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patofisilogi cdle

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C H R O N I C D I S C O I D L U P U S E R I T H E M A T O Faktor Host Gen Hormon Seks Hormon Androgen Shift profil sitokin Cell mediated imun respon: Th1 HLA-A2 HLA-DR3,HLA-DR2, HLA-B8,HLA-B7,HLA-DQA0102 Rasio CD4/CD8 Jumlah self-reaktif limfosit Jumlah B-Cell yg meninggalkan sumsum tulang Kadar Estrogen & progesterone yang tinggi Kadar prolaktin yg tinggi Mempercepat autoimun disease Kadar anti-DNA titer Faktor Lingkungan Paparan Radiasi UVB berulang Rokok Drug Virus toantigen, La/SS-B, calretikulin) didalam epidermal keratinosit ke permukaan sel Release berlebihan mediator imun Induced realese CCL27 Aktivasi T-Cell, IFN-α, serta produksi DCs Lipogenic aromatic amine T Cell DNA hipometilantion Keratinosit Apoptosis Infeksi α-virus (Sindbis, rubella, cytomegalovirus) Induced ekspresi cell surface (Ro/SS-A) Virus-induced apoptosis Keratinosit Apoptosis

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BAGAN PATOFISIOLOGI CDLE

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Page 1: Patofisilogi CDLE

CHRONIC

DISCOID

LUPUS

ERITHEMATOSUS

Faktor Host

Gen Hormon Seks

Hormon Androgen

Shift profil sitokin

Cell mediated imun respon: Th1

HLA-A2HLA-DR3,HLA-DR2, HLA-B8,HLA-B7,HLA-DQA0102

Rasio CD4/CD8Jumlah self-reaktif limfosit Jumlah B-Cell yg meninggalkan sumsum tulang

Kadar Estrogen & progesterone yang tinggi Kadar prolaktin yg tinggi

Mempercepat autoimun disease

Kadar anti-DNA titer

Faktor Lingkungan

Paparan Radiasi UVB berulang Rokok Drug Virus

Memindahkan autoantigen (Ro/SS-A, related autoantigen, La/SS-B, calretikulin) didalam epidermal keratinosit ke permukaan sel Release berlebihan mediator imun

Induced realese CCL27

Aktivasi T-Cell, IFN-α, serta produksi DCs

Lipogenic aromatic amineT Cell DNA hipometilantion

Keratinosit Apoptosis

Infeksi α-virus (Sindbis, rubella, cytomegalovirus)

Induced ekspresi cell surface (Ro/SS-A)

Virus-induced apoptosis

Keratinosit Apoptosis

Gambar 2 Bagan Patofisiologi CDLE


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