phar2000 foundations of pharmaceutics semester 1,...

Unit study package code: PHAR2000

Mode of study: Internal

Tuition pattern summary: Note: For any specific variations to this tuition pattern and for precise information refer to the Learning Activities section.

Lecture: 1 x 2 Hours Weekly Science Laboratory: 8 x 3 Hours Semester Tutorial: 1 x 1 Hours Weekly Workshop: 1 x 2 Hours Semester

This unit does not have a fieldwork component.

Credit Value: 25.0

Pre-requisite units:313462 (v.0) Pharmaceutics 123 or any previous version OR PHAR1000 (v.0) Fundamentals of Pharmaceutical Science or any previous version OR PHAR1002 (v.0) Pharmacy Practice 1 or any previous version

AND

CHEM1006 (v.0) Pharmaceutical Chemistry or any previous version OR 313463 (v.0) Pharmaceutical Chemistry 124 or any previous version

AND

313402 (v.0) Introduction to Pathophysiology 100 or any previous version OR PATH1000 (v.0) Introduction to Pathophysiology or any previous version

AND

INDH1006 (v.0) Indigenous Cultures and Health Behaviours or any previous version OR INDH1000 (v.0) Indigenous Cultures and Health or any previous version OR CMHL1003 (v.0) Health and Health Behaviour or any previous version

AND CMHL1001 (v.0) Evidence Informed Health Practice or any previous version

Co-requisite units: Nil

Anti-requisite units: Nil

Result type: Grade/Mark

Approved incidental fees: Information about approved incidental fees can be obtained from our website. Visit fees.curtin.edu.au/incidental_fees.cfm for details.

Unit coordinator:

Title: Dr

Unit Outline

PHAR2000 Foundations of Pharmaceutics Semester 1, 2017

Faculty of Health SciencesSchool of Pharmacy

PHAR2000 Foundations of Pharmaceutics Bentley Campus 21 Feb 2017 School of Pharmacy, Faculty of Health Sciences

Page: 1 of 13CRICOS Provider Code 00301J

The only authoritative version of this Unit Outline is to be found online in OASIS

http://fees.curtin.edu.au/incidental_fees.cfm

Acknowledgement of Country We respectfully acknowledge the Indigenous Elders, custodians, their descendants and kin of this land past and present. The Centre for Aboriginal Studies aspires to contribute to positive social change for Indigenous Australians through higher education and research.

Syllabus This unit introduces students to the pharmaceutical science and formulation of liquid and solid dosage forms Pharmaceutical science aspects: Physicochemical properties of pharmaceutical solids including crystalline form, solubility and distribution. Powder technology including particle size analysis, particle size reduction, powder mixing and drying. Physicochemical properties of pharmaceutical solutions including solvents, effects of pH, buffers, phase rule and phase diagrams. Formulation aspects: Formulation, preparation and evaluation of solid oral dosage forms and pharmaceutical solutions. Principles of preservation, flavouring, colouring and stabilisation of pharmaceutical solutions.

Introduction Welcome to Foundations of Pharmaceutics

The main objective of this unit is to develop an understanding and the application of physicochemical principles to dosage form design and evaluation. Students are expected to develop their knowledge in properties of pharmaceutical solids, solid mixing and drying; formulation of powders, capsules, tablets, solutions and basic dermatological products; principles and practice of solubility, pH and buffer, preservation of solution, particle size analysis, phase rule and phase diagram in formulation of dosage forms. Preformulation and compatibility issues in the formulation will also be addressed in this unit. The applications of fundamental knowledge will be demonstrated in tutorial and practical sessions.

Unit Learning Outcomes All graduates of Curtin University achieve a set of nine graduate attributes during their course of study. These tell an employer that, through your studies, you have acquired discipline knowledge and a range of other skills and attributes which employers say would be useful in a professional setting. Each unit in your course addresses the graduate attributes through a clearly identified set of learning outcomes. They form a vital part in the process referred to as assurance of learning. The learning outcomes tell you what you are expected to know, understand or be able to do in order to be successful in this unit. Each assessment for this unit is carefully designed to test your achievement of one or more of the unit learning outcomes. On successfully completing all of the assessments you will have achieved all of these learning outcomes.

Your course has been designed so that on graduating we can say you will have achieved all of Curtin's Graduate Attributes through the assurance of learning process in each unit.

