PENGLIHATAN PENGLIHATAN ( ( VISION VISION VISION VISION VISION VISION VISION VISION ))

YETTY MACHRINAYETTY MACHRINA

MILAHAYATI DAULAYMILAHAYATI DAULAYMILAHAYATI DAULAYMILAHAYATI DAULAY

DEPARTEMEN FISIOLOGIDEPARTEMEN FISIOLOGI

FAKULTAS KEDOKTERAN FAKULTAS KEDOKTERAN

UNIVERSITAS SUMATERA UTARAUNIVERSITAS SUMATERA UTARA

SPESIAL SENSE SPESIAL SENSE (Indra Khusus)(Indra Khusus)

VISIONVISION

HEARINGHEARING HEARINGHEARING

SMELLSMELL

TASTETASTE

EQUILIBRIUMEQUILIBRIUM

Mata sebagai sumber informasi awal

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PROSES PENGLIHATANPROSES PENGLIHATAN

Cahaya masuk melalui pupil refleks pupil

Proses refraksi proses akomodasi

Photoreseptor (retina)Photoreseptor (retina)

N. Opticus

thalamus

Corteks cerebri area 17 Dan 18 (lobus occipitalis)

Function of the Major Componen Of Function of the Major Componen Of the Eyethe Eye

EyelidsEyelids

EyelashesEyelashes

TearsTears

CorneaCornea

PupilPupil

LensaLensa

Vitreous HumorVitreous Humor

ScleraSclera CorneaCornea

Aqueous HumorAqueous Humor

IrisIris

ConjunctivaConjunctiva

Cilliary BodyCilliary Body

Suspensory Suspensory LigamentLigament

ScleraSclera

ChoroidChoroid

RetinaRetina

FoveaFovea

Optic NerveOptic Nerve

Optic DiscOptic Disc

TEARSTEARS

Tears are produced Tears are produced continously by lacrimal continously by lacrimal glandgland

Lacrimal gland lying at the Lacrimal gland lying at the upper lateral corner of upper lateral corner of upper lateral corner of upper lateral corner of under the eyelidsunder the eyelids

Lacrimal gland innervate by Lacrimal gland innervate by ANS (parasympatis)ANS (parasympatis)

Tears thTears thrrough out each ough out each time eyelids closetime eyelids close

Tears Flow Lacrimal gland

Ductus Lacrimal

Anterior surface

Lacrimal canal

Ductus nasolacrimalis

Inferior concha

Cavum nasi

Tears Function Tears Function

ProtectionProtection

Keep cornea wetKeep cornea wet Keep cornea wetKeep cornea wet

Protect the eye Protect the eye from infectionfrom infection

AQUEOUS HUMORAQUEOUS HUMOR

Aqueous Humor is clear liquid material Aqueous Humor is clear liquid material produced about 5ml/day by capillary produced about 5ml/day by capillary network witnetwork withinhin cilliary bodycilliary body

It nourishes the cornea and lensaIt nourishes the cornea and lensa It nourishes the cornea and lensaIt nourishes the cornea and lensa It flows through the pupil and fills tha It flows through the pupil and fills tha anterior chamber. Drains into a venous anterior chamber. Drains into a venous canal between iris and cornea (canal of canal between iris and cornea (canal of schlemm) , enters the bloodschlemm) , enters the blood

If there is a blokage in the drainage canal, If there is a blokage in the drainage canal, the excess will accumulate in the anterior the excess will accumulate in the anterior cavity, causing the pressure to rise call cavity, causing the pressure to rise call

