sense of coherence and carotid artery intima media thickness measurements: presenting four case...
TRANSCRIPT
Sense of coherence and carotid artery intima media thickness measurements presenting four case reports from the Spili cohort in rural Crete
Greece
D Anyfantakis EK Symvoulakis C LionisClinic of Social and Family Medicine University of Crete
Greece
ldquoThe Future of Primary Health Care in Europe IIIrdquo 30 - 31 August 2010 Pisa Italy
Summary of the presentation
bull Background
bull Methods
bull Results
bull Conclusions
THE SPILI PROJECT-PHASE I
Spili project the initial sample (1988)
bull 445 inhabitants aged 15-79
bull 343 examined for CV risk factors and morbidity (170 males ndash 173 females)
bull Participation rate 77
bull High smoking prevalence
bull High alcohol consumption
bull High cholesterol levels
bull High prevalence of diabetes and hypertension
Source Lindholm et al Eur Heart J 1992
THE SPILI PROJECT-PHASE II
Spili project phase II (2001)bull 48 subjects deceased (25
males ndash 23 females)bull 37 moved awaybull 248 currently living in the
rural area of Spilibull Re-examined 200 subjects
(91 males ndash 109 females)bull 2nd phase participation
8072bull
Source Karalis et al BMC Public Health 2007
THE SPILI PROJECT-PHASE III
Lionis C Anyfantakis D Symvoulakis EK et al accepted for publication on
BMC Research Notes
To report on four cases from the Spili cohort in rural Crete with the aim of raising a discussion on potential cardio-protective effects of socio-cultural factors such as sense of coherence religiosity and spirituality in conjunction with biological and preclinical markers of atherosclerosis
AIM
METHODS
Two males aged 71 and 85 year old and two females aged 77 and 85 year old were examinedMedical approach included Electrocardiogram (ECG)Carotid intima media thickness (CIMT) measurement on the Common Carotid Artery (CCA)Blood pressure assessmentLaboratory tests Body mass index evaluation Sense of coherence (29-item Antonovskyrsquos SOC questionnaire)
CASE REPORT 1
A 77-year old female with Positive history of hypertension (usual BP14070)Positive 7 year history of diabetes mellitusNo clinical evidence of CDPhysical examination normal Body Mass Index 305 kgm2
Laboratory Fasting plasma glucose 128 mgdl Total Cholesterol 247mgdlLDL 163 mgdl ECG normal IMT(R) 07 mm IMT(L) 06 mm (normal values04-1mm)
RESULTS
SOC score158
CASE REPORT 2
A 85-year old female with Positive history of hypertension (usual BP14080) No clinical evidence of CD Physical examination normalBMI 29 kgm2
Laboratory Fasting plasma glucose 103 mgdl Total Cholesterol 247 mgdl LDL 138 mgdl ECG normal IMT(R) 05 mm IMT(L) 06 mm (normal values04-1mm)
SOC score165
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
Summary of the presentation
bull Background
bull Methods
bull Results
bull Conclusions
THE SPILI PROJECT-PHASE I
Spili project the initial sample (1988)
bull 445 inhabitants aged 15-79
bull 343 examined for CV risk factors and morbidity (170 males ndash 173 females)
bull Participation rate 77
bull High smoking prevalence
bull High alcohol consumption
bull High cholesterol levels
bull High prevalence of diabetes and hypertension
Source Lindholm et al Eur Heart J 1992
THE SPILI PROJECT-PHASE II
Spili project phase II (2001)bull 48 subjects deceased (25
males ndash 23 females)bull 37 moved awaybull 248 currently living in the
rural area of Spilibull Re-examined 200 subjects
(91 males ndash 109 females)bull 2nd phase participation
8072bull
Source Karalis et al BMC Public Health 2007
THE SPILI PROJECT-PHASE III
Lionis C Anyfantakis D Symvoulakis EK et al accepted for publication on
BMC Research Notes
To report on four cases from the Spili cohort in rural Crete with the aim of raising a discussion on potential cardio-protective effects of socio-cultural factors such as sense of coherence religiosity and spirituality in conjunction with biological and preclinical markers of atherosclerosis
AIM
METHODS
