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Myocardial Ischaemia National Audit Project myocardial ischaemia national audit project [minap] How the NHS cares for patients with heart attack Tenth Public Report 2011 Prepared on behalf of the MINAP Steering Group NICOR: NATIONAL INSTITUTE FOR CARDIOVASCULAR OUTCOMES RESEARCH

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Page 1: myocardial ischaemia national audit project minap · The Myocardial Ischaemia National Audit Project (MINAP) is a national clinical audit of the management of heart attack. It supplies

How

the NH

S cares for patients with heart attack

MIN

AP Tenth P

ublic Report 2011

Myocardial IschaemiaNational Audit Project

Myocardial IschaemiaNational Audit Project

myocardial ischaemia national audit project [minap]

How the NHS cares for patients with heart attack

Tenth Public Report 2011 Prepared on behalf of the MINAP Steering Group

NICOR: NATIONAL INSTITUTE FOR CARDIOVASCULAR OUTCOMES RESEARCH

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heart attacks recorded in minap in 2010/11This report is written for the public to show the performance of hospitals, ambulance services and Cardiac networks in England and Wales against national standards for the care of patients with heart attack in 2010/11.

Report prepared by: Lucia Gavalova, Project co-ordinator MINAP

With assistance from:Dr Clive Weston, MINAP Clinical Director Dr John Birkhead, MINAP Clinical Director Ronald van Leeven, MINAP Project co-ordinatorLynne Walker, MINAP Programme managerProfessor Tom Quinn, MINAP Steering Group memberProfessor Adam Timmis, Chairman MINAP Academic GroupMrs Sirkka Thomas, MINAP Patient/carer representativeMr David Geldard, MINAP Patient representative

Electronic copies of this report can be found at: www.ucl.ac.uk/nicor/audits/minap

For further information about this report, contact:

Myocardial Ischaemia National Audit Project National Institute for Cardiovascular Outcomes ResearchInstitute of Cardiovascular ScienceUniversity College London175 Tottenham Court RoadLondon W1T 7NU

Tel: 0203 108 3931 Email: [email protected]

University College London (media enquiries)Media Relations Manager Ruth Howells Tel: 020 3108 3845Email: [email protected]

Acknowledgements

Department of Health Enquiries to the Department should be directed to the Customer Service CentreTel: 0207 210 4850 (line open from 8.30am to 17.00pm Monday to Friday). Textphone for hard of hearing: 0207 210 5025. Or use the web contact form available at; http://www.info.doh.gov.uk/contactus.nsf/memo?openform

In writing to the Minister of State for Health Services at: The Department of Health Richmond House 79 Whitehall London SW1A 2NS

Welsh Assembly Government Ms Cathy WhiteHead of Adult & Children’s HealthMedical DirectorateDepartment for Health, Social Services & ChildrenWelsh GovernmentCathays Park,Cardiff CF10 3NQ

Tel: 029 20826108Email: [email protected]

Hospital or ambulance service data If you require further information on the performance of your local hospital or ambulance service, please contact the relevant hospital or ambulance service, details of which are available at NHS Choices http://www.nhs.uk/Pages/HomePage.aspx

The MINAP team would like to thank all the hospitals and ambulance services that have collected data.

This report was completed in close collaboration with the Central Cardiac Audit Database (CCAD) team who are now part of National Institute for Cardiovascular Outcomes Research (NICOR), and performed the data management and analysis. Sue Manuel has again been especially involved.

The MINAP Steering Group is proud that one of its members, Professor Roger Boyle was recently awarded a knighthood for services to Medicine.

MINAP is commissioned and funded by the Healthcare Quality Improvement Partnership (HQIP). For more information, please visit www.hqip.org.uk.

This report may not be published or used commercially without permission.

Designed and published by:

| www.padcreative.co.uk

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3MINAP Tenth Public Report 2011

contents

By the National Director for Heart Disease and Stroke

1. Background to heart attacks 7

1.1 ST elevation myocardial infarction 7 and non ST elevation myocardial infarction

1.2 Aims of management 7

1.3 Reperfusion therapy 8

2. Background to MINAP 8

2.1 A look back 8

2.2 Organisation of MINAP 10

2.3 How the data are collected 10

2.4 Security and patient confidentiality 10

2.5 Case ascertainment 10

2.6 Data quality 10

3. Improving quality, improving outcomes 11

3.1 Use of MINAP data to inform the British 11 Cardiovascular Society working group on the use of the cardiac care unit

3.2 Use of primary angioplasty 11

3.3 Access to coronary angiography 12 for patients with non ST elevation myocardial infarction

3.4 International comparisons 13

4. MINAP: a patient’s perspective 14

1. Characteristics of patients with heart attack 16 in 2010/11

2. Hospitals that perform primary angioplasty 18

3. Hospitals using thrombolytic treatment 19

4. Angiography for ST elevation infarction 20 patients not having primary angioplasty

5. Reperfusion treatment by hospital 20

6. Ambulance service performance 21

7. Use of secondary prevention medication 21

8. Cardiac networks 21

9. Care for patients with non ST elevation infarction 22

10. Change in mortality of heart attack patients 23

11. Results by hospitals, ambulance services 24 and cardiac networks

Table 1 Primary angioplasty in hospitals in 24 England, Wales & Belfast

Table 2 Thrombolytic treatment in hospitals 28 in England

Table 3 Thrombolytic treatment in hospitals 36 in Wales & Belfast

Table 4 Ambulance services in England & Wales 37

Table 5 Secondary prevention medication 38 in England

Table 6 Secondary prevention medication 50 in Wales & Belfast

Table 7 Cardiac networks in England & Wales 52

Table 8 Care of patients with non ST elevation 54 infarction in England

Table 9 Care of patients with non ST elevation 66 infarction in Wales & Belfast

12. Difference in performance in England 68 and Wales

Implementing a Primary PCI service in Oxford 69

MINAP, promoting prevention 70

Establishing a primary angioplasty service in 71 Lincolnshire

Improvement in call-to-balloon times at London 72 Chest Hospital, Barts & the London NHS Trust

Using data from MINAP to model a PPCI Service 73 in the Chesire & Merseyside network area

Use of MINAP data to analyse and improve 74 the PPCI service

1. MINAP Academic Group - 5 year overview 75

2. Use of MINAP data to evaluate the impact of 75 acute coronary syndrome care by patient age

3. Enriching MINAP through linkage to primary 76 care & investigator led cohorts

4. Management of hyperglycaemia in acute 76 coronary syndromes

foreword 4

executive summary 5

part two: results 16

part five: appendices 78

part four: research use of 75 minap data

part three: case studies 69

part one: introduction 7

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4 MINAP How the NHS cares for patients with heart attack

This is quite an achievement and reflects on the hard work of staff across the NHS both in the ambulance services and in hospitals supported by the improvement programmes led by NHS Improvement and implemented locally by cardiac networks.

As more patients with heart attack have primary angioplasty these reports increasingly will also rely on information from the British Cardiovascular Intervention Society’s (BCIS) database, and future reports are likely to include analyses from this source.

We would like to thank all those that have been involved.

Professor Sir Roger Boyle, CBE, FRCP

National Director for Heart Disease and Stroke [to August 2011]

foreword

This year we celebrate the 11th anniversary of the initial roll out of MINAP in October 2000. During this time, we have witnessed a series of transformations in the management of heart attack which have long-term benefits for individual patients and the NHS as a whole. In the first few years we saw thrombolytic treatment provided with high levels of expertise, timeliness and efficiency by hospitals and by ambulance services. Over the last four years primary angioplasty has rapidly replaced thrombolytic treatment as the preferred treatment for heart attack, centralising acute care in specialist heart attack centres. At present, over 80% of heart attack patients receive primary angioplasty which is associated with shorter hospital stays, is safer and provides better outcomes. The chances of survival after heart attack have improved year on year despite an ageing population so that the outcomes in this country match the best in the world. Data show that death rates after heart attack have fallen faster in the UK than in any other European country.

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This is the tenth annual MINAP Public Report. It presents analyses from all hospitals and ambulance services in England and Wales that provided care for patients with suspected heart attack between April 2010 and March 2011 (2010/11). For the first time we present data from hospitals in Belfast. The report also presents some data from previous years. Its purpose is to inform the public about the quality of local care for heart attack patients.

Heart attack is common and remains a major cause of death and ill health. Importantly, prompt and appropriate treatment reduces the likelihood of death and recurrent heart attack. Good treatment coupled with cardiac rehabilitation promotes optimal recovery. Heart attack, or myocardial infarction, is part of the spectrum of conditions known as acute coronary syndromes (ACS). This term includes both ST elevation myocardial infarction (STEMI), for which emergency reperfusion treatment with primary angioplasty or thrombolytic drugs is beneficial, and non ST elevation myocardial infarction (nSTEMI), which represent the majority and for which a different approach is required.

Initial treatment of patients with ST elevation myocardial infarction

High quality care for STEMI includes early diagnosis and rapid treatment to re-open the blocked coronary artery responsible for the heart attack. Two forms of treatment are available; primary angioplasty, where the artery is re-opened mechanically using a balloon catheter inserted into the blocked artery, and thrombolytic treatment, where the clot is dissolved by a drug given by ambulance or hospital staff. Delay to providing either treatment is associated with poorer outcomes.

Patients who received primary angioplasty for ST elevation myocardial infarction

Primary angioplasty is the preferred treatment if it can be provided promptly. Once a patient is recognised as having a heart attack, ambulance staff take the patient directly to the catheter laboratory of the nearest heart attack centre, often bypassing smaller hospitals and the Accident and Emergency (A&E) department.

� This year, in England, 82% of patients who received any reperfusion treatment received primary angioplasty compared to 63% in 2009/10. In Wales the increase was from 22% to 30%. In the Belfast hospitals 99% of patients who received any reperfusion treatment received primary angioplasty compared to 59% in 2009/10.

� This year 90% of eligible patients in England, 68% in Wales and 87% in Belfast were treated with primary angioplasty within 90 minutes of arrival at the heart attack centre.

� 81% of eligible patients in England, 75% in Wales and 90% in Belfast were treated with primary angioplasty within 150 minutes of calling for professional help.

� Access to primary angioplasty is variable. The percentage of patients in English cardiac networks that received primary angioplasty ranged between 5% and 93%; in 6 cardiac networks fewer than 50% of patients received primary angioplasty.

� 75% of patients that were treated with primary angioplasty were admitted directly to a heart attack centre in England, 79% in Wales and 60% in the Belfast hospitals.

executive summary

The Myocardial Ischaemia National Audit Project (MINAP) is a national clinical audit of the management of heart attack. It supplies participating hospitals, ambulance services and commissioners with a record of their management and compares this with nationally and internationally agreed standards. MINAP provides comparative data to help clinicians and managers monitor and improve the quality and outcomes of their local services.

5MINAP Tenth Public Report 2010

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6 MINAP How the NHS cares for patients with heart attack

Patients who received thrombolytic treatment for ST elevation myocardial infarction

As the number of patients having primary angioplasty has increased, the number having thrombolytic treatment, either before or on arrival at hospital, has fallen.

� 68% of eligible patients received thrombolytic treatment within 60 minutes of calling for professional help in England; 53% in Wales. Thrombolytic treatment is not used in the Belfast hospitals.

� 69% of patients who received thrombolytic treatment or who had no reperfusion treatment had, or were later referred for, coronary angiography in England; 83% in Wales and 50% in Belfast.

Thrombolytic treatment given by paramedics before the patient reaches hospital

For many ambulance services, the focus has shifted from provision of early pre-hospital thrombolytic treatment to identifying those patients with a heart attack who might benefit from primary angioplasty, and transferring these patients rapidly to a heart attack centre. This means that for many ambulance services the number of patients receiving pre-hospital thrombolytic treatment has declined.

� 824 patients received pre-hospital thrombolytic treatment in England in 2010/11 compared to 1633 in 2009/10, a decrease of 50%. In Wales 219 patients received pre-hospital thrombolytic treatment compared to 250 in 2009/10. Pre-hospital thrombolytic treatment is not used in Belfast.

Care of patients with non ST elevation myocardial infarction

Patients with nSTEMI have a lower early risk of death (within the first month), but appear to be at similar or even greater long-term risk than patients with STEMI. Perhaps because they do not require very rapid emergency treatment (reperfusion therapy), they are not always admitted to cardiac care units and are not always cared for by cardiologists. However, specialist involvement has been shown to lead to better outcomes. The performance of angiography and coronary intervention soon, within the first 2-4 days, is an

important facet of treatment for the majority of these patients. Ideally, admission should be to a cardiac facility where nursing staff have cardiac expertise and there is easy access to cardiological advice. This year:

� 50% of nSTEMI patients were admitted to a cardiac unit or ward in England, 59% in Wales and 81% in Belfast.

� 91% of nSTEMI patients were seen by a cardiologist or member of their team in England, 84% in Wales and 99% in Belfast. However the Welsh data are incomplete as 4/18 hospital did not enter data on their nSTEMI patients.

Prescription of secondary prevention medication

Taking secondary prevention drugs after the acute event (for both STEMI and nSTEMI patients) reduces the risk of death and further heart attack. The proportion of patients in England, Wales and Belfast who are suitable for treatment and in whom secondary prevention medication is prescribed on discharge from hospital continues at over 90% for each of the 5 drug classes monitored.

Falling mortality

There has been a year on year fall in the percentage of patients with STEMI and nSTEMI who die within 30 days of admission to hospital.

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7MINAP Tenth Public Report 2011

If ischaemia is sufficiently prolonged or complete, death of heart muscle results. This is myocardial infarction and is confirmed if evidence of heart muscle cell death is found on blood testing. Such evidence may take some hours to appear and, to be most effective, treatment must start before the results of such tests are available. Ischaemia is suggested by characteristic symptoms (for example central chest discomfort, sweating, breathlessness) and abrupt changes in blood pressure, heart rate and heart rhythm (sometimes leading to collapse or sudden death). Features of ischaemia often can be seen as electrical alterations on the electrocardiogram (ECG). At the onset of symptoms it is uncertain whether the ischaemia will be transient and of no long-term consequence, or whether it will progress to infarction and consequent failure of the heart to pump strongly. So all patients require urgent treatment to reverse ischaemia and prevent infarction.

1.1 ST elevation myocardial infarction and non ST elevation myocardial infarction

Based upon the ECG, patients are categorised into those with, and those without, ST segment elevation – leading to the final diagnosis of those with ST elevation myocardial infarction (STEMI) and those with non ST elevation myocardial infarction (nSTEMI). ST elevation usually indicates complete blockage of a coronary artery and warrants specific immediate treatment to re-open the artery – see Section 1.3 Reperfusion therapy. The absence of ST elevation usually indicates that any coronary thrombosis is only partially occluding the artery.

Although those with STEMI are at greater early risk, the medium to long-term outcome (in terms of recurrent heart attack or death) is similar, if not worse, for those with nSTEMI. Within the last two years the National Institute for Health and Clinical Excellence (NICE)1 has published guidelines for the management of patients with nSTEMI. NICE have a STEMI guideline and Quality Standard in development.2

1.2 Aims of management

The aims of management of acute coronary syndrome are presented in Figure 1 together with examples of some interventions that have been shown to be associated with better outcomes for patients and have therefore been included in various guidelines. Not all patients require all the interventions and some interventions are unsuitable – contraindicated – in some patients. Therefore, clinicians involved in providing care do not blindly follow protocols of treatment but must use their clinical judgement to determine when particular treatments should be used, and when best avoided, in individual patients.

Aims Examples of interventions

Prompt recognition of symptoms

Public education

Education of professionals

Provision of heart monitoring & resuscitation

Ambulance ‘999’ response

Hospital Cardiac Care Units

Restoration of coronary blood flow

Reperfusion treatment

� Primary angioplasty

� Thrombolytic therapy

Nitrates

Elective angioplasty/surgery

Prevention of further coronary thrombosis

Anticoagulants

Antiplatelet agents

Reduction & reversal of ischaemia

Reperfusion treatment

Anti-anginal drugs

e.g. beta blockers, nitrates

Stabilisation of coronary artery Statins

Optimise healing ACE inhibitors

Prevention of future myocardial infarction

Secondary prevention drugs

Lifestyle changes

Education & support, promotion of healthy lifestyles

Hospital cardiac nurse specialists

Cardiac Rehabilitation classes

Patient support groups

Fig 1. Aims of management of acute coronary syndrome

part one: introduction

1. Background to heart attacks

The term ‘heart attack’, while used widely in discussions between clinicians and their patients, and therefore in this public report, is too imprecise to define the clinical condition that is the subject of this national audit. The preferred term is acute coronary syndrome. This covers the symptoms and clinical features that occur when there is an abrupt reduction in the blood supply to a segment of heart muscle. Usually this is a consequence of a gradual build-up of fibro-fatty material (atheroma) within the wall of the coronary artery, which may have happened over years and often without symptoms, followed by sudden disruption of the internal artery wall at this site. This causes blood to clot within the artery – a coronary thrombosis – and leads to a state of myocardial ischaemia, in which the demands of the effected heart muscle for oxygen-rich blood exceed the supply of such blood down the clot-containing artery.

