neurorad-3 spine 061306
TRANSCRIPT
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Introduction to Introduction to Neuroimaging Neuroimaging
Aaron S. Field, MD, PhDAaron S. Field, MD, PhDNeuroradiologyNeuroradiology
University of Wisconsin–MadisonUniversity of Wisconsin–Madison
SPINESPINE
Updated 6/13/06
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Anatomy
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Radiographic Anatomy
ML Richardson, Univ. Of Washington
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ML Richardson, Univ. Of Washington
Cervical Spine – AP View
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ML Richardson, Univ. Of Washington
Cervical Spine – Lateral View
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ML Richardson, Univ. Of Washington
Cervical Spine – Oblique View
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ML Richardson, Univ. Of Washington
Cervical Spine – Open-Mouth (Dens) View
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ML Richardson, Univ. Of Washington
Lumbar Spine – AP View
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ML Richardson, Univ. Of Washington
Lumbar Spine – Lateral View
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MRI Anatomy
Source: CW Kerber and JR Hesselink, Spine Anatomy, UCSD Neuroradiology
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Source: CW Kerber and JR Hesselink, Spine Anatomy, UCSD Neuroradiology
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Spine Pathology
• Trauma • Degenerative disease • Tumors and other masses• Inflammation and infection • Vascular disorders• Congenital anomalies
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Trauma
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Evaluating Trauma
• Fracture – plain film / CT
• Dislocation – plain film / CT
• Ligamentous injury – MRI
• Cord injury – MRI
• Nerve root avulsion – MRI
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Plain film findings may be very subtle or absent!
Anterolisthesis of C6 on C7
(Why??)
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CT
Fractures of C6 left pedicle and lamina
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CT – 2D ReconstructionsCT – 2D Reconstructions
Acquire images axially…
…reconstruct sagittal / coronal
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26M MVA
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Vertebral body burst fx with retropulsion into
spinal canal
2D Reformats
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Vertebral Artery Dissection/Occlusion Secondary to C6 Fracture
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Hyperflexion fx with ligamentous disruption and
cord contusion
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Nerve root avulsion
Axial Coronal Sagittal
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Degenerative Disease
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Degenerative Disc (and Facet Joint) Disease
Foraminal stenosis
Thickening/Buckling of Ligamentum
Flavum
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Degenerative Disc (and Facet Joint) Disease
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Degenerative Disc (and Facet Joint) Disease
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Lumbar Spinal Stenosis
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Lumbar Spinal Stenosis
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Lumbar Spinal Stenosis
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Lumbar Spinal Stenosis
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Lumbar Spinal Stenosis
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Lumbar Spinal Stenosis
Disc bulge, facet hypertrophy and flaval ligament thickening frequently combine to cause central spinal stenosis
Note the trefoil shape of stenotic spinal canal
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Lumbar Spinal Stenosis
Disc bulge, facet hypertrophy and flaval ligament thickening frequently combine to cause central spinal stenosis
Note the trefoil shape of stenotic spinal canal
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Foraminal Stenosis
Neural foramen
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Cervical Spinal Stenosis
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MRI - Degenerative Disc Disease
• 20-40 36% have degenerated disc
• 50 85-95% have degenerated disc
• 60-80 98% have degenerated disc
• <60 20% have asymptomatic disc herniation
Age:
Conclusion: Abnormal findings on MRI frequently DO NOT relate to symptoms (and vice versa) !!
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MRI – Herniated Disc Levels
• 85-95% at L4-L5, L5-S1
• 5-8% at L3-L4
• 2% at L2-L3
• 1% at L1-L2, T12-L1
• Cervical: most common C4-C7
• Thoracic: 15% in asymptomatic pts. at multiple levels, not often symptomatic
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Annular
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Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.
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Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.
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Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.
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Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.
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Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.
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Protrusion Extrusion Extrusion
Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.
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Protrusion Protrusion w/migration
Protrusion w/migration +
sequestration
Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.