Name: Yan ChenPhone: +618 9266 2738Email: [email protected]: Building: 305 - Room: 113Consultation times: Email for appointment

Teaching Staff: Name: Heather BensonPhone: 08 9266 2338Email: [email protected]: Building: 305 - Room: 118

Name: Jenny DolzadelliPhone: 08 9266 1966Email: [email protected]: Building: 306 - Room: 236

Name: Hani Al-SalamiPhone: 08 9266 9816Email: [email protected]: Building: 305 - Room: 158

Administrative contact: Name: Joyce ThomasPhone: 08 9266 2518Email: [email protected]: Building: 306 - Room: 118

Learning Management System: Blackboard (lms.curtin.edu.au)

Faculty of Health Sciences School of Pharmacy




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Curtin's Graduate Attributes

Learning Activities Learning activities include lectures, tutorials and practical sessions.

Lecture, tutorial and practical materials, including ilectures will be accessible from FLECS-Blackboard. Students are expected to attend lectures, tutorials and practical sessions to fully participate in the learning activities this unit offers.

The purpose of tutorials is to reinforce the knowledge taught in the lectures. Tutorials on each lecture topic will be held in small classes and in some cases students are expected to complete given tutorial exercises independently prior to the class.

Practical sessions are designed to apply selected physical pharmacy theory and to provide opportunities to establish students’ competency in extemporaneous compounding. Students will have hands-on experience with compounding of pharmaceutical products as well as manufacturing of selected dosage forms and testing their properties

Learning Resources Library Reading List

The Reading List for this unit can be accessed through Blackboard.

Essential texts

The required textbook(s) for this unit are:

l Florence AT, Attwood D. Physicochemical Principles of Pharmacy. 6th ed: Pharmaceutical Press; 2016.

5th Edition is available online at http://lib.myilibrary.com.dbgw.lis.curtin.edu.au/Open.aspx?id=324969

(ISBN/ISSN: 978-0853699842)

l Aulton ME. Aulton’s Pharmaceutics: The Design and Manufacture of Medicines 4th ed: Edinburgh: Churchill Livingstone; 2013. NB: 2nd edition available online at this link

(http://web.ebscohost.com.dbgw.lis.curtin.edu.au/ehost/detail?sid=1ab57d37-f805-4b3f-8497-58032b103cdf%40sessionmgr10&vid=1&hid=22&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=nlebk&AN=114778)

(ISBN/ISSN: 9780702042904 / 0702042900)

l The Poisons Standard (the Standard for the Uniform Scheduling of Medicines and Poisons, SUSMP). Australian Government latest version

http://www.comlaw.gov.au/Details/F2014L01343

(ISBN/ISSN: F2014L01343)

l Australian Pharmaceutical Formulary and Handbook. 23rd ed: Pharmaceutical Society of Australia; 2015.

(ISBN/ISSN: 9780646570198)

On successful completion of this unit students can: Graduate Attributes addressed

1 Explain and apply the physicochemical principles and concepts underpinning the formulation of solid and liquid dosage form

2 Explain the formulation, manufacture and use of pharmaceutical solid and liquid dosage forms and evaluate formulations for quality

3 Perform accurate calculations and demonstrate safe use of laboratory equipment to produce high standard pharmaceutical preparations in accordance with professional standards

Apply discipline knowledge Thinking skills (use analytical skills to solve problems)

Information skills (confidence to investigate new ideas)

Communication skills Technology skillsLearning how to learn (apply principles learnt to new situations) (confidence to tackle unfamiliar problems)

International perspective (value the perspectives of others)

Cultural understanding (value the perspectives of others)

Professional Skills (work independently and as a team) (plan own work)

Find out more about Curtin's Graduate attributes at the Office of Teaching & Learning website: ctl.curtin.edu.au





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l Sinko P. Martin's physical pharmacy and pharmaceutical sciences physical chemical and biopharmaceutical principles in

the pharmaceutical sciences. 6th ed: Wolters Kluwer/Lippincott Williams & Wilkins; 2011.

(ISBN/ISSN: 978-1-60913-402-0)

Online resources

l Banker G, Rhodes C. Modern Pharmaceutics 4th ed: Informa Healthcare; 2002.

