no significant difference in overall survival (OS) between the treatment arms (data not shown).

Pathologic CR (pCR) was a significant predictor of OS, regardless of treatment.

Bear HD, et al. J ClinOncol. 2006;24(13):2019-2027.

Disease free-survival Overall Survival

pCR to Neoadjuvant Chemotherapy is correlated with improved DFS & OS

(NSABP B-27)

Outcomes of Neoadjuvant Trials with unselected tumor characteristics

Mazouni C, et al. J Clin Oncol. 2007

Intrinsic sub-types have different prognosis and

different response to NACT

MD Anderson Neoadjuvant TrialDFS at 72 months FU

Budzar A. et al Asco 2009

“ ..if indicated, the majority of the Panel considered that the neoadjuvant chemotherapy regimen should include both a taxane and an anthracycline and(for HER2-positive disease) an anti-HER2 drug.Thus, the choice of a regimen for adjuvant or neoadjuvant chemotherapy might be made using similar criteria..’’

Goldhirsch A, et al. Ann Oncol. 2009;20(8):1319-1329.

Impact of treatment characteristics on the pCR

Untch M. et al J Nat Cancer Inst Monogr

2011.

Impact of treatment characteristics on the pCR

Untch M. et al J Nat Cancer Inst Monogr

2011.

V, vinorelbine; X, capecitabine; C, carboplatin ;FEC, 5-fluorouracil, epirubicin, cyclophosphamide.

Schedules and pCR rate in HER2-positive disease

Pre and Post-operative Chemotherapy plus Trastuzumab Improve DSF

… Future Clinical Practice….

Anti-HER2 Treatment:Mechanisms of action

Three Neoadjuvant Trials Using Targeted Therapies for HER-2 Positive BC

pCRS in Three Trials with Target Therapies

Guarneri V. et al. ASCO 2011

Efficacy: Breast and Axillary pCR Rate

Guarneri V. et al. ASCO 2011

Status lymph node (sentinel node biopsy)

SLNB in relation to neoadjuvant therapy

Which is the aim of SLNB in breast cancer patients?

Which patients are usually receiving neoadjuvant?

Is there a role of SLNB in patients undergoing neoadjuvant therapy?

Should SLNB be performed before or after neoadjuvant therapy?

Are there sufficient data supporting either approach ?

St Gallen 2007, Annals of Oncol 18: 1133–1144, 2007

SLN Biopsy Prior to Therapy

Disadvantages• Two operations• Potentially delays start of chemotherapy

Advantages• Higher identification rate• Lower false negative rate

St Gallen 2007, Annals of Oncol 18: 1133–1144, 2007

The Role of SNLB

Inflammatory breast cancer not indicated– breast lymphedema, due to occluded lymphatics by metastatic

cells

inadequate lymphatic drainage

mapping agents would also be trapped and not travel to the SLN

false-negative rate very high

Locally Advanced (large tumor size)- Palpable lymphadenopathy FNA –No Role for SNLB

- Non palpable or Clinically negative LNs SLNB is acceptable

- Before or after neo-adjuvant chemotherapy ?

St Gallen 2007, Annals of Oncol 18: 1133–1144, 2007

Marchiò C. & Sapino A. JNCI Monogr 2011;43:86–90

St Gallen 2011:SN and ALND

Downstaging Axilla & Complete Axillary Response

Strong prognostic factor

Axillary pCR: 93%

Residual disease: 60%

Hennessey BT, et al. J Clin Oncol.2005;23(36):9304-9311.

Instrumental evaluation: MRI and PET and Neoadjuvant Chemo in HER2BC

MRI: Evaluation Neoadjuvant Chemotherapy

MRI highest accurracy for monitoring chemotherapy Change in (residual) tumor size, signal intensity, and

contrast kinetics Underestimation possible!

Mc Guire K.P. et al.Ann Surg Oncol 2011

MRI Staging after NACT : Does Tumor Biology Affect Accuracy?

