molecular cancer research table of contentsgreg d. degala, jimin shin, aik-choon tan,...
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Highlights of This Issue 1
PERSPECTIVE
3 Lung-Enriched Mutations in the p53 TumorSuppressor: A Paradigm for Tissue-Specific Gainof Oncogenic FunctionJulie A. Barta and Steven B. McMahon
CELL CYCLE AND SENESCENCE
10 Phosphatase 1 Nuclear Targeting Subunit(PNUTS) Regulates Aurora Kinases and MitoticProgressionFeifei Wang, Ling Wang, Laura A. Fisher, Chunling Li,Weidong Wang, and Aimin Peng
CELL DEATH AND SURVIVAL
20 Endothelial Cells Promote Colorectal CancerCell Survival by Activating the HER3-AKTPathway in a Paracrine FashionRui Wang, Rajat Bhattacharya, Xiangcang Ye, Fan Fan,Delphine R. Boulbes, and Lee M. Ellis
CHROMATIN, EPIGENETICS, AND RNAREGULATION
30 Reversal of Triple-Negative Breast Cancer EMTby miR-200c Decreases Tryptophan Catabolismand a Program of ImmunosuppressionThomas J. Rogers, Jessica L. Christenson, Lisa I. Greene,Kathleen I. O'Neill, Michelle M. Williams,Michael A. Gordon, Travis Nemkov, Angelo D’Alessandro,Greg D. Degala, Jimin Shin, Aik-Choon Tan,DianaM. Cittelly, James R. Lambert, and Jennifer K. Richer
DNA DAMAGE AND REPAIR
42 Repurposing of mTOR Complex InhibitorsAttenuates MCL-1 and Sensitizes to PARPInhibitionAbid R. Mattoo, Alex Joun, and J. Milburn Jessup
54 Combining Homologous Recombination andPhosphopeptide-binding Data to Predict theImpact of BRCA1 BRCT Variants on Cancer RiskAmbre Petitalot, Elodie Dardillac, Eric Jacquet,Naima Nhiri, Jos�ee Guirouilh-Barbat, Patrick Julien,Isslam Bouazzaoui, Dorine Bonte, Jean Feunteun,Jeff A. Schnell, Philippe Lafitte, Jean-Christophe Aude,Catherine Nogu�es, Etienne Rouleau, Rosette Lidereau,Bernard S. Lopez, Sophie Zinn-Justin, andSandrine M. Caputo, on behalf of the UNICANCERGenetic Group BRCA network
GENOMICS
70 Human Organoids Share Structural and GeneticFeatures with Primary PancreaticAdenocarcinoma TumorsIsabel Romero-Calvo, Christopher R. Weber, Mohana Ray,Miguel Brown, Kori Kirby, Rajib K. Nandi, Tiha M. Long,Samantha M. Sparrow, Andrey Ugolkov, Wenan Qiang,Yilin Zhang, Tonya Brunetti, Hedy Kindler, Jeremy P. Segal,Andrey Rzhetsky, Andrew P. Mazar, Mary M. Buschmann,Ralph Weichselbaum, Kevin Roggin, and Kevin P. White
84 Integrative Epigenetic and Gene ExpressionAnalysis of Renal Tumor Progression toMetastasisHye-Young Nam, Darshan S. Chandrashekar,Anirban Kundu, Sandeep Shelar, Eun-Young Kho,Guru Sonpavde, Gurudatta Naik, Pooja Ghatalia,Carolina B. Livi, Sooryanarayana Varambally, andSunil Sudarshan
97 Genomic Alterations Associated with Recurrenceand TNBC Subtype in High-Risk Early BreastCancersTimothy R. Wilson, Akshata R. Udyavar, Ching-Wei Chang,Jill M. Spoerke, Junko Aimi, Heidi M. Savage,Anneleen Daemen, Joyce A. O’Shaughnessy,Richard Bourgon, and Mark R. Lackner
109 A Leukocyte Infiltration Score Defined by a GeneSignature Predicts Melanoma Patient PrognosisYanding Zhao, Evelien Schaafsma, Ivan P. Gorlov,Eva Hernando, Nancy E. Thomas, Ronglai Shen,Mary Jo Turk, Marianne Berwick, Christopher I. Amos, andChao Cheng