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Abnormal Disc
Bulge
Symmetric Asymmetric
Herniation
Broad-based Focal
Extrusion Protrusion
Sequestered Migrated Neither
> 180º< 180º
< 90º90º–180º
No waistWaist*
Adapted from: “Nomenclature and Classification of Lumbar Disc Pathology: Recommendations of the Combined Task Forces of the North American Spine Society, American Society of Spine Radiology, and American Society of Neuroradiology,” 2001.
*(In any plane)
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Central Disc Protrusion
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L5-S1 Disc Extrusion Into Lateral Recess with Impingement of R S1 Nerve Root
L-S1DiscR-S1
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Schmorl’s Nodes
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Cervical Radiculopathy
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Lumbosacral Radiculopathy (Sciatica)
Important: A herniated disc at (e.g.) L4-5 may impinge either the L4 or L5 nerve roots!
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L5-S1 Disc Extrusion Into Lateral Recess with Impingement of R S1 Nerve Root
L-S1DiscR-S1
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Spondylolysis / Spondylolisthesis
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Confusing “Spondy-” Terminology
• Spondylosis = “spondylosis deformans” = degenerative spine
• Spondylitis = inflamed spine (e.g. ankylosing, pyogenic, etc.)
• Spondylolysis = chronic fracture of pars interarticularis with nonunion (“pars defect”)
• Spondylolisthesis = anterior slippage of vertebra typically resulting from bilateral pars defects
• Pseudospondylolisthesis = “degenerative spondylolisthesis” (spondylolisthesis resulting from degenerative disease rather than pars defects)
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Tumors and Other Masses
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• Extradural = outside the thecal sac (including vertebral bone lesions)
• Intradural / extramedullary = within thecal sac but outside cord
• Intramedullary = within cord
Classification of Spinal Lesions
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• Herniated disc
• Vertebral hemangioma
• Vertebral metastasis
• Epidural abscess or hematoma
• Synovial cyst• Nerve sheath tumor (also intradural/extramedullary)
Neurofibroma Schwannoma
Common Extradural Lesions
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• Nerve sheath tumor (also extradural)
Neurofibroma
Schwannoma
• Meningioma
• Drop Metastasis
Common Intradural Extramedullary Lesions
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• Astrocytoma
• Ependymoma
• Hemangioblastoma
• Cavernoma
• Syrinx
• Demyelinating lesion (MS)
• Myelitis
Common Intramedullary Lesions
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Classification of Spinal Lesions
Extradural IntramedullaryIntraduralExtramedullaryDuraCord
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Extradural: Vertebral Body Tumor
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Extradural: Vertebral Metastases
T2 (Fat Suppressed) T1 T1+C (fat suppressed)
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Extradural: Vertebral Metastases
T2 (Fat Suppressed) T1 T1+C (fat suppressed)
?
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Vertebral Metastases vs. Hemangiomas
Hemangiomas (Benign, usually asymptomatic, commonly incidental):
Bright on T1 and T2 (but dark with fat suppression) Enhancement variable
Metastases:
Dark on T1, Bright on T2 (even with fat suppression) Enhancement
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Vertebral Hemangiomas
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Diffusely T1-hypointense marrow signal may represent widespread vertebral metastases as in this patient with prostate Ca
This can also be seen in the setting of anemia, myeloproliferative disease, and various other chronic disease states
Extradural: Vertebral Metastases
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Extradural: Epidural Abscess
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Extradural: Nerve Sheath Tumor(Schwannoma)
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Intradural Extramedullary: Meningioma
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Intradural Extramedullary: Meningioma
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Intradural Extramedullary: Nerve Sheath Tumor(Neurofibroma)
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Intradural Extramedullary: “Drop Mets”
T2 T1 T1+C
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Intradural Extramedullary: “Drop Mets”
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Intradural Extramedullary: Arachnoid Cyst
T2 T1
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Intramedullary: Astrocytoma
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Intramedullary: Astrocytoma
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Intramedullary: Cavernoma