((http://www.curtin.eblib.com.au.dbgw.lis.curtin.edu.au/patron/FullRecord.aspx?p=216088&tstamp=1361608632&userid=x/CCia1nhCQpR/R09avGjg==&id=1BFF4502426AED0992EE0657D2728D6B8A91391C)

(ISBN/ISSN: 9781420065657)

l Florence AT, Attwood D. Physicochemical Principles of Pharmacy. 6th ed: Pharmaceutical Press; 2016.

5th Edition is available online at http://lib.myilibrary.com.dbgw.lis.curtin.edu.au/Open.aspx?id=324969

((http://lib.myilibrary.com.dbgw.lis.curtin.edu.au/Open.aspx?id=324969))

(ISBN/ISSN: 978-0853699842)

l British Pharmacopoeia . London : Stationery Office; 2015

http://www.pharmacopoeia.co.uk.dbgw.lis.curtin.edu.au/login.htm

(http://www.pharmacopoeia.co.uk.dbgw.lis.curtin.edu.au/login.htm)

(ISBN/ISSN: 9780113229871)

l Allen LV (Ed). Remington: the Science and Practice of Pharmacy. 22nd ed. London: Pharmaceutical Press; 2013

(http://www.medicinescomplete.com.dbgw.lis.curtin.edu.au/mc/rem/current/)

((http://www.medicinescomplete.com.dbgw.lis.curtin.edu.au/mc/rem/current/))

(ISBN/ISSN: 978 0 85711 062 6)

l Sweetman SC (Ed). Martindale. The Complete Drug Reference, 37th ed: London:The Pharmaceutical Press; 2010.

(http://bit.ly/1cXBMLj)

(http://bit.ly/1cXBMLj)

(ISBN/ISSN: 9780853694991)

l Aulton ME. Aulton’s Pharmaceutics: The Design and Manufacture of Medicines 4th ed: Edinburgh: Churchill Livingstone; 2013. NB: 2nd edition available online at this link

(http://web.ebscohost.com.dbgw.lis.curtin.edu.au/ehost/detail?sid=1ab57d37-f805-4b3f-8497-58032b103cdf%40sessionmgr10&vid=1&hid=22&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=nlebk&AN=114778)

((http://web.ebscohost.com.dbgw.lis.curtin.edu.au/ehost/detail?sid=1ab57d37-f805-4b3f-8497-58032b103cdf%40sessionmgr10&vid=1&hid=22&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#db=nlebk&AN=114778))

(ISBN/ISSN: 9780702042904 / 0702042900)

l The Poisons Standard (the Standard for the Uniform Scheduling of Medicines and Poisons, SUSMP). Australian Government latest version


( http://www.comlaw.gov.au/Details/F2014L01343 )

(ISBN/ISSN: F2014L01343)

Other resources

Recommended texts

You do not have to purchase the following textbooks but you may like to refer to them.

Allen LV Jr, Popovich NG, Ansel HC. Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems. 9th ed: Philadelphia: Lippincott Williams & Wilkins; 2011.

Lund W (Ed). The Pharmaceutical Codex. 12th ed: London:The Pharmaceutical Press; 1994.

Allen LV (Ed). Remington: the Science and Practice of Pharmacy. 22nd ed. London: Pharmaceutical Press; 2013.

Sweetman SC (Ed). Martindale. The Complete Drug Reference, 37th ed: London:The Pharmaceutical Press; 2010.

Banker G, Rhodes C. Modern Pharmaceutics 4th ed: Informa Healthcare; 2002.





http://www.pharmacopoeia.co.uk.dbgw.lis.curtin.edu.au/login.htm

http://bit.ly/1cXBMLj


Assessment Assessment schedule

Detailed information on assessment tasks

1. The theory test covers 10 lectures delivered in week 1- 4. It consists of multiple choice questions (MCQ), short and long answer questions.

2. The practical portfolio consists of 1) the result of compounding assessment (3%); 2) seven (7) compounding sessions (18%): the best 13 preparations are used to calculate the marks. Materials for assessment must be submitted at each compounding session. Marks will be awarded for Compounding Record Form ( CRF) preparation, records of demonstration of correct technique skills and competent preparation of quality pharmaceutical products.; 3) the result of laboratory test covering tabletting practical and compounding calculation (4%)

3. The final examination is a combination of MCQ, short and long answer questions.

Pass requirements

To obtain a pass in this unit, students MUST achieve a mark of at least 50% in the final examination, in addition to achieving a pass mark (50%) overall for the unit.

