Nutrition and chronic diseases II 147

HPN is over-utilised in Denmark and Scotland comparedto the service provided in New Zealand or whether thereis ongoing inequality of access in NZ.

Disclosure of Interest: None declared

PP316ORAL HEALTH, DENTAL PROPHYLAXIS AND CATHETERRELATED BLOODSTREAM INFECTIONS IN HOMEPARENTERAL NUTRITION PATIENTS: RESULTS OF AUK SURVEY AND COHORT STUDYA.M. Lee1, S.M. Gabe2, J.M. Nightingale3, J. Fiske4,M. Burke5. 1Clinical Fellow, North West LondonHospitals NHS Trust, 2Consultant Gastroenterologist &Co-Chair of the Lennard-Jones Intestinal Failure Unit,St Mark’s Hospital; Hon. Senior Lecturer, ImperialCollege, 3Consultant Gastroenterologist & Co-Chairof the Lennard-Jones Intestinal Failure Unit, St Mark’sHospital, 4Senior Lecturer/Honorary Consultant inSpecial Care Dentistry, 5Consultant in Special CareDentistry, Guys and St Thomas’ NHS Foundation Trust,London, United Kingdom

Rationale: There are concerns that catheter relatedbloodstream infections (CRBSIs) arise from poor oralhealth and there are no standard guidelines for antibioticprophylaxis for dental treatment in home parenteralnutrition (HPN) patients.Methods:A.An email survey of the UK HPN group requesting

provider’s opinions, observations and prescribing prac-tices related to oral health and CRBSIs.

B. Review of data from 52 HPN patients comparing oralhealth parameters and dental treatment in relationto CRBSI experience in the last 12 months; using Chi-square analysis to assess associations.

Results:A. 68% responded. 89% linked dental health/treatment

with a CRBSI and 61% recommended parenteral pro-phylactic antibiotics (82% IV, 18% IM). Streptococci,bacteroides and fuscobacteria caused most concern.Amoxicillin, metronidazole, co-amoxyclav and gen-tamycin are most prescribed. Many practitionersfollowed the historic infective endocarditis (IE) dentaltreatment guidelines, although regimes varied fromcurrent IE guidance. 36% may delay HPN if oralhealth was poor; 89% believe a new central venouscatheter should not delay dental treatment; 89% couldnot recall dental treatment impacting on HPN and79% had no recall of oral health impacting on HPN.57% recommended dental examination or oral healthscreening, and 25% dental extractions, to prevent ortreat CRBSIs. 71% believed patient care should be in aspecialist setting.

B.There was no significant link between dental plaque,the interval since last dental treatment or antibioticprophylaxis and CRBSIs over the previous 12 months.

Conclusion: Despite no evidence to support an associ-ation between dental health/treatment and CRBSIs, UKHPN providers tend to prescribe prophylactic antibioticsfor dental treatment; a multicentre study would providemore robust evidence to help establish valid guidelines.

Disclosure of Interest: None declared

PP317CHOLESTERYL ESTER TRANSFER PROTEIN LEVELS ANDITS RELATIONSHIP WITH CARDIOVASCULAR RISK OFADOLESCENTSA.P.D.Q. Mello1, I. Silva1, C. Sanibal1, N. Damasceno1.1Department of Nutrition, School of Public Health,University of Sao Paulo, Sao Paulo, Brazil

Rationale: Cholesteryl ester transfer protein (CETP)promotes the transfer of cholesteryl esters from HDLs toapolipoprotein B containing lipoproteins and its deficiencyis associated with a profile antiatherogenic. Our goalwas to assess the level of CETP and investigate itspossible relationship with cardiovascular risk factors ofadolescents.Methods: 242 adolescents, aged 10 19 years, both sexesfrom public school (Sao Paulo, Brazil) were includedin this study. Anthropometric (body mass index BMIand waist circumference WC), body composition (per-centage of fat BIA) parameters and sexual maturation(Tanner method) were monitored. Lipid profile (totalcholesterol, LDL-C, HDL-C, triglycerides) and CETP con-centration were analyzed in plasma. Statistical analysiswas performed by SPSS 15.0.Results: Adolescents were distributed in tertiles of CETP.It was not observed differences in sex, sexual maturation,total cholesterol and LDL-C in function of tertiles ofCETP. However, body fat percentage (p = 0.012), BMI(p� 0.005), WC (p = 0.001) and total cholesterol/HDL-Cratio (p = 0.039) were significantly higher in adolescentsin the highest tertile compared to those in the lowesttertile. In opposite, HDL-C showed lower values in ado-lescents in the highest tertile compared to those in thelowest tertile (p = 0.011). The negative impact of CETPon cardiovascular risk factors was confirmed by positivecorrelation with body fat percentage (r = 0.24, p� 0.005),BMI (r = 0.28, p� 0.005), WC (r = 0.28, p� 0.005), LDL-C(r = 0.15, p = 0.025), non-HDL-C (r = 0.15, p = 0.022) andtotal cholesterol/HDL-C ratio (r = 0.21, p� 0.005). Nega-tive correlation were found between CETP and body masspercentage (r = 0.20, p� 0.005) and HDL-C (r = 0.22,p� 0.005).Conclusion: Elevated CETP level is associated withobesity and dyslipidemia in adolescents.

Disclosure of Interest: None declared

PP318RISK FACTORS OF HEPATIC CYTOLYSIS AND EVOLUTIONOF TRANSAMINASES DURING RENUTRITION IN ANOREXIANERVOSAM. Guidoum1, N. Cournede1, P. De Truchis1,J.C. Melchior1, P. Crenn1. 1Unite de Nutrition Clinique,Hopital Raymond Poincare, Garches, France

Rationale: Hepatic cytolysis is often observed in malnour-ished patients with anorexia nervosa (AN). The aim ofthis study was to identify the risk factors of elevatedtransaminases and to observe their evolution duringnutritional rehabilitation.Methods: Comprehensive study of AN patients (BMI < 18),hospitalized for nutritional rehabilitation (enteral and/ororal, including vitamins and trace elements) between