1. www.nice.org.uk/guidance/CG94

2. http://guidance.nice.org.uk/CG/WAVE25/8

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8 MINAP How the NHS cares for patients with heart attack

1.3 Reperfusion therapy

These are treatments that re-open the blocked coronary artery that is causing the ACS; thereby reducing the amount of heart damage. If re-opening the artery is to be of benefit it needs to happen as quickly as possible, before all the heart muscle at risk has been damaged. These therapies are therefore used in the immediate management of those with STEMI (see above). If patients delay too long after the start of their symptoms reperfusion therapy may be of no value and would not then be advised.

Two forms of treatment exist, primary angioplasty (percutaneous coronary intervention (PCI) – where the artery is opened mechanically using a balloon catheter and a stent is then left in the artery to prevent re-occlusion – and thrombolytic therapy – where the clot is dissolved by a drug. Thrombolytic therapy is given by intravenous injection and can therefore be delivered rapidly, preferably even before arriving at hospital. While the drug can be given quickly its effect on the blood clot is not immediate and varies from person to person – in some failing to re-open the artery at all. Primary angioplasty requires specialised equipment and highly-trained clinical staff within the hospital. Patients tend to wait longer for primary angioplasty than they would for thrombolytic treatment, but the final results are more reliable in terms of complete restoration of coronary blood flow, see Fig 2.

Advantages Disadvantages

Thrombolytic drugs

Established treatment

Simple administration (intravenously)

Potentially available in all hospitals

Pre-hospital use by ambulance paramedics

Fails in at least 20%

Risk of bleeding and stroke

Primary angioplasty

Successful in at least 95%

Lower stroke risk

Allows visualisation of all coronary arteries

Cardiologist necessarily involved in care of all patients

Randomised trials suggest primary angioplasty more effective than thrombolytic therapy

Not available in all centres

Treatment must be delayed until arrival at hospital

Risk of bleeding

Fig 2. Reperfusion therapy in ST elevation myocardial infarction

2. Background to MINAP

2.1 A look back

It is only by collecting data and using them that you get senseWilliam Osler, 1928

The publication of the tenth annual report of MINAP provides an opportunity to reflect on the development of the audit project, and to consider its future role in supporting and assuring good quality care for patients with ACS.

The concept of collecting a common dataset of

information on geographically distinct groups of people with heart attack was proposed by the European Regional Office of the World Health Organisation in 1968, and led to the promotion of Myocardial Infarction Community Registers, (and later to the WHO MONICA research project). In Britain, early community registers were developed in Oxford, Edinburgh and Tower Hamlets.

The primary purpose of such registers was ‘educational’ – to more precisely report the incidence of coronary events in a community; both within and without hospital, to describe the manifestations of heart attacks and to allow a comparison of fatality rates between localities. Little information was collected about the care provided within hospital. To be of more practical use to clinicians and the general population a change of emphasis was needed. As Hugh Tunstall Pedoe commented in 1978.

“The collection of information for its own sake is of doubtful value unless it is acted upon. Community registers should not become the equivalent of village war memorials.” 3

He also recognised that such information could be used in “monitoring the effects of treatment” and ensuring that it was “reaching those who needed it”. Here was recognition that data collection could be used to assure appropriate treatment; to go beyond a register toward an audit function.

Clinicians have for many years maintained hospital-based cardiac care unit registers. Perhaps the most enduring is the Nottingham Heart Attack Register, which began in simple form in 1972, and has collected more definitive data since 1982 4.

3. Tunstall Pedoe H. Uses of coronary heart attack registers. Br Heart J 1978;40:510-5.

4. Rowley JM, Mounser P, Harrison EH, et al. Management of myocardial infarction: implications for current policy derived from the Nottingham Heart Attack Register. Br Heart J 1992;67:255-62.

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Such registers have been of great value in showing variation over time in the presentation and outcome of patients with heart attacks. Being unique to each hospital, they are of limited value in revealing and quantifying variation between hospitals.

By the end of the 1980s large randomised trials, in carefully selected groups of patients, confirmed the effectiveness of clinical treatments of heart attack, and provided robust evidence upon which to base recommendations for best management. In particular, the recognition that thombolytic drugs had substantial benefits when given early after the onset of symptoms led to the realisation that it also mattered how and when a treatment was given as well as whether it was given. Measurable standards for treatment, such as door-to-needle time and call-to-needle time appeared in national guidelines, together with advice that hospitals “should provide audit data of delays to treatment” (against agreed standards)5.

Some cardiologists actively lobbied for a common audit in which all hospitals would participate. They believed that a truly national audit would lead to a more rapid implementation of evidence-based clinical practice and thus to improved outcomes for patients with heart attack. Beginning with paper records and later using portable pre-programmed Psion organisers, these cardiologists formed the Myocardial Infarction Audit Group and began, from 1992, to share their (anonymised) data, providing evidence of significant variation in practice6. A regionwide comparative audit conceived by Dr John Birkhead and Professor Rod Griffiths, the West Midlands Thrombolysis Project, reported significant improvement in call-to-needle time as a result of this approach7 . Around this time certain significant advances facilitated the aspiration of the group. Anthony Rickards and David Cunningham conceived and developed the Central Cardiac Audit Database (CCAD) to which data from all participating hospitals could be sent electronically, with automatic encryption8.

Government policy emphasised the potential gain to health from the optimum management of heart attack. Setting, delivering and monitoring standards became an imperative, resulting in much professional and public engagement in describing both potential health outcome indicators9 and the standards of care expected by patients with coronary disease10. This latter document, a National Service Framework (NSF), mandated every acute hospital to have available clinical audit data that was no more than 12 months old and suggested that “where relevant” these should be “derived from participation in national audits”.

The Myocardial Infarction (later, Ischaemia) National Audit Project (MINAP) was established in 1999. It was founded on the following propositions:

� The audit should be a complete record of care rather than a snapshot – all (rather than a sample of) patients being included

� The audit should be prospective – information being collected as soon after treatment as possible

� Participating hospitals should agree both common definitions of clinically important variables and common standards of good quality care against which to audit their practice

� Standards of care should be chosen that have a proven link to improved outcome – i.e. those aspects of care being audited, whilst capable of being expressed as measures of process or performance, should link directly to better patient outcomes

� The practices of individual hospitals should be aggregated into a national figure – a hospital could audit against agreed standards and compare against the national aggregate

� Sufficient data should be recorded to allow for case-mix adjustment and other techniques for investigating differences in outcomes between hospitals,

� The dataset should be revised periodically to account for the introduction of newer treatments

� The audit should maintain its credibility and validity by being guided and supported by relevant professional and patient groups and be managed by a small project team

� A publicly accessible report should be published annually.

The standards presented in the NSF became the standards against which care was compared and a core dataset was prepared for participating hospitals11. Data collection began in October 2000 and by mid-2002 all acute hospitals in England and Wales were participating in the audit.

5. Weston CFM, Penny WJ, Julian DG. Guidelines for the early management of patients with myocardial infarction. BMJ 1994;308:767-71.

6. Birkhead JS. Thrombolytic treatment for myocardial inraction: an examination of practice in 39 United Kingdom hospitals. Myocardial Infarction Audit Group. Heart 1997;78:28-33

7. Quinn T, Allan TF, Birkhead J et al. Impact of a region-wide approach to improving systems for heart attack care: the West Midlands thrombolysis project. Eur J Cardiovasc Nurs 2003 Jul;2(2):131-9.

8. Rickards A, Cunningham D. From quantity to quality: the Central Cardiac Audit Database Project. Heart 1999;82:II18-II22.

9. Birkhead J, Goldacre M, Mason A, et al. Health Outcome Indicators: Myocardial Infarction. Oxford, Centre for Health Outcomes Development, 1999.

10. National Service Framework for Coronary Heart Disease. Modern standards and service models. Accessed on 25 June 2011 at http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/documents/digitalasset/dh_4057526.pdf

11. Birkhead JS. Responding to the requirements of the National Service Framework for coronary disease: a core data set for myocardial infarction. Heart 2000;84:116-7.

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2.2 Organisation of MINAP

MINAP is one of 7 national cardiac clinical audits that are now managed by the National Institute for Cardiovascular Outcomes Research (NICOR) which is part of the Institute for Cardiovascular Science at University College London (UCL).

MINAP is overseen by a Steering Group that represents key stakeholders including professional bodies, national government and patient representation, in conjunction with the British Cardiovascular Society (Appendix 1). MINAP is commissioned by the Healthcare Quality Improvement Partnership (HQIP) who hold commissioning and funding responsibility for MINAP and other national clinical audits. An academic group, which reports to the Steering Group, has been established to facilitate research use of the data, see part 4.

2.3 How the data are collected

The current dataset v9.1 contains 122 fields and includes information on pre- and in- hospital treatment, patient demographics and previous medical history. The dataset is revised every 2 years to meet the requirements of users and to respond to developments in the management of ACS. The dataset is available on the MINAP web pages12.

Data are collected by nurses and clinical audit staff and entered in a dedicated data application (either on-line or web based). Alternatively hospitals can also use commercial software that is able to collect the data. The project uses a highly secure electronic system of data entry, transmission and analysis developed by the CCAD team that is now part of NICOR. The audit has been running continuously since 2000 and all hospitals in England and Wales that admit patients with ACS contribute data.

Participating hospitals are requested to enter all patients with suspected myocardial infarction. About 90,000 records are created annually and in June 2011 the database contained over 873,000 records.

2.4 Security and patient confidentiality

All data uploaded by hospitals are encrypted on transmission and stored encrypted on the CCAD servers. CCAD manages access control to the servers via user IDs and passwords. All patient identifiable data are pseudonymised by CCAD before release to NICOR via a secure drop box on the CCAD server. Data held within NICOR are managed within a secure environment for storage and processing provided by the UCL network and within the UCL information governance and security policy.

The national cardiac audit data held by CCAD are registered under the Data Protection Act. NICOR has support under section 251 of the National Health Service (NHS) Act 2006. (Ref: NIGB: ECC 1-06 (d)/2011).

In addition, NICOR staff recognise that confidentiality is an obligation and regularly undergo information governance training to ensure understanding of the duty of confidentiality and how it relates to patient data.

2.5 Case ascertainment

In practice MINAP records the great majority of patients having STEMI in England and Wales. However it is accepted that a number of hospitals do not enter all their nSTEMI patients mainly due to lack of resources. The true number is difficult to establish as it is not possible to compare MINAP data with Hospital Episode Statistics (HES), the only possible comparator, except in aggregate. Although HES reports approximately 105,000 hospital admissions annually with myocardial infarction, it is not possible to separate this number into the clinical categories used within MINAP. MINAP records about 30,000 STEMIs, but only about 50,000 nSTEMIs annually. From internal data we consider that approximately 80,000 nSTEMIs per year would be an appropriate number.

Where all patients with ACS are admitted to the same ward or area it is easy to identify patients. It is much harder where patients are not all cared for in one area, and are looked after in several wards. Under-reporting of nSTEMIs varies between hospitals and reflects variation in resources allocated to data collection. Many hospitals do not have the resource to identify and record all nSTEMIs as these may not be admitted to a cardiac facility. Instead, patients with nSTEMI may be cared for in many areas in a hospital, and identification is difficult.

2.6 Data quality

Assessment of data completion and validation is presently based on patients with nSTEMI. The completeness of 20 key fields is continually monitored and is available to hospitals in an online view. Currently these fields are 99% complete.

MINAP performs an annual data validation study to assess the agreement of data held on the CCAD servers with data re-entered from the case notes. Hospitals are required to re-enter data from case notes in 20 key fields in 20 randomly selected nSTEMI records using an online data validation tool. Agreement between the original and the re-entered data is assessed for each variable and for each record. Reports

12. www.ucl.ac.uk/nicor/audits/minap

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showing the agreement of each variable compared to national aggregate data

are sent to hospitals to allow them to

identify and act on areas of weakness with

respect to data collection and entry. 97.5% of eligible

hospitals in England and Wales participated in this year’s data

validation study. The median score for 2009/10 was 94.8% (IQR 90.0-

97.8). However the data are only as good as the data provided by hospitals

and there is no independent validation.

The MINAP data application contains error checking routines, including range and

consistency checks, designed to minimise common errors and online help. MINAP provides

detailed guidelines for data entry and provides a dedicated helpdesk to support problems regarding

data entry and clinical definitions.

3. Improving quality, improving outcomes

3.1 Use of MINAP data to inform the British Cardiovascular Society working group on the use of the cardiac care unit.

MINAP data continue to be used at local level and nationally to inform the development of cardiac services. MINAP data have recently been used to provide a report to the British Cardiovascular Society’s (BCS) working group on the future of the cardiac care unit (CCU).

Cardiac or coronary care units have been in existence since the early 1960s –almost 50 years – and in that time the management for heart attack has evolved in a fashion that would be unrecognisable to those working at that time. Coronary care units, to use the term originally applied, were primarily for the care of STEMI, a group of infarctions with a high early mortality. Death was, in the main, due to primary ventricular fibrillation (VF), a lethal condition treatable by immediate electrical cardioversion. It made sense therefore to admit all patients with STEMI, at high risk of VF, to a CCU. For other ACS, the majority, who were at lesser risk of early sudden death it was not thought necessary to admit to a CCU. CCUs were expensive to staff, and tended to be small in size, with 4 - 8 beds being typical. Units changed little over the next 40 years, and continued to provide excellent care for the limited number of patients that could be managed there.

Pressure for change has recently come from a number of directions. The first has been the rapid development of primary angioplasty performed in a limited number of hospitals for a number of surrounding hospitals. CCUs are no longer admitting the patients with STEMI that they had cared for over more than 40 years. At the same time there has been increased awareness of the opportunities for care for nSTEMI, previously often cared for in general medical facilities and by non-specialist physicians. In addition the value of specialised nursing and medical management for cardiac arrhythmias and severe forms of heart failure has long been apparent. However, a short term financially driven view of a CCU that no longer admits the patients for which it was designed almost 50 years ago is to close it, and deploy nursing staff elsewhere. This disturbing approach has been noted in a number of parts of the country.

It was in the light of reports of pressures to close CCUs, and an awareness that the facilities of existing CCUs might potentially be put to very good use that led to the setting up of the working group of the BCS. MINAP was invited to comment to the working group, and produced a report based on MINAP data for the care of patients with nSTEMI. This report, the contents of which will inform part of the report of the working group, indicated very clearly the benefits of admission of patients with nSTEMI to a CCU in terms of more appropriate care, the economic benefit of a shortened length of stay, and improvement in early mortality.

3.2 Use of primary angioplasty

The number of patients having STEMI who receive reperfusion treatment has declined slightly in the last few years. This decline appears to be associated with the increased use of primary angioplasty and, on reflection, might have been expected as primary angioplasty is preceded by a detailed radiographic examination of the coronary arteries.

When thrombolytic treatment was the reperfusion treatment of choice for STEMI the decision to use thrombolytic treatment was based on clinical findings and crucially on the appearances of the ECG. The appearances of the ECG do not always allow for a clear cut treatment decision; sometimes the appearances on which thrombolytic treatment is based are borderline and the clinician must make a judgement on the available evidence. This approach can potentially result in a small number of patients receiving thrombolytic treatment where clinical benefit is unlikely. By contrast all patients having primary angioplasty undergo a coronary angiogram as part of the procedure, and this provides detailed information on the presence of a coronary artery occlusion, it’s site, and likely impact on outcome. An additional benefit to patients admitted for primary angioplasty is that they come under the care of a consultant cardiologist almost immediately.

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MINAP data allow an analysis of what procedure was ultimately performed for patients who present with ECG appearances of STEMI and who are therefore considered suitable candidates for primary angioplasty.

In 2010/11 MINAP data show that 8.6% of patients for whom it was intended to perform primary angioplasty did not receive it. Of those, 6.4% received an angiogram after which it was decided not to proceed to angioplasty. The commonest reasons for this was that the infarct related vessel had re-opened spontaneously or, that the coronary disease was too severe for angioplasty and that coronary artery bypass grafting was a more suitable treatment option. Another 1.8% of patients were not thought to require an angiogram.

Thus, the adoption of primary angioplasty, now provided for more than 80% of the population of England has resulted in reperfusion treatment for STEMI being more accurately tailored to those who might benefit most.

3.3 Access to coronary angiography for patients with non ST elevation myocardial infarction

In 2010 NICE published a guideline on the management of patients with nSTEMI13. A significant part of this report was written based on data from MINAP. One of the recommendations was that patients having infarctions of moderate severity, and those in whom it is possible to demonstrate residual ischaemia

on testing (evidence of persisting narrowing of a coronary artery) should have a coronary angiogram within 96 hours of admission, in order to determine the need for further treatment, typically coronary angioplasty or in a minority of cases, coronary artery bypass grafting.