PERGERAKAN OTOT MATAPERGERAKAN OTOT MATA

M.Rektus

M.Rektus superior M. Obliq inf

M.Rektus medial

M. Rektus inferior M. Obliq sup

M. Rektus lat

Kerja otot luar mataKerja otot luar mata

OtotOtot Kerja primerKerja primer Kerja sekunderKerja sekunder

Rektur lateralRektur lateral

Rektus medialisRektus medialis

Rektus superiorRektus superior

AbduksiAbduksi

AdduksiAdduksi

ElevasiElevasi

Tidak adaTidak ada

Tidak adaTidak ada

Adduksi, intorsiAdduksi, intorsiRektus superiorRektus superior

Rektus inferiorRektus inferior

Obikus superiorObikus superior

Oblikus inferiorOblikus inferior

ElevasiElevasi

DepresiDepresi

IntorsiIntorsi

EkstorsiEkstorsi

Adduksi, intorsiAdduksi, intorsi

Adduksi, ekstorsiAdduksi, ekstorsi

Depresi, abduksiDepresi, abduksi

Elevasi, abduksiElevasi, abduksi

Persarafan Otot Pergerakan Persarafan Otot Pergerakan MataMata

MM. Obliqus inferior . Obliqus inferior

M. Rektus M. Rektus superiorsuperior

M. Rektus M. Rektus inferiorinferior

N. III (okulomotorius)

M. Rektus M. Rektus inferiorinferior

M. Rektus M. Rektus medialmedial

M. Obliqus superiorM. Obliqus superior

M. Rektus M. Rektus laterallateral

N. IV (trokhlearis)

N. VI ( abducens)

Reflex pupil constriction occurs in bright light to Reflex pupil constriction occurs in bright light to decrease the amount of light entering the eye decrease the amount of light entering the eye The circular muscle contract (become shorten), The circular muscle contract (become shorten), pupil gets smallerpupil gets smaller

Bright light Bright light circular muscle contractcircular muscle contractmiosis miosis

Reflex pupil dilatasion occurs in dim light to Reflex pupil dilatasion occurs in dim light to allow the entrance of more light. The radial allow the entrance of more light. The radial muscle contract, pupil size is increasemuscle contract, pupil size is increase

Dim light Dim light radial muscle contractradial muscle contractdilatasidilatasi

PUPIL REFLEXPUPIL REFLEX

Pupil is controled by Pupil is controled by irisiris

Iris contains 2 set of smooth muscle Iris contains 2 set of smooth muscle network :network :network :network :

1.1. Circular muscle (ringlike fashion Circular muscle (ringlike fashion within the iris)within the iris)

2.2. Radial muscle (like bicycle spokes)Radial muscle (like bicycle spokes)

Iris muscle is controlled by autonomic nervous Iris muscle is controlled by autonomic nervous system.system.Parasympatis innervate the circular muscleParasympatis innervate the circular muscleSympatis innervate the radial muscleSympatis innervate the radial muscle

If light directed into the pupil, pupil will constrict If light directed into the pupil, pupil will constrict If light directed into the pupil, pupil will constrict If light directed into the pupil, pupil will constrict and pupil the also other eye (consensual light and pupil the also other eye (consensual light reflex). It because optic nerve fibers bring reflex). It because optic nerve fibers bring impuls to the optic nerve near the lateral impuls to the optic nerve near the lateral genuculate nucleus genuculate nucleus midbrainmidbrain ipsilateral ipsilateral EdingerEdinger--Westphal nucleus and contralateral Westphal nucleus and contralateral EdingerEdinger--westphal, cilliary gangglion N.III, westphal, cilliary gangglion N.III, sebagian dari ganglion ke ciliary bodysebagian dari ganglion ke ciliary body

ORGAN REFRACTIEORGAN REFRACTIE

1.1. CorneaCornea

2.2. LensaLensa

The refractive ability of persons corneaThe refractive ability of persons corneaThe refractive ability of persons corneaThe refractive ability of persons cornea

Always constan because the curvature ofAlways constan because the curvature of

cornea never change. cornea never change.

The refactive ability of the lens can be The refactive ability of the lens can be adjusted by chaging its curvature as adjusted by chaging its curvature as needed for near or far visionneeded for near or far vision

ACCOMODATIONACCOMODATION

The ability to adjustThe ability to adjust

Regulated by the cilliary muscleRegulated by the cilliary muscle

Cilliary muscle is circular ring of smooth muscle Cilliary muscle is circular ring of smooth muscle attached to the lens by suspensory ligamentattached to the lens by suspensory ligament

Normal eye :Normal eye :Normal eye :Normal eye :

-- m. cilliary relax, suspensory lig. Is pulled, m. cilliary relax, suspensory lig. Is pulled, lens is flat for far vision (lens is flat for far vision (simpatissimpatis))