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Intramedullary: Ependymoma
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Seen with:• congenital lesions
• Chiari I & II• tethered cord
• acquired lesions• trauma• tumors• arachnoiditis
• idiopathic
Intramedullary: Syringohydromyelia
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Seen with:• congenital lesions
• Chiari I & II• tethered cord
• acquired lesions• trauma• tumors• arachnoiditis
• idiopathic
Intramedullary: Syringohydromyelia
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Confusing “Syrinx” Terminology
• Hydromyelia: Fluid accumulation/dilatation within central canal, therefore lined by ependyma
• Syringomyelia: Cavitary lesion within cord parenchyma, of any cause (there are many). Located adjacent to central canal, therefore not lined by ependyma
• Syringohydromyelia: Term used for either of the above, since the two may overlap and cannot be discriminated on imaging
• Hydrosyringomyelia: Same as syringohydromyelia
• Syrinx: Common term for the cavity in all of the above
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Infection and Inflammation
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Infectious Spondylitis / Diskitis
Common chain of events (bacterial spondylitis):
1. Hematogenous seeding of subchondral VB
2. Spread to disc and adjacent VB
3. Spread into epidural space epidural abscess
4. Spread into paraspinal tissues psoas abscess
5. May lead to cord abscess
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Infectious Spondylitis / Diskitis
T2 T1 T1+C T1+C
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Infectious Spondylitis / Diskitis
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Pyogenic Spondylitis / Diskitis with Epidural Abscess
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T1
T2
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T1 + C
Spinal TB (Pott’s Disease)
• Prominent bone destruction• More indolent onset than pyogenic• Gibbus deformity• Involvement of several VB’s
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Spinal TB (Pott’s Disease)
• Prominent bone destruction• More indolent onset than pyogenic• Gibbus deformity• Involvement of several VB’s
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Transverse Myelitis
Inflamed cord of uncertain cause
Viral infections
Immune reactions
Idiopathic
Myelopathy progressing over hours to weeks
DDX: MS, glioma, infarction
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Multiple Sclerosis
Inflammatory demyelination eventually leading to gliosis and axonal loss
T2-hyperintense lesion(s) in cord parenchyma
Typically no cord expansion (vs. tumor); chronic lesion may show atrophy
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Multiple Sclerosis
Inflammatory demyelination eventually leading to gliosis and axonal loss
T2-hyperintense lesion(s) in cord parenchyma
Typically no cord expansion (vs. tumor); chronic lesion may show atrophy
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Cord Edema
As in the brain, may be secondary to ischemia (e.g. embolus to spinal artery)
or
venous hypertension (e.g. AV fistula)
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Spine Imaging Guidelines1. Uncomplicated LBP usually self-limited, requires no imaging
2. Consider imaging if:
• Trauma
• Cancer
• Immunocompromise / suspected infection
• Elderly / osteoporosis
• Significant neurologic signs / symptoms
3. Back pain with signs / symptoms of spinal stenosis or radiculopathy, no trauma:
Start with MRI; use CT if:
• Question regarding bones or surgical (fusion) hardware
• Resolve questions / solve problems on MRI (typically use CT myelography)
• MRI contraindicated
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4. Begin with plain films for trauma; CT to solve problems or to detail known
fractures; MRI to evaluate soft-tissue injury (ligament disruption, cord contusion)
5. MRI for sx of radiculopathy, cauda equina syn, cord compression, myelopathy
6. Fusion hardware is safe for MRI but may degrade image quality; still worth a try
7. Indications for IV contrast in MRI:
• Tumor, infection, inflammation (myelitis), any cord lesion
• Post-op L-spine (discriminate residual/recurrent disk herniation from scar)
8. Emergent or scheduled? Emergent only if immediate surgical or radiation therapy
decision needed (e.g. cord compression, cauda equina syndrome)
9. Difficult to image entire spine in detail; target study to likely level of pathology
10. CT chest/abdomen/pelvis includes T-L spine (no need to rescan trauma pts*)
* If image data still on scanner (24-48 hours)
Spine Imaging Guidelines (cont.)
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Introduction to Introduction to Neuroimaging Neuroimaging
Aaron S. Field, MD, PhDAaron S. Field, MD, PhDNeuroradiologyNeuroradiology
University of Wisconsin–MadisonUniversity of Wisconsin–Madison
SPINESPINE