laparoscopy: historic, present and emerging trends
TRANSCRIPT
Laparoscopy: Historic, Laparoscopy: Historic,
Present and Emerging Present and Emerging
TrendsTrends
Dr. George S Ferzli MD FACSDr. George S Ferzli MD FACS
Professor of Surgery - State University of New York Professor of Surgery - State University of New York (Downstate)(Downstate)
Chairman of Surgery - Lutheran Medical Center, New Chairman of Surgery - Lutheran Medical Center, New York, USAYork, USA
History of LaparoscopyHistory of Laparoscopy
A three bladed speculum was found in the ruins A three bladed speculum was found in the ruins
of Pompeii*. of Pompeii*.
*A *A roman town buried by a volcano eruption roman town buried by a volcano eruption
near modern Naples, Italy - 79 AD).near modern Naples, Italy - 79 AD).
The first description dates to Hippocrates in The first description dates to Hippocrates in Greece, for use of a speculum to visualize Greece, for use of a speculum to visualize the rectum (460–375 BC).the rectum (460–375 BC).
History of LaparoscopyHistory of Laparoscopy
1806: Philip Bozzini developed an 1806: Philip Bozzini developed an
instrument called a instrument called a LichtleiterLichtleiter
(light-guiding instrument)(light-guiding instrument)
1853: Antoine Jean Desormeaux 1853: Antoine Jean Desormeaux
used Bozziniused Bozzini’’s Lichtleiters Lichtleiter
1867: Desormeaux used an open 1867: Desormeaux used an open
tube to examine the genitourinary tube to examine the genitourinary
tracttract
History of LaparoscopyHistory of Laparoscopy
Maximilian Nitze (1848 – 1906) Maximilian Nitze (1848 – 1906)
invented the first cystoscope invented the first cystoscope
((Nitze-Leiter cystoscope) using an Nitze-Leiter cystoscope) using an
electrically heated platinum wire electrically heated platinum wire
for illuminationfor illumination..
In 1887, he modified Edison`s light In 1887, he modified Edison`s light
bulb and created the first electrical bulb and created the first electrical
light bulb for use during urological light bulb for use during urological
procedures.procedures.Original carbon-filament bulb- Thomas Edison
History of LaparoscopyHistory of Laparoscopy
1901: George Kelling, Dresden, 1901: George Kelling, Dresden,
SaxonySaxony (Germany) (Germany) performed the performed the
1st experimental laparoscopy, 1st experimental laparoscopy,
calling it ‘Celioscopy’. calling it ‘Celioscopy’.
Kelling insufflated the abdomen of Kelling insufflated the abdomen of
a dog with filtered air and used a a dog with filtered air and used a
Nitze cystoscope to look inside.Nitze cystoscope to look inside.
Hans Christian Jacobaeus Hans Christian Jacobaeus (1879 – 1937) (1879 – 1937)
1910: Swedish internist; first 1910: Swedish internist; first
thoracoscopic diagnosis with a thoracoscopic diagnosis with a
cystoscope in a human subject.cystoscope in a human subject.
Treatment of a patient with tubercular Treatment of a patient with tubercular
intra-thoracic adhesions.intra-thoracic adhesions.
The Possibilities for Performing Cystoscopy in The Possibilities for Performing Cystoscopy in Examinations of Serous Cavities. Examinations of Serous Cavities. Münchner Medizinischen Münchner Medizinischen Wochenschrift,Wochenschrift, 1911 1911
Bertram BernheimBertram Bernheim
1911 : First laparoscopy at Johns Hopkins
12mm proctoscope into epigastric incision on one of Halstead’s patients to stage pancreatic cancer
Bernheim called his procedure ‘organoscopy’
Findings confirmed on laparotomy
History of LaparoscopyHistory of Laparoscopy
1920: Zollikofer discovered the benefit of CO1920: Zollikofer discovered the benefit of CO22 gas for insufflation gas for insufflation
1938: Janos Veress developed a spring loaded needle for the 1938: Janos Veress developed a spring loaded needle for the induction of pneumoperitoneum.induction of pneumoperitoneum.
After World War II, the development of fiberoptics represented an After World War II, the development of fiberoptics represented an important step forward for endoscopyimportant step forward for endoscopy
1966: Hopkins rod lens scope & cold light1966: Hopkins rod lens scope & cold light
1974: Dr Harrith M Hasson, MD working in Chicago, 1974: Dr Harrith M Hasson, MD working in Chicago, proposed a blunt proposed a blunt mini-laparotomy which permitted direct visualization of the trocar mini-laparotomy which permitted direct visualization of the trocar entrance into the peritoneal cavity. It is popularly known today as entrance into the peritoneal cavity. It is popularly known today as Hasson‘s technique.Hasson‘s technique.