During the last 10 years there has been a very substantial expansion of the number of catheterisation laboratories, with 141 hospitals in England (133) and Wales (8) having catheter laboratories compared with 86 in England and 2 in Wales 10 years ago.14

Since 2004, the percentage of patients with a final diagnosis of nSTEMI (broadly reflecting the NICE classification of moderate or greater severity) who have angiography during the admission has increased from just under 45% in 2004 to 71% in 2010. It should be recognised that angiography is not appropriate for all patients with nSTEMI. The average age of patients having a first nSTEMI is 70 years, and where performance of angiography is unlikely to alter longer term outlook because of co-morbidity, it may not be appropriate to perform it.

The improved access to angiography for patients with nSTEMI has resulted in a significant fall in the median length of stay for patients having angiography from 7.4 days in 2004/5 to 5.5 days in 2010/11. Over the same time the length of stay of patients not having angiography has fallen from 7.1 to 6.6 days.

13. The early management of unstable angina and non-ST-segment-elevation myocardial infarction. CG 94. National Institue for Health and Clinical Excellence. London 2010.

14. Birkhead J, Pearson J and Walker L. Management of acute coronary syndromes in England and Wales: a survey of facilities in 2006. Royal College of Physicians 2007. ISBN 978-1-86016-314-2.

Coronary angiogram of blocked left anterior descending artery before PCI Coronary angiogram of left anterior descending artery after PCI

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3.4 International comparisons

Outcomes from heart attack have been a source of controversy in the ongoing debate about proposals for NHS reform in England. The Prime Minister has stated that “Someone [in this country] is twice as likely to die from a heart attack as someone in France”15. Statements from other Ministers have subsequently given a similar message.

The comparison with France appears to have been based on an Organisation for Economic Co-operation and Development (OECD) report using data from 200616 and includes the whole of the UK, rather focusing on than the NHS in England. MINAP has demonstrated in this and previous reports that mortality for both main types of heart attack –STEMI and nSTEMI- has fallen significantly in recent years in England and Wales, not least because of the success of the NSF for coronary heart disease17, the rapid introduction of primary angioplasty services with around 80% of the population of England now having access to this ‘gold standard’ treatment, and better uptake of evidence-based therapies for secondary prevention. Others, including the highly respected Kings’ Fund have suggested that the rate of improvement in outcomes from heart attack has been the fastest in Europe18.

Comparing outcomes between different countries is a complex undertaking, with evidence of miscoding and misclassification of the cause of death, variation in the entry criteria for national registries and completeness of data19 20. An international consensus on the definition of a heart attack is expected to improve the quality of comparison for the future.21

The MINAP team are working with our international partners in heart attack registries and professional societies to provide more robust international comparisons for the future, to help inform ongoing debate about the quality of cardiovascular care.

15. BBC News 16 March 2011 http://www.bbc.co.uk/news/uk-politics-12760865

16. Organisation for Economic Cooperation and Development. Health data 2010—October. www.ecosante.org/index2.

17. Department of Health. Evaluation of the Coronary Heart Disease National Service Framework. 2010 http://www.dh.gov.uk/en/FreedomOfInformation/Freedomofinformationpublicationschemefeedback/FOIreleases/DH_126679

18. Appleby J. Does poor health justify NHS reform? BMJ 2011; 342: d566

19. Lozano R, Murray CJL, Lopez AD, et al. Miscoding and misclassification of ischaemic heart disease mortality. Global Programme on Evidence for Health Policy Working Paper No 12. World Health Organisation; 2001. p. 1-19

20. Widimsky P, Wijns W, Fajadet J, et al European Association for Percutaneous Cardiovascular Interventions. Reperfusion therapy for ST elevation acute myocardial infarction in Europe: description of the current situation in 30 countries. Eur Heart J. 2010 31(8):943-57

21. Thygesen K, Alpert JS, White HD; Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction. Universal definition of myocardial infarction. Eur Heart J. 2007;28(20):2525-38

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14 MINAP How the NHS cares for patients with heart attack

4. MINAP: a patient’s perspective

Sirkka Thomas, Cardiac nurse, Health visitor, Cardiac carer and patient, member of Patient Network for London Cardiovascular Project 2011, member South West London Cardiac and Stroke Network and member of Healthcare Quality Improvement Partnership Patient Panel

MINAP has become a major influence in my life in my demanding passage of nurse, carer, and finally cardiac patient. I turned to Cardiac nursing and trained at the Royal Brompton Hospital because I was inspired by the efforts of my native country Finland in managing such high incidence of heart conditions and I wanted to join the campaign against Britain’s greatest killer disease.

That knowledge was to help me so much when my husband suffered a heart attack 14 years ago followed by heart failure and the need for an Implantable Cardioverter Defibrillator (ICD). I was able to support him, medically as a nurse and psychologically as a carer.

It is only being a close partner that one can understand the problems of a patient with a serious illness. Doctors are highly qualified to diagnose and give treatment and my husband and I have received first class therapy. However, it is our view that only the patient and close partner know the pain, physical and psychological, and the stress of their illness. That is when a carer’s understanding presence is so vital.

We first became aware of MINAP when my husband recovered sufficiently to join the MINAP Steering Group, as he put it, “to repay in some way the high class cardiac treatment I had received from so many branches of the NHS”. MINAP was no magic remedy but it did provide a recovery incentive for me as a carer and for my husband as a patient.

MINAP is not a Government target for heart treatment. But it is an encouragement for hospitals and ambulance services to demonstrate their performances in standards for coronary artery disease as set out by the National Service Framework of 2000.Those standards include the time from onset of heart symptoms until appropriate treatment, clot-busting drugs and now primary angioplasty, is received. They also include the use of secondary medication on hospital discharge.

It was so important for my husband and me to learn from MINAP about hospital performances, the speed of immediate treatment and the attention given to the prescribing of drugs on discharge.

Mortality rates due to coronary heart disease have been falling since the 1970s. Surely MINAP has helped in some way with its pursuit of excellence. MINAP has definitely contributed with its

data to encourage speed of treatments and guidance to improve drug provision on discharge, (see the data in this 10th Report).

Unfortunately, I turned from carer to patient two years ago, having experienced a non-STEMI which has required a pacemaker. Fortunately, I had MINAP to lift me up, along with that wonder treatment for heart patients, a caring, understanding husband.

David Geldard, MINAP Patient representative and Steering Group member, past president Heart Care Partnerships (UK)

At a recent national conference, Celebrating Leadership in Heart Disease and Stroke in London on 4th July, 2011, MINAP was frequently mentioned in the context of developing standards of care in the treatment of people with heart disease. Equally pleasing, and for the tenth year running, this Report is a record of steady change and improvement.

With the advent of primary angioplasty as the preferred treatment for people suffering an ST elevation myocardial infarction, the need to treat these people at centres where round-the-clock equipment and appropriately trained staff are available is paramount. This shift in treatment from localised Accident and Emergency facilities, to heart attack centres that can provide 24/7 response is often a cause of concern to communities that feel they are losing a vital and local resource. People want the best treatment, but they also want it at their local hospital, and that is no longer realistic. This Report will do much to allay concerns. This year, with the assistance of NHS Improvement Heart, and the thirty two cardiac networks in England and Wales, and of Heart Care Partnership (UK), the patient arm of the British Cardiovascular Society, copies of this Report will be sent to local patient representatives at the time of publication. In this way patient representatives will be able to examine how things are going

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15MINAP Tenth Public Report 2011

in their locality. Hopefully they will see improvement, and this will provide them with evidence to dispel local anxieties. They will discover many causes for passing on congratulations, and some, but not too many, “could do betters”. These local patient representatives will be the local banner bearers for their local heart attack services.

Despite the success of hounding smoking and smoke from public places, tobacco smoking is still a significant contributing factor to poor health and heart attack. This report also provides evidence that shows how some heart attack victims and their companions are misjudging the event and neglecting to seek assistance in timely fashion. The success of primary angioplasty in hastening the recovery of victims has an unusual side effect in that many patients quickly seem to forget the seriousness of their condition and the responsibility they owe to themselves and their families to pay heed to the advice they receive concerning their future lifestyle, their medication, and their cardiac rehabilitation. It is extraordinary that nearly three times as many cardiac surgery patients participate in cardiac rehabilitation as do heart attack patients.

On the bright side, it is ten years after the first Public Report and it is wonderful to observe the continuing commitment of the ambulance services, the hospital services, primary care and the rehabilitation services, along with the those of the central support of Professor Sir Roger Boyle, National Clinical Director for Heart Disease and Stroke and his team, and all those colleagues on the front line and behind the scenes, for they have all gone “above and beyond” in their service to people who have suffered heart attack.

It is through audit that one can objectively observe the success or otherwise of any activity, and it is to John Birkhead, the pioneer of MINAP, and the MINAP team who now bring it all together, that the heart patient community owes such a warm vote of thanks.

I encourage all patient representatives for people with heart disease to read this Report carefully, and to share their joy and their aspirations; it is a good news story, in fact it is a great news story, and with their help it can get even better.

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202003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

25

30

35

40

45

50%

55

60

65

70

Fig 5. Hypertension in patients having first heart attack.

Females

Males

The number of records eligible for analysis from each hospital is shown in the tables. Where a hospital reports less than 20 cases for the year analyses may not be meaningful. The number of cases are shown but not the percentages. There are several reasons why hospitals may report less than 20 patients.

� In hospitals providing a primary angioplasty service, most patients receive primary angioplasty rather than thrombolytic treatment. Different audit standards apply for timeliness of treatment with primary angioplasty and thrombolytic treatment, and delays for the two treatments cannot be combined.

� Hospitals that do not provide primary angioplasty may report few, if any, cases having thrombolytic treatment, as patients from their area will be admitted directly to a primary angioplasty centre.

� About 18% patients make their own way to hospital without involving either the ambulance service or their GP. These patients are excluded from analyses of call-to-needle time and may account for small numbers in some hospitals.

� Smaller hospitals manage few heart attack patients.

� Hospitals may have only recently started a primary angioplasty service or have performed primary angioplasty on an occasional basis.

1. Characteristics of patients with heart attack in 2010/11

In 2010/11, 89,511 records in England and Wales were submitted to the MINAP database and 79,863 were records of patients with a final diagnosis of myocardial infarction. Of these some 40% had STEMI. [Fig 3] MINAP recognises that not all patients having nSTEMI are entered into the database and that the true ratio for nSTEMI to STEMI should be at least 2:1.

The average age for patients having a first heart attack in England and Wales was 69 years, for men 66 years and for women 74 years. Heart attack is more common in men, with two men having a heart attack for every woman. STEMI tends to present in younger age groups than nSTEMI. The average age for a first STEMI is 65 years, while that of nSTEMI is 70 years. Overall more than 52% of all heart attacks recorded in MINAP were in people over 70 years of age [Fig 4].

part two: results

All hospitals in England and Wales that treat heart attack patients submit data to MINAP. This year we also present data from 3 Belfast hospitals. The 204 hospitals in England and 18 hospitals in Wales are listed alphabetically in Tables 1-3, 5, 6, 8 and 9 with the location of the hospital alongside its name.

79863 admissions with heart attack

31765 (40%) STE MI

48098 (60%) nSTEMI

8859 (28%) had no reperfusion treatment

660 (2%) treatment option not clear

18042 (57%) referred for pPCI

4204 (13%) had thrombolytic treatment

1110 (27%) had thrombolytic treatment in an ambulance

3094 (73%) had thrombolytic treatment in hospital

Fig 3. Hearts attacks recorded in MINAP in 2010/11

There was a total of 89511 records, the others having either another confirmed diagnosis or chest pain of uncertain cause.

Fig 4. Frequency distribution of STEMI and nSTEMI in financial year 2011

0

5

10

15

25

20

30

%

Years

<30 >9030-39 40-49 50-59 60-69 70-79 80-89

STEMI

nSTEMI

Fig 4. Frequency distribution of STEMI and nSTEMI in 2010/11

STEMI is more common in younger age groups, while more than 60% of nSTEMI occur after age 70.

102003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

11

12

13

14

15

16%

17

18

19

20

Fig 6. Frequency of diabetes in patients having first heart attack

Females

Males

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202003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

25

30

35

40

45

50%

55

60

65

70

Fig 5. Hypertension in patients having first heart attack.

Females

Males

Fig 5. Hypertension in patients having first heart attack

Patients with final diagnosis of AMI treated for hypertension at the time of admission.

Among those admitted with heart attack there is a continuing increase over time in the frequency of previously diagnosed hypertension and diabetes. The upwards trend for hypertension continues for females, but may be levelling out for males.[Fig 5] The increase in the frequency of diabetes on admission for first heart attacks continues in both males and females. Further analysis shows that the increase is limited to those having type 2 diabetes (non-insulin dependent diabetes) [Fig 6]. It is not clear to what extent this represents a real increase, or whether this in part reflects improved recognition of type 2 diabetes in primary care. The proportion already prescribed cholesterol lowering drugs (usually statins) at the time of admission may now be becoming constant at about 30% of those presenting with a first heart attack [Fig 7]. This may reflect more efficient recognition and treatment in primary care of those at risk.

Cigarette smoking remains a major contributor to heart attacks in younger people, being a risk factor present in more than half of men and women under 55 years of age having a first heart attack. While the smoking rate in younger males is stable or falling slightly, that in females of less than 55 years continues to increase [Fig 8].

102003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

11

12

13

14

15

16%

17

18

19

20

Fig 6. Frequency of diabetes in patients having first heart attack

Females

Males

Fig 6. Frequency of diabetes in patients having first heart attack

The large majority of the increase in frequency of diabetes is in type 2 (non-insulin dependent) diabetics.

02003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

5

10

15

20%

25

30

35

Fig 7. Patients admitted with a first heart attack already receiving treatment for hyperlipidaemia at admission

Hyperlipidaemia having treatment

Fig 7. Patients admitted with a first heart attack already receiving treatment for hyperlipidaemia at admission

Fig 8. Current smoking amongst patients admitted with heart attack.

2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2010-112009-10

%

Females

60

50

40

30

20

10

0

20-54 yrs

55-64 yrs

65-74 yrs

›75 yrs

Males

20-54 yrs

55-64 yrs

65-74 yrs

›=75 yrs

2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2010-112009-10

%

60

50

40

30

20

10

0

Fig 8. Current smoking amongst patients admitted with heart attack

Smoking amongst females presenting with first heart attack under 55 years continues to increase, against the generally decreasing trend for smoking rates.

Fig 8. Current smoking amongst patients admitted with heart attack.

2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2010-112009-10

%

Females

60

50

40

30

20

10

0

20-54 yrs

55-64 yrs

65-74 yrs

›75 yrs

Males

20-54 yrs

55-64 yrs

65-74 yrs

›=75 yrs

2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2010-112009-10

%

60

50

40

30

20

10

0

Fig 8. Current smoking amongst patients admitted with heart attack.

2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2010-112009-10

%

Females

60

50

40

30

20

10

0

20-54 yrs

55-64 yrs

65-74 yrs

›75 yrs

Males

20-54 yrs

55-64 yrs

65-74 yrs

›=75 yrs

2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2010-112009-10

%

60

50

40

30

20

10

0

Females

Males

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2. Hospitals that perform primary angioplasty

National and international guidance22 23 24 recommend that in the emergency treatment of patients with STEMI, primary angioplasty should be performed within 90 minutes of arrival at the angioplasty site (door-to-balloon time) and within 150 minutes of a patient’s call for help (call-to-balloon time). Results are presented against these best practice standards in Table 1.

The use of primary angioplasty continued to increase in 2010/11. This year in England, 15,817 patients in England were treated by primary angioplasty compared to 12,505 in 2009/10, an increase of 26%. In Wales 301 patients were treated compared to 232 in 2009/10, an increase of 30%. Of patients who received reperfusion treatment in 2010/11, 82% of patients in England, 30% in Wales and 99% in Belfast received primary angioplasty. The overall median time from arrival at hospital to primary angioplasty was 43 minutes in 2010/11. In 25% of records this interval was less than 30 minutes and for 75% the interval was less than 64 minutes.

This year, 68 hospitals in England performed primary angioplasty. In Wales 3 hospitals performed primary angioplasty. Hospitals performing primary angioplasty may provide this for their own patients only or may do so for groups of other hospitals. Of 62 hospitals in England reporting that they were performing primary angioplasty on a routine basis, 43 provided the service throughout the 24 hour period. A small number shared a night time rota on an alternate basis. An additional 10 hospitals have started to provide a 24/7 service from April 2010. In Wales two hospitals perform primary angioplasty with 24 hour availability. In Belfast, two hospitals performed primary angioplasty.