Two males aged 71 and 85 year old and two females aged 77 and 85 year old were examinedMedical approach included Electrocardiogram (ECG)Carotid intima media thickness (CIMT) measurement on the Common Carotid Artery (CCA)Blood pressure assessmentLaboratory tests Body mass index evaluation Sense of coherence (29-item Antonovskyrsquos SOC questionnaire)
CASE REPORT 1
A 77-year old female with Positive history of hypertension (usual BP14070)Positive 7 year history of diabetes mellitusNo clinical evidence of CDPhysical examination normal Body Mass Index 305 kgm2
Laboratory Fasting plasma glucose 128 mgdl Total Cholesterol 247mgdlLDL 163 mgdl ECG normal IMT(R) 07 mm IMT(L) 06 mm (normal values04-1mm)
RESULTS
SOC score158
CASE REPORT 2
A 85-year old female with Positive history of hypertension (usual BP14080) No clinical evidence of CD Physical examination normalBMI 29 kgm2
Laboratory Fasting plasma glucose 103 mgdl Total Cholesterol 247 mgdl LDL 138 mgdl ECG normal IMT(R) 05 mm IMT(L) 06 mm (normal values04-1mm)
SOC score165
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
THE SPILI PROJECT-PHASE I
Spili project the initial sample (1988)
bull 445 inhabitants aged 15-79
bull 343 examined for CV risk factors and morbidity (170 males ndash 173 females)
bull Participation rate 77
bull High smoking prevalence
bull High alcohol consumption
bull High cholesterol levels
bull High prevalence of diabetes and hypertension
Source Lindholm et al Eur Heart J 1992
THE SPILI PROJECT-PHASE II
Spili project phase II (2001)bull 48 subjects deceased (25
males ndash 23 females)bull 37 moved awaybull 248 currently living in the
rural area of Spilibull Re-examined 200 subjects
(91 males ndash 109 females)bull 2nd phase participation
8072bull
Source Karalis et al BMC Public Health 2007
THE SPILI PROJECT-PHASE III
Lionis C Anyfantakis D Symvoulakis EK et al accepted for publication on
BMC Research Notes
To report on four cases from the Spili cohort in rural Crete with the aim of raising a discussion on potential cardio-protective effects of socio-cultural factors such as sense of coherence religiosity and spirituality in conjunction with biological and preclinical markers of atherosclerosis
AIM
METHODS
Two males aged 71 and 85 year old and two females aged 77 and 85 year old were examinedMedical approach included Electrocardiogram (ECG)Carotid intima media thickness (CIMT) measurement on the Common Carotid Artery (CCA)Blood pressure assessmentLaboratory tests Body mass index evaluation Sense of coherence (29-item Antonovskyrsquos SOC questionnaire)
CASE REPORT 1
A 77-year old female with Positive history of hypertension (usual BP14070)Positive 7 year history of diabetes mellitusNo clinical evidence of CDPhysical examination normal Body Mass Index 305 kgm2
Laboratory Fasting plasma glucose 128 mgdl Total Cholesterol 247mgdlLDL 163 mgdl ECG normal IMT(R) 07 mm IMT(L) 06 mm (normal values04-1mm)
RESULTS
SOC score158
CASE REPORT 2
A 85-year old female with Positive history of hypertension (usual BP14080) No clinical evidence of CD Physical examination normalBMI 29 kgm2
Laboratory Fasting plasma glucose 103 mgdl Total Cholesterol 247 mgdl LDL 138 mgdl ECG normal IMT(R) 05 mm IMT(L) 06 mm (normal values04-1mm)
SOC score165
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
THE SPILI PROJECT-PHASE II
Spili project phase II (2001)bull 48 subjects deceased (25
males ndash 23 females)bull 37 moved awaybull 248 currently living in the
rural area of Spilibull Re-examined 200 subjects
(91 males ndash 109 females)bull 2nd phase participation
8072bull
Source Karalis et al BMC Public Health 2007
THE SPILI PROJECT-PHASE III
Lionis C Anyfantakis D Symvoulakis EK et al accepted for publication on
BMC Research Notes
To report on four cases from the Spili cohort in rural Crete with the aim of raising a discussion on potential cardio-protective effects of socio-cultural factors such as sense of coherence religiosity and spirituality in conjunction with biological and preclinical markers of atherosclerosis
AIM
METHODS