MRI response versus pathologic response by tumor subtype. Discrimination and predictive value (a) overall, (b) luminal A/B, and (c) HER2+/TN

Mc Guire K.P. et al.Ann Surg Oncol 2011

Early metabolic responseusing PET in Neoadjuvant BC

Keam B.et al.BMC Cancer 2011

Toxicity and neoadjuvant Chemotherapy in HER2BC

LVEF during and after therapy

HER2-positive control

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HER2-positive trastuzumab

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Gianni L. et al Lancet 2010

LVEF change during and after therapy

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HER2-positive controlHER2-positive trastuzumabE

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Gianni L. et al Lancet 2010

Cardiac Toxicity & Trastuzumab

Gianni L. et al Lancet 2010

Cardiac monitoring guidance: Trastuzumab

• All patients for Herceptin treatment should undergo baseline cardiac assessment prior to treatment initiation

• For patients with EBC, cardiac assessment should be performed every 3 months during treatment and at 6, 12 and 24 months following cessation of treatment

• For patients with MBC, cardiac function should be monitored during treatment (eg every 3 months)

• Patients who develop asymptomatic cardiac dysfunction may benefit from more frequent monitoring (eg every 6-8 weeks)

CGCC, Cardiac Guidelines Consensus Committee;EMEA, European Medicines Evaluation Agency

HER2 BC & Neoadjuvant St Gallen 2011

Intrinsic sub-types have different prognosis and

different response to NACT

Conclusive comments • NACT should be considered as an option for every woman as

far as the indication for adjuvant treatment has been confirmed• Many good quality clinical trials suggest that trastuzumab

should be incorporated in the preoperative treatment of women with HER2-pos (..NCCN guidelines).

open questions• the preferred combination chemotherapy with trastuzumab• the optimal duration of trastuzumab in pts who achieve a pCR

after preoperative chemotherapy.

Comments and questions

The end

• Stop here

NOAH Neoadjuvant Trial:pCR Rates

Gianni L. et al. Lancet 2010

pCR After NACT Plus Trastuzumab Predicts Favorable Survival in HER2+ BC:

Results From the TECHNO

Untch M. et al, JCO 2011

Neoadjuvant Therapy (NAT):Potential Advantages

Improved Tumor Downstaging Inoperable Operable Mastectomy BCS

Provides in vivo assessment of anti-tumor effects

Provides opportunity to assess surrogate biological endpoints

Early initiation of systemic therapy

Inhibition of post-surgical growth spurt

May expedite new drug development

no

pCR and Treatment Outcome

pCR is a robust measure of therapeutic effects and surrogate a DFS in responder

Increase pCR rate should correspond to improved efficacy in the overall patient population

Prediction of pCR should predict for benefit and allow for tailoring treatment to indivudual tumor characteristics

no

BC after NACT:The M.D. Anderson Cancer Center Experience

Chen AM et al. J Clin Oncol. 2004;22:2303-2312.

no

Scenario for Neoadjuvant Therapy in HER2 Positive Breast Cancer

no

Trastuzumab in NACT – pCR

T-FEC T-FEC + H

pCR 26.3 % 66.7 %

pCR ER pos 27 % 61 %

pCR ER neg 25 % 70 %

pN0 78.9 % 90.3 %

Buzdar AU et al, PASCO 2004 ; Clin Cancer Res 2007

Study closed after first 42 pts due to the strong advantage for H combination H stopped at the end of NACT (6 months)

no

Locally Advanced with non palpable or clinically negative LNs

no

St Gallen 2007, Annals of Oncology 18: 1133–1144, 2007

Sentinel Lymph Node Biopsy in BC patients Treated With NACT

Pecha V. et al. Cancer 2011

no

Valutare se utile per finire

o simile

Timing of SLNB

Hunt KK, et al. Ann Surg. 2009;250(4):558-566

Vedere il lavoro di Sapino e mettere lo schema interessante

PET and Neoadjuvant Chemotherapy

…Open Question in Clinical Practice…?

?