Sensorial evaluations - ?· innollient™ LO at work Skin barrier Skin resiliency Estolide structures…

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<ul><li><p> 2012 by Innovacos corp. All rights reserved Conception and design Symbiose design-graphique </p><p>Background</p><p>Efficacy</p><p>Formulation</p><p>innollientLOinnollient LO is a liquid estolide (an ester linkage of one fatty acid to the hydroxyl </p><p>group of a second one) mainly composed of saturated and unsaturated fatty </p><p>acids displaying hydrophilic groups with high affinity for water molecules. A struc-</p><p>tural feature of innollient LO is the presence of a Guerbet derivative creating a </p><p>lipophilic lateral branch. This derivative imparts fluidity and low-friction characteristics </p><p>to innollient LO and contributes to its low melting point. The main benefits provided </p><p>by innollient LO are the spreadability index and a unique skin feel coupled to a </p><p>significant improvement of the skin resiliency. </p><p>Clinical actions and sensorial properties Improvement of skin barrier function (TEWL)</p><p> Increase in skin resiliency (cutometry)</p><p> High spreadability index</p><p> Superior emollient action</p><p> Cyclomethicone-like skin feel</p><p> Long-lasting effect</p><p>Technical information INCI (proposed): Octyldodecyl Oleate (and) Octyldodecyl Stearoyl Stearate (and) Polyhydroxystearic Acid (and) Octyldodecanol </p><p> Soluble in oils</p><p> Recommended use level: 1-10 %</p><p> Ideal for: Skin moisturizing, emollience Improving barrier function Improving formulation texture, gloss Hair care Makeup formulations Improving skin elasticity/resiliency Natural alternative to cyclomethicone Sunscreen solubilization/dispersion</p><p>of water and senses www.innovacos.com</p></li><li><p>innollient LO at work</p><p>Skin barrier</p><p>Skin resiliency</p><p> Estolide structures Containing a Guerbet-derivative</p><p> Creation of hydrophilic pockets</p><p> High spreadability index</p><p> Promotes skin hydration</p><p> Cyclomethicone-like feel</p><p> Long-lasting effect</p><p>Clinical efficacy</p><p> One single application of a formulation containing 3% innollientLO significantly improves the skin barrier function. The positive action is observed already 1 hour after its application and lasts for up to 8 hours</p><p> One single application of a formulation containing 3% innollientLO significantly improves the skin resiliency (cutometry). The positive action is observed already 1 hour after its application and lasts for up to 8 hours</p><p>OO</p><p>O</p><p>O</p><p>O O</p><p>O</p><p>O</p><p>H2O</p><p>H2O H2OH2O</p><p>H2O</p><p>1 hour</p><p>-8</p><p>-4</p><p>-6</p><p>-10</p><p>-2</p><p>0</p><p>8 hours</p><p>% r</p><p>educ</p><p>tion </p><p>in T</p><p>EW</p><p>L vs</p><p> bas</p><p>elin</p><p>e</p><p>Time after product application</p><p>*</p><p>* </p><p>-12</p><p>* p &lt; 0.05 vs Placebo p &gt; 0.05 vs 1 hour</p><p>innollientLO</p><p>Placebo</p><p>1 hour</p><p>2</p><p>5</p><p>3</p><p>4</p><p>1</p><p>6</p><p>7</p><p>8 hours</p><p>% in</p><p> ski</p><p>n re</p><p>silie</p><p>ncy </p><p>vs b</p><p>asel</p><p>ine *</p><p>0</p><p>* p &lt; 0.05 vs Placebo p &gt; 0.05 vs 1 hour</p><p>innollientLO</p><p>Placebo</p><p>* </p><p>innollient LO vs Cyclomethicone</p><p>ClinicalSelf-assessment</p><p>Sensorial evaluations</p><p> innollientLO brings unique senso- rial properties to a formulation. The sensorial profile of innollientLO shows