The provision of primary angioplasty is complex and involves close collaboration between ambulance, portering, nursing, medical, and radiographic teams. This is particularly important for out of hours working. The percentage of patients with an admission diagnosis of STEMI who receive primary angioplasty within 90 minutes of arrival at the heart attack centre has increased from 52% in 2003/4 to 89% in 2010/11 and is a reflection of this close collaboration [Fig 9]. In particular direct transfer of the patient from ambulance to the catheter lab without involvement of other departments or wards, has reduced delays.

In Belfast the Royal Victoria Hospital essentially provided a city wide service in 2010/11. In Northern Ireland routine use of primary angioplasty is presently limited to the Belfast area. Outside Belfast thrombolytic treatment is understood to be the primary reperfusion treatment of choice for STEMI, though primary angioplasty is occasionally available in some hospitals. The Northern Ireland cardiac network is currently developing a national strategy for the management of STEMI. We look forward to the other hospitals in Northern Ireland joining MINAP before long.

Door-to-balloon time

In England this year, 90% of eligible patients were treated with primary angioplasty within 90 minutes of arrival at the heart attack centre compared to 89% in 2009/10. In Wales 68% of eligible patients were treated within 90 minutes compared to 71% in 2009/10. In Belfast 87% of eligible patients were treated within 90 minutes compared to 53% in 2009/10.

Call-to-balloon time

This reflects the interval from a call for professional help to the time that the primary angioplasty procedure is performed. This involves ambulance crews making an accurate diagnosis, including skilled interpretation of the ECG. Ideally all patients with a diagnosis of STEMI confirmed by a paramedic crew should then be taken to a heart attack centre. This however is not always possible, particularly where there is diagnostic uncertainty, or in remoter parts of the country. In 2010/11 75% of patients treated with primary angioplasty were admitted directly to a heart attack centre in England, 79% in Wales and 60% in Belfast.

22. http://www.improvement.nhs.uk/heart/?TabId=66

23. Van de Werf F, Ardissino D et al. (2003) Management of acute myocardial infarction in patients presenting with ST-segment elevation. The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J 24(1): 28–66.

24. Antman EM, Hand M, Armstrong PW et al. (2008) 2007 focused update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction. J Am Coll Cardiol 2008; 51: 210–247.

Fig 9. Percentage of patients with an admission diagnosis of STEMI having primary angioplasty within 90 minutes of arrival in hospital in E&W.

0

10

20

30

50

60

70

80

40

90100

%

2003-4 2010-112004-5 2005-6 2006-7 2007-8 2008-9 2009-10

52.856.5 58

72.3

79.784.5

88.2 89.3

Fig 9. Percentage of patients with an admission diagnosis of STEMI having primary angioplasty within 90 minutes of arrival in hospital

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In England, 81% of all eligible patients were treated within 150 minutes of calling for professional help compared to 80% in 2009/10. In Wales 75% of patients were treated within 150 minutes compared to 76% in 2009/10. In Belfast 90% of patients were treated within 150 minutes compared to 77% in 2009/10.

In England, 88% of patients taken directly to the heart attack centre were treated with primary angioplasty within 150 minutes of calling for professional help compared to 49% of patients taken first to a local hospital and then transferred to a heart attack centre. In Wales 76% of such patients were treated within 150 minutes. In Belfast 89% of patients taken directly to the heart attack centre were treated with primary angioplasty within 150 minutes of calling for professional help.

The proportion of patients admitted directly to an interventional centre who receive primary angioplasty within 150 minutes of a call for professional help continues to improve [Fig 10]. There is a limit to how rapidly ambulance services can assess patients and transfer them safely to hospital. The scope for further improvement in this interval may be limited.

3. Hospitals using thrombolytic treatment

Thrombolytic treatment is now used for a rapidly diminishing number of patients. At present approximately 15% of those eligible for reperfusion treatment have thrombolytic treatment, and this occurs mainly in a few areas where timely access

to a heart attack centre is not yet available. This number is expected to fall further over the next 12 months.

The national standard for thrombolytic treatment is for this to be given within 60 minutes of a call for professional help. This is a joint responsibility of acute hospital trusts and ambulance services. Performance against this standard continues to be monitored as an existing commitment within the NHS Operating Framework for England in 2010/11. The aim is for at least 68% of cases to achieve this standard in England, and 70% in Wales.

Tables 2 and 3 show hospital thrombolytic treatment analyses for 2009/10 and 2010/11 for England and Wales respectively. The Belfast hospitals did not report use of any thrombolytic treatment in 2010/11.

Door-to-needle time

In England, 75% of eligible patients received thrombolytic treatment within 30 minutes of arrival at hospital compared to 79% in 2009/10. In Wales 62% of eligible patients received treatment with 30 minutes compared to 67% in 2009/10.

Call-to-needle time

As more patients have primary angioplasty fewer receive thrombolytic treatment. However, the percentage of patients receiving thrombolytic treatment who do so within 60 minutes of a call for help is essentially unchanged. In England 68% of eligible patients received thrombolytic treatment within 60 minutes of calling for professional help compared to 69% in 2009/10. In Wales 53% of eligible patients received treatment within 60 minutes compared to 55% in 2009/10.

19MINAP Tenth Public Report 2010

Fig 10. Proportion of patients admitted directly to an interventional centre who receive primary angioplasty within 150 minutes of a call for professional help

50

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75

80

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%

Financial year

2004-5 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

Fig 10. Proportion of patients admitted directly to an interventional centre who receive primary angioplasty within 150 minutes of a call for professional help

The sudden improvement between 2005/6 and 2006/7 is likely to be due to the rapid increase in new cardiac units performing angioplasty and the influence of the National Infarct Angioplasty Project (NIAP)

Normal coronary angiogram

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20 MINAP How the NHS cares for patients with heart attack

4. Angiography for STEMI patients not having primary angioplasty

It is recognised that despite timely thrombolytic treatment some patients are at early risk of further heart attack. This risk is reduced by performance of angiography to determine the extent and severity of disease in coronary arteries, and where appropriate, angioplasty to the affected artery. The performance of angiography for STEMI patients not having primary angioplasty is now considered to be routine, whereas in 2003/4 only about one third of patients had angiography for this indication (Fig 11).

Due to a database fault that could not be rectified in time for publication, this analysis excludes some data from hospitals using the MINAP web application. The national analyses are based on the remaining hospitals, and may be subject to revision in 2012. Individual hospital data are not presented for 2010/11.

In 2010/11, 69% of STEMI patients in England, 83% in Wales, and 50% in Belfast who received thrombolytic treatment, or who had no reperfusion treatment were referred for coronary angiography or, in a minority, had this arranged to take place after discharge.

5. Reperfusion treatment by hospital

Rates of reperfusion treatment by hospital have become difficult to present and interpret as so many patients who would previously have been treated with thrombolytic treatment in a local hospital now receive primary angioplasty in a heart attack centre, and may not even return to the local hospital after treatment. Performance of individual hospitals is not shown for 2010/11.

There has been a small increase in the number of patients with STEMI who do not receive reperfusion treatment, from about 25% in 2005/6 to 28.5% in 2010/11. The commonest reason why no reperfusion treatment is given is that the patient presents too late for treatment, which typically is not given more than 12 hours after onset of symptoms because of limited benefit by this time. In a small number of cases severe co-morbidity such as advanced malignancy or severe dementia may make reperfusion treatment inappropriate. These features do not change significantly over time. However, the performance of angiography before an intended primary angioplasty may demonstrate features that indicate that primary angioplasty is not required or is not feasible. These features can only be determined by angiography. Thus, angiography allows treatment to be offered only to those for whom benefit can be expected, and enables clinicians to exclude those where benefit is not anticipated. Trends in reperfusion treatment since 2003/4 are shown in Fig 12.

As the intention is to treat patients by primary angioplasty as quickly as possible, those initially referred to a hospital without facilities for primary angioplasty are assessed rapidly for possible onwards transfer to the interventional hospital (heart attack centre), and will not be admitted. If patients are not formally admitted to the non-interventional hospital before onward transfer they do not appear in MINAP analyses for the non-interventional hospital. Only those patients that are formally admitted to a non-interventional hospital, a small minority, are included in the columns referring to transfer elsewhere for primary angioplasty.

Fig 12. Use of reperfusion treatment for patients with a final diagnosis of STEMI

0

10

20

30

40

50

60

%

70

80

90

100

2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

In-hospital lysis

Pre-hospital lysis

Primary angioplasty

Fig 12. Use of reperfusion treatment for patients with a final diagnosis of STEMI

Primary angioplasty makes up more than 80% of reperfusion treatment.

Fig 11. Use of angiography for patients having STEMI who did not receive primary angioplasty, but instead received receiving thrombolytic treatment or had no reperfusion treatment

0

10

20

30

40

50

60

%

70

80

2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2010-112009-10

31.1

45.550.1

55.658.6

63.3

70.173.2

Fig 11. Use of angiography for patients having STEMI who do not receive primary angioplasty, but instead received thrombolytic treatment or had no reperfusion treatment.

Where angiography is thought inappropriate because of co-morbidity or the patient refused, these are excluded from analysis. All age groups are included.

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21MINAP Tenth Public Report 2011

6. Ambulance service performance

Ambulance services collaborate closely with receiving hospitals and networks to improve care. For many, the focus has shifted from provision of pre-hospital thrombolytic treatment to identifying those patients with heart attack who might benefit from primary angioplasty, and transferring them rapidly to a heart attack centre. So, for many ambulance services, the number of patients receiving pre-hospital thrombolytic treatment has declined.

Table 4 shows ambulance service performance in England and Wales. In England in 2010/11, 824 patients received pre-hospital thrombolytic treatment compared to 1,633 in 2009/10. In Wales 219 patients received pre-hospital thrombolytic treatment compared to 250 in 2009/10.

7. Use of secondary prevention medication

Use of secondary prevention medication after the acute event is proven to improve outcomes for patients. These benefits apply after both STEMI and nSTEMI.

NICE guidance25 recommends that all patients who have had an acute heart attack should be offered treatment with a combination of the following drugs:

� ACE inhibitor

� aspirin

� beta blocker

� statin.

Tables 5 and 6 show the percentage of patients prescribed secondary prevention medication on discharge by hospital in England, Wales and Belfast in 2010/11. For each hospital those patients surviving to be discharged home from that hospital are included but those transferred to another hospital and those patients in whom such drugs were contraindicated are excluded. Historically, we have used the NSF audit standard of 80% for aspirin, beta blockers and statins treatment. There are no national standards for the prescription of ACE inhibitors, Clopidogrel/thienopyridine inhibitors and newer antiplatelet agents.

Use of secondary prevention medication at discharge from hospital is very satisfactory, continuing to exceed the national standards, and there is little room for further improvement [Fig 13]. In England prescription of aspirin was 99%, beta blockers 96%, statins 97%, ACE inhibitors 94% and Clopidogrel/thienopyridine inhibitors 95%. In Wales prescription of aspirin was 98%, beta blockers 95%, statins 95%, ACE inhibitors 91% and Clopidogrel/thienopyridine inhibitors 92%. In the Belfast hospitals prescription of aspirin was 99%, beta blockers 99%, statins 99%, ACE inhibitors 97% and Clopidogrel/thienopyridine inhibitors 98%.

8.Cardiac networks

Cardiac networks (also known as ‘heart and stroke networks’ since they also now facilitate improvements in stroke care) are local NHS organisations that seek to improve the way that services are planned and delivered. Bringing together clinicians, managers, commissioners and patients, and aware of the entire ‘cardiac pathway’, the networks can provide a powerful voice in the local health economy to enable frontline staff to secure the changes needed to deliver best care. They provide a forum through which the public can influence their services. Some cardiac networks have patient carer representatives providing a voice among the professionals.

Table 7 shows the performance of the call-to-needle and call-to-balloon targets and the percentage of patients that received pre-hospital thrombolytic treatment, in-hospital thrombolytic treatment, primary angioplasty and no reperfusion treatment by cardiac network. The two cardiac networks in Wales are shown separately.

Countrywide access to primary angioplasty remains incomplete, although the picture is changing rapidly. The percentage of patients in English cardiac networks that received primary angioplasty ranged between 5-93% and in 6 cardiac networks less than 50% of their patients received primary angioplasty.

Fig 13. Use of secondary prevention medication.

All heart attacks, [transfers, deaths, contraindicated and patient refused are all excluded.]

Fig 13. Use of secondary prevention medication for myocardial infarction

Aspirin

Statin

Beta blocker

ACEI/ARB

Clopidogrel/thienopyridine inhibitors

2003-4 2004-5 2005-6 2006-7 2007-8 2008-9 2010-112009-1050

55

60

65

70

75%

80

85

90

95

100

25. http://guidance.nice.org.uk/CG48/QuickRefGuide/pdf/English

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22 MINAP How the NHS cares for patients with heart attack

National audit lends itself to the demonstration of variation in practice and outcome. The MINAP Public Reports repeatedly have shown this. Variation in practice is an expected phenomenon in healthcare, and there is a difficulty determining whether such variation is simply the ‘play of chance’ or whether it represents some systematic difference in performance. One of the methods being considered, to more clearly describe such variation is the funnel plot.

Funnel plots were first introduced26 27 in 1984 as a means of estimating bias in meta-analysis of clinical trials that contained varying numbers of subjects. In essence, each individual value is compared to the overall mean, and the control limits around that mean diminish as the number of subjects (or admissions) increases (as one would expect). A value which falls outside the ‘funnel’ is considered an outlier, and can represent abnormally high performance as well as abnormally low performance.

The width of the control limits is determined by the statistical significance level from which they are calculated. To diminish the risk of a false positive ‘outlier’ we use +/- 3 standard deviations, which means that the chance of an outlier happening ‘accidentally’ (i.e. by random chance) is no more than 0.4%.

9. Care for patients with non ST elevation infarction

For some years the focus of heart attack management has been upon the early provision of reperfusion treatment to those patients presenting with STEMI, and MINAP Public Reports have reflected this. Patients with nSTEMI have a lower early risk of death and perhaps because they do not require very rapid emergency treatment (reperfusion therapy), they are not always admitted to CCUs, nor always cared for by cardiologists. However, specialist involvement is important, and it is recognised that performance of angiography and coronary intervention within the first 4 days is an important facet of treatment for the majority. Ideally admission should be to a cardiac facility where nursing staff have a cardiac background, and there is easy access to cardiological expertise.

As mentioned above the numbers of nSTEMI reported in MINAP are incomplete, and in particular it is likely that patients who are not admitted to a CCU are omitted. Failure to enter all cases often reflects a lack

26. RJ Light, DB Pillemer. Summing up: The Science of Reviewing Research. Cambridge, Massachusetts.: Harvard University Press. 1984. ISBN 0674854314.

27. Egger M, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. British Medical Journal 1997; 315:629–634.

Fig 13. Use of secondary prevention medication for myocardial infarction

UCL 99.6% LCL 99.6%

GMCN

South WalesNorth Wales

West Yorkshire

SE London

CTN60%National Average

100 200 300 400 500 6000

10

20

30

40

50%

60

70

80

90

100

Admissions

Fig 13. Use of secondary prevention medication for myocardial infarction

North EnglandCMCN

NEYNLLancs/Cumbria

NE London

NW LondonSE London

Kent

Peninsula

West Yorkshire

200 400 600 800 1000 120040

50

60

%70

80

90

100

PeninsulaPeninsula

NEYNLNEYNLLancs/Cumbria

Admissions

UCL 99.6% LCL 99.6% Avg of CTB150National Average

Fig 13. Use of secondary prevention medication for myocardial infarction

North England

SW LondonKent

Cov Warks

NC London West Yorkshire

50 100 150 200 250 300 350 400 450

40

30

20

10

0

60

50

70

80

%

Admissions

90100

UCL 99.6% LCL 99.6% Avg of CTB150National Average

Fig 14. Call-to-needle within 60 minutes by cardiac network

Fig 15. Call-to-balloon within 150 minutes for direct admissions only by cardiac network

Fig 16. Call-to-balloon within 150 minutes for inter-hospital transfers by cardiac network

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23MINAP Tenth Public Report 2011

of resources, but it remains the case that the quality of care for patients not entered into MINAP remains unknown. In addition the variable nature of recording nSTEMI between hospitals may distort some analyses.

Table 8 shows the percentage of nSTEMI patients that were admitted to a cardiac unit or ward and the percentage of nSTEMI patients seen by a cardiologist or member of their team, by hospital, in 2009/10 and 2010/11. The same analyses for hospitals in Wales and Belfast are shown in Table 9. In England in 2010/11, 50% of nSTEMI patients were admitted to a cardiac unit or ward compared to 47% in 2009/10. In Wales 59% of patients were admitted to a cardiac unit or ward compared to 55% in 2009/10. In the Belfast hospitals, 81% of patients were admitted to a cardiac unit or ward compared to 82% in 2009/10.

In England in 2010/11, 91% of nSTEMI patients were seen by a cardiologist or member of their team compared to 89% in 2009/10. In Wales 84% of nSTEMI patients were seen by a cardiologist or member of their team compared to 74% in 2009/10. In the Belfast hospitals 99% of nSTEMI patients were seen by a cardiologist or member of their team compared to 100% in 2009/10.

