Supplementary Table 1. Impact of pretransplant factors on the incidence of pulmonary complications

Factor Univariate RR (95% CI) P-value Multivariate RR*1 (95% CI) P-value Multivariate RR*1*2 (95% CI) P-value

Age< 42 years 1.00 ≥ 42 years 1.31 (0.86-1.99) 0.21

SexMale 1.00 Female 0.65 (0.41-1.01) 0.06

Disease risk*3

Low 1.00 1.00 1.00 High 1.57 (1.03-2.38) 0.04 1.61 (1.04-2.48) 0.03 1.60 (1.04-2.46) 0.03

Stem cell source

Bone marrow 1.00 Peripheral blood 0.48 (0.22-1.06) 0.07 Cord blood 1.52 (0.87-2.66) 0.14

Donor typeRelated 1.00 1.00 1.00 Unrelated 2.10 (1.22-3.62) < 0.01 2.09 (1.20-3.67) 0.01 1.93 (1.09-3.41) 0.02

Conditioning regimenMyeloablative 1.00 Reduced intensity 1.53 (0.98-2.38) 0.06

GVHD prophylaxisCyclosporine-based 1.00 Tacrolimus-based 1.18 (0.79-1.76) 0.44

Smoking dose (BI)0 1.00 1.00 1-399 1.51 (0.92-2.47) 0.11 1.43 (0.87-2.36) 0.16 ≥ 400 2.02 (1.21-3.35) < 0.01 1.78 (1.06-3.00) 0.03

Smoking dose (BI*2 per 10) 1.01 (1.00-1.01) < 0.01 1.01 (1.00-1.01) 0.02 Abbreviations: RR, relative risk; CI, confidence interval; BI, Brinkman index*1: The variables with P < 0.05 on univariate analysis were subjected to multivariate analysis.*2: BI was treated as a continuous variable*3: Low-disease risk included acute leukemia in first complete resmission (CR), chronic myelogenous leukemia in first chronic phase, myelodysplasia refractory anemia, malignant lymphoma in CR and non-malignant hematologic diseases; while high-disease risk included all other diagnoses.

Supplementary Table 2. Causes of pulmonary complications 　 　

Never smokers(N=31)

Smokers

Low-dose (BI, 1-399)(N=31)

High-dose (BI ≥400)(N=28)

Infection

Pneumonia 21 (17%) 23 (25%) 22 (33%)

Tuberculosis 1 (1%) 0 1 (2%)

Non-infection

Organizing pneumonia 4 (3%) 3 (3%) 2 (3%)

Interstitial pneumonia 4 (3%) 1 (1%) 1 (2%)

Bronchiolitis obliterans 1 (1%) 3 (3%) 1 (2%)

Pulmonary veno-occlusive disease 0 1 (1%) 0

Lung cancer 0 0 1 (2%)

Abbreviation: BI, Brinkman index

Supplementary Table 3. Causes of death (N = 122)

Never smokers(N=58)

Smokers

Low-dose (BI, 1-399)(N=37)

High-dose (BI ≥400)(N=37)

Disease progression 19 (33%) 11 (30%) 13 (35%)

Non-relapse mortalityPulmonary　 　 Pneumonia 14 (24%) 5 (14%) 10 (27%) Bronchiolitis obliterans 0 1 (3%) 0 Alveolar hemorrhage 0 1 (3%) 1 (3%) Interstitial pneumonia 1 (2%) 1 (3%) 0

Infections other than pneumonia 10 (17%) 7 (18%) 3 (7%)

GVHD 3 (5%) 3 (8%) 4 (11%)

VOD/TMA 3 (5%) 2 (5%) 0

Organ failure 3 (5%) 3 (8%) 3 (7%)

Others 5 (9%) 3 (8%) 3 (7%)　 　 　 　 　Abbreviations: BI, Brinkman index; GVHD, graft-versus-host disease; VOD, veno-occlusive disease; TMA, thrombotic microangiopathy