Students much also satisfactorily attend and complete a minimum of 70% of the practical class work. The submission of a medical certificate does not alter the satisfactory completion requirement.

Fair assessment through moderation

Moderation describes a quality assurance process to ensure that assessments are appropriate to the learning outcomes, and that student work is evaluated consistently by assessors. Minimum standards for the moderation of assessment are described in the Assessment and Student Progression Manual, available from policies.curtin.edu.au/policies/teachingandlearning.cfm

Late assessment policy

This ensures that the requirements for submission of assignments and other work to be assessed are fair, transparent, equitable, and that penalties are consistently applied.

1. All assessments students are required to submit will have a due date and time specified on this Unit Outline. 2. Late submission of assessments is not accepted in this unit. Students will receive a zero mark for any assessment item submitted

late.

Assessment extension

A student unable to complete an assessment task by/on the original published date/time (e.g. examinations, tests) or due date/time (e.g. assignments) must apply for an assessment extension using the Assessment Extension form (available from the Forms page at students.curtin.edu.au/administration/) as prescribed by the Academic Registrar. It is the responsibility of the student to demonstrate and provide evidence for exceptional circumstances beyond the student's control that prevent them from completing/submitting the assessment task.

The student will be expected to lodge the form and supporting documentation with the unit coordinator before the assessment date/time or due date/time. An application may be accepted up to five working days after the date or due date of the assessment task where the student is able to provide an acceptable explanation as to why he or she was not able to submit the application prior to the assessment date. An application for an assessment extension will not be accepted after the date of the Board of Examiners' meeting.

Task Value % Date DueUnit Learning Outcome(s)

Assessed

1Theory test 25 percent Week: 9

Day: Friday Time: 8-10am

1,2

2Practical portfolio 25 percent Week: As per timetable

Day: As per timetable Time: As per timetable

3

3 Final examination 50 percent TBA 1,2





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Deferred assessments

Supplementary assessments

Supplementary assessments, if granted by the Board of Examiners, will have a due date or be held between 10/07/2017 and 14/07/2017 . Notification to students will be made after the Board of Examiners’ meeting via the Official Communications Channel (OCC) in OASIS.

It is the responsibility of students to be available to complete the requirements of a supplementary assessment. If your results show that you have been granted a supplementary assessment you should immediately check OASIS for details.

Reasonable adjustments for students with disabilities/health circumstances likely to impact on studies

A Curtin Access Plan (CAP) is a document that outlines the type and level of support required by a student with a disability or health condition to have equitable access to their studies at Curtin. This support can include alternative exam or test arrangements, study materials in accessible formats, access to Curtin’s facilities and services or other support as discussed with an advisor from Disability Services (disability.curtin.edu.au). Documentation is required from your treating Health Professional to confirm your health circumstances.

If you think you may be eligible for a CAP, please contact Disability Services. If you already have a CAP please provide it to the Unit Coordinator at the beginning of each study period.

Referencing style

The referencing style for this unit is Vancouver.

More information can be found on this style from the Library web site: http://libguides.library.curtin.edu.au/referencing.

Copyright © Curtin University. The course material for this unit is provided to you for your own research and study only. It is subject to copyright. It is a copyright infringement to make this material available on third party websites.

Academic Integrity (including plagiarism and cheating) Any conduct by a student that is dishonest or unfair in connection with any academic work is considered to be academic misconduct. Plagiarism and cheating are serious offences that will be investigated and may result in penalties such as reduced or zero grades, annulled units or even termination from the course. Assessments under investigation will not be given a mark until the matter is concluded. This may result in the unit grade being withheld or a grade of Fail Incomplete (F-IN) until a decision has been made by the Student Disciplinary Panel. This may impact on enrolment in further units/study periods.

Plagiarism occurs when work or property of another person is presented as one's own, without appropriate acknowledgement or referencing. Submitting work which has been produced by someone else (e.g. allowing or contracting another person to do the work for which you claim authorship) is also plagiarism. Submitted work is subjected to a plagiarism detection process, which may include the use of text matching systems or interviews with students to determine authorship.

Cheating includes (but is not limited to) asking or paying someone to complete an assessment task for you or any use of unauthorised materials or assistance during an examination or test.