Two males aged 71 and 85 year old and two females aged 77 and 85 year old were examinedMedical approach included Electrocardiogram (ECG)Carotid intima media thickness (CIMT) measurement on the Common Carotid Artery (CCA)Blood pressure assessmentLaboratory tests Body mass index evaluation Sense of coherence (29-item Antonovskyrsquos SOC questionnaire)
CASE REPORT 1
A 77-year old female with Positive history of hypertension (usual BP14070)Positive 7 year history of diabetes mellitusNo clinical evidence of CDPhysical examination normal Body Mass Index 305 kgm2
Laboratory Fasting plasma glucose 128 mgdl Total Cholesterol 247mgdlLDL 163 mgdl ECG normal IMT(R) 07 mm IMT(L) 06 mm (normal values04-1mm)
RESULTS
SOC score158
CASE REPORT 2
A 85-year old female with Positive history of hypertension (usual BP14080) No clinical evidence of CD Physical examination normalBMI 29 kgm2
Laboratory Fasting plasma glucose 103 mgdl Total Cholesterol 247 mgdl LDL 138 mgdl ECG normal IMT(R) 05 mm IMT(L) 06 mm (normal values04-1mm)
SOC score165
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
THE SPILI PROJECT-PHASE III
Lionis C Anyfantakis D Symvoulakis EK et al accepted for publication on
BMC Research Notes
To report on four cases from the Spili cohort in rural Crete with the aim of raising a discussion on potential cardio-protective effects of socio-cultural factors such as sense of coherence religiosity and spirituality in conjunction with biological and preclinical markers of atherosclerosis
AIM
METHODS
Two males aged 71 and 85 year old and two females aged 77 and 85 year old were examinedMedical approach included Electrocardiogram (ECG)Carotid intima media thickness (CIMT) measurement on the Common Carotid Artery (CCA)Blood pressure assessmentLaboratory tests Body mass index evaluation Sense of coherence (29-item Antonovskyrsquos SOC questionnaire)
CASE REPORT 1
A 77-year old female with Positive history of hypertension (usual BP14070)Positive 7 year history of diabetes mellitusNo clinical evidence of CDPhysical examination normal Body Mass Index 305 kgm2
Laboratory Fasting plasma glucose 128 mgdl Total Cholesterol 247mgdlLDL 163 mgdl ECG normal IMT(R) 07 mm IMT(L) 06 mm (normal values04-1mm)
RESULTS
SOC score158
CASE REPORT 2
A 85-year old female with Positive history of hypertension (usual BP14080) No clinical evidence of CD Physical examination normalBMI 29 kgm2
Laboratory Fasting plasma glucose 103 mgdl Total Cholesterol 247 mgdl LDL 138 mgdl ECG normal IMT(R) 05 mm IMT(L) 06 mm (normal values04-1mm)
SOC score165
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
To report on four cases from the Spili cohort in rural Crete with the aim of raising a discussion on potential cardio-protective effects of socio-cultural factors such as sense of coherence religiosity and spirituality in conjunction with biological and preclinical markers of atherosclerosis
AIM
METHODS
Two males aged 71 and 85 year old and two females aged 77 and 85 year old were examinedMedical approach included Electrocardiogram (ECG)Carotid intima media thickness (CIMT) measurement on the Common Carotid Artery (CCA)Blood pressure assessmentLaboratory tests Body mass index evaluation Sense of coherence (29-item Antonovskyrsquos SOC questionnaire)
CASE REPORT 1
A 77-year old female with Positive history of hypertension (usual BP14070)Positive 7 year history of diabetes mellitusNo clinical evidence of CDPhysical examination normal Body Mass Index 305 kgm2
Laboratory Fasting plasma glucose 128 mgdl Total Cholesterol 247mgdlLDL 163 mgdl ECG normal IMT(R) 07 mm IMT(L) 06 mm (normal values04-1mm)
RESULTS
SOC score158
CASE REPORT 2
A 85-year old female with Positive history of hypertension (usual BP14080) No clinical evidence of CD Physical examination normalBMI 29 kgm2
Laboratory Fasting plasma glucose 103 mgdl Total Cholesterol 247 mgdl LDL 138 mgdl ECG normal IMT(R) 05 mm IMT(L) 06 mm (normal values04-1mm)
SOC score165
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
METHODS