a high spreadability index and advantageously compares to that of cyclomethicone especially for the emolliency parameter </p><p>innollientLO vs Cyclomethicone</p><p>INCI Formula A %Formula B </p><p>% Function</p><p>A</p><p>Glyceryl Stearate (and) Cetearyl Alcohol (pending) 5.00 5.00 Emulsifier</p><p>Dicaprylyl Ether 3.50 3.50</p><p>Emollients</p><p>Cetearyl Isononanoate 4.50 4.50</p><p>Dimethicone 1.00 1.00</p><p>Cyclomethicone 2.00 </p><p>innollientLO 2.00</p><p>BAqua (Water) up to 100 up to 100</p><p>Glycerin 3.00 3.00 Humectant</p><p>Sodium Polyacrylate 0.30 0.30 Thickener</p><p>C Preservative a.n. a.n. Preservative</p><p>PROCEDURE (O/W emulsion; formulae A and B): Prepare phase A and phase B separately and warm them up to 75C;Add phase A to phase B, at 75C under agitation; Homogenize for a few minutes;Cool down under gentle stirring and add preservative below 40 C (phase C).</p><p> Viscosity after 24h Brk, RVDV-I Prime, Sp 93, 10 rpm: 50.000 55.000 cps pH (100%): 5.0 7.0</p><p>Self-assessment of a formu l ation containing 3% innollientLO, versus placebo, for various sensorial parameters</p><p> 20 subjects Assessment after 3 days of use; half-face regimen Placebo-controlled; blind protocol</p><p> innollientLO positively contributes to the sensorial properties of a formulation</p><p>20 6040 80 100</p><p>Appearance ofthe skin improved</p><p>% of positive response</p><p>Skin is smoother</p><p>Skin is more hydrated</p><p>Spreadability</p><p>Texture of the product</p><p>Absorbs quickly</p><p>innollientLO</p><p>Placebo</p><p>Cyclomethicone (Formula A)</p><p>innollientLO (Formula B)</p><p>Cyclomethicone (Formula A)innoLLIENT LO (Formula B) </p><p>Brightness Stickiness</p><p>Film forming effect Absorption</p><p>Spreadability</p><p>Emolliency</p><p>01</p><p>56789</p><p>10</p><p>234</p></li><li><p>innollient LO at work</p><p>Skin barrier</p><p>Skin resiliency</p><p> Estolide structures Containing a Guerbet-derivative</p><p> Creation of hydrophilic pockets</p><p> High spreadability index</p><p> Promotes skin hydration</p><p> Cyclomethicone-like feel</p><p> Long-lasting effect</p><p>Clinical efficacy</p><p> One single application of a formulation containing 3% innollientLO significantly improves the skin barrier function. The positive action is observed already 1 hour after its application and lasts for up to 8 hours</p><p> One single application of a formulation containing 3% innollientLO significantly improves the skin resiliency (cutometry). The positive action is observed already 1 hour after its application and lasts for up to 8 hours</p><p>OO</p><p>O</p><p>O</p><p>O O</p><p>O</p><p>O</p><p>H2O</p><p>H2O H2OH2O</p><p>H2O</p><p>1 hour</p><p>-8</p><p>-4</p><p>-6</p><p>-10</p><p>-2</p><p>0</p><p>8 hours</p><p>% r</p><p>educ</p><p>tion </p><p>in T</p><p>EW</p><p>L vs</p><p> bas</p><p>elin</p><p>e</p><p>Time after product application</p><p>*</p><p>* </p><p>-12</p><p>* p &lt; 0.05 vs Placebo p &gt; 0.05 vs 1 hour</p><p>innollientLO</p><p>Placebo</p><p>1 hour</p><p>2</p><p>5</p><p>3</p><p>4</p><p>1</p><p>6</p><p>7</p><p>8 hours</p><p>% in</p><p> ski</p><p>n re</p><p>silie</p><p>ncy </p><p>vs b</p><p>asel</p><p>ine *</p><p>0</p><p>* p &lt; 0.05 vs Placebo p &gt; 0.05 vs 1 hour</p><p>innollientLO</p><p>Placebo</p><p>* </p><p>innollient LO vs Cyclomethicone</p><p>ClinicalSelf-assessment</p><p>Sensorial evaluations</p><p> innollientLO brings unique senso- rial properties to a formulation. The sensorial profile of