From Semester 1, 2016, all incoming coursework students are required to complete Curtin’s Academic Integrity Program (AIP). If a student does not pass the program by the end of their first study period of enrolment at Curtin, their marks will be withheld until they pass. More information about the AIP can be found at: https://academicintegrity.curtin.edu.au/students/AIP.cfm

Refer to the Academic Integrity tab in Blackboard or academicintegrity.curtin.edu.au for more information, including student guidelines for avoiding plagiarism.

If your results show that you have been granted a deferred assessment you should immediately check OASIS for details.

Deferred examinations/tests will be held from 10/07/2017 to 14/07/2017 . Notification to students will be made after the Board of Examiners’ meeting via the Official Communications Channel (OCC) in OASIS.





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Information and Communications Technology (ICT) Expectations Curtin students are expected to have reliable internet access in order to connect to OASIS email and learning systems such as Blackboard and Library Services.

You may also require a computer or mobile device for preparing and submitting your work.

For general ICT assistance, in the first instance please contact OASIS Student Support: oasisapps.curtin.edu.au/help/general/support.cfm

For specific assistance with any of the items listed below, please contact The Learning Centre: life.curtin.edu.au/learning-support/learning_centre.htm

l Using Blackboard, the I Drive and Back-Up files l Introduction to PowerPoint, Word and Excel

Additional information Mathematics Support

Extra help with pharmaceutical calculations encountered in this unit is available via a self-paced Blackboard unit, "Pharmaceutical Mathematics".

This unit explains many common pharmaceutical calculations and the fundamental mathematical concepts behind them. The unit includes instructional audio-visual presentations and interactive quizzes.

Please contact Mrs Jenny Dolzadelli for registration.

Apparatus to be used and retained by students

l Safety Glasses l Disposable Gloves l White laboratory coat l 2 x tea towels l 1 x bench cloth (e.g. Chux) l 1 x sponge (e.g. Wettex) l Detergent l Scissors l Bottle brush

To ensure laboratory safety, any students who are not properly attired with fully enclosed shoes, long pants or skirts, safety glasses and lab coat will not be permitted to work in the laboratory.

Enrolment

It is your responsibility to ensure that your enrolment is correct - you can check your enrolment through the eStudent option on OASIS, where you can also print an Enrolment Advice.

Student Rights and Responsibilities It is the responsibility of every student to be aware of all relevant legislation, policies and procedures relating to their rights and responsibilities as a student. These include:

l the Student Charter l Values and Signature Behaviours l the University's policy and statements on plagiarism and academic integrity l copyright principles and responsibilities l the University's policies on appropriate use of software and computer facilities

Information on all these things is available through the University's "Student Rights and Responsibilities" website at: students.curtin.edu.au/rights.





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Student Equity There are a number of factors that might disadvantage some students from participating in their studies or assessments to the best of their ability, under standard conditions. These factors may include a disability or medical condition (e.g. mental illness, chronic illness, physical or sensory disability, learning disability), significant family responsibilities, pregnancy, religious practices, living in a remote location or another reason. If you believe you may be unfairly disadvantaged on these or other grounds please contact Student Equity at [email protected] or go to http://eesj.curtin.edu.au/student_equity/index.cfm for more information

You can also contact Counselling and Disability services: http://www.disability.curtin.edu.au or the Multi-faith services: http://life.curtin.edu.au/health-and-wellbeing/about_multifaith_services.htm for further information.

It is important to note that the staff of the university may not be able to meet your needs if they are not informed of your individual circumstances so please get in touch with the appropriate service if you require assistance. For general wellbeing concerns or advice please contact Curtin's Student Wellbeing Advisory Service at: http://life.curtin.edu.au/health-and-wellbeing/student_wellbeing_service.htm

Recent unit changes Students are encouraged to provide unit feedback through eVALUate, Curtin's online student feedback system. For more information about eVALUate, please refer to evaluate.curtin.edu.au/info/.

Recent changes to this unit include:

- This is a new program.

- Many lecture topics and tutorial, practical sessions are different to previous years.

- The assessment of practical session is different compared to previous years.

- An introduction workshop on pharmaceutical dosage forms is added.

- A risk assessment exercise is included in the first practical session.

- Analysis of drug potency will be conducted for selected pharmaceutical preparations in practical sessions.