The frequency with which patients are referred for angiography for nSTEMI also continues to increase, [Fig 17]. Due to a database fault that could not be rectified in time for publication, this analysis excludes some data from hospitals using the web application. The national analyses are based on the remaining hospitals, and may be subject to revision in 2012. Individual hospital data are not presented for 2010/11. In 2009/10, 63% of nSTEMI patients in England were referred for angiography after nSTEMI, and 70% in 2010/11. In Wales 74% were referred in 2009/10, and 81% in 2010/11. In Belfast 82% were referred in 2009/10 and 85% in 2010/11.

10. Change in mortality of heart attack patients

Mortality data are obtained from the NHS Central Register by CCAD. The percentage of patients having STEMI and nSTEMI who die within 30 days of admission to hospital has fallen annually from 2003/4-2010/11 [Figs 18, 19].

Fig 17. Use of angiography for patients with a diagnosis of non ST segment elevation MI. [Inappropriate of refused (small numbers) excluded. All age groups.]

0

10

20

30

50

60

70

80

40%

2003-4 2010-112004-5 2005-6 2006-7 2007-8 2008-9 2009-10

35.1

44.847.8 49.6 51.6

54.4

64.1

71

Fig 17. Use of angiography for patients with a diagnosis of non ST segment elevation MI.

Inappropriate or refused (small numbers) excluded. All age groups.

Fig 19.

14

13

12

11

10

9

8

7

6

%

Financial year

2004-52003-4 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

Fig 19. 30 day mortality (with 95% confidence limits) for nSTEMI.

The data for 2010/11 are provisional and may be revised.

Fig 18.

14

13

12

11

10

9

8

7

%

Financial year

2004-52003-4 2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

Fig 18. 30 day mortality, (with 95% confidence limits) for all patients having STEMI.

The data for 2010/11 are provisional and may be revised.

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table

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Page 25: myocardial ischaemia national audit project minap · The Myocardial Ischaemia National Audit Project (MINAP) is a national clinical audit of the management of heart attack. It supplies

25MINAP

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Page 26: myocardial ischaemia national audit project minap · The Myocardial Ischaemia National Audit Project (MINAP) is a national clinical audit of the management of heart attack. It supplies

26 MINAP

27MINAP

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26

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27MINAP

Sund

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Page 28: myocardial ischaemia national audit project minap · The Myocardial Ischaemia National Audit Project (MINAP) is a national clinical audit of the management of heart attack. It supplies

Thro

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28 MINAP

29MINAP

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29MINAP

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30 MINAP

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31MINAP

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Thro

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Year

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%

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32 MINAP

33MINAP

Que

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83%

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33MINAP

Salis

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Step

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Thro

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34 MINAP

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34

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“MIN

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dat

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37MINAP

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3 th

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36 MINAP

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table

4 am

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Pri

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37MINAP

MIN

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table

5 se

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on m

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38 MINAP

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MIN

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Rep

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als

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39MINAP

Bri

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150

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Pat

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40 MINAP

41MINAP

Dor

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41MINAP

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Rep

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Pat

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42 MINAP

43MINAP

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43MINAP

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.indd

43

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Pat

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44 MINAP

45MINAP

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45MINAP

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Pat

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46 MINAP

47MINAP

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47MINAP

Traf

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Pat

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48 MINAP

49

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49MINAP

“The

cha

nces

of s

urvi

val a

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rt a

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k

have

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n so

that

the

outc

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in th

is c

ount

ry

mat

ch th

e be

st in

the

wor

ld.”

Pro

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or S

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Nat

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r H

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Dis

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table

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50 MINAP

51MINAP

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51MINAP

Wes

t Wal

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amar

then

1112

1211

10

With

ybus

h G

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al H

ospi

tal,

Hav

erfo

rdw

est

100%

5996%

4793%

5796%

5194%

49

Ysby

ty G

wyn

edd

, Ban

gor

100%

3197%

3097%

3193%

30100%

31

Bel

fast

ave

rage

99%

483

99%

459

99%

480

97%

408

98%

459

Bel

fast

City

Hos

pita

l99%

149

99%

141

98%

151

91%

121

98%

141

Mat

er In

firm

orum

Hos

pita

l100%

9998%

95100%

9998%

91100%

97

Roy

al V

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ria

Hos

pita

l99%

235

100%

223

100%

230

100%

196

97%

221

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table

7 ca

rdia

c ne

twor

ks i

n en

glan

d an

d wa

les

52 MINAP

53MINAP

Thro

mbo

lytic

tr

eatm

ent w

ithin

60

min

s of

ca

lling

for

help

Pri

mar

y an

giop

last

y w

ithin

150

min

s of

cal

ling

for

help

Pat

ient

s ha

ving

pr

e-ho

spita

l ly

sis

Pat

ient

s ha

ving

in

-hos

pita

l lys

isP

atie

nts

havi

ng p

rim

ary

angi

opla

sty

Pat

ient

s ha

ving

no

rep

erfu

sion

tr

eatm

ent

Thro

mbo

lytic

tr

eatm

ent w

ithin

60

min

s of

ca

lling

for

help

Pri

mar

y an

giop

last

y w

ithin

150

min

s of

cal

ling

for

help

Pat

ient

s ha

ving

pr

e-ho

spita

l ly

sis

Pat

ient

s ha

ving

in

-hos

pita

l lys

isP

atie

nts

havi

ng p

rim

ary

angi

opla

sty

Pat

ient

s ha

ving

no

rep

erfu

sion

tr

eatm

ent

Year

20

09/1

020

10/1

1

%n

%n

%n

%n

%n

%n

%n

%n

%n

%n

%n

%n

Engl

and

nati

onal

ave

rage

69%

3458

1001280%

1646

6%5183

20%

1250549%

6374

25%

68%

1723

1286881%

848

3%2450

10%

1581762%

6217

25%

Angl

ia C

ardi

ac N

etw

ork

69%

84725

80%

100

7%76

6%814

61%

348

26%

80%

20802

81%

463%

171%

897

67%

379

28%

Avon

, Glo

uces

ters

hire

, Wilt

shir

e &

So

mer

set C

ardi

ac &

Str

oke

Net

wor

k70%

222

452

77%

137

11%

280

22%

507

40%

329

26%

53%

38832

81%

181%

615%

917

69%

334

25%

Bed

ford

shir

e &

Her

tfor

dshi

re C

ardi

ac

Net

wor

k10

130

91%

319

152

56%

9736%

1111

91%

04

135

61%

8137%

Bir

min

gham

, San

dwel

l & S

olih

ull

Car

diac

Net

wor

k4

484

77%

118

638

80%

139

17%

4486

84%

17

680

81%

155

18%

Bla

ck C

ount

ry C

ardi

ac N

etw

ork

3369

80%

102

476

77%

131

21%

2386

81%

73

537

83%

100

15%

Car

diac

& S

trok

e N

etw

orks

in C

umbr

ia

& L

anca

shir

e70%

264

144

88%

7810%

338

42%

195

24%

186

23%

73%

206

140

95%

568%

274

41%

173

26%

164

25%

Che

shir

e &

Mer

seys

ide

Car

diac

N

etw

ork

76%

190

387

84%

262%

412

31%

413

31%

499

37%

82%

55601

82%

1989

8%715

62%

326

28%

Cov

entr

y &

War

wic

kshi

re C

ardi

ac

Net

wor

k2

274

90%

21

368

92%

307%

4304

85%

07

370

93%

205%

Dor

set C

ardi

ac &

Str

oke

Net

wor

k70%

113

9795%

4413%

163

47%

120

34%

226%

70%

7793

91%

4315%

102

37%

106

38%

2810%

East

Mid

land

s C

ardi

ac N

etw

ork

68%

613

348

75%

343

20%

628

36%

426

24%

345

20%

70%

429

595

87%

245

13%

462

24%

728

38%

468

25%

Esse

x C

ardi

ac N

etw

ork

87%

126

347

85%

110

13%

153

18%

382

44%

226

26%

72%

29589

84%

435%

71%

588

64%

278

30%

Gre

ater

Man

ches

ter

& C

hesh

ire

Car

diac

Net

wor

k70%

328

399

77%

322%

600

34%

628

36%

492

28%

74%

245

492

74%

262%

395

24%

679

41%

540

33%

Her

efor

dshi

re &

Wor

cest

ersh

ire

Car

diac

Net

wor

k57%

141

067

18%

210

56%

21%

9425%

72%

115

1164

21%

183

60%

145%

4515%

Ken

t Car

diac

Net

wor

k82%

200

1106

14%

458

59%

51%

209

27%

13441

75%

20%

537%

555

69%

196

24%

Nor

th &

Eas

t Yor

kshi

re &

Nor

ther

n Li

ncol

nshi

re C

ardi

ac N

etw

ork

59%

105

125

75%

9513%

157

22%

155

22%

308

43%

57%

21300

89%

436%

548%

370

52%

249

35%

Nor

th C

entr

al L

ondo

n C

HD

Net

wor

k1

272

76%

15

357

83%

6515%

2310

81%

24

360

81%

7717%

Nor

th E

ast L

ondo

n C

ardi

ac N

etw

ork

1500

56%

04

554

86%

8513%

2418

80%

05

557

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6711%

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53MINAP

Nor

th o

f Eng

land

Car

diov

ascu

lar

Net

wor

k52%

841253

85%

271%

141

6%1410

64%

620

28%

71%

991150

89%

402%

137

7%1349

69%

437

22%

Nor

th T

rent

Net

wor

k of

Car

diac

Car

e82%

170

274

70%

105

10%

211

20%

371

35%

383

36%

14581

75%

101%

253%

570

60%

342

36%

Nor

th W

est L

ondo

n C

HD

Net

wor

k3

709

81%

09

829

84%

145

15%

2666

80%

09

950

78%

265

22%

Pen

insu

la C

ardi

ac M

anag

ed C

linic

al

Net

wor

k69%

205

294

84%

141

13%

216

20%

455

42%

260

24%

66%

121

380

82%

798%

124

13%

498

52%

264

27%

Shro

pshi

re &

Sta

fford

shir

e C

ardi

ac

Net

wor

k66%

87240

84%

365%

153

23%

353

53%

129

19%

8282

73%

122%

397%

410

71%

115

20%

Sout

h C

entr

al V

ascu

lar

Net

wor

k54%

252

658

85%

604%

352

22%

835

52%

365

23%

55%

76956

85%

342%

106

6%1189

72%

323

20%

Sout

h Ea

st L

ondo

n C

ardi

ac N

etw

ork

3339

60%

18

414

82%

8216%

0%26

359

70%

24

491

86%

7413%

Sout

h W

est L

ondo

n C

ardi

ac N

etw

ork

1278

87%

04

319

80%

7719%

0306

90%

11

346

89%

4211%

Surr

ey H

eart

& S

trok

e N

etw

ork

80%

8294

88%

469%

234

44%

134

25%

119

22%

83%

42203

85%

194%

124

23%

255

48%

135

25%

Suss

ex H

eart

Net

wor

k79%

120

158

77%

639%

242

36%

194

29%

181

27%

69%

49281

83%

264%

110

16%

346

50%

211

30%

Wes

t Yor

kshi

re C

ardi

ac N

etw

ork

25%

44661

80%

1289

6%999

66%

408

27%

13%

23793

64%

1044

3%1032

65%

502

32%

Wal

es n

atio

nal a

vera

ge55%

484

180

76%

239

18%

608

45%

232

17%

276

20%

53%

402

225

75%

212

17%

476

38%

301

24%

274

22%

Nor

th W

ales

Car

diac

Net

wor

k51%

156

271

20%

192

53%

493

26%

52%

148

372

21%

170

50%

689

26%

Sout

h W

ales

Car

diac

Net

wor

k57%

328

178

77%

168

17%

416

42%

228

23%

183

18%

54%

254

222

76%

140

15%

306

33%

295

32%

185

20%

Bel

fast

ave

rage

48%

3147

77%

137%

4123%

7845%

4325%

0124

90%

00%

10%

173

70%

7430%

99%

MIN

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table

8 ca

re o

f pa

tien

ts w

ith

non

st e

leva

tion infarction(nSTEMI) in england

nSTE

MI p

atie

nts

adm

itted

to

card

iac

unit

or w

ard

nSTE

MI p

atie

nts

seen

by

a ca

rdio

logi

st o

r m

embe

r of

team

nSTE

MI p

atie

nts

adm

itted

to

card

iac

unit

or w

ard

nSTE

MI p

atie

nts

seen

by

a ca

rdio

logi

st o

r m

embe

r of

team

Year

2009

/10

2010

/11

n%

n%

n %

n %

54 MINAP

55MINAP

Engl

and

nati

onal

ave

rage

21843

47%

41269

89%

23286

50%

42555

91%

Adde

nbro

oke'

s H

ospi

tal,

Cam

brid

ge150

53%

282

100%

179

68%

263

100%

Aire

dale

Gen

eral

Hos

pita

l, St

eeto

n75

50%

122

81%

8453%

155

98%

Arro

we

Par

k H

ospi

tal,

Wir

ral

263

65%

352

87%

269

66%

341

83%

Bar

net G

ener

al H

ospi

tal,

Bar

net

3141%

7296%

2346%

50100%

Bar

nsle

y D

istr

ict G

ener

al H

ospi

tal,

Bar

nsle

y187

89%

190

90%

127

73%

153

88%

Bar

ts &

the

Lond

on, L

ondo

n85

99%

86100%

433

98%

440

100%

Bas

ildon

Hos

pita

l, B

asild

on229

93%

240

98%

356

97%

364

99%

Bas

ings

toke

& N

orth

Ham

pshi

re H

ospi

tal,

Bas

ings

toke

6064%

3537%

4542%

107

99%

Bas

setl

aw D

istr

ict G

ener

al H

ospi

tal,

Not

tingh

am168

79%

180

85%

181

72%

212

84%

Bed

ford

Hos

pita

l, B

edfo

rd50

47%

102

95%

5355%

9599%

Bir

min

gham

Hea

rtla

nds

Hos

pita

l, B

irm

ingh

am156

67%

233

100%

189

61%

308

99%

Bra

dfor

d R

oyal

Infir

mar

y, B

radf

ord

119

32%

369

99%

178

46%

381

99%

Bri

stol

Roy

al In

firm

ary,

Bri

stol

112

55%

203

100%

101

51%

193

97%

Bro

omfie

ld H

ospi

tal,

Che

lmsf

ord

7923%

281

81%

7319%

338

88%

It is

reco

gnis

ed t

hat

not

all n

STEM

I are

ent

ered

into

MIN

AP.

A nu

mbe

r of h

ospi

tals

repo

rt a

lack

of r

esou

rces

to

colle

ct d

ata

on n

STEM

I, an

d m

ore

gene

rally

tho

se p

atie

nts

not

adm

itte

d to

a c

ardi

ac

unit

are

less

like

ly t

o be

ent

ered

. Thu

s th

e pe

rcen

tage

s re

port

ed b

elow

do

not

take

into

acc

ount

eve

ry p

atie

nt a

dmit

ted

to h

ospi

tal w

ith

nSTE

MI.

In a

ddit

ion

som

e ho

spit

als

in t

he L

ondo

n ar

ea t

hat

have

no

nSTE

MI a

re p

arti

cipa

ting

in a

pro

ject

for d

irec

t ad

mis

sion

of t

hese

pat

ient

s to

a h

eart

att

ack

cent

re in

a m

anne

r sim

ilar t

o th

at fo

r pri

mar

y an

giop

last

y fo

r STE

MI.