120 Establishment and Genetic Landscape ofPrecancer Cell Model Systems from the Headand Neck Mucosal LiningD. Vicky de Boer, Arjen Brink, Marijke Buijze,Marijke Stigter-vanWalsum, Keith D. Hunter, Bauke Ylstra,Elisabeth Bloemena, C. Ren�e Leemans, andRuud H. Brakenhoff
January 2019 � Volume 17 � Number 1
Molecular Cancer Research
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METABOLISM
131 A Role for Tryptophan-2,3-dioxygenase in CD8T-cell Suppression and Evidence of TryptophanCatabolism in Breast Cancer Patient PlasmaLisa I. Greene, Tullia C. Bruno, Jessica L. Christenson,Angelo D’Alessandro, Rachel Culp-Hill, Kathleen Torkko,Virginia F. Borges, Jill E. Slansky, and Jennifer K. Richer
140 De Novo Fatty Acid Synthesis-Driven SphingolipidMetabolism Promotes Metastatic Potential ofColorectal CancerNaser Jafari, James Drury, Andrew J. Morris,Fredrick O. Onono, Payton D. Stevens, Tianyan Gao,Jinpeng Liu, Chi Wang, Eun Y. Lee, Heidi L. Weiss,B. Mark Evers, and Yekaterina Y. Zaytseva
ONCOGENES AND TUMOR SUPPRESSORS
153 p53–Pirh2 Complex Promotes Twist1Degradation and Inhibits EMTYang Yang-Hartwich, Roslyn Tedja, Cai M. Roberts,Jamie Goodner-Bingham, Carlos Cardenas, Marta Gurea,Natalia J. Sumi, Ayesha B. Alvero, Carlotta A. Glackin, andGil Mor
165 Increased Genetic Instability and AcceleratedProgression of Colitis-Associated ColorectalCancer through Intestinal Epithelium–specificDeletion of Klf4Vincent W. Yang, Yang Liu, Julie Kim, Kenneth R. Shroyer,and Agnieszka B. Bialkowska
177 Mutational Landscape of Ovarian AdultGranulosa Cell Tumors from Whole Exome andTargeted TERT Promoter SequencingMaria Alexiadis, Simone M. Rowley, Simon Chu,Dilys T.H. Leung, Colin J.R. Stewart,Kaushalya C. Amarasinghe, Ian G. Campbell, andPeter J. Fuller
186 p53 Function Is Compromised by Inhibitor 2 ofPhosphatase 2A in Sonic HedgehogMedulloblastomaYun Wei, Victor Maximov, Sorana A. Morrissy,Michael D. Taylor, David C. Pallas, andAnna Marie Kenney
199 Hyperactivation ofMAPK Signaling Is Deleteriousto RAS/RAF-mutant MelanomaGrace P. Leung, Tianshu Feng, Frederic D. Sigoillot,Felipe C. Geyer, Matthew D. Shirley, David A. Ruddy,Daniel P. Rakiec, Alyson K. Freeman, Jeffrey A. Engelman,Mariela Jaskelioff, and Darrin D. Stuart
SIGNAL TRANSDUCTION
212 Alectinib Resistance in ALK-Rearranged LungCancer by Dual Salvage Signaling in a ClinicallyPaired Resistance ModelTakahiro Tsuji, Hiroaki Ozasa, Wataru Aoki,Shunsuke Aburaya, Tomoko Funazo, Koh Furugaki,Yasushi Yoshimura, Hitomi Ajimizu, Ryoko Okutani,Yuto Yasuda, Takashi Nomizo, Kiyoshi Uemasu,Koichi Hasegawa, Hironori Yoshida, Yoshitaka Yagi,Hiroki Nagai, Yuichi Sakamori, Mitsuyoshi Ueda,Toyohiro Hirai, and Young Hak Kim
225 The Role of Alcohol-Induced GolgiFragmentation for Androgen Receptor Signalingin Prostate CancerSonia Manca, Cole P. Frisbie, Chad A. LaGrange,Carol A. Casey, Jean-Jack M. Riethoven, andArmen Petrosyan