- All compounding techniques are assessed during practical sessions.

If you were a repeat student, you must attend all teaching activities.

To view previous student feedback about this unit, search for the Unit Summary Report at https://evaluate.curtin.edu.au/student/unit_search.cfm. See https://evaluate.curtin.edu.au/info/dates.cfm to find out when you can eVALUate this unit.





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Program calendar

Foundations of Pharmaceutics Lecture Program calendar 2017

YC: Yan Chen (Unit Coordinator); HB: Heather Benson; JD: Jenny Dolzadelli; HAS: Hani Al-Salami

Week Week Begin Date

Friday

8-9am 408.1019

Friday

9-10am 408.1019

Ilectures

Orientation

1. 27th Feb Introduction to dosage form

Design workshop 300.204,Tuesday 1-3pm (YC, JD,HAS,HB,VC, 2hrs)

Introduction to dosage form design workshop 300.204 Tuesday 3-5pm

(YC,JD,HAS.HB, 2hrs)

1. 27th Feb

pH and buffer (HB)

Solutions 1

(HB)

Pharmaceutical solids 1 & 2

( YC 2 hrs)

2. 6th March Solubility and dissolution formulation (HAS)

Compounding ( JD)

Pharmaceutical solids 3 ( YC)

3. 13th March

Dermatological ( HB)

Solutions 2

(HB) Powder formulation

(JD)

4 20th March Mixing and size reduction (HAS) Preservation of solution (VC)

Capsule formulation (JD)

5. 27th March Friday 10-11 401.002

Tablet 1 (JD)

Friday 11-12 401.002

Tablet 2 (JD)

6. 3rd April Compatibility issues in the formulation (HAS)

Mid –test information/help session

Tablet 3& 4 (JD,

2hrs)

7. 10th April Tuition Free

8. 17th April Tuition Free

9. 24th April Mid-test Mid-test

10. 1st May

Drying 1 (YC) Drying 2 (YC)

11. 8th May Particle size analysis 1

(YC) Particle size analysis 2 (YC)

12. 15th May Phase rule 1 ( YC) Phase rule 2 (YC)

13. 22nd May Preformulation (YC) Theory Test Review (YC)

14. 29th May Lab written test ( tablet and compounding calculation)

Exam help session





Foundations of Pharmaceutics Tutorial Program calendar 2017: Monday

Foundations of Pharmaceutics Laboratory calendar 2017


Topic

Staff ( Monday)

10-12am (306.124); 12-2pm (306.124),

3-4pm (402.310); 4-5pm (402.323)

1. 27th Feb Compounding intro tutorial 1 Mrs Dolzadelli (10-12)Dr Chen(12-2)Dr Al-

Salami (3-5)

2. 6th March Solids Dr Al-Salami (10-12) Mrs Dolzadelli (12-2) , Dr Chen (3-5)

3. 13th March Solution, pH and buffer Dr Al-Salami (10-12) Mrs Dolzadelli (12-2) , Dr Chen (3-5)

4. 20th March No tutorial

5. 27th March Dermatologicals Mrs Dolzadelli (10-12; 3-5) Dr Chen (12-2)

6. 3rd April Powders and capsules Dr Al-Salami (10-12), Dr Chen (12-2), Mrs Dolzadelli (3-5)

7. 10th April No Tutorial ( Tuition free week )

8. 17th April No tutorial ( Tuition free week)

9. 24th April No tutorial on Monday,

Compounding help session on Friday 11-1pm

Friday 12-2pm 300.204

Mrs Dolzadelli, Dr Chen, Jane, Margaret, Tiffany, Sher, Kirstein, Sonia (TBA)

10. 1st May Compounding tutorial 2

Mrs Dolzadelli (10-12, 3-4) Dr Chen (12-2, 4-5)

11. 8th May Mixing and drying Dr Al-Salami (10-12)Mrs Dolzadelli (12-2), Dr Chen (3-5)

12. 15th May Tablets Dr Al-Salami (10-12)Mrs Dolzadelli (12-2), Dr Chen (3-5)

13. 22nd May Particle sizing Dr Al-Salami (10-11), Dr Chen (11-12-2),

Mrs Dolzadelli (3-5)

14. 29th May Phase rule Dr Al-Salami (10-12), Dr Chen (12-2), Mrs Dolzadelli (3-5)