MIN

AP P

ublic

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55MINAP

Cal

derd

ale

Roy

al H

ospi

tal,

Hal

ifax

126

43%

254

86%

134

39%

291

85%

Cas

tle H

ill H

ospi

tal,

Hul

l317

94%

333

99%

383

90%

420

98%

Cen

tral

Mid

dles

ex H

ospi

tal,

Lond

on4

117

97%

5111

98%

Cha

ring

Cro

ss H

ospi

tal,

Lond

on8

43100%

540

100%

Cha

se F

arm

Hos

pita

l, En

field

118

99%

119

100%

155

100%

155

100%

Che

lsea

& W

estm

inis

ter

Hos

pita

l, Lo

ndon

2328%

82100%

982

100%

Che

ltenh

am G

ener

al H

ospi

tal,

Che

ltenh

am45

38%

109

93%

4031%

113

88%

Che

ster

field

Roy

al, C

hest

erfie

ld155

48%

295

91%

110

48%

216

95%

Cho

rley

Hos

pita

l, C

horl

ey7

221

25%

6781%

City

Hos

pita

l, B

irm

ingh

am39

20%

192

100%

3924%

163

100%

Col

ches

ter

Gen

eral

Hos

pita

l, C

olch

este

r300

57%

430

82%

220

56%

342

87%

Con

ques

t Hos

pita

l, St

Leo

nard

s on

Sea

177

86%

204

100%

163

72%

201

89%

Cou

ntes

s of

Che

ster

Hos

pita

l, C

hest

er167

41%

382

94%

126

29%

386

89%

Cou

nty

Hos

pita

l Her

efor

d, H

eref

ord

4637%

8366%

4029%

103

74%

Cou

nty

Hos

pita

l Lou

th, L

outh

2292%

170

0

Cum

berl

and

Infir

mar

y, C

arlis

le86

27%

283

89%

7630%

225

89%

Dar

ent V

alle

y H

ospi

tal,

Dar

tfor

d170

82%

203

98%

253

80%

311

98%

Dar

lingt

on M

emor

ial H

ospi

tal,

Dar

lingt

on64

27%

211

89%

5224%

193

91%

Der

rifo

rd H

ospi

tal,

Ply

mou

th3

311

3359%

Dew

sbur

y D

istr

ict H

ospi

tal,

Dew

sbur

y117

49%

165

69%

102

38%

217

82%

Dia

na, P

rinc

ess

of W

ales

Hos

pita

l, G

rim

sby

151

58%

250

96%

161

65%

229

93%

Don

cast

er R

oyal

Infir

mar

y, D

onca

ster

6927%

224

87%

9031%

268

92%

MIN

AP P

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Rep

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56 MINAP

57MINAP

nSTE

MI p

atie

nts

adm

itted

to

card

iac

unit

or w

ard

nSTE

MI p

atie

nts

seen

by

a ca

rdio

logi

st o

r m

embe

r of

team

nSTE

MI p

atie

nts

adm

itted

to

card

iac

unit

or w

ard

nSTE

MI p

atie

nts

seen

by

a ca

rdio

logi

st o

r m

embe

r of

team

Year

2009

/10

2010

/11

n%

n%

n %

n %

Dor

set C

ount

y H

ospi

tal,

Dor

ches

ter

9649%

186

94%

9751%

177

94%

Ealin

g H

ospi

tal,

Sout

hall

4291%

46100%

7091%

7699%

East

Sur

rey

Hos

pita

l, R

edhi

ll136

49%

9434%

177

46%

315

83%

East

bour

ne D

GH

, Eas

tbou

rne

157

72%

178

81%

170

81%

193

92%

Epso

m H

ospi

tal,

Epso

m165

84%

197

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121

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143

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Fair

field

Gen

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Hos

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l, B

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3625%

138

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3623%

151

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Free

man

Hos

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741

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776

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786

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Fren

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Hos

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118

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137

41%

263

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Hos

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101

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ley

Par

k H

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146

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6449%

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144

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185

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Roy

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115

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Gen

eral

Hos

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l, Su

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278

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, Gra

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m100

34%

284

98%

8243%

191

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Ham

mer

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Hos

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l, Lo

ndon

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148

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101

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148

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Har

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tal

206

98%

207

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136

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119

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Har

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294

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288

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57MINAP

Hex

ham

Gen

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292

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Hud

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Roy

al In

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129

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Jam

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Uni

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ity H

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Mid

dles

boro

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190

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Jam

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Yar

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203

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172

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Ken

t & C

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Can

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Ken

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Kin

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s G

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r R

oyal

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mar

y, L

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98%

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44%

344

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132

33%

374

94%

Linc

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286

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58 MINAP

59MINAP

nSTE

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Year

2009

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n%

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List

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Stev

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Live

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Mac

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7123%

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196

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Mai

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Man

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Roy

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Man

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May

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way

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Man

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59MINAP

Nor

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60 MINAP

61MINAP

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Year

2009

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n%

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212

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252

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203

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61MINAP

Roy

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62 MINAP

63MINAP

nSTE

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Year

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n%

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63MINAP

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64 MINAP

nSTE

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“ D

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table

9 ca

re o

f pa

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ts w

ith

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66 MINAP

67MINAP

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67MINAP

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68 MINAP How the NHS cares for patients with heart attack

12. Difference in performance in England and Wales

In the last three reports we have commented on differences in performance between Wales and England. These differences have been felt to reflect the largely rural nature of Wales, and the effect this has had on the configuration of cardiac services – with an emphasis on the delivery of pre-hospital thrombolytic treatment. The move from thrombolytic therapy to primary angioplasty has occurred more slowly in Wales than in most (but not all) of the English regions. So, it is still the case that in Wales the majority (70%) of patients receiving reperfusion therapy for STEMI receive thrombolytic therapy rather than primary angioplasty – 53% within 60 minutes of calling for help. In keeping with best practice, most (81%) of those who receive thrombolytic treatment for STEMI, or have no reperfusion treatment at all, subsequently undergo coronary angiography.

Two cardiac centres (in Swansea and Cardiff) are now able to offer primary angioplasty to their local populations, with continuous availability, and there has been a 29% increase in the number of patients so treated. 75% of these patients were treated within 150 minutes of calling for help. The Welsh cardiac networks are working closely with the Welsh Ambulance Service and local hospitals to develop management strategies that promote the use of primary angioplasty. This will include an increase the number of centres providing continuously available primary angioplasty and the number of patients transported directly to these centres. These strategies will be put in place over the next 12 months.

Importantly, a review of 30-day mortality rate after STEMI and nSTEMI for both England and Wales is presented in Fig 20 and Fig 21. It should be noted that these data are unadjusted for known predictors of outcome, such as age and co-morbidity and so formal statistical analysis has not been performed. Reassuringly the figures show falling mortality rates in both countries and the mean 30 day mortality for STEMI is now virtually identical for England and Wales.

It is of continuing concern that, as shown within the relevant tables, some of the Welsh hospitals are not submitting data on the management they provide to patients with nSTEMI (the most common type of acute coronary syndrome). This weakens the capacity of the National Audit to assure good quality care is being provided in these hospitals. Fig 21 shows 30 day mortality following nSTEMI, though obviously this only reflects those patients managed in hospitals that enter data. For that group mortality rates have continued to fall and are similar to results from England.

The use of secondary preventive medication remains good and equivalent to English hospitals.

Fig 19.

14

15

16

17

18

13

12

11

10

9

8

7

6

%

Financial year

2004-52003-4

Wales

2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

England

Fig 19.

15

5

%

Financial year

6

7

8

9

14

13

12

11

10

2004-52003-4

Wales

2005-6 2006-7 2007-8 2008-9 2009-10 2010-11

England

Fig 20. 30 day mortality for STEMI (mean and 95% confidence intervals) for England and Wales.

All age groups, and all treatment modalities

Fig 21. 30 day mortality for nSTEMI (mean and 95% confidence intervals) for England and Wales.

The wider confidence limits for Wales reflect the smaller numbers recorded

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69MINAP Tenth Public Report 2011

Implementing a primary PCI service in Oxford

Oxford Heart Centre

Jan Keenan, Consultant Nurse Dr Robin Choudhury, Senior Research Fellow

The Oxford Heart Centre began developing a PPCI service in late 2006. Like other areas of the UK we began by introducing a daytime service, rolling out to develop a 24/7 service from the summer of 2007. With the opening of the new Heart Centre in October 2009 direct access to the angiography suite became possible, and further developments came in 2009/10 with the roll-out of a regional service to Buckinghamshire and parts of Northants and Wiltshire. Chart one shows the increase in activity over the three years to date, and it is interesting to reflect on the continuing achievements for people in our care.

To introduce a new service and roll this out to a 24/7 service places demands on the clinical teams to develop new ways of working across the patient pathway, and to give up conventional professional boundaries and to use and develop skills that best serve patient needs, at the point of presentation, often in an unfamiliar environment. We have seen our ambulance crews and CCU nursing team supporting patients and medical colleagues in the lab, focusing on more active management of the acute care team. Importantly we were able to use MINAP data to see developments over time as we focused our energies on improving team working and availability to see a significant reduction over time in door to balloon time (see chart two).

Alongside a rollout of PPCI across the region however, come longer transit times and to an extent this is understandable. However significant variation in call to door times for people arriving from the same areas, again seen within MINAP data, offers further opportunities for development in terms of transit time to hospital and, using the data, we are able to work closely with our ambulance service colleagues to expedite the patient pathway. Importantly however as also shown in chart two, we are also able to continue to progress important developments in the in-hospital pathway that allow us to continue to reduce the call to balloon time overall, particularly by making significant reductions in door to balloon time. In terms of national drivers in addition to this, we are able to examine trends in length of hospital stay (see chart three).

MINAP data is a significant tool supporting service development, identifying areas for current and future work. Achieving national standards offers no room for complacency in an era in which we know that the impact of early treatment means better survival, and whilst MINAP data demonstrates the achievement of national standards, for those interested in improving the lot of our patients it shows us where to focus our efforts.

Fig 9. Percentage of patients with an admission diagnosis of STEMI having primary angioplasty within 90 minutes of arrival in hospital in E&W.

0

50

100

150

200

250

300

350

400

2008-9 2009-10 2010-11

0

20

40

60

80

100

120

2008-9 2009-10 2010-11

Call-to-door time

Door-to-balloon time

Call-to-balloon time

Mins

part three: case studies

How hospitals, ambulance services and cardiac networks have used MINAP data to improve patient care.

Chart one: Increase in total number of PPCI cases since 2008

Chart two: Increase in call-to-door time with increasing geo-graphical spread with concurrent decrease in door to balloon time with pathway development

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70 MINAP How the NHS cares for patients with heart attack

MINAP, promoting prevention.

The Heart Hospital, University College London Hospitals Foundation Trust

Dr Costas O’Mahoney, Cardiology

Dr Clare Dollery, Clinical Director.

The Heart Hospital (University College Hospitals NHS trust) is a heart attack centre with an established 24 hour primary PCI service. Monthly multidisciplinary MINAP meetings, with the participation of cardiologists, nurses, physiologists, London Ambulance Service representatives, Accident and Emergency department staff and other support personnel scrutinise challenging cases in a constructive and transparent manner. Feedback is given to the primary PCI team and other stakeholders to maintain and improve the quality of the service. Analysis of data provided by MINAP have led to a number of interventions over the years which helped reduce the time to reperfusion (MINAP public report 2009).

Even though shortening the time to reperfusion remains a central aim of our service, review of routinely collected MINAP data has also been used in the local implementation of NICE guidelines on secondary prevention interventions in post MI patients. We use our monthly MINAP meetings to review

referrals to cardiac rehabilitation services, and the use of anti-platelet agents, statins, angiotensin converting enzyme inhibitors/angiotensin receptor blockers, beta-blockers in patients post primary PCI. The interventional cardiology integrated care pathway was modified to include a checklist of secondary prevention interventions for the physicians responsible for discharging the patients (see figure below). A weekly feedback project also included discussion of these metrics in a multidisciplinary coronary care unit hand over. We also continue this surveillance after discharge via a quality scorecard owned by our heart failure team.

MINAP has thus helped shape the long term as well as the short term management of patients undergoing primary PCI at our unit.

0

1

2

3

4

5

6

2008-9 2009-10 2010-11

Mean length of stay

Median length of stay

Chart three: Whilst median hospital stay has remained relatively constant, there is a downward trend in mean length of stay

% o

f pat

ient

s

Year

Cardiac Rehab ACEi beta-blocker

Statin Aspirin Clopidogrel

2003

60

80

100

40

20

02004 2005 2006 2007 2008 2009 2010

Patients discharged on secondary prevention medication

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71MINAP Tenth Public Report 2011

Establishing a primary angioplasty service in Lincolnshire

United Lincolnshire Hospitals NHS Trust

Dr David O’Brien, Interventional Cardiologist,

Alun Roebuck, Consultant Nurse Critical and Acute Care

A review by the East Midlands Strategic Health Authority considered the clinical case for change in primary reperfusion practice and established that a 24/7 primary angioplasty service must be provided within Lincolnshire; with the provision of a new heart attack centre based at Lincoln County Hospital. Without such service, Lincolnshire would remain the only region within England without a primary angioplasty service for its population. The decision and justifications to base such a service in Lincolnshire were largely based on assessment of the number of patients presenting with both

ST elevation and non-ST elevation myocardial infarction as recorded in MINAP.

The Lincolnshire Heart Attack Centre started a primary angioplasty service in December 2010. This new service is currently limited to a restricted geography on an 8 a.m. until 6 p.m. basis, five days a week. In order to realise our aspiration to provide the service 24/7 and county-wide, plans are currently underway to build a second cardiac catheter laboratory, a cardiac short stay unit and a larger recovery ward. These plans aim to deliver the service to all eligible patients within Lincolnshire in 2012.

This huge change in how cardiac care is delivered has only been achievable by team work between United Lincolnshire Hospitals NHS Trust, Lincolnshire Primary Care Trust, East Midlands Ambulance Service and the East Midlands Heart and Stoke Network. Initial feedback from patients and relatives needing to access this service has been overwhelmingly positive and we all look forward to rolling out the service fully next year.

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72 MINAP How the NHS cares for patients with heart attack

Improvement in call-balloon times at the London Chest Hospital, Barts and the London NHS Trust

London Chest Hospital, Barts and the London NHS Trust

Eileen Ferguson, Heart attack centre coordinator

Ajay Jain, HAC lead clinician

Andrew Wragg, Clinical Effectiveness Lead

Anthony Mathur, Cardiology lead clinician

Charles Knight, CAU director

Andrew Archbold, North East London Cardiac Network lead

London Ambulance Service NHS Trust

Mark Whitbread, Clinical Practice Manager/ Cardiac Lead

Joanne Smith, Clinical Advisor to the Medical Director

The London Chest Hospital is the heart attack centre for North East London cardiac network and serves a large population spread over a large geographical area and receives referrals from 6 district general hospitals. This referral base posed significant logistical problems to get patients with STEMI treated in a timely manner. The MINAP and BCIS audits demonstrated that we had to evolve our service to achieve the important call-to-balloon standard (CTB) and improve the outcome of our patients with STEMI.

In 2010/11 Barts and the London NHS Trust was successful in achieving the national standard for call-to-balloon times and this was based on using MINAP/ BCIS data to drive a quality improvement program.

We initially invested in improving the quality and reporting of our audit data. The trust and local cardiac network invested significant manpower resources. This included a Heart Attack Centre (HAC) coordinator to manage the whole HAC pathway, a dedicated HAC team and investment in data analysis. This resulted in high quality audit data that could be analysed in real time and support a process of formal weekly reporting. Once this audit process was established we could then focus on improving the clinical pathway.

The first challenge was to increase the direct transfer rate as patients who came via the network A&Es rarely achieved the call-to-balloon national standard. Armed with accurate audit data of performance, the HAC team set about working in collaboration with the London Ambulance Service (LAS) and A&E departments. This was based around sharing audit data, education using case by case feedback and formal study days. A weekly HAC meeting was established with LAS where audit data was studied in great detail.

Simultaneously we worked on our internal pathway to improve our door-to-balloon times. Producing weekly reports from MINAP helped focus organisational and individual attention on performance. These weekly reports demonstrated the immediate benefit from locally implemented changes and the team members were encouraged by seeing the real time audit result. Changes that had positive effects included a policy of going direct to lab 24 hours a day (instead of going to CCU out of hours), employing a dedicated nurse to meet all heart attack patients and setting an internal door-to-balloon national standard of 60 minutes (the national standard being 90 minutes). To focus the team on the clock- every individual breach was investigated.

These improvements led to a marked transformation in our call-to-balloon performance for 2010-2011. 80% of STEMI patients now receive reperfusion within 150 minutes from call for help, a great achievement in view of the geographical challenges of North East Thames. This improvement has been associated with a reduction of mortality of our heart attack patients according to data from Dr Foster Intelligence.

MINAP and BCIS proved great tools to drive these changes but it was recognition by our Trust and local Network that service improvements of this kind do require significant investment to be successful, coupled with a lot of hard work by the entire HAC team.

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73MINAP Tenth Public Report 2011

Using data from MINAP to model a PPCI service in the Cheshire and Merseyside network area

Cheshire and Merseyside Cardiac and Stroke Network

Ruth Grainger, Clinical Information Analyst

Cheshire and Merseyside is now one of the largest Cardiac and Stroke Networks in England and covers a geographical area with a population of approximately 2.3 million. MINAP has been used in our network area for many years to audit and improve reperfusion times and numbers of those receiving the appropriate medication.

We have recently improved our services for patients who have a heart attack known as a ST elevation Myocardial Infarction (STEMI) by introducing a primary percutaneous coronary intervention (PPCI ) service. PPCI is the preferred treatment if it can be provided promptly, providing faster perfusion and better outcomes for patients. Whilst thrombolysis treatment offers benefits to patients suffering from a STEMI, PPCI is a far more effective and safer option, with the added benefits of shorter recovery times and reduced morbidity.

