note to presenters:
DESCRIPTION
Note to presenters: Images of vaccine-preventable diseases are available from the Immunization Action Coalition website at http://www.vaccineinformation.org/photos/index.asp. Haemophilus influenzae type b Clinical Features*. *prevaccination era. Incidence* of Invasive Hib Disease, 1980-2009. - PowerPoint PPT PresentationTRANSCRIPT
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Note to presenters:
Images of vaccine-preventable diseases are available from the Immunization Action Coalition website at http://www.vaccineinformation.org/photos/index.asp
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Cellulitis6%
Arthritis8% Bacteremia
2%
Meningitis50%
Epiglottitis17%
Pneumonia15%
Osteomyelitis2%
Haemophilus influenzae type bClinical Features*
*prevaccination era
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Incidence* of Invasive Hib Disease, 1980-2009
0
5
10
15
20
25
30
1980 1984 1988 1992 1996 2000 2004 2008
Rat
e/10
0,00
0 ch
ildre
n <
5 yr
s
*Rate per 100,000 children <5 years of age
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Haemophilus influenzae type b Epidemiology
• Reservoir Human Asymptomatic carriers
• Transmission Respiratory droplets
• Temporal pattern Peaks in Sept-Dec and March-May
• Communicability Generally limited buthigher in somecircumstances
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Haemophilus influenzae type b—United States, 2002-2006
• Incidence has fallen more than 99% since prevaccine era
• 123 confirmed Hib cases reported (average of 25 cases per year)
• Most recent cases in unvaccinated or incompletely vaccinated children
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Haemophilus influenzae type b Conjugate Vaccines
• Two conjugate vaccines licensed for use in infants as young as 6 weeks of age
• Use different carrier proteins
• 3 doses of any combination confers protection
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PRP-T ActHIB, TriHIBit
PRP-T Hiberix
PRP-OMP PedvaxHIB, Comvax
Conjugate Hib Vaccines*
*HbOC (HibTiter) no longer available in the United States
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Haemophilus influenzae type b Vaccine Interchangeability
• Both conjugate Hib vaccines (except TriHIBit) are interchangeable for primary series and booster dose
• 3 dose primary series if more than one brand of vaccine used
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Hiberix (PRP-T)
• Approved for children 12 months of age and older
• Approved only for the last dose of the Hib series
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Haemophilus influenzae type b VaccineVaccination Following Invasive Disease
• Children younger than 24 months may not develop protective antibody after invasive disease
• Vaccinate during convalescence
• Complete series for age
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Haemophilus influenzae type b VaccineUse in Older Children and Adults
• Generally not recommended for persons older than 59 months of age• Consider for high-risk persons:
asplenia, immunodeficiency, HIV infection–One pediatric dose of any conjugate
vaccine• 3 doses recommended for all persons
who have received a hematopoietic stem cell transplant
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• Swelling, redness, or pain in 5%-30% of recipients
• Systemic reactions infrequent
• Serious adverse reactions rare
Haemophilus influenzae type b Vaccine Adverse Reactions
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Haemophilus influenzae type b Vaccine
Contraindications and Precautions
• Severe allergic reaction to vaccine component or following a prior dose
• Moderate or severe acute illness
• Age less than 6 weeks