Kurt Semm (1927-2003)Kurt Semm (1927-2003) Once, while making a slide Once, while making a slide
presentation on ovarian cysts; presentation on ovarian cysts;
suddenly the projector was suddenly the projector was
unplugged - with the unplugged - with the
explanation that explanation that “such “such
unethical surgery should not unethical surgery should not
be presented” be presented” In 1970, after becoming the In 1970, after becoming the
chairman of Ob/Gyn at the chairman of Ob/Gyn at the
University of Kiel, his co-workers University of Kiel, his co-workers
demanded that he undergo a demanded that he undergo a
brain scan because, they said, brain scan because, they said,
“only a person with brain damage “only a person with brain damage
would perform laparoscopic would perform laparoscopic
surgery”surgery”
German Engineer and Gynecologist.Introduced automatic insufflator,thermocoagulation ,loop knots,irrigation device in 1983, performedendoscopic appendectomy as part ofA gynecologic procedure.
History of LaparoscopyHistory of Laparoscopy
1985: Dr. Muhe (Prof Dr Med - Böblingen, Germany)1985: Dr. Muhe (Prof Dr Med - Böblingen, Germany) performed performed
the first successful laparoscopic cholecystectomy in a human. the first successful laparoscopic cholecystectomy in a human.
However, this was not well publicized until years later. The However, this was not well publicized until years later. The
German Surgical Society rejected Mühe in 1986 after he reported German Surgical Society rejected Mühe in 1986 after he reported
that he had performed the first laparoscopic cholecystectomy.that he had performed the first laparoscopic cholecystectomy.
Laparoscopy Takes OffLaparoscopy Takes Off 1988: 1st Lap cholecystectomy in the USA, Surgiport 1st 1988: 1st Lap cholecystectomy in the USA, Surgiport 1st
availableavailable
1989: US TV picks up on “Key Hole” surgery EndoClip™ 1989: US TV picks up on “Key Hole” surgery EndoClip™ releasedreleased
1990: Cuschieri (Aberdeen) warns on the explosion of 1990: Cuschieri (Aberdeen) warns on the explosion of endoscopyendoscopy
1991: ‘Lap Chole’ is accepted and routine procedure1991: ‘Lap Chole’ is accepted and routine procedure
1992: The National Institutes of Health Consensus 1992: The National Institutes of Health Consensus Conference concludes that laparoscopic cholecystectomy is Conference concludes that laparoscopic cholecystectomy is now the preferred alternative to open cholecystectomynow the preferred alternative to open cholecystectomy
VERESS NEEDLEVERESS NEEDLE
1938 - 1938 - Janos VeressJanos Veress, of Hungary, developed the spring-, of Hungary, developed the spring-loaded needle. to perform therapeutic pneumothorax loaded needle. to perform therapeutic pneumothorax (TB).(TB).
Made of surgical stainless steel with a single trap valve. Made of surgical stainless steel with a single trap valve. 2mm diameter x 80mm length 2mm diameter x 80mm length
It consists of an outer cannula with a beveled needle It consists of an outer cannula with a beveled needle point for cutting through tissues. point for cutting through tissues.
GAS INSUFFLATIONGAS INSUFFLATION
Controlled pressure insufflation of the peritoneal Controlled pressure insufflation of the peritoneal cavity is used to achieve the necessary work cavity is used to achieve the necessary work space for laparoscopic surgery. space for laparoscopic surgery.
Automatic insufflators allow the surgeon to Automatic insufflators allow the surgeon to preset the insufflating pressure, and the device preset the insufflating pressure, and the device supplies gas until the required intra-abdominal supplies gas until the required intra-abdominal pressure is reached. pressure is reached.
TrocarTrocar
The trocar has a blade with The trocar has a blade with
a shaft and body.a shaft and body.
The body includes a The body includes a
pointed tip which makes pointed tip which makes
the initial incision in the the initial incision in the
abdominal wall of the abdominal wall of the
patient. patient.
(Trocar diameters range from (Trocar diameters range from
2mm-30 mm)2mm-30 mm)
TrocarsTrocars
Types:Types: CuttingCutting
Pyramidal tippedPyramidal tipped
Flat bladeFlat blade
NoncuttingNoncuttingPointed conicalPointed conical
Blunt conicalBlunt conical
OpticalOptical
TelescopeTelescope
There are three important There are three important
structural differences in structural differences in
telescope available telescope available
1. 6 to 18 rod lens system 1. 6 to 18 rod lens system
telescopes are availabletelescopes are available
2. 0 to 120 degree telescopes 2. 0 to 120 degree telescopes
are availableare available
3. 1.5 mm to 15 mm of 3. 1.5 mm to 15 mm of
telescopes are availabletelescopes are available
Optic cablesOptic cables
These cables are These cables are made up of a bundle of made up of a bundle of optical fibers glass optical fibers glass thread swaged at both thread swaged at both ends. ends.
The fiber size used is The fiber size used is usually between 10 to usually between 10 to 25 mm in diameter.25 mm in diameter.
They have a very high They have a very high quality of optical quality of optical transmission, but are transmission, but are fragile.fragile.