Two males aged 71 and 85 year old and two females aged 77 and 85 year old were examinedMedical approach included Electrocardiogram (ECG)Carotid intima media thickness (CIMT) measurement on the Common Carotid Artery (CCA)Blood pressure assessmentLaboratory tests Body mass index evaluation Sense of coherence (29-item Antonovskyrsquos SOC questionnaire)
CASE REPORT 1
A 77-year old female with Positive history of hypertension (usual BP14070)Positive 7 year history of diabetes mellitusNo clinical evidence of CDPhysical examination normal Body Mass Index 305 kgm2
Laboratory Fasting plasma glucose 128 mgdl Total Cholesterol 247mgdlLDL 163 mgdl ECG normal IMT(R) 07 mm IMT(L) 06 mm (normal values04-1mm)
RESULTS
SOC score158
CASE REPORT 2
A 85-year old female with Positive history of hypertension (usual BP14080) No clinical evidence of CD Physical examination normalBMI 29 kgm2
Laboratory Fasting plasma glucose 103 mgdl Total Cholesterol 247 mgdl LDL 138 mgdl ECG normal IMT(R) 05 mm IMT(L) 06 mm (normal values04-1mm)
SOC score165
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
CASE REPORT 1
A 77-year old female with Positive history of hypertension (usual BP14070)Positive 7 year history of diabetes mellitusNo clinical evidence of CDPhysical examination normal Body Mass Index 305 kgm2
Laboratory Fasting plasma glucose 128 mgdl Total Cholesterol 247mgdlLDL 163 mgdl ECG normal IMT(R) 07 mm IMT(L) 06 mm (normal values04-1mm)
RESULTS
SOC score158
CASE REPORT 2
A 85-year old female with Positive history of hypertension (usual BP14080) No clinical evidence of CD Physical examination normalBMI 29 kgm2
Laboratory Fasting plasma glucose 103 mgdl Total Cholesterol 247 mgdl LDL 138 mgdl ECG normal IMT(R) 05 mm IMT(L) 06 mm (normal values04-1mm)
SOC score165
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
CASE REPORT 2
A 85-year old female with Positive history of hypertension (usual BP14080) No clinical evidence of CD Physical examination normalBMI 29 kgm2
Laboratory Fasting plasma glucose 103 mgdl Total Cholesterol 247 mgdl LDL 138 mgdl ECG normal IMT(R) 05 mm IMT(L) 06 mm (normal values04-1mm)
SOC score165
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
CASE REPORT 3
A 71-year old male withbull Positive history of hypertension (usual BP 14090)bull Positive 5 year history of diabetes mellitus bullNo clinical evidence of CDbullBMI 28 kgm2 bullLaboratorybullFasting plasma glucose 98mgdl bullTotal cholesterol 197 mgdlbullLDL 135 mgdlbull ECG normalbull IMT(R) 07mm IMT (L) 06 mm (normal values04-1mm)
SOC score169
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
CASE REPORT 4
bull A 85-year old male with
bull Positive history of hypertension (usual BP 13080)
bull Positive 8 year history of diabetes mellitus
bullNo clinical evidence of CD
bullBMI 265 Kgm2
Laboratory
bull Fasting plasma glucose 105 mgdl
bull Total Cholesterol 213 mgdl
bullLDL 151 mgdl
bull ECG normal
bullIMT(R) 06 mm IMT(L) 06 mm (normal values04-1mm)
SOC score161
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
Trials 2009 10119
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
Renaud S de Lorgeril M Wine alcohol platelets and the French paradox for coronary heart disease Lancet 1992 339(8808)1523-6
Is there any paradox in these observations
We cannot exclude the plausibility of research hypotheses involving protective environmental interactions on the cardiovascular well being of certain population groups elsewhere in the world
B Simini Serge Renaud from French paradox to Cretan miracle Lancet 2000 355 (9197) 48
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-
What is the reason for this paradox
bull Psycho-socio-cultural determinantsPsychological factorsSocial coherence of the local communitySocio-economic statusFamily and social supportReligiosity and spiritualitybull Mediterranean dietbull Genetics
What is the reason for this paradox
Alan Rozanski and Laura Kubsansky Psychosomatic Medicine 2005
- Slide 1
- Slide 2
- Slide 3
- Slide 4
- Slide 5
- Slide 6
- Slide 7
- Slide 8
- Slide 9
- Slide 10
- Slide 11
- Slide 12
- Slide 13
- Slide 14
- Slide 15
- Slide 16
- Slide 17
-