-- m. cilliary contract, slackening the tension m. cilliary contract, slackening the tension in suspensory lig, lens is more convex and in suspensory lig, lens is more convex and stonger for near vision (stonger for near vision (parasimpatisparasimpatis))

Anatomy PemfokusanAnatomy Pemfokusan 233

PHOTORESEPTOR (PHOTORESEPTOR (retinaretina))

Retina consist of three Retina consist of three layers :layers :

1. outer segment (close to 1. outer segment (close to choroid)choroid)

rodrodrodrod

conecone

2. 2. midlemidle segmensegmen

Bipolar neuronBipolar neuron

3. inner segment3. inner segmentGanglion cellGanglion cell

Ganglion axons Ganglion axons membentuk optik nervemembentuk optik nerve

Titik di retina tempat keluarnya saraf Titik di retina tempat keluarnya saraf optikus dan lewatnya pembuluh darah optikus dan lewatnya pembuluh darah disebut disebut Diskus optikus (bintik buta)Diskus optikus (bintik buta)disebut disebut Diskus optikus (bintik buta)Diskus optikus (bintik buta)

PadaPada foveafovea, cahaya yang masuk langsung , cahaya yang masuk langsung mencapai fotoreseptor tidak melalui lapisan mencapai fotoreseptor tidak melalui lapisan ganglion dan bipolar ok lapisan ganglion ganglion dan bipolar ok lapisan ganglion

dan bipolar tertarik ke sampingdan bipolar tertarik ke samping

Pada fovea hanya ada sel Pada fovea hanya ada sel kerucut, sehingga titik ini kerucut, sehingga titik ini berfungsi untuk penglihatan berfungsi untuk penglihatan tajam.tajam.

Daerah tepat disekitar fovea Daerah tepat disekitar fovea disebut disebut makula luteamakula lutea

Pada makula lutea, sel Pada makula lutea, sel --sel sel Pada makula lutea, sel Pada makula lutea, sel --sel sel kerucut banyak, sehingga kerucut banyak, sehingga ketajaman daerah ini tinggi. ketajaman daerah ini tinggi. Namun tidak lebih besar Namun tidak lebih besar daripada fovea ok terdapat daripada fovea ok terdapat lapisan bipolar dan sellapisan bipolar dan sel--sel sel ganglion diatas makula.ganglion diatas makula.

OUTER SEGMEN OUTER SEGMEN

Banyak mengandung fotopigmenBanyak mengandung fotopigmen

Terdiri atas protein enzimatik yaitu opsin yang Terdiri atas protein enzimatik yaitu opsin yang berikatan dengan retinen (derivat vitamin A, berikatan dengan retinen (derivat vitamin A, red).red).red).red).

Retinen = 1 di sel batang Retinen = 1 di sel batang

3 di masing3 di masing--masing sel kerucut masing sel kerucut (sel merah,hijau, biru)(sel merah,hijau, biru)

FOR COLOR VISIONFOR COLOR VISION

Photoreceptor Activity in the DarkPhotoreceptor Activity in the Dark

The plasma membrane chemically channel of The plasma membrane chemically channel of photoreceptor respond to internal second photoreceptor respond to internal second massenger, massenger, cGMP. cGMP. BindBindiing cGMP + Nang cGMP + Na++

channels keeps them open.channels keeps them open.

When the is absence(stimulation), concentration When the is absence(stimulation), concentration of cGMP higher of cGMP higher NaNa++ channel open.channel open.of cGMP higher of cGMP higher NaNa++ channel open.channel open.

Passive resultant inward NaPassive resultant inward Na++leak depolarize the leak depolarize the photoreseptor photoreseptor spread to synapitic terminal spread to synapitic terminal (where the photoreceptors neurotransmitter is (where the photoreceptors neurotransmitter is trored) trored) synaptic terminal voltage gated synaptic terminal voltage gated channels open channels open CaCa2+2+ entry entry trigger release of trigger release of neurotransmitterneurotransmitter from the synapticfrom the synaptic

Inhibitory neurotransmitter that srecreted by amacrine cells are gamma-aminobutyric acid, glycine, dopamine, aminobutyric acid, glycine, dopamine, acetylcholine, dolamine

Photoreceptor inhibited of their adequate Photoreceptor inhibited of their adequate stimulus (hyperpolarized by light).stimulus (hyperpolarized by light).