Dissecting & Grasping Dissecting & Grasping Forceps Forceps
AtraumaticAtraumatic
KELLY atraumaticKELLY atraumatic
Atraumatic, with hollow Atraumatic, with hollow jawsjaws
MANGESHIKAR Grasping MANGESHIKAR Grasping Forceps, serratedForceps, serrated
General General instrumentsinstruments
Reusable three-piece designReusable three-piece design
Available in 2 mm, 3 mm, Available in 2 mm, 3 mm, 3.5mm, 5 mm and 10 mm 3.5mm, 5 mm and 10 mm sizes, with lengths of 20 cm, sizes, with lengths of 20 cm, 30 cm, 36 cm and 43 cm.30 cm, 36 cm and 43 cm.
Choice of handle styles.Choice of handle styles. Fully rotating 360° sheath.Fully rotating 360° sheath.
No hidden spaces that can No hidden spaces that can trap operative blood and trap operative blood and tissue debris. tissue debris.
Scissors Scissors
HOOK SCISSORS, single HOOK SCISSORS, single action jawsaction jaws
METZENBAUM SCISSORS, METZENBAUM SCISSORS, curved, length of blades 12-17 curved, length of blades 12-17 mm, widely used as an mm, widely used as an instrument for mechanical instrument for mechanical dissection in laparoscopic dissection in laparoscopic surgery. surgery.
STRAIGHT SCISSOR STRAIGHT SCISSOR can give can give controlled depth of cutting controlled depth of cutting because it has only one moving because it has only one moving jaw. jaw.
TROCAR PLACEMENT TROCAR PLACEMENT BY QUADRANTBY QUADRANT
Thoracic triangle
Pelvic triangle
1 2
34
TROCAR PLACEMENT TROCAR PLACEMENT BY QUADRANTBY QUADRANT
Each quadrant must be addressed from frontal as well as lateral positions.
yz
x
Correct trocar placement should Correct trocar placement should provide direct access to the provide direct access to the
target organs, target organs, an optimal view of the operative an optimal view of the operative
field field and minimize mental and and minimize mental and
muscular fatigue.muscular fatigue.
tro-car - [Fr., troisis, three +
carre, side] noun
a sharp-pointed surgical instrument
fitted with a cannula and used
especially to insert the cannula into
a body cavity
cannula - [L., dim of canna,reed] noun
a tube that is inserted into a cavity
by means of a trocar filling it’s lumen
Working against the camera and ‘blind spots’
“Dueling swords” phenomenon (scissoring effect)
Avoid Avoid competing competing
for the same for the same space:space:
No obstacle between trocar entry No obstacle between trocar entry and targetand target
To avoid iatrogenic injuries.
Avoid the epigastric vesselsAvoid the epigastric vessels
Saber et al. Safety zones for anterior abdominal wall entry during laparoscopy. Ann Surg 2004; 239:182
(adapted from) Anatomy of ilioinguinal and iliohypogastric nerves in relation to trocar placement and low transverse incisions James L. Whiteside, MD, Matthew D. Barber, MD, MHS, Mark D. Walters, MD, and Tommaso Falcone, MD (Am J Obstet Gynecol 2003;189:1574-8.)
Anatomic distribution of nerves across anterior abdominal wall
Iliohypogastric nerveIlioinguinal nerve
(adapted from) Anatomy of ilioinguinal and iliohypogastric nerves in relation to trocar placement and low transverse incisions James L. Whiteside, MD, Matthew D. Barber, MD, MHS, Mark D. Walters, MD, and Tommaso Falcone, MD (Am J Obstet Gynecol 2003;189:1574-8.)
Iliohypogastric n.
Ilioinguinal n.
Incision line/trocar sites vs. nerve distribution
Epigastric a.
Trocar site
Pfannenstiel incision
Be aware of bladder location Be aware of bladder location for suprapubic trocarfor suprapubic trocar
Avoid areas of prior surgeryAvoid areas of prior surgery
Trocar distance from the target organ depends upon the size of the patient.
Individual trocars can be moved closer to the target along an
axis line.
Additional trocars can
be added along
thesemicircular
line.
Gold Standard Laparoscopic Gold Standard Laparoscopic Procedures TodayProcedures Today
Laparoscopic cholecystectomyLaparoscopic cholecystectomy
Laparoscopic RYGB for obesityLaparoscopic RYGB for obesity
Laparoscopic adrenalectomyLaparoscopic adrenalectomy
Laparoscopic splenectomyLaparoscopic splenectomy
Huge DifferenceHuge Difference
* 600,000 cholecystectomies annually in the U.S.,8%-20% have CBD stones, no consensus on optimal management.
** “No single clinical indicator is completely accurate
in predicting CBD stones prior to cholecystectomy.”
* Liu, TH et al. Ann Surg 234(1), July, 2001.
**Abboud, et al. Gastrointestinal Endoscopy, 44(4), October 1996
Liu TH et al: Patient evaluation and management with selective use of magnetic resonance cholangiography and endoscopic retrograde cholangiopancreatography before laