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Seeing What They See @ PAMELA

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Page 1: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Seeing What They See @ PAMELA

Page 2: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

PAMELA Platform Examples

Cross

slope

Longitudinal

slope Step

Flat

Page 3: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Seeing What They See Project

• Design a number of domestic spaces for people to

walk through

• Ask people with posterior cortical atrophy,

memory-led Alzheimer’s disease, and age-

matched controls to navigate through these

spaces

• Assess efficiency by measuring time taken to walk

from A to B

• Plot walking paths and identify any hesitation

during walking

Page 4: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Seeing What They See – Example Set-ups

Page 5: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Tracking Position and Assessing Hesitation

Page 6: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Example: U-Shaped Corridor

Control PCA

Page 7: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Example: Shadow Experiment

Control PCA

Page 8: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

General Observations

• In general, people with PCA take longer to

perform tasks

• They display, to a greater or lesser extent, one or

more of the following traits:

– Delay in starting to walk while scanning the space

– Walking slower

– Impaired adaptation when a change in direction is

required

– Hesitation at specific locations

Page 9: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Navigation• Visual Cues

• Lighting variability

Object localisation• Visual clutter

Example PAMELA tasks

Page 10: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Visual Cues

Page 11: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led
Page 12: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Visual Cues

Page 13: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led
Page 14: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Contrast Cue

Page 15: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Contrast Cue + Motion

Page 16: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Contrast Cue + Motion

Page 17: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Reduction in time taken to reach destinations

[95% CI]:

• Contrast Cue: 12% [3, 20]

• Contrast Cue + Motion: 7% [-3, 15]

Visual Cues: effects on navigation

Results

Page 18: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

AM Bright lights are not very good at

all.

Interviewer Are not good?

AM Yes. Strip lights in particular.

They are very difficult. It's almost as if…

it's like, if you can imagine a very small

space with lots of light coming from all

different directions, that's what it feels…

that's what it's like.

Page 19: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Lighting variability

Page 20: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Results

Reduction in time taken to reach destinations [95% CI]

• Medium v High Shadow: 5% [-1, 10]

• Low v High Shadow: 7% [2, 11]

Lighting variability: effects on navigation

Page 21: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Lighting variability: effects on navigation

Page 22: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Lighting variability: detecting hesitant steps

Page 23: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Object localisation

Effects of clutter

Clutter (N distractors: 0, 2, 5)

Page 24: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Effects of clutter

on time to pick

up object

Clutter (N distractor objects)

Tria

l tim

e (

s)

Object localisation

Effects of clutter

Page 25: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Effects of clutter

on time to pick

up object

Clutter (N distractor objects)

Tria

l tim

e (

s)

Object localisation

Effects of clutter

Page 26: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Effects of clutter

on time to pick

up object

Clutter (N distractor objects)

Tria

l tim

e (

s)

Object localisation

Effects of clutter

Page 27: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

• Limited evidence of overall benefit on navigation or stair

climbing for the following:

– Increase in overall lighting levels

– Hazard tape emphasising step edges

– Moving LED effects

• Tasks carried out in an unfamiliar, controlled setting

PAMELA caveats

Page 28: Seeing What They See @ PAMELASeeing What They See Project •Design a number of domestic spaces for people to walk through •Ask people with posterior cortical atrophy, memory-led

Dementia Research Centre

Sebastian Crutch

Amelia Carton

Emma Harding

Dilek Ocal

Ivanna Pavisic

UCL Engineering

Nick Tyler

Catherine Holloway

Tatsuto Suzuki

Ayako Suzuki

Biao Yang

Derrick Boampong

Nikolaos Papadosifos

Karen Hayrapetyan

Nicholas Firth

Kyriaki Mengoudi

Brunel University

Mary Gilhooly

Ken Gilhooly

Mary Pat Sullivan

Anne McIntyre

Rachel Woodbridge

University of Toronto

David Tang-Wai

Alison Lake

Hebrew University of

Jerusalem

Yoni Pertzov

UCL Institute of

Ophthalmology

Imre Lengyel

Moorfields Eye Hospital

Tunde Peto

London School of Hygiene

and Tropical Medicine

Chris Frost

Teresa Poole

Julia Langham

Institute of Neurology

Brian Day

Daniel Voyce

Amy Peters