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TIME SPEAKER TITLE

7:00 AM–8:00 AM Breakfast with Exhibitors

8:00 AM–8:15 AM Chair: Michael Glick Welcome and Introduction

8:15 AM–9:00 AM Donald M. Brunette Causation, Correlation, Complexity, Confusion, and Oral Health

9:00 AM– 9:45 AM Thomas E. Van Dyke The Role of Infl ammation in Oral-Systemic Interactions

9:45 AM–10:15 AM Break and Refreshments with Exhibitors

10:15 AM–11:00 AM Wenche S. Borgnakke The Oral Microbiome and Systemic Health

11:00 AM–11:45 AM Maurizio Tonetti The Cardiovascular System and Oral Infections

11:45 AM –12:30 PM Ira B. Lamster Obesity and Oral Health

12:30 PM–2:00 PM Lunch with Exhibitors

2:00 PM–2:45 PM Robert J. Genco The Association of Periodontal Disease and Diabetes

2:45 PM–3:30 PM Panos N. Papapanou Pregnancy Outcomes and Oral Infections

3:30 PM–5:00 PM Panel Discussion and Questions and Answers

TIME SPEAKER TITLE

8:00 AM–8:15 AM Chair: Michael Glick Welcome

8:15 AM–9:00 AM Frank A. Scannapieco Links Between the Oral Microbiota and Pulmonary Disease

9:00 AM–9:45 AM Robert E. Marx Osteoporosis: The Oral-Systemic Connection

10:15 AM–11:00 AM Yiping W. Han Fusobacterium nucleatum: A Model Organism for Investigating the Mechanisms of Oral Bacteria in Extraoral Infections

11:00 AM–11:45 AM Douglas E. Peterson Oral Complications in Immunocompromised Patients: The Oncology Prototype

11:45 AM–12:30 PM Sook-Bin Woo Oral Manifestations of Systemic Diseases

2:00 PM–2:45 PM David T. Wong Salivary Biomarkers for Oral and Systemic Diseases

2:45 PM– 3:30 PM Barbara L. Greenberg The Role of the Oral Health Care Professional in Overall Health and Well-Being

Program Chair: Michael Glick

FRIDAY, FEBRUARY 7, 2014

SATURDAY, FEBRUARY 8, 2014

Participants will: • Learn how to appraise the literature on the oral-systemic connection• Understand the etiology of the oral-systemic connection• Learn how to diff erentiate between associations linking oral health with general health• Understand the role of oral health care professionals in improving overall patient health

Please print. To register additional participants, please photocopy this form.

Mail or fax entire page to:Quintessence Publishing Co Inc.4350 Chandler Drive | Hanover Park, IL 60133Fax: 630-736-3633 | Email: [email protected]

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By December 31, 2013 After December 31, 2013

Regular rate ❏ US $748 (R10) ❏ US $798 (R20)

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ADVANCE PROGRAM

Michael GlickProgram Chair

Wenche S. BorgnakkeDonald M. BrunetteRobert J. GencoBarbara L. GreenbergYiping W. Han

Ira B. LamsterRobert E. MarxPanos N. PapapanouDouglas E. PetersonFrank A. Scannapieco

Maurizio TonettiThomas E. Van DykeDavid T. WongSook-Bin Woo

FEBRUARY 7–8, 2014 | SHERATON SAN DIEGO HOTEL & MARINA

In partnership withPresented by

THE 1ST INTERNATIONAL

QUINTESSENCE SYMPOSIUM ON ORAL HEALTH

PROGRAM SCHEDULE

PROGRAM OBJECTIVES

REGISTRATION FORM

Speakers

WELCOME INVITATION

Dear Colleagues,

It is with great pleasure that I invite you to attend the 1st International Quintessence Symposium on Oral Health: The Oral-Systemic Connection in San Diego, February 7–8, 2014, at the Sheraton San Diego Hotel & Marina. This unique gathering will bring to-gether the most prominent clinicians and researchers on the subject of the oral-systemic connection.

Over the past several decades, an impressive body of knowledge has accumulated about the impact of oral infections on overall health and well-being. Studies have found im-portant associations that are now being evaluated for causative relationships. New infor-mation is being published at a rapid pace, and clinicians must sort through sometimes confl icting published fi ndings.

This symposium provides an opportunity for participants to hear the latest scientifi c in-formation on the associations between oral diseases and health and learn how to inter-pret claims made by scientists working on this subject.

I am confi dent that this symposium will bring clarity and understanding to a subject of utmost importance to all health care professionals. Not only will you benefi t from the knowledge gained from the gathered experts, but you will also be able to apply this knowledge for the benefi t of your patients.

