Organ-System-Based Integration of Biochemistry: Cells Do It; Can We Do It as Well?

Eric NiederhofferSouthern Illinois University

School of Medicine

http://www.ebi.ac.uk/microarray/biology_intro.html

nutrition

informational macromolecules

hemostasis/thrombosis

cytoskeleton/extracellular matrix

extracellular/intracellular communications

bioenergetics/metabolism

proteins/enzymes

Organ-System-Based Integration of Biochemistry

Basic SciencesClinical Sciences

Y1 (Carbondale) Y2 Y3clerkships

Y4electives

CRRSSBERG

HIICNBERG

AnatomyBSSBiochemistryDoctoringGeneticsHistologyPharmacologyPhysiologyPHP

DoctoringGeneticsImmunologyMicrobiologyNeoplasiaPathologyPharmacologyRadiology

CRR Unit Organization

SAQs(mc, T/F, short answers)

MU & EOU Exams(clinical scenarios)

Familial hyperlipidemianutrition/metabolism

Genetics MC

SOB MC

Lifestyle MC

CVD MC

F&E MC

Shock MC

Collagen/anemia

Nutrition

Surfactant

G proteins/signal transduction

Clinical markersG proteins/signal transduction

Electrolyte imbalance

Cholesterol/lipoproteins/plaques/lipid processing

SCD

ASD

PE

COPD

Arrhythmia

MI

PSGN

CHF

Hb gene/product/defect

Glycolysis/2,3-BPG, PPP/GSHRBC structure

HbO2/CO2

ECM/proteases/antiproteases/1AT

Chem panels

G proteins/signal transduction

Coagulation/clinical markers

Cardiac markers

Amino acid processing/urea cycle

Ion channels/membrane transport

ATP production

Overview of gene expression

Ion channels/action potentials

Thrombolytic agentsMuscle contraction/energy production

Filtration barrier

Clinical markers

Clinical markers/BNP

ePBLM Organization

Sickle Cell Disease

Red blood cells: structure and function, glycolysis (2,3-BPG), pentose phosphate pathway, glutathione

Introduction to genetics (basic principles)

Introduction to molecular biology of gene expression: transcription, translation, protein processing

Hemoglobin structure: HbA (22), HbF (22), HbA2 (22), HbS; overview of hemoglobin function

Complete blood count: RBC parameter (Hct, Hb content, MCV, MCHC) and WBCs

Structure and function of the spleen

Pathogenesis and natural history of sickle cell disease

Introduction to child development: Denver development chart, normal milestones

Introduction to immunology: cause of inflammation and pain (cytokines and phagocytes)

The Best and Worst at Times

Best Features

Integration with other disciplines/clinical medicine

overlap/redundancy of topics

clinical relevance

low priority

Worst Features

Perceived orphan topics

Competition with other disciplines

Non-biochemistry resources