In 2008, working with management consultants, Cap Gemini, we used MINAP data to demonstrate how a new PPCI service would look. One of the main aims when setting up the service was to quantify the impact on current services. It was necessary to know how many patients would be accessing this service and by what method. In order to do this an extract of data was downloaded from MINAP to establish firstly, how many STEMIs would be expected at the tertiary centre, Liverpool Heart and Chest Hospital (LHCH), secondly, were there any trends in day/time of presentation and thirdly, what impact would the new service have on the North West Ambulance Service (NWAS). The intended outcome was to understand the balance of risks and benefits of service change.

Comparing with previous years’ data it was concluded that the numbers, channels and locations of STEMI presentations would continue to be similar in future years and that there would be no expected differences in ambulance handover and turnaround times. All data sources and assumptions used in the model were agreed during a series of meetings between LHCH, NWAS and the network.

Using both MINAP data and modelled ambulance journey times it was possible to establish an average extra journey time for each patient. This was then used to gauge both worst case and best case scenarios, and combined with financial information provided by NWAS, to establish how many extra ambulance shifts NWAS would need, how much this would cost, and using postcode information where to locate the extra ambulances.

Funds were secured and it was agreed that PPCI should be rolled out in two phases. Phase one would cover the three hospitals nearest to LHCH (Aintree, Whiston and Royal Liverpool) and was implemented on 26th January 2009. Phase two was then rolled out to the rest of the Cheshire and Merseyside area (Southport, Warrington, Wirral and Countess of Chester) on 1st June 2010.

MINAP data is still used to audit and improve services for STEMI patients. Staff from local district general hospitals, NWAS, LHCH and the network meet regularly as part of the PPCI monitoring group to discuss any local issues and suggest areas for improvement.

Since the full roll-out we have seen patient outcomes improve greatly, national standards are consistently being met and the service is running smoothly. After 1st June 2011 we will have one full year’s worth of complete Cheshire and Merseyside PPCI data and are looking forward to validating the model used to implement our PPCI service.

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Use of MINAP data to analyse and improve the PPCI service

Papworth Hospital NHS Foundation Trust

Dr Sarah Clarke, Clinical Director for Cardiac Services

Hayley Dimmock, Cardiac Information Analyst

Papworth Hospital NHS Foundation Trust opened a Primary Percutaneous Coronary Intervention (PPCI) service in September 2008. Since then there have been over 1500 activations of the service and for the year 2010-11 Papworth averaged 60 PPCI patient activations per month. MINAP is used within Papworth hospital to accurately record data on each patient who arrives at the heart attack centre following a PPCI activation. We believe data accuracy is extremely important and ensure that each individual PPCI patient’s MINAP entry is validated and checked alongside their hospital notes post discharge to ensure excellent data completeness. MINAP is used as an analysis tool as much as for data collection in order to produce figures for activity, outcomes and especially to monitor Papworth hospital’s performance in achieving national standards.

In 2010-11 there were 702 activations of the PPCI service with two thirds of patients continuing to have an intervention and the remaining third either not going into the lab or not proceeding to PCI post angiogram for various reasons. The national standard of door to balloon time (90 minutes) was achieved in 98% of all cases with an average time of 37 minutes.

The use of MINAP was instrumental in improving communication with our colleagues from the East of England Ambulance Service NHS Trust (EEAST) and has been particularly helpful in increasing the accuracy of timings. This has helped facilitate information flow concerning the patients’ journey including any delays or complications encountered which could affect their overall outcome. Papworth hospital use the data collected in MINAP to look in detail at every patient who breaches either the national or local standards. These reports are discussed in multi-disciplinary team meetings on a bi-weekly basis and the information used to highlight ways of improving patient flow and patient’s clinical care.

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1. MINAP Academic Group – five year overview

Professor Adam Timmis, Chairman, MINAP Academic Group

1.1 Background

We recognise the value of the MINAP data certainly in improving patient care but also in its secondary use for research. The MINAP Academic Group (MAG) was established in 2005 to maximise the research potential of MINAP database and to establish processes for the safe distribution and return of sub-sets of MINAP data to research groups. The MAG is responsible for ensuring that data are only accessed by researchers with bona fide projects of high scientific probity who respect the conditions of confidentiality and security. The MAG was delegated the responsibility for releasing MINAP data by the Health Quality Improvement Partnership (HQIP) through which MINAP is funded.

All datasets issued to research groups are sourced from the dataset that is collected from CCAD annually and cleaned in a way that it is not significantly changed by this process. Although NICOR (UCL) was granted Section 251 exemption of the NHS Act 2006 for all the cardiac audits, including MINAP to hold patient identifiable data without consent, this approval is not extended to release of patient identifiable data. We are however in a position to release data for research in anonymised, or pseudo-anonymised for and the linkage with other dataset(s) can be performed by the trusted 3rd party.

1.2 Current position

The last year has seen major developments driven by the MINAP Academic Group. We now have a truly nationwide programme incorporating many of the top cardiological and epidemiological research groups in the UK. In the last 12 months alone approvals have been given for data-sharing with researchers in London, Birmingham, Belfast, Leeds, Leicester, Surrey and Edinburgh Previous applications have already led to seven publications in major cardiovascular and general journals in 2010, more than ever before, with a further four publications by May 2011.

Particularly significant has been the establishment of international collaborations with the SWEDEHEART investigators in Upsalla (Sweden) to complement the international collaborative analysis of pre-hospital thrombolysis previously undertaken in Europe and North America.

The development that will underpin research activity through the next decade and beyond has been the successful bid by the NICOR executive to become responsible for the management of MINAP and five other national cardiovascular registries. Leaders within MINAP and MAG played a key role in securing the bid which will now allow direct involvement of the management and linkage of this unique data resource. Only in the UK are national registry data on this scale available providing opportunities for cardiovascular researchers that cannot be found elsewhere.

1.3 How to apply

For more information on how to make an application for MINAP data please email Lucia Gavalova, MINAP Project Co-ordinator at [email protected].

2. Use of MINAP data to evaluate the impact of acute coronary syndrome care by patient age: resolving inequities in care?

Dr Chris Gale, University of Leeds

Dr Robert West, University of Leeds

Professor Keith Fox, University of Edinburgh

Evidence suggests that primary percutaneous coronary intervention (pPCI) results in better outcomes than thrombolysis for the treatment of STEMI provided it is delivered promptly. Due to initial perceived risk of complications in pPCI in very elderly (80 years of age or older), pPCI was not considered to be a preferred treatment option in this age group. Recently Shelton28 and colleagues compared outcomes in patients aged ≥80 years presenting with STEMI who were treated pPCI with patients who received thrombolytic treatment. Their work suggested that primary PCI can be effectively delivered to very elderly patients resulting in a substantial reduction in mortality compared to patients treated by thrombolytic treatment. So is there inequality in care in patients presenting with ACS in England and Wales?

Current data suggest that elderly patients who are hospitalised with an ACS are less likely to receive the preferred treatment (PCI) and that they have higher mortality rates than their younger counterparts. We studied 616,011 ACS events at 255 hospitals in England and Wales recorded in MINAP between 2003 and 2010 to establish whether age-dependent inequalities in care existed and to measure effects on in-hospital mortality over time for ACS in different age groups.

This revealed that almost 40% admissions with ACS in England and Wales were elderly (≥75 years). They were less likely to receive specialist care and evidence-based treatments including pPCI for STEMI. As a result, the elderly were found to have significantly longer hospital lengths of stay and higher in-hospital mortality rates.

Although progressive improvements in risk of in-hospital mortality were noted, for example, STEMI ≥85 years, in-hospital mortality reduced from 30.1% in 2003 to 19.4% in 2010 and for nSTEMI ≥85 years from 31.5% in 2003 to 20.4% in 2010, overall rates of emergency reperfusion (primary PCI and thrombolysis) for STEMI in those <55 years of age were nearly a third higher than for those aged ≥85 years.

28. Shelton RJ, Crean AM, Somers K, et al. Real-world outcome from ST eleva-tion myocardial infarction in the very elderly before and after the introduction of a 24/7 primary percutaneous coronary intervention service. Am Heart J. 2010 Jun; 159(6):956-63.

part four: research use of minap data

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Data also suggest that use of secondary prevention medication such as aspirin, clopidogrel, beta-blockers, ACE inhibitors, and statins are effective in secondary prevention of coronary heart disease in patients aged 65 years and over. This benefit is similar to, and often greater than that observed in younger patients. We have shown that older patients with heart attack were less likely to be discharged on aspirin, clopidogrel, beta-blockers, ACE inhibitors, and statins.

These findings support a notion of age-dependent inequality in ACS care – biases in elderly ACS care remain and the elderly do have significantly longer hospital lengths of stay and high in-hospital mortality. It therefore highlights gaps in key aspects of the management of elderly patients with ACS who benefit equally as much as their young counterparts from an early invasive strategy.

The causes for discrepancies in quality of care for elderly are multifactorial. In part, the shortfall in treatment may be due to lack of appropriate specialist care and inappropriate placement within the hospital. The elderly are more likely to present differently and less likely to have the same diagnosis on discharge from hospital as that which they were given on admission. It is also not very unlikely that that age dependent inequalities in treatments may be the legacy of a risk-adverse strategy to ACS care through lack of accurate estimate of ACS risk.

Despite this, we can report an improvements in the application of evidence-based ACS care across all age groups from 2003 to 2010, and year-on-year reductions in in-hospital mortality equally across all age groups, both sexes as well as for STEMI and nSTEMI.

3. Enriching MINAP through linkage to primary care and investigator led cohorts

Professor Harry Hemingway University College London

Internationally and nationally MINAP is a special resource. England and Wales along with Sweden are among the few countries which have a national registry of acute coronary syndromes in which all hospitals participate. Registries in the US do not have this coverage. Like SwedeHeart, MINAP has developed Information and Research Governance structures to facilitate access to and use of MINAP data for research purposes. Over the last years this has led to some success with 23 projects.

Further enhancement of the MINAP resource is made possible thought linkage to other forms of electronic health record data. One example of this has been the linkage of the general

practice research database (GPRD) with MINAP, carried out for the first time in 2010. Primary care data in the UK are in their own right a special research resource; offering a longitudinal record of diagnoses, symptoms, tests, drugs and procedures. Because nearly every adult in the UK is registered with a GP there is an opportunity for population based studies.

Linking MINAP to primary care electronic health records allows two different types of question to be addressed. First, what is the quality of care across the ‘patient journey’. In other words examining care before, during and after a MINAP event can lead to a better understanding of what needs to change.

Second, what is the aetiology and prognosis of specific forms of coronary syndrome? Most epidemiological enquiry to date has investigated broad aggregates of coronary heart disease or heart attack and there are few prospective studies which examine whether risk factors for STEMI and nSTEMI are qualitatively or quantitatively different. Because MINAP distinguishes these ‘endpoints’, there are new possibilities for analysis.

Examination of genetic, biomarker and other research based measures in relation to MINAP ‘phenotypes’ is made possible by linkages with investigator led (i.e. bespoke data collection) cohort studies (e.g. 200,000 women in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) 2011. Discussion is underway for a linkage of MINAP with UK Biobank, with over 500,000 consented participants one of the largest, best characterised cohorts in the world.

CALIBER (Cardiovascular disease research using Linked Bespoke studies and Electronic Records) is a collaborative programme of such research using linked MINAP data funded by the Wellcome Trust (under the electronic health records initiative) and an NIHR programme grant. Further details can be obtained from [email protected].

4. Management of hyperglycaemia in acute coronary syndromes

Dr Clive Weston, University of Swansea

In addition to its primary purpose, as an audit of actual care received against ideal care, the MINAP database lends itself to a variety of subsidiary uses of potential clinical value in the form of observational studies. One such area of work has been the confirmation of an association between blood glucose in ACS and outcome. Those patients who on arrival at hospital have high blood glucose concentrations – hyperglycaemia – have a greater risk of dying than those with normal concentrations (Figure 22).

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From the Figure 22 it can be seen that the association between blood glucose and mortality occurs both in diabetic patients and those without a prior diagnosis of diabetes. In fact the increase in risk is greater in the latter group. So, while at normal levels of admission glucose diabetic patients have a higher death rate than non-diabetics, this difference is reversed in the presence of hyperglycaemia (from approximately 11 mmol/L and greater).

The possible reasons for the association: the link to previously undiagnosed diabetes, to ‘stress hyperglycaemia associated with larger heart attacks, and to potential direct adverse effects of glucose during ACS, has been detailed elsewhere29.

Further observations from the database show that the use of insulin infusions to treat hyperglycaemia in non-diabetic patients with ACS is associated with a reduction in risk of death by about a third30. Despite this, the use of insulin in this high risk group is the exception rather than the rule and lags behind the use of insulin in the (relatively) lower-risk diabetic group. In 2008/9, for those arriving at hospital with blood glucose >10.0 mmol/L, infused (intravenous) insulin was given to, 14.6% of non-diabetics, 39.8% of diabetics who normally took tablet treatment and 47.4% of diabetic patients who normally took subcutaneous insulin.

So observational data analysis suggests that: high levels of blood glucose are a marker of increased risk, treatment that reduces blood glucose is associated with a reduction of risk, but only a minority of patients who are eligible for treatment actually receive it. Is this a cause for concern?

Here, such observational analysis reaches its limit, but can at least expose a gap in knowledge. Some clinicians will interpret the available data to support the use of insulin in all patients with ACS presenting with hyperglycaemia. Others will look on the evidence as circumstantial and will be unpersuaded. What is required is a large randomised trial of insulin treatment given in the early stage of ACS (particularly in the non-diabetic group) to rapidly and reliably normalise blood glucose. Only then will it become clear whether untreated patients presenting with ACS and hyperglycaemia presently are being denied an effective life-saving treatment.

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Figure 23 Survival to 180 days after admission to hospital with STEMI, in patients not known to be diabetic with an admission blood glucose >11.0 mmol/L, with respect to normal treatment or an insulin infusion

29. Anantharaman R, Heatley M, Weston CFM. Hyperglycaemia in acute coronary syndromes: risk marker or therapeutic target? Heart 2009;95:697-703.

30. Weston CFM, Walker L, Birkhead JS. Early impact of insulin treatment on mortality for hyperglycaemic patients without known diabetes who present with an acute coronary syndrome. Heart 2007;93:1542-6.

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Figure 22 Death rates at 30 days after admission to hospital with ACS for those with and those without prior diagnosis of diabetes, with respect to admission blood glucose (mmol/L) – patients with blood glucose <6mmol/L excluded for clarity.

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78 MINAP How the NHS cares for patients with heart attack

Appendix 1: MINAP Steering Group

Chairman Dr Clive Weston Clinical Director MINAP

Dr John Birkhead Previous Clinical Director MINAP

Department of Health Professor Sir Roger Boyle CBE National Director for Heart Disease and Stroke (to Aug 2011)

Ms Sue Dodd Emergency and Acute Care Manager, Vascular Programme (to July 2011)

NICOR Dr David Cunningham Senior Strategist for National Cardiac Audits

Royal College of Dr Jonathan Potter Physicians Director, Clinical Effectiveness and Evaluation Unit (to May 2011)

British Heart Foundation Professor Peter Weissberg Medical Director

Ambulance Services Dr Steven Rawstone Medical Director, Great Western Ambulance Service

Welsh Assembly Dr Phillip Thomas Government Lead Cardiac Clinician

British Cardiovascular Professor Keith Fox Society President

Royal College of Nursing Professor Tom Quinn University of Surrey

MINAP Patient/Carer Group Mr Iain Thomas South West London Cardiac and Stroke Network Patient Carer Group

MINAP Patient/Carer Group Mr David Geldard MBE Past President, Heart Care Partnership (UK)

MINAP Hospital User Ms Fiona Dudley Lead Nurse for Cardiology, Mid Yorkshire Hospitals NHS Trust

MINAP Academic Group Professor Adam Timmis Chairman

NHS Improvement Dr Mark Dancy National Clinical Chair

British Cardiovascular Dr Mark de Belder Intervention Society President

Cardiac Networks Mr Mark Walsh Network Director, Black Country Cardiovascular Network

part five: appendices

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Appendix 2: Glossary

ACE inhibitors A class of drug with powerful dilating effects on arteries. Used – in the context of heart attack - for the treatment and prevention of heart failure. Also used widely for treatment of high blood pressure. Angiotensin receptor blockers (ARBs) have broadly similar effects.

Acute coronary syndrome This term covers all cardiac episodes that result from sudden and spontaneous blockage or near blockage of a coronary artery; often resulting in some degree of heart muscle damage. The usual underlying cause is rupture of the fine lining of a heart artery, which allows blood to come in contact with the tissues of the wall of the artery, promoting the development of a blood clot (thrombus). The degree of damage, and the type of syndrome (heart attack), that results from the blockage depends on the size of the artery, where in the course of the artery the blockage occurs, the amount of clot that develops and how long it persists within the artery. Not all acute coronary syndromes are suitable for treatment with primary angioplasty or thrombolytic drugs, and the decision is mainly guided by the appearances of the ECG when such treatments are being considered.