innollientLO shows a high spreadability index and advantageously compares to that of cyclomethicone especially for the emolliency parameter </p><p>innollientLO vs Cyclomethicone</p><p>INCI Formula A %Formula B </p><p>% Function</p><p>A</p><p>Glyceryl Stearate (and) Cetearyl Alcohol (pending) 5.00 5.00 Emulsifier</p><p>Dicaprylyl Ether 3.50 3.50</p><p>Emollients</p><p>Cetearyl Isononanoate 4.50 4.50</p><p>Dimethicone 1.00 1.00</p><p>Cyclomethicone 2.00 </p><p>innollientLO 2.00</p><p>BAqua (Water) up to 100 up to 100</p><p>Glycerin 3.00 3.00 Humectant</p><p>Sodium Polyacrylate 0.30 0.30 Thickener</p><p>C Preservative a.n. a.n. Preservative</p><p>PROCEDURE (O/W emulsion; formulae A and B): Prepare phase A and phase B separately and warm them up to 75C;Add phase A to phase B, at 75C under agitation; Homogenize for a few minutes;Cool down under gentle stirring and add preservative below 40 C (phase C).</p><p> Viscosity after 24h Brk, RVDV-I Prime, Sp 93, 10 rpm: 50.000 55.000 cps pH (100%): 5.0 7.0</p><p>Self-assessment of a formu l ation containing 3% innollientLO, versus placebo, for various sensorial parameters</p><p> 20 subjects Assessment after 3 days of use; half-face regimen Placebo-controlled; blind protocol</p><p> innollientLO positively contributes to the sensorial properties of a formulation</p><p>20 6040 80 100</p><p>Appearance ofthe skin improved</p><p>% of positive response</p><p>Skin is smoother</p><p>Skin is more hydrated</p><p>Spreadability</p><p>Texture of the product</p><p>Absorbs quickly</p><p>innollientLO</p><p>Placebo</p><p>Cyclomethicone (Formula A)</p><p>innollientLO (Formula B)</p><p>Cyclomethicone (Formula A)innoLLIENT LO (Formula B) </p><p>Brightness Stickiness</p><p>Film forming effect Absorption</p><p>Spreadability</p><p>Emolliency</p><p>01</p><p>56789</p><p>10</p><p>234</p></li><li><p> 2012 by Innovacos corp. All rights reserved Conception and design Symbiose design-graphique </p><p>Background</p><p>Efficacy</p><p>Formulation</p><p>innollientLOinnollient LO is a liquid estolide (an ester linkage of one fatty acid to the hydroxyl </p><p>group of a second one) mainly composed of saturated and unsaturated fatty </p><p>acids displaying hydrophilic groups with high affinity for water molecules. A struc-</p><p>tural feature of innollient LO is the presence of a Guerbet derivative creating a </p><p>lipophilic lateral branch. This derivative imparts fluidity and low-friction characteristics </p><p>to innollient LO and contributes to its low melting point. The main benefits provided </p><p>by innollient LO are the spreadability index and a unique skin feel coupled to a </p><p>significant improvement of the skin resiliency. </p><p>Clinical actions and sensorial properties Improvement of skin barrier function (TEWL)</p><p> Increase in skin resiliency (cutometry)</p><p> High spreadability index</p><p> Superior emollient action</p><p> Cyclomethicone-like skin feel</p><p> Long-lasting effect</p><p>Technical information INCI: Octyldodecyl Oleate (and) Octyldodecyl Stearoyl Stearate (and) Polyhydroxystearic Acid (and) Octyldodecanol </p><p> Soluble in oils</p><p> Recommended use level: 1-10 %</p><p> Ideal for: Skin moisturizing, emollience Improving barrier function Improving formulation texture, gloss Hair care Makeup formulations Improving skin elasticity/resiliency Natural alternative to cyclomethicone Sunscreen solubilization/dispersion</p><p>of water and senses www.innovacos.com</p></li></ul>