15. Study Week

Compounding sessions in 300.204/306.129





Physical Pharmacy Sessions


Wed 9am-12 noon

Wed. 2-5 pm Wed 9am-12noon Wed. 2-5 pm

I,II,III,IV

V,VI,VII,VIII

I

II

III

IV

V

VI

VII

VIII

1. 27th Feb

Compounding intro

JD/MS

Compounding intro

JOC/MS

2. 6th March

Mixture 1

JD/MS

Mixture 1

JOC /MS

3. 13th March

Mixture 2

JD/MS

Mixture 2

JOC/MS

4. 20th March

Mixture 3

JD/MS

Mixture 3

JOC/MS

5. 27th March

Mixture 4

JD/MS

Mixture 4

JOC/MS

6. 3rd April

Powder & capsules

JOC/MS

Powder & capsules

JOC/MS

7. 10th April

Tuition free week

8. 17th April

Tuition free week

9 24th April

Mixture 5

JD/MS

Mixture 5

JOC/MS

10. 1st May

Compounding Assessment

JD

Compounding Assessment

JD

I

II

III

IV

V

VI

VII

VIII

11. 8th May

Tableting& testing

308.166

JD/JM/SJ

Tableting& testing

308.166

JD/JM/SJ

12. 15th May

Tableting& testing

308.166

JD/JM/SJ

Tableting & testing

308.166

JD/JM/SJ

13 22nd May

Tableting & testing

308.166

JD/JM/SJ

Tableting & testing

308.166

JD/JM/SJ

14. 29th May

Tableting & testing 308.166 JD/JM/SJ

Tableting & testing 308.166 JD/JM/SJ

15 Study week





Foundations of Pharmaceutics Laboratory Program 2017

Week Week beginning

Exercises Additional activities Techniques assessed/ theory learnt

1 27th Feb Compounding introduction

1. Introduction to compounding

2. Lignocaine solutions (accuracy exercises)

3. Menthol and Pine Inhalation APF

Risk assessment exercise for Menthol and Pine Inhalation APF

Lignocaine assay by HPLC

Location of all equipment used in lab

Weighing & measuring accuracy

Pipetting

Filtering

Performing a risk assessment

2 6th Mar Mixture 1

1. Salicylic Acid Ear Drops APF

2. The Liniment

Filtering

Weighing

Dissolution

3 13th Mar Mixture 2

1. Salicylic acid and Coal tar Lotion APF

3. Camphor Spirit Compound APF

Solid-in-liquid aliquots

Liquid-in-liquid aliquots


1. Cetrimide and Chlorhexidine Paint APF (with dilution calculation)

2. Paracetamol Elixir CF APF 15

3. Potassium Citrate Mixture APF

PP2 – perform dose check and prepare labels for all 3 products in week 5

Atomic absorption analysis for potassium ions

Solutions – dilution calculations

Solutions, including cosolvency


1. Acne treatment solution

2. Naproxen Mixture

3. Ferrous Sulphate Mixture APF

PP2 – revise on dose calculation and labelling on Analgesic powders and aspirin capsules; labelling for nappy rash powder

Atomic absorption analysis for ferrous ions

Calculation using Chlorhexidine Gluconate Solution BP 20% as source of chlorhexidine gluconate

Alcohol dilution

pH incompatibility issues

Solid-in-liquid aliquot

Dissolving oxidation sensitive ingredient in antioxidant solution

6 3rd Apr Powders and capsules

1. The Nappy rash powder

2. Analgesic powders

3. Aspirin capsules

Aspirin assay Solid-in-solid aliquot

Trituration of powders in mortar

Preparation of capsules using capsule machine

Aspirin assay

7 10th Apr Tuition free week





8 17th Apr Tuition free week

9 24th Apr Mixture 5

1. Trimethoprim Mixture CF APF

2. Adrenaline Solution BP

3. Phenylephrine Instillation APF

Double aliquots

Using commercial tablets as source of active ingredient

Dissolving oxidation sensitive ingredient in antioxidant solution

Dissolving poorly soluble volatile substances (chlorbutol and chlorocresol)

Performing an aliquot for chlorocresol

10 1st May Compounding assessment consisting of 2 in-class exercises

11 8th May Tabletting


13 22nd May Tabletting






phar2000 foundations of pharmaceutics semester 1,...

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