psychoactive plant may hold key to reversing diabetes _ the journey continues

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  • TheJourneyContinues

    HEALTH

    PsychoactivePlantMayHoldKeytoReversingDiabetes

    MARCH12,2015|BREATHOFLIFE|1COMMENTAchemicalfoundinayahuascahasthepotentialtoregeneratepancreascellsthathavebeenlosttodiabetes.

    NewresearchpublishedinNatureMedicine(http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.3820.html)mayhaveunlockedanewlineoftreatmentfordiabetes.

    Theresearchershonedinonthemainculpritsindiabetes:betacells.Thesecellsconcentrateinthepancreasinlittleclusterscalledislets,andthey

    producetheinsulinnecessarytokeepthebodysbloodsugarlevelsstable.

    Inchildrenandadultswithtype1diabetes,theyvelost99percentoftheirbetacells,sotheycannotmake

  • Inchildrenandadultswithtype1diabetes,theyvelost99percentoftheirbetacells,sotheycannotmakeenoughinsulin.Thatsthecauseoftheirdiabetes,saidAndrewStewart,directoroftheDiabetes,ObesityandMetabolismInstituteattheIcahnSchoolofMedicineatMountSinai,NewYorkCityandseniorauthorofthestudy,inaninterviewwithHealthline.Peoplewithtype2diabetesalsohaveabouta50or60percentreductionintheirnumberofbetacellsintheirpancreas,andsotheytoocannotmakeenoughinsulin.

    LearnMoreAboutDiabetes(http://www.healthline.com/health/diabetes)

    GrowingBetaCells

    Althoughmanydrugsexisttocontrolthesymptomsofdiabetes,therecurrentlyisnoreliablewaytoreplacebetacellsandcurethedisease.StewartjoinedwithleadauthorPengWangandothersonamultidisciplinaryteamtotackletheproblem.

    Intheworldofbetacellregeneration,youcandoitintwoways.Youcaneitherusestemcells,createstemcellsandthentransplantthem.Oryoucouldtakeadrugthatmakesyourownbetacellsgrow,Stewartexplained.

    Althoughthestemcelltransplantresearchispromising,itinvolvesaninvasiveprocedureandwillhavedifficultymeetingthemassivedemand,hesaid.

    Diabetesaffectsmorethan20millionAmericans(http://www.cdc.gov/diabetes/statistics/prev/national/figpersons.htm),accordingtotheCentersforDiseaseControlandPrevention(CDC).

    Theneedvastlyoutstripsthestemcellisletsupply,saidStewart.Itwouldbesimplymuchsimplerto

  • Theneedvastlyoutstripsthestemcellisletsupply,saidStewart.Itwouldbesimplymuchsimplertotakeapilltomakeyourbetacellsgrow.

    Usingahighvolumescreeningmethod,Stewartsteamcheckedmorethan100,000differentchemicalstoseewhichhadthepotentialtomakebetacellsgrow.Theyidentified86possiblesolutionsandtestedeachmanually.Ofthese,asingledrugtriggeredbetacellgrowth:harmine.

    Harmineoccursnaturallyinanumberofplantsaroundtheworld.Itsoneoftheingredientsinthepsychoactivemixtureayahuasca,whichisusedbysomeindigenouspeopleforreligiouspurposes.

    RelatedNews:ScientistsMakeInsulinProducingCellsfromStemCellstoCureType1Diabetes(http://www.healthline.com/healthnews/scientistsmakeinsulinproducingcellsfromstemcells101514)

    ThePathtoNewTreatments

    Toconfirmthatharminewouldcausebetacellgrowth,theteamtookisletsfromthepancreasesofdeceasedhumanorgandonors.

    Then,theytransplantedtheisletsintodiabeticmice.Theyusedfarfewerthanwerenecessarytocurethemicesdiabetes.Dosingthemicewithharminetriggeredthebetacellstomultiplyenoughthattheycouldrestorethemicesbloodsugarlevelstonormal.

    Stewartcautionsthatharmineitselfisnttheanswer.Instead,harminemightinspiresimilardrugsthathoneinonbetacellsandleavetherestofthebody,especiallythebrain,alone.

    Wehavenowaytotargetdrugsspecificallytohumanbetacells.Thatswhatweneedtodonext.AndrewStewart,IcahnSchoolofMedicineWehavenowaytotargetdrugsspecificallytohumanbetacells,Stewartsaid.Thatswhatweneedtodonext.Weneedtofigureoutawaytogetharminedirectedtobetacellsspecificallyandtonoothertissue.

    ReadthefullarticleatHealthLine(http://www.healthline.com/healthnews/psychoactiveplantmayholdkeytoreversingdiabetes030915#3)

  • OnethoughtonPsychoactivePlantMayHoldKeytoReversingDiabetes

    1. ElizaWaterssays:MARCH12,2015AT10:59AMAmazing!

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    GROWINGBETACELLS NATURALCURESFORDIABETES

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