Excited absence of stimulation (depolarized Excited absence of stimulation (depolarized by darkness)by darkness)

No light

Concentration cGMP

Na+channels open in outer segmen

Membran depolarization

Spread to the terminal synaptic

Ca2+ channels open

Release neurotransmitter ((inhibitory neurotransmitter)

Bipolar cells inhibited

No action potential in ganglion cell

No action potential propagation to visual cortex

Light

Activation o fotopigment (rod and cone)

Activation of transducin (G protein)

cGMP

Na+ channel closure

Membran hyperpolarizasion (receptor potential)

Spread to the terminal synaps

Closure ca2+ channels

Release inhibitory neurotrasnmitter

Bipolar cell uninhibited

Graded potential change in bipolar cell

Action potential in ganglion cell

Visual cortex in the occipital lobe of the brain

Benda (memantulkan cahaya)Benda (memantulkan cahaya)cornea cornea lensa lensa convergensi cahaya convergensi cahaya bayangan jatuh tepat di bayangan jatuh tepat di retina (fovea) retina (fovea) aktivasi fotopigmen aktivasi fotopigmen a a aktivasi transducin aktivasi transducin cGMPcGMP saluran Nasaluran Na++tertutup tertutup hyperpolarisasi membran hyperpolarisasi membran CaCa2+2+tertutup tertutup Penghambatan pelepasan Penghambatan pelepasan CaCa tertutup tertutup Penghambatan pelepasan Penghambatan pelepasan Neurotransmitter Neurotransmitter action potential action potential bipolar cell bipolar cell graded potensial pada cell ganglion graded potensial pada cell ganglion N. N. Opticus Opticus Optic disc Optic disc chiasma opticum chiasma opticum tractus geniculatus lateral di thalamus tractus geniculatus lateral di thalamus lobus lobus occipitalis area 17 occipitalis area 17 diasosiakan ke area 18diasosiakan ke area 18

Kiasma optikumKiasma optikum(Optic chiasma)(Optic chiasma)

238

Visual deficits with Visual deficits with specific lesionsspecific lesions

Leftt optic Leftt optic nervenerve

Left eyeLeft eye Right eyeRight eye

Optic Optic Optic Optic chiasmchiasm

Left optic Left optic tract (or tract (or radiation)radiation)

VISUAL ADAPTATIONVISUAL ADAPTATION

DARK ADAPTATIONDARK ADAPTATION

-- Break down of photopigment during Break down of photopigment during exposure of sunlight fremendously exposure of sunlight fremendously exposure of sunlight fremendously exposure of sunlight fremendously decreases photoreceptor sensitivitydecreases photoreceptor sensitivity

--As a result, the sensitivity of our eyes As a result, the sensitivity of our eyes gradually increase gradually increase u can see in the u can see in the darkdark

LIGHT ADAPTATIONLIGHT ADAPTATION

As some of photopigment are rapidly As some of photopigment are rapidly brokendown by intense light, the brokendown by intense light, the brokendown by intense light, the brokendown by intense light, the sensitivsensitivIIty of the eye decreases and ty of the eye decreases and normal contras can once again be normal contras can once again be detected.detected.

CCOOLLOORR VISIONVISION

Cone type = green, blue, redCone type = green, blue, red

A wave length perceived as blue excite blue A wave length perceived as blue excite blue cone maximally does not stimulate red or cone maximally does not stimulate red or cone maximally does not stimulate red or cone maximally does not stimulate red or green cone at all.green cone at all.

White is a mixture of all wavelength of lightWhite is a mixture of all wavelength of light

Black is the absence of light.Black is the absence of light.

We see the same color because we have We see the same color because we have the same type of cone.the same type of cone.

COLOR VISIONCOLOR VISION

Color Color Percent maximum stimulationPercent maximum stimulation

Visible spectrum

Color Color perceivedperceived

Percent maximum stimulationPercent maximum stimulation

Red cones green cones blue conesRed cones green cones blue cones

blueblue 00 0 0 100100

greengreen 3131 67 3667 36

redred 83 83 083 83 0

Visual fieldVisual field

Visual field is field of view that can be Visual field is field of view that can be seen without moving the headseen without moving the head