238 SOX9/FXYD3/Src Axis Is Critical for ERþ BreastCancer Stem Cell FunctionYue Xue, Lihua Lai, Wenwen Lian, Xintao Tu,Jiaojiao Zhou, Ping Dong, Dan Su, Xiaojia Wang,Xuetao Cao, Yiding Chen, and Qingqing Wang
250 Targeting TAZ-Driven Human Breast Cancer byInhibiting a SKP2-p27 Signaling AxisHe Shen, Nuo Yang, Alexander Truskinovsky,Yanmin Chen, Ashley L. Mussell, Norma J. Nowak,Lester Kobzik, Costa Frangou, and Jianmin Zhang
263 Targeting the MIF/CXCR7/AKT SignalingPathway in Castration-Resistant Prostate CancerShahrzad Rafiei, Bin Gui, Jiaxin Wu, X. Shirley Liu,Adam S. Kibel, and Li Jia
277 TGFb1 Cell Cycle Arrest Is Mediated by Inhibitionof MCM Assembly in Rb-Deficient ConditionsBrook S. Nepon-Sixt and Mark G. Alexandrow
289 Targeting of SGK1 by miR-576-3p InhibitsLung Adenocarcinoma Migration and InvasionEvan J. Greenawalt, Mick D. Edmonds, Neha Jain,Clare M. Adams, Ramkrishna Mitra, andChristine M. Eischen
299 miR-122-5p Expression and Secretion inMelanoma Cells Is Amplified by the LPAR3SH3–Binding Domain to Regulate Wnt1Charnel C. Byrnes, Wei Jia, Ali A. Alshamrani,Sudeepti S. Kuppa, and Mandi M. Murph
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TUMOR MICROENVIRONMENT
310 A Novel Approach for Image-Guided 131I Therapyof Pancreatic Ductal Adenocarcinoma UsingMesenchymal Stem Cell-Mediated NIS GeneDeliveryChristina Schug, Aayush Gupta, Sarah Urnauer,Katja Steiger, Phyllis Fung-Yi Cheung, Christian Neander,Konstantinos Savvatakis, Kathrin A. Schmohl,Marija Trajkovic-Arsic, Nathalie Schwenk,Markus Schwaiger, Peter J. Nelson, Jens T. Siveke, andChristine Spitzweg
321 The Aged Microenvironment Influences theTumorigenic Potential of Malignant ProstateEpithelial CellsDaniella Bianchi-Frias, Mamatha Damodarasamy,Susana A. Hernandez, Rui M. Gil da Costa,Funda Vakar-Lopez, Ilsa M. Coleman, May J. Reed, andPeter S. Nelson
332 Acknowledgment to Reviewers
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ABOUT THE COVER
In this issue, Manca and colleagues (beginning on page 225) demonstrate for the first time themolecular link between alcohol consumption and the progression of prostate cancer. Usingboth human tissue, from non-alcoholic or alcoholic patients, and ethanol-fed animals, theauthors demonstrate that ethanol is able to enhance the proliferation of prostate cancer cellsand their metastatic potential. Specifically, they found that ethanol-induced Golgifragmentation is associated with the relocation of glycogen synthase kinase b (GSK3b) fromGolgi to the cytoplasm, thus activating the HDAC6-HSP90-AR pathway. The cover image showsthat the fluorescence signal of GSK3b (red) segregated from Golgi membranes (stained bygiantin, green) in the tissue section from a patient with prostate adenocarcinoma (Gleason 10).
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2019;17:1-334. Mol Cancer Res 17 (1)
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