I look forward to welcoming you to San Diego and the 1st International Quintessence Symposium on Oral Health: The Oral-Systemic Connection.

Oral Health: The Oral-Systemic ConnectionEdited by Michael Glick

Is there a biologic plausibility for an association between oral infections/disorders and systemic health? Can treatment of oral infections and disorders reduce the risk of adverse sys-temic outcomes? Is it safe to provide dental care for patients with a specifi c systemic condition? Written with the practicing dentist in mind, this book answers questions about the associa-tion between oral infections/disorders and systemic health and provides clinicians with information relevant to daily practice.

Available February 2014

The Oral-Systemic Connection

ORAL HEALTHThe Oral-Systemic Connection

Edited by Michael Glick

OHS_AdvProg_0513.indd 1-4 5/2/13 1:40 PM

TIME SPEAKER TITLE

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City __________________________________________ State ____________________ Zip ___________________________

Country ________________________________________________________________________________________________

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ADVANCE PROGRAM

PROGRAM SCHEDULE

PROGRAM OBJECTIVES

REGISTRATION FORM

Speakers

WELCOME INVITATION

Dear Colleagues,

GENERAL INFORMATION

REGISTRATIONYour registration fee includes admission to all symposium sessions and exhibits, daily breakfast, coffee breaks, lunch, and the symposium reception on Friday evening. Take ad-vantage of specially reduced fees by registering in advance.

REGISTRATION FEES By December 31, 2013 After December 31, 2013 Regular rate $748 $798Resident rate* $398 $398

* Please submit verification of resident status with the reg-istration form.

HOW TO REGISTER• Register online at www.quintpub.com/iqsoh• Complete the registration form and mail with your check

(payable to Quintessence Publishing Co Inc) to Quintes-sence Publishing at the address indicated on the form.

• Fax your form with credit card information (Visa, Master-Card, American Express, or Discover) to Quintessence at 630-736-3633.

• On-site registration will be accepted only on the basis of space availability and therefore cannot be guaranteed. Early advance registration is strongly recommended.

The deadline for registering for the symposium is January 21, 2014.

CANCELLATIONS/REFUNDSCancellations made in writing and received by Quintes-sence before January 21, 2014, will be refunded in full. For cancellations received on or after January 21, 2014, but be-fore the start of the meeting, a cancellation fee of US $75 will be charged. No refunds will be made after the sympo-sium begins on February 7, 2014.

CONTINUING EDUCATION CREDITSOne hour of continuing education (CE) credit is offered for each hour of program attendance. CE credit awarded for participation in a course may not apply toward licensing renewal in all states. It is the responsibility of each partici-pant to verify the requirements of his or her state licensing board. Meeting attendees are responsible for ensuring that their education credits are current and on file with their re-spective state board or other licensing/regulatory agency. Attendees of the symposium may receive up to 14½ hours of CE credit. If you have any questions regarding CE credit, contact Carol Thomas at [email protected].

REGISTRATION DESKYour symposium packet will await you at the symposium registration desk. The desk will be open from 1:00 PM to 5:00 PM on Thursday, February 6, and from 7:00 AM to 5:00 PM on Friday and Saturday.

TECHNICAL EXHIBITSTechnical exhibits will be held on Friday and Saturday dur-ing the symposium in the Nautilus Rooms. Visit the exhibits to observe the latest developments in dental products of-fered by the leading manufacturers.

EXHIBIT HOURSFriday, February 7, 2014 7:00 AM–5:30 PMSaturday, February 8, 2014 7:00 AM–5:30 PM

SYMPOSIUM RECEPTIONA Welcome Reception will be held on Friday, February 7, from 5:30 PM to 7:00 PM in the Lanai Area, located in the beautiful gardens of the hotel. Food and an open bar will be provided. Take this opportunity to renew friendships and meet colleagues from around the world.

LOST BADGESYour badge represents your ticket of admittance to all lectures. If you lose or misplace your badge, you will be charged a replacement fee of US $400; there are no excep-tions to this policy. You must wear your badge each time you wish to enter the lecture hall.

HOTEL RESERVATIONSHotel rooms have been blocked at the Sheraton San Diego Hotel & Marina. Reservations at the special symposium rate of US $215 will be accepted until the cut-off date of Janu-ary 13, 2014 or until the room block is sold out, whichever comes first. Call the hotel reservation desk direct at 1-877-734-2726, or you can find a link to the Sheraton San Diego at our website, www.quintpub.com. Make sure to indicate the name of the symposium to receive the special meeting rate of $215 per night plus applicable tax. A deposit equal to one night’s room and tax will be required to guarantee the reservation. This deposit is refundable if the hotel receives cancellation notice at least ten (10) days prior to arrival and a cancellation number is obtained. An early departure fee of US $100 will apply if you check out prior to the confirmed checkout date. For any other conditions applicable to your reservation, please contact the hotel directly for explana-tion.