Angina Symptoms of chest discomfort that occur when narrowing of the coronary arteries prevent enough oxygen-containing blood reaching the heart muscle when its demands are high, such as during exercise.

Angiogram An X-ray investigation, performed under a local anaesthetic, which produces images of the flow of blood within an artery (in this case the coronary artery). Narrowings and complete blockages within the arteries can be identified during the angiogram and this allows decisions to be made regarding treatment. Often an angiogram is an immediate precursor to an angioplasty and stent implantation or to later coronary artery bypass grafting.

Anti-platelet drugs Drugs, including aspirin, clopidogrel, prasugrel and ticagrelor, which prevent blood clotting. These drugs act by reducing the ‘stickiness’ of the small blood cells (platelets) that can clump together to form a clot.

Aspirin An anti-platelet drug used to help prevent blood clots forming.

Beta-blockers Beta-blockers are drugs that block the actions of the hormone adrenaline (that makes the heart beat faster and more vigorously). They are used to help prevent attacks of angina, to lower blood pressure, to help control abnormal heart rhythms

and to reduce the risk of further heart attack in people who have already had one. They may also be used in small doses in heart failure.

Call-to-balloon (CTB) time The interval between the patient alerting the health services that they have symptoms of a heart attack and the performance of primary angioplasty.

Call-to-needle (CTN) time The interval between the patient alerting the health services that they have symptoms of a heart attack and the administration of thrombolytic therapy.

Cholesterol A fatty substance that plays a vital role in the functioning of every cell wall throughout the body and in the production of various hormones. However, too much cholesterol in the blood increases the risk of coronary heart disease and heart attacks.

Clopidogrel An anti-platelet drug that has been shown to produce added benefit when given with aspirin during an acute coronary syndrome.

Clot-dissolving drugs Drugs used to dissolve the clot (or thrombus) within a heart artery which is the underlying cause of heart attack, see ‘thrombolytic treatment’.

Contraindication The presence of a reason why a treatment is unsuitable in a particular patient.

Door-to-balloon (DTB) time The interval between the ambulance arriving at a hospital and the performance of primary angioplasty.

Door-to-needle (DTN) time The interval between the ambulance arriving at a hospital and the administration of thrombolytic therapy.

Electrocardiogram Also known as ‘ECG’. A test to record the rhythm and electrical activity of the heart. The ECG can often show if a person has had a heart attack, either recently or some time ago. It can also tell if reperfusion therapy is appropriate and if it has been effective.

Heart attack The term applied to the symptoms, usually, but not always, including chest pain, which develop when a clot (thrombus) develops within a heart artery as a result of spontaneous damage to the inner lining of the artery (plaque rupture). The heart muscle supplied by the blocked artery suffers permanent damage if the blood supply is not restored quickly. The damage to heart muscle carries a risk of sudden death, and heart failure in people who survive.

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Heart failure Heart failure occurs when a damaged heart becomes less efficient at pumping blood round the body. This may result from damage to the heart muscle caused by a heart attack – either at the time of the attack or many months or even years afterwards. There are typically symptoms of breathlessness during exertion and, later, swelling (oedema) of ankles.

Hyperglycaemia A high concentration of glucose (sugar) in the blood

Meta-analysis A statistical technique for combining the findings from independent studies.

Median The number falling in the middle of a ranked series of numbers.

IQR Interquartile range; the value at 25% and 75% of an ordered set of values.

Myocardial infarction A heart attack in which heart muscle damage is confirmed by blood testing.

Non ST elevation myocardial infarction (nSTEMI) A heart attack that occurs in the absence of ST segment elevation on the ECG. In these patients urgent admission to hospital is mandated but immediate reperfusion therapy is not required.

PCI Percutaneous coronary intervention (see Primary angioplasty)

Pre-hospital thrombolysis Thrombolytic treatment given before arrival in hospital, usually in the ambulance by paramedics. This saves time in providing treatment and is used where journey times to hospital are prolonged.

Primary angioplasty A technique to re-open the blocked coronary artery responsible for the heart attack. A fine catheter (tube) is passed, under local anaesthetic, from an artery in the leg or arm into the blocked heart artery. A small inflatable balloon is then passed through the catheter and across the blockage, allowing the artery to be re-opened by temporary inflation of the balloon. This technique is called angioplasty and when used as the initial treatment for heart attack it is referred to as ‘primary angioplasty’. Following opening of the artery, this is normally kept open by a small expandable metal tube (stent) which is passed into the artery with the angioplasty balloon. The umbrella term that encompasses both balloon dilatation (angioplasty) and stent insertion (stenting) is ‘percutaneous coronary intervention’ (PCI) and primary PCI is increasingly used to describe what in this report we refer to simply as primary angioplasty.

Primary PCI Primary percutaneous coronary intervention – see Primary angioplasty

Re-infarction The development of evidence of re-occlusion (further blockage) of, or development of blood clot within, the coronary artery that was responsible for the original heart attack. This would normally occur after the original blockage had been successfully treated.

Reperfusion treatment The term used to cover both techniques, thrombolytic treatment and primary angioplasty, for urgently reopening a coronary artery. These treatments are suitable only for certain types of heart attack characterised by typical electrocardiographic appearances described as ST segment elevation.

Secondary prevention treatment Medication that reduces the risk of further heart attack, or the risk of complications such as heart failure. See aspirin, beta blockers, ACE inhibitors and ARBs, clopidogrel and statins. These medications are usually initially prescribed to all patients who can tolerate them.

Statins Drugs used to reduce cholesterol levels in the blood. These have been shown to reduce the risk of further heart attacks when taken regularly after a first heart attack

ST elevation myocardial infarction A heart attack characterized by a specific abnormal appearance on the ECG (ST segment elevation) thought to be indicative of complete occlusion of a coronary artery. Reperfusion therapy with thrombolysis or angioplasty has been shown to do more good than harm in these cases.

Thienopyridine inhibitors Antiplatelet agents, of which clopidogrel and prasugrel are presently licensed for use.

Thrombolytic treatment The outcome for certain types of heart attack can be improved by using clot-dissolving (thrombolytic) drugs. Thrombolytic treatment is effective up to about 12 hours after the onset of symptoms but is most effective when given very early after the symptoms started. Thrombolytic drugs are not given unless there are typical changes on the electrocardiogram (ECG). Patients at significant risk of bleeding may not be given this treatment where the risk of bleeding is greater than any potential benefit. Where this risk exists primary angioplasty may be an effective alternative.

Thrombus A blood clot, the development of which is known a thrombosis.

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Appendix 3: MINAP publications

1999

Rickards A, Cunningham D. From quantity to quality: the central cardiac audit database project. Heart 1999;82: 1118-1122.

Birkhead JS, Norris RM, Quinn T et al. Acute myocardial infarction: a core dataset. Royal College of Physicians 1999.

2000

Birkhead JS. Responding to the requirements of the National Service Framework for coronary heart disease: a core dataset for myocardial infarction. Heart 2000; 84: 116-7.

2001

Birkhead JS, Pearson M, Norris RM et al. Measurement of Clinical Performance: Practical approaches in acute myocardial infarction. Eds Robert West and Robin Norris. Royal College of Physicians 2001.

Birkhead JS, Georgiou A, Knight L et al. (eds) A baseline survey of facilities for the management of acute myocardial infarction in England 2000. London: Royal College of Physicians 2001.

2002

Birkhead JS. The National Audit of Myocardial Infarction: A new development in the audit process. Journal of Clinical Excellence 2002; 4: 379-85.

2004

Norris RM, Lowe D, Birkhead JS. Can successful treatment of cardiac arrest be a performance indicator for hospitals? Resuscitation. 2004; 60: 263-269.

Birkhead J, Walker L. MINAP, a project in evolution. Hospital medicine 2004; 452-53.

Birkhead J, Walker L, Pearson M, at al. Improving care for patients with acute coronary syndromes; initial results from the National Audit of Myocardial Infarction (MINAP). Heart 2004; 90: 1004-9.

2005

Quinn T, Weston C, Birkhead J, et al on behalf of Steering Group. Redefining the coronary care unit: an observational study of patients admitted to hospital in England and Wales in 2003- 2005. Quarterly Journal of Medicine 2005; 98 (11): 797-802.

2006

Birkhead, J, Weston, C, Lowe, D on behalf of the National Audit of Myocardial Infarction project (MINAP) Steering Group. Impact of specialty of admitting physician and type of hospital on care and outcome for myocardial infarction in England and Wales during 2004-5: observational study. BMJ 2006; 332:1306-1311.

Gale CP, Roberts AP, Batin PD, Hall AS. Funnel plots, performance variation and the Myocardial Infarction National Audit Project 2003-2004. BMC Cardiovasc Disord. 2006 Aug 2;6:34.

2007

Weston C, Walker L, and Birkhead J. Early impact of insulin treatment on mortality for hyperglycaemic patients without known diabetes who present with an acute coronary syndrome. Heart 2007; 93: 542-1546.

Birkhead J, Pearson J, Walker L on behalf of the MINAP Steering Group. Management of acute coronary syndromes in England and Wales: a survey of facilities in 2006. Royal College of Physicians, London 2007. ISBN 978-1-86016-314-2.

2008

Weston C. Performance indicators in acute myocardial infarction: a proposal for future assessment of good quality care. Heart 2008; 94:139-1401.

Gale CP, Manda SO, Batin PD, et al. Predictors of in-hospital mortality for patients admitted with ST-elevation myocardial infarction: a real-world study using the Myocardial Infarction National Audit Project (MINAP) database. 2008 Nov;94(11):1407-12.

Ben-Shlomo Y, Naqvi H, Baker I. Ethnic differences in healthcare-seeking behaviour and management for acute chest pain: secondary analysis of the MINAP dataset 2002–2003. Heart 2008; 94: 354 - 359.

Gale CP, Manda SO, Weston CF, et al. Evaluation of risk scores for risk stratification of acute coronary syndromes in the Myocardial Infarction National Audit Project (MINAP) database. 2009 Mar;95(3):221-7.

2009

Bhaskaran K, Hajat S, Haines A, et al. Effects of air pollution on the incidence of myocardial infarction. Heart, 2009; 95, 1746-59.

Horne S, Weston C, Quinn T, et al. The impact of pre-hospital thrombolytic treatment on re-infarction rates: analysis of the Myocardial Infarction National Audit Project (MINAP). Heart 2009; 95: 559-563.

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82 MINAP How the NHS cares for patients with heart attack

2009 cont.

Birkhead J, Weston C, Chen R. Determinants and outcomes of coronary angiography after non-ST-segment elevation myocardial infarction. A cohort study of the Myocardial Ischaemia National Audit Project (MINAP). Heart 2009; 95:1593-9.

2010

Herrett E, Smeeth L, Walker L, Weston C; on behalf of the MINAP Academic Group. The Myocardial Ischaemia National Audit Project (MINAP). Heart 2010;96:1264-1267.

Bhaskaran K, Hajat S, Haines AP, et al. The short term effects of temperature on the risk of myocardial infarction in England and Wales – a multicity daily time series study using the Myocardial Ischaemia National Audit Project (MINAP) database. BMJ 2010;341: c3823.

Bhaskaran K, Hajat S, Haines AP, et al. Effects of ambient temperature on the incidence of myocardial infarction. Heart 2009, 95, 1760-9.

Gale CP, Roberts AP, Batin PD, et al. Funnel plots, performance variation and the Myocardial Infarction National Audit Project 2003-2004. BMC Cardiovasc Disord. 2006 Aug 2;6:34.

West RM, Cattle BA, Bouyssie M, et al. Impact of hospital proportion and volume on primary percutaneous coronary intervention performance in England and Wales. Eur Heart J. 2010.

McNamara RL. Cardiovascular registry research comes of age. Heart 2010; 96:908-10.

Brophy S, Cooksey R, Gravenor MB, et al. Population based absolute and relative survival to 1 year of people with diabetes following a myocardial infarction: a cohort study using hospital admissions data. BMC Public Health 2010;10:338.

Widimsky P, Wijns W, Fajadet J, et al. European Association for Percutaneous Cardiovascular Interventions. Reperfusion therapy for ST elevation acute myocardial infarction in Europe: description of the current situation in 30 countries. Eur Heart J 2010; 31:943-57.

2011

Gale CP, Cattle BA, Moore J, et al. Impact of missing data on standardised mortality ratios for acute myocardial infarction: evidence from the Myocardial Ischaemia National Audit Project (MINAP) 2004-7. Heart 2011.

Gale C, West RM, Cattle BA et al. Impact of hospital proportion and volume on primary PCI performance in England and Wales European Heart Journal (in press)

Huynh T, Birkhead J, Huber K, et al. Pre-hospital Fibrinolysis in Europe and North America. JACC: Cardiovascular Interventions (in press).

Cattle BA, Greenwood DC, Gale CP, et al. Multiple Imputation of a Large Clinical Audit Dataset. Statistics in Medicine (in press).

Appendix 4: Contacts for information on heart conditions

American Heart Association http://www.americanheart.org/hearthub/index.htm

Blood Pressure Association http://www.bpassoc.org.uk/Home

British Cardiac Patients Association http://www.bcpa.co.uk/

British Cardiovascular Society http://www.bcs.com/pages/default.asp

British Heart Foundation http://www.bhf.org.uk/

NB: The British Heart Foundation runs a heart information line that

provides information about heart conditions and their management.

It cannot respond to questions about services in individual hospitals.

Tel: 08450 70 80 70

Diabetes UK http://www.diabetes.org.uk/

Department of Health website http://www.dh.gov.uk/en/Home

HEART UK http://www.heartuk.org.uk/

NHS Evidence – cardiovascular http://www.library.nhs.uk/cardiovascular/

NHS Choices http://www.nhs.uk/Pages/HomePage.aspx

NHS Direct Tel: 0845 4647

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heart attacks recorded in minap in 2010/11This report is written for the public to show the performance of hospitals, ambulance services and Cardiac networks in England and Wales against national standards for the care of patients with heart attack in 2010/11.

Report prepared by: Lucia Gavalova, Project co-ordinator MINAP

With assistance from:Dr Clive Weston, MINAP Clinical Director Dr John Birkhead, MINAP Clinical Director Ronald van Leeven, MINAP Project co-ordinatorLynne Walker, MINAP Programme managerProfessor Tom Quinn, MINAP Steering Group memberProfessor Adam Timmis, Chairman MINAP Academic GroupMrs Sirkka Thomas, MINAP Patient/carer representativeMr David Geldard, MINAP Patient representative

Electronic copies of this report can be found at: www.ucl.ac.uk/nicor/audits/minap

For further information about this report, contact:

Myocardial Ischaemia National Audit Project National Institute for Cardiovascular Outcomes ResearchInstitute of Cardiovascular ScienceUniversity College London175 Tottenham Court RoadLondon W1T 7NU

Tel: 0203 108 3931 Email: [email protected]

University College London (media enquiries)Media Relations Manager Ruth Howells Tel: 020 3108 3845Email: [email protected]

Acknowledgements

Department of Health Enquiries to the Department should be directed to the Customer Service CentreTel: 0207 210 4850 (line open from 8.30am to 17.00pm Monday to Friday). Textphone for hard of hearing: 0207 210 5025. Or use the web contact form available at; http://www.info.doh.gov.uk/contactus.nsf/memo?openform

In writing to the Minister of State for Health Services at: The Department of Health Richmond House 79 Whitehall London SW1A 2NS

Welsh Assembly Government Ms Cathy WhiteHead of Adult & Children’s HealthMedical DirectorateDepartment for Health, Social Services & ChildrenWelsh GovernmentCathays Park,Cardiff CF10 3NQ

Tel: 029 20826108Email: [email protected]

Hospital or ambulance service data If you require further information on the performance of your local hospital or ambulance service, please contact the relevant hospital or ambulance service, details of which are available at NHS Choices http://www.nhs.uk/Pages/HomePage.aspx

The MINAP team would like to thank all the hospitals and ambulance services that have collected data.

This report was completed in close collaboration with the Central Cardiac Audit Database (CCAD) team who are now part of National Institute for Cardiovascular Outcomes Research (NICOR), and performed the data management and analysis. Sue Manuel has again been especially involved.

The MINAP Steering Group is proud that one of its members, Professor Roger Boyle was recently awarded a knighthood for services to Medicine.

MINAP is commissioned and funded by the Healthcare Quality Improvement Partnership (HQIP). For more information, please visit www.hqip.org.uk.

This report may not be published or used commercially without permission.

Designed and published by:

| www.padcreative.co.uk

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How

the NH

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MIN

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Myocardial IschaemiaNational Audit Project

Myocardial IschaemiaNational Audit Project

myocardial ischaemia national audit project [minap]

How the NHS cares for patients with heart attack

Tenth Public Report 2011 Prepared on behalf of the MINAP Steering Group

NICOR: NATIONAL INSTITUTE FOR CARDIOVASCULAR OUTCOMES RESEARCH

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