ORAL AND MAXILLOFACIAL PATHOLOGY OOOO

e220 Abstracts February 2014

PE-448 - PREVALENCE OF BIOPSIED ORAL MUCOCU-TANEOUS LESIONS IN A STOMATOLOGY SERVICE:RETROSPECTIVE STUDY OVER 12 YEARS. TAIARADE OLIVEIRA COSTA, BRUNA LAVINAS SAYEDPICCIANI, GERALDO OLIVEIRA SILVA-JUNIOR, RUTHTRAMONTANI RAMOS, THIAGO PESSOA MOREIRA,MARÍLIA HEFFER CANTISANO, FABIO RAMOA PIRES.UNIVERSIDADE DO ESTADO DO RIO DE JANEIRO.

Oral lesions may represent the first manifestations ofimmunologically mediated mucocutaneous diseases. This studyevaluated the prevalence of these entities in a stomatology serviceover a 12-year period. Materials and Methods: Patients’ medicalrecords were reviewed and data regarding gender, age, location ofthe lesions, and histological diagnosis were retrieved. Results:The sample included 84 patients, mostly women (77%), Cauca-sians (69%), whose mean age was 52 years (range 21 to 100years). Lichen planus was the most frequent entity (64%), fol-lowed by pemphigus vulgaris (18%), pemphigoid (14%), andsystemic lupus erythematosus and erythema multiforme (2%each). The most common location was the buccal mucosa (61%).Conclusion: These results reflect the prevalence of immunologi-cally mediated mucocutaneous diseases in a public stomatologyservice in southeastern Brazil. Knowledge of these trends canimprove early diagnosis and prompt treatment of these entities inthis population.

PE-449 - PREVALENCE OF ORAL LESIONS ANDMAXILLOFACIAL BIOPSY IN A STOMATOLOGY SER-VICE: RETROSPECTIVE STUDY OF 2078 CASES.ANDREZA MARIA DE OLIVEIRA FILGUEIRAS, MARCUSVINÍCIUS REGO BENEVIDES, MONALISA CRISTINAAGUILLERA M. ALBUQUERQUE, GERALDO OLIVEIRASILVA-JUNIOR, RUTH TRAMONTANI RAMOS, BRUNALAVINAS SAYED PICCIANI, MARÍLIA HEFFERCANTISANO. UNIVERSIDADE DO ESTADO DO RIO DEJANEIRO.

The clinical examination and radiographs provide a provi-sional clinical diagnosis that should be confirmed by biopsy inmany cases. Oral and maxillofacial lesions biopsied in Brazilianpatients treated at the stomatology clinic from 2000 to 2012were surveyed. Materials and Methods: The medical records of2078 patients with a histopathological diagnosis of oral cavityand maxillofacial lesions were studied. The patient’s clinicaldata were registered and evaluated retrospectively. Results: Thehistological findings were varied, with a total of 108 differentdiagnoses. Of the lesions biopsied, 104 (7.9%) were squamouscell carcinomas. The most frequent lesions biopsied were non-neoplastic proliferative processes, including in particular in-flammatory fibrous hyperplasia (33.7%), pyogenic granuloma(4.5%), and peripheral ossifying fibroma (1.0%). Mucusextravasation/retention phenomenon (7.0%) and lichen planus(4.2%) were also common in our series. Conclusion: The fre-quency of oromaxillofacial complex lesions susceptible to his-topathology study was similar to the figures reported elsewherein the literature.

PE-450 - PREVALENCE OF ORAL LESIONS AT THEORAL MEDICINE OUTPATIENT CLINIC AT HEMO-CENTRO CAMPINAS/UNICAMP. VINICIUS RABELOTORREGROSSA, JOSE LAURENTINO FERREIRA FILHO,VINICIUS RABELO TORREGROSSA, NATHALIA CAROLINE

DE SOUZA LIMA, MARIA ELVIRA PIZZIGATTI CORREA.AMBULATÓRIO DE ODONTOLOGIA, HEMOCENTRO,UNIVERSIDADE ESTADUAL DE CAMPINAS/UNICAMP.

The oral outpatient clinic at Hemocentro Campinas/Unicampprovides dental treatment and oral diagnosis for oncohemato-logical patients. This study evaluated the prevalence of oral le-sions in this specific group of patients. Materials and Methods: Aretrospective analysis studied biopsies and oral cytology resultsobtained between 2009 and 2012. Results: A total of 121 biopsieswere carried out, with 44 (33.4%) of these in patients undergoinghematopoietic stem cell transplant (HSCT). Three patients (2.5%)showed oral non-Hodgkin’s lymphoma, 20 (16.5%) had inflam-matory gingival hyperplasia, and 7 (5.8%) had squamous cellcarcinoma, among others. From 50 oral cytology results, 11 (9%)showed fungal infection and 9 (7.4%) showed herpetic infection.HSCT patients represented those who were most in need of anoral biopsy. Oral cytology was useful for oral fungal and viralinfection diagnosis. Conclusion: Hospital dentistry includes thediagnosis of oral manifestations of an underlying disease and/orits treatment.

PE-451 - PROFILE AND SCIENTIFIC PRODUCTIONOF BRAZILIAN RESEARCHERS IN ORAL PATHOLOGY.PATRÍCIA HELENA COSTA MENDES, MARIA IVANILDEPEREIRA SANTOS, RAFAEL AMÂNCIO DIAS DEOLIVEIRA, FRANCISCO MARCONE VERÍSSIMO, LÍVIAMÁRIS RIBEIRO PARANAÍBA, EDUARDO ARAUJOOLIVEIRA, HERCÍLIO MARTELLI-JÚNIOR. UNI-VERSIDADE ESTADUAL DE MONTES CLAROS.

This study evaluated the scientific production of researchersin oral pathology who received grants from the Brazilian NationalResearch and Development Council in 2008 through 2010 thatwere included in the curriculum Lattes of 34 researchers. Thevariables analyzed were as follows: gender, affiliation, time fromcompletion of the PhD program, scientific production, supervi-sion of undergraduate students, and Master’s and PhD programs.Men and category 2 grants were predominant. The states of SãoPaulo and Minas Gerais were responsible for 79.41% of the re-searchers. They published 906 articles, with a median of 26.64articles per researcher in the triennium. It was found that of 906articles published, 366 were published in strata A (qualis-CAPES). Oral pathology researchers supervised 437 scientificinitiation and post-graduate students. Our study demonstrated animportant scientific production of oral pathology researchers inthis triennium.

PE-452 - PTEN DOWNREGULATION LEADS TOAUGMENTEDANGIOGENESIS AND INCREASEDCOX-2EXPRESSION IN HNSCC. ALINE CORREA ABRAHAO,ROGERIO M. CASTILHO, ALFREDO MOLINOLO,MARK W. LINGEN, J. SILVIO GUTKIND, CRISTIANE H.SQUARIZE. UNIVERSITY OF MICHIGAN SCHOOL OFDENTISTRY.

Tumor suppressor PTEN and PI3K oncogene are deregu-lated and mutated in head and neck squamous cell carcinoma(HNSCC). We investigated the in vivo molecular changes led byPTEN and PI3K deregulation during HNSCC tumor develop-ment and progression. Study Design: Oral tumors from an oralspecific and genetically defined HNSCC animal model with Ptendownmodulation was used to identify the molecular changesusing immunoblot, immunohistochemistry, and microvessel