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Supercritical Fluid Extractions, Reactions and High Pressure Chemistry www.supercriticalfluids.com

SFT-NPX-10 Natural Products Extractor

One Innovation Way • Newark, DE 19711 • 302-738-3420 • Fax 302-738-4320 • www.supercriticalfluids.com

SFT-NPX-10 Natural Products Extractor

• Capacity:5,10or20LiterSampleExtractionVessels;Single5Liter,Single/Dual10LiterorSingle20LiterConfigurationsAvailable

• OptionalPLC/HMITouchScreenOperatorInterfaceFully ControllableProcessingVariables

• PneumaticLiquidCO2Pumping;WaterlessPre-Chiller,TypicalFlowRatesfrom0.1to1.0kg/min

• 10,000psi,689BAR,68.9MPaOperation• CO2FlowMeasuredbyCoriolisMassFlowMeter• SingleorOptionalDualCollectionSeparators• CodeCompliantVesselsandComponents• CompactDesignforPortability• OptionalLiquidCO2andCo-SolventFluidRecycleAvailable

Supercritical Fluid Extractions, Reactions and High Pressure Chemistry www.supercriticalfluids.com

Supercritical Fluid Extractions, Reactions and High Pressure Chemistry www.supercriticalfluids.com

SFT-NPX-10 Processing System

TheSFT-NPX-10ProcessingSystemisdesignedtoperformsupercriticalfluidextractionsincorporatinga5Litervessel,singleoroptionaldual10Litersamplevesselsorasingle20Litervesselwithsingleoroptionaldualseparators,andintegratedinterfacecontrols.Thesystemincludesfeaturesthatfacilitatethetransitionfromourlaboratoryscaleequipmenttopilotandproductionprocessingsystems.

Thissystemisconfiguredtoenablesupercriticalcarbondioxide(SCCO2)extractionusinga5Literextractionvesselor10Literextractionvessel(s)inasingleordualconfigurationorasingle20Literextractionvesselratedforoperationupto10,000psi(689BAR,68.9MPa)and120°C.Thesystemincludeseitheroneortwoseparatorvessels,apneumaticCO2pumpwithanintegratedwaterlesspre-chillertomaximizepumpingefficiency,andallassociatedvalvesandpiping.Thesystemismountedonapowdercoatedsteelframe.Pressuresandtemperaturesarecontrolledintheextractor(s)andseparator(s)withcontrolvalves,electronicheatexchangers,andpumpcontrol.

Benefits of Supercritical Fluid Extraction

UsingSupercriticalCO2toperformextractionsonbotanicals,herbs,spicesandothernaturalproductmaterialshassignificantbenefitsovertheuseoftraditionalliquidsolvents.CO2entersthesupercriticalregionatanelevatedtemperatureandpressure,whereitisnolongeraliquidorgas.Itbecomesasupercriticalfluid.Undertheseconditions,thefluidpossessesmanyofthesamecharacteristicsofaliquidsolventwiththeaddedbenefitofthehighdiffusivityofagas,andpressuretunablesolvencypower.ThereisnoneedtoperformadistillationstepsinceuponreturningtoatmosphericpressuretheCO2becomesagasandcanberecycled.ThismeansNOresidualsolventsareintheextract.Additionally,giventhatthesolvencypowerofthefluidispressuredependent,itispossibletofractionateandobtainmultiplefractionsfromasinglerawmaterial.Thisisimpossibletodowithtraditionalliquidsolventanddistillationprocessing.SupercriticalFluidTechnologiesalsoofferstrainingwitheachsystemcustomizedtoyourspecificapplication.

System OperationTheprocesscyclebeginswithfreshCO2gasfromliquid

bulkstorage.Theprocessstreampassesthroughacoriolismassflowmetertoprovideaccurateflowmeasurementthatisinsensitivetovariationsinpressureandtemperature.TheCO2streamisdeliveredat5

oCand725psi(5.0MPa)toapneumaticair-drivenpump(PMP1).CO2massflowiscontrolledbymodulatingtheairpressureappliedtothepumpviaanelectropneumaticregulator.Theprocessstreamisheatedtoamaximumprocesstemperatureof120oC.

Apressuretransducermeasurestheextractionvesselpressure.TheCO2flowiscontrolledthroughmodulationofamicrometeringcontrolvalve(PCV201).TheprocessstreamsubsequentlyflowsintotheSeparator#1.