8:15 AM–9:00 AM

Causation, Correlation, Complexity, Confusion, and Oral HealthDonald M. Brunette, PhD

To establish causation, the cause and the effect should be connected through a biologically plau-sible mechanism. The definitive means of estab-lishing causation is through experimentation, such as randomized controlled clinical trials. But such trials are often not possible, and criteria for judging the strength of the evidence for causa-

tion from less rigorous study designs demonstrating associations consequently have evolved. The standard causal inference criteria include strength of the association, dose-response relationship, time sequence, consistency, specificity, biologic plausibility, and independence from confounders. Besides frequentist-based sta-tistical models, other ways of investigating relationships, such as Bayesian networks and complexity theory, have been developed. The output of sophisticated statistical analyses can be confusing even for scientists, so there is a need to consider how best to pres-ent such information. This presentation will discuss these concepts using examples from the dental literature and focusing on ques-tions dentists can use in assessing causal relationships, as well as methods of presenting their analysis in understandable terms to their patients.

9:00 AM–9:45 AM

The Role of Inflammation in Oral-Systemic InteractionsThomas E. Van Dyke, DDS, PhD

Recent studies have suggested a relationship be-tween oral infection, in particular periodontal disease, and systemic diseases that goes beyond simple associations. Epidemiologic studies have implicated periodontal disease as imparting ex-cess risk for the development of cardiovascular disease and stroke and as a risk factor for preterm

low–birth weight babies in pregnant women. In addition, studies in diabetics have revealed that untreated periodontal disease can lead to diabetic complications and have a direct impact on glyce-mic control in diabetic patients. The available evidence associat-ing periodontal disease with risk for systemic disease centers on the role of bacteria from the oral cavity and bacteremia but always in the context of initiation or amplification of local and systemic inflammation. The role of inflammation in cardiovascular disease, pregnancy complications, obesity, and diabetes, particularly type 2, is well documented. The role of periodontal inflammation as a local, extravascular source of inflammation that has significant im-pact on systemic inflammation and inflammatory disease is begin-ning to be understood. This presentation will provide an overview of current concepts in local infection and inflammation as modi-fiers of systemic disease.

10:15 AM–11:00 AM

The Oral Microbiome and Systemic HealthWenche S. Borgnakke, DDS, MPH, PhD

Collectively, the microorganisms in the oral cavity have been referred to as the oral microflora, oral microbiota, or, more recently, the oral microbiome. Our understanding of the human oral microbi-ome is in a revolutionary phase of development to the point of science having to rethink and re-write most of what was hitherto known. High-

throughput genetic-based assays and powerful, novel bioinfor-matics tools recently made it possible to comprehensively survey the human oral microbiome to identify and determine the preva-lence of previously unknown or not culturable organisms. The abil-ity to fully describe the microbiome that inhabits the human body, including the oral microbiome, suggests a need to restudy these flora and their relationships with health and disease. With these new methods, the role of the oral microbiome in periodontal dis-ease and in diseases and conditions associated with periodontal disease is currently being studied. Evidence will be presented for systemic diseases and conditions that implicate oral organisms.

11:00 AM–11:45 AM

The Cardiovascular System and Oral InfectionsMaurizio Tonetti, DMD, PhD, MMSc

Periodontitis and atherosclerotic cardiovascu-lar disease are highly prevalent, socially relevant chronic diseases. Epidemiologic evidence has linked these two diseases, although the nature of the association remains a matter of debate. Is it due to shared risk factors, or is there a true causal link? Intervention trials provide an initial reading

light. Under both scenarios, there are important clinical conse-quences and reasonable action that needs to be implemented by oral health care professionals. These concepts and their practical implications will be explored.

11:45 AM–12:30 PM

Obesity and Oral HealthIra B. Lamster, DDS, MMSc

There is an epidemic of obesity in the United States and across the globe. It has been estimated that 1 in 4 adults is overweight and 1 in 10 is obese. Obe-sity is associated with a variety of significant health problems, including an increased risk of type 2 dia-betes, hypertension and cardiovascular diseases, and certain malignancies. Obesity has also been

linked to a number of changes in the oral cavity. Obesity has been investigated as a risk factor for periodontitis. Obesity is also a cause of obstructive sleep apnea, a condition associated with abnormal pauses in breathing. In the future, dental professionals can have a role in the general management of obesity by identifying patients who are overweight or obese, referring them to a health care pro-vider for comprehensive care, and then becoming involved in the longer-term management of these individuals.

GENERAL INFORMATION ABSTRACTS

2:00 PM–2:45 PM

The Association of Periodontal Disease and DiabetesRobert J. Genco, DDS, PhD

Periodontal disease is an infectious complica-tion of diabetes. People with diabetes, especially those with poor glycemic control, are two to three times more likely than those without diabetes to have periodontal disease. Diabetes likely increases susceptibility to periodontal disease by impairing wound healing. Diabetes also leads to a hyperin-

flammatory state, which exaggerates periodontal tissue destruc-tion. It is, however, a two-way street in that diabetes is a risk factor for periodontal disease, and periodontal disease makes diabetes glycemic control worse. Patients with diabetes and periodontal disease also suffer from higher mortality and morbidity from heart and kidney disease. Periodontal treatment in patients with diabe-tes contributes to better glycemic control and helps to preserve a functioning dentition, which allows individuals to maintain a diet higher in fiber and lower in fats and refined carbohydrates. Such a diet is also beneficial to the long-term management of patients with diabetes.

2:45 PM–3:30 PM

Pregnancy Outcomes and Oral InfectionsPanos N. Papapanou, DDS, PhD

For the past two decades, the link between peri-odontal diseases and adverse pregnancy out-comes has been extensively studied in both animalmodels and observational and experimental inter-vention trials. Although uncertainties still remain, patients need to be informed and provided with care according to the best available evidence. This

presentation will explore the scientific rationale, discuss current epidemiologic data, and address results from intervention studies in order to provide oral health care professionals with an under-standing of the association between oral infections and pregnan-cy outcomes.

8:15 AM–9:00 AM

Links between the Oral Microbiota and Pulmonary DiseaseFrank A. Scannapieco, DDS

Associations between poor oral health and pul-monary diseases are possible through a variety of mechanisms. This presentation will provide an overview of the latest information on the problems of aspiration pneumonia and nosoco-mial-acquired pneumonia, especially ventilator- associated pneumonia (VAP). Both infections lead

to serious consequences for morbidity and mortality in institution-al settings. Results from a recent randomized trial that tested the effects of the oral topical antimicrobia chlorhexidine on the oral flora of ventilated patients will be presented. Biologic mechanisms involving the oral microflora and host response that influence pneumonia will be discussed. Practical advice on how to translate this information into everyday practice will be presented.

9:00 AM–9:45 AM

Osteoporosis: The Oral-Systemic ConnectionRobert E. Marx, DDS

Osteoporosis is an age- and hormone-related thinning of the cancellous trabeculae and cortex, which structurally weakens bone at varying de-grees and thus makes it more prone to fracture. Osteoporosis involving the jaws causes a thinning of their bony trabeculae and cortex, just as it does in other bones; this is often referred to as type III

or type IV bone. It is much more difficult to gain primary stability during implant placement, and there is reduced osseointegration potential. However, the greatest impact of osteoporosis on the jaws is a condition now known as drug-induced osteonecrosis of the jaws (DIONJ). All oral and intravenous bisphosphonates marketed for osteoporosis, as well as oral denosumab, have caused DIONJ. Yet, alendronate (Fosamax) because of its potency and a recom-mended dose that is twice that of other oral bisphosphonates, has been responsible for more than 90% of all reported cases and has even caused femur fractures. It is the osteoporosis drug of greatest oral impact.

10:15 AM–11:00 AM

Fusobacterium nucleatum: A Model Organism for Investigating the Mechanisms of Oral Bacteria in Extraoral InfectionsYiping W. Han, PhD

Fusobacterium nucleatum (Fn), a heterogeneous gram-negative anaerobe, is ubiquitous in the oral cavity and associated with various forms of peri-odontal diseases. It is infrequently found in the normal floras elsewhere in the body but highly prevalent in the diseased microbiota, having been isolated from infections and abscesses in the liver,

spleen, lungs, blood, brain, and intrauterine cavities. Recently, Fn has been recognized as an emerging gut pathogen associat-ed with inflammatory bowel disease and colorectal cancer. Is Fn merely associated with these diseases, or does it play a causative

ABSTRACTS

role? We have previously demonstrated the mechanisms by which oral Fn cause intrauterine infection leading to adverse pregnancy outcomes. We have recently started to investigate the role of Fn in colorectal carcinoma. Fn promotes carcinogenesis both in vitro and in vivo. A specific virulence determinant and its interaction with the host have been identified. The details of this investigation will be discussed.

11:00 AM–11:45 AM

Oral Complications in Immunocompromised Patients: The Oncology PrototypeDouglas E. Peterson, DMD, PhD, FDS RCSEd

Oral complications in immunocompromised pa-tients can result in clinically impactful sequelae, in-cluding compromised quality of life as well as de-creased patient survival in select cases. In addition, the oral lesions can be expensive to manage, re-sulting in increased use of typically limited health care resources. This presentation will address the

state-of-the-science of this field, focusing on the myelosuppressed oncology patient as the prototype. Evidence-based strategies for prevention and management of oral disease caused by high-dose as well as emerging molecularly targeted cancer therapies will be discussed. Acute toxicities, including oral mucosal injury, pain, and infection, will be emphasized in relation to the complex interface of the oral cavity with overall systemic status. The presentation will highlight novel basic, translational, and clinical research that could lead to transformational strategies for oncology patient manage-ment in the future. The discussion will also compare and contrast the cancer patient prototype with other relevant models of immu-nocompromised patients, including those with AIDS.

11:45 AM–12:30 PM

Oral Manifestations of Systemic DiseasesSook-Bin Woo, DMD, MMSc

The general dentist in his or her daily practice en-counters a variety of mucosal disorders, most of which are straightforward and easy to diagnose. However, even banal-appearing lesions may be a manifestation of systemic disease or a side effect of treatment for systemic disease. Furthermore, the oral signs may be the first presentation, and

the dentist is in a unique position to help render an early diagno-sis. This presentation will consider six common oral conditions that are encountered in routine general dental practice. For each, there will be a common “default” diagnosis, followed by a discussion of other conditions that may look similar but represent the oral presentation of a systemic condition. The differences in history and clinical findings, as well as diagnostic tests that may help dis-tinguish between each of them, will also be presented. The con-ditions to be discussed include aphthous-like oral ulcers, lichen planus and lichenoid lesions, gingivitis, gingival hyperplasia, pig-mented macules, and nonhealing extraction sockets.

2:00 PM–2:45 PM

Salivary Biomarkers for Oral and Systemic DiseasesDavid T. Wong, DMD

Saliva has long been considered a “mirror of the body” that reflects the state of overall health. A wide range of systemic diseases, such as diabetes and Sjögren syndrome, have oral manifestations that clinicians (physicians and dentists) encounter in patients at various stages of disease develop-ment. Advances in the science of salivary diagnos-

tics have led to identification of disease signatures of candidate biomarkers and/or confirmation of genetic susceptibility for sys-temic conditions, particularly in molecular oncology. Development of the salivary proteome, transcriptome, micro-RNA, metabolome, and microbiome as diagnostic alphabets fully enables saliva to be translated for personalized individual medicine applications. Sali-vary biomarker panels have been developed for oral cancer, lung cancer, pancreatic cancer, breast cancer, and ovarian cancer. Cou-pled with the development of point-of-care technologies and the emerging trend of chairside screening for medical conditions, the clinical impact of scientifically credentialed salivary biomarkers for molecular oncology application will improve access to care, reduc-ing health disparities and impacting global health.

2:45 PM–3:30 PM

The Role of the Oral Health Care Professional in Overall Health and Well-BeingBarbara L. Greenberg, MSc, PhD

The role of prevention and the integration of health care providers across disciplines is a critical component of the recent health care reform era. Early identification of individuals at increased risk of developing diseases of increasing significance, such as coronary heart disease and diabetes mel-litus, through point-of-care testing in a dental set-

ting could be a significant component of any prevention-oriented health care initiative. Early detection and, consequently, interven-tion could prevent the onset or control the severity of disease and improve health care delivery. Involving oral health care pro-fessionals in strategies to identify individuals at increased risk for coronary heart disease and diabetes can be an effective means of expanding preventive efforts aimed at slowing the development of these diseases and provide a portal into the general health care system for individuals who are not routinely engaged with a pri-mary care provider. This session will provide updated information on the epidemiology of the diseases, recommended and validated available diagnostic screening tests, use of the screening tests, in-terpretation of the test results, and approaches to discussing test results with patients and making referrals to a physician.

ABSTRACTS

Friday, February 7, 2014 Saturday, February 8, 2014

GENERAL INFORMATION

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GENERAL INFORMATION

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GENERAL INFORMATION

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TIME SPEAKER TITLE

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Dear Colleagues,

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WELCOME INVITATION

Dear Colleagues,

program schedule registration form welcome …€¦ · welcome invitation dear colleagues, it is...

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