Thesystemincludesaheatexchangerpriortotheextractorpressurecontrolvalve(PCV201).Thisheatexchangerisusedtowarmtheprocessstreamupto120oC,dependingonprocessrequirements,priortoflowthroughPCV201.Undersupercriticalconditions,thesetemperaturesincreasethesolubilityofextractintheSCCO2.FollowingexpansionthroughPCV201,aportionoftheextractfallsoutofsolution.ThepipingfromPCV201toSeparator#1isextremelyshortsothatthereisvirtuallynoopportunityfortheextracttoclogthelinesandsothatthereishighflowvelocityuponentryintoSeparator#1tofacilitatecentrifugalseparationoftheextractsolidfromtheCO2gasstream.

AfterSeparator#1,theCO2flowsthroughaheatexchanger.TheCO2nextflowsthroughapressurecontrolvalveandintothesecondseparator.ThepressurewithinSeparator#2ismaintainedwithabackpressureregulator(PCV203)attherecyclepressure.

Allshutoffvalvesinthehighpressureportionofthesystemareratedtoatleast10,000psi(689bar,68.9MPa).Highpressuretubingisatleast1/4inchouterdiameterandwillberatedto10,000psi(689bar,68.9MPa).

System Configuration Options

Optional PLC/HMI ControlsOptionalPLC/HMIcontrolledsystemsutilizeaNational

InstrumentscRIOprogrammableautomationcontrollertoregulatethepressure,flowandtemperatureprocessvariables.Thesearetheidenticalcontrolstothosetypicallyfoundinlargerscalecommercialproductionsystems.Theprocessconditionsinthiscontrolsystemenabledirecttranslationtoalargescaleprocessingsystem.Theoperatorwilluseatouchscreenoperatorpaneltomonitorprocessconditions,observesystemstatus,reviewprocesshistories,initiateprocesscycles,andenterprocessparameters.

Basic System:(1)10LiterVessel10,000psi,689bar,68.9MPa1kgflowofCO2ManualControlsSingleSeparatorCoriolisMassFlowMeter

Available Options:DualExtractorsDualSeparatorsAutomatedControlValve

PLC/HMIControlsCo-SolventModuleClass1Division2CO2RecycleStainlessSteelFrameSCADAControls20LiterExtractionVessel5LiterExtractionVessel1LiterExtractionVesselASMEorPEDCodeStamps

SFT-NPX-10 Flow Diagram

SFT-NPX-10 Natural Products Extractor Specifications

Touch Screen Display, SFT-Pilot SFE Processing System

Standard ConfigurationMaximum Operating Pressure:10,000psi(689bar,

68.9MPa)Maximum Operation Temperature:Ambientto120oCFlow Rates:Pneumaticair-drivenCO2pumpupto1.0kg/

minat10,000psi(689bar,68.9MPa).Patentedelectro-pneumaticregulatorforaccurateCO2fluiddelivery.

Extraction Vessel(s):Insulatedandheated5Lvessel,10Lvesselinsingleoroptionaldualvesselconfiguration,orsingle20Litervessel.

Restrictor Valve(s):Micrometeringregulatingcontrolvalveforextractor

Collection:Separator#1volume:0.75LwithboltedendclosureSeparator#11.5kWheatexchangertochangetheCO2

temperatureforSeparator#1MaximumSeparator#1uptopressure2,900psi(200bar,

20.0MPa)PTPEU-CupSealMaximumtemperatureofOperationSeparator#1:80oCBackpressurecontrolvalveforsettingpressurein

Separator#1Activeregulationoftemperatureandpressurein

Separator#1.Flow Measurement:CoriolisMassFlowMeterfor

measuringCO2flow1.5kWElectricCO2high-efficiencypre-heater/heat

exchanger

Configuration OptionsSeparator #2AutomaticfeedbacktoregulatetheliquidCO2

Separator#2Volume:0.75LwithboltedendclosuresMaximumSeparator#2pressure2,900psi(200bar,

20.0MPa)MaximumSeparator#2temperature:50oCRegulationoftemperatureandpressureinSeparator#2.

Control OptionsProcesscontrolsviaNationalInstrumentscRIOcontrollerProcessmonitoringandloggingofallprocessconditions

andprocessstatevariablesTouchscreenoperatorwith15inchdiagonaldisplayAutomaticflowcontrolvalve

System RequirementsPower Requirements: 3Phase,208/240/380/400/480VAC,

50-60HzCO2 Supply: LiquidCO2cylinderwithdiptube.House Air: Dryair,regulatedto110psi,80SCFMThesystemisdesignedincompliancewithOSHA1910.109;NFPANEC(NationalElectricalCode;NFPA70E;ASMEcodesforpressurevessels,pipingandhighpressuresystems;andRecognizedandGenerallyAcceptedGoodEngineeringPractice

2/15P/N:SFT-NPX-SPEC

Supercritical Fluid Extractions, Reactions and High Pressure Chemistry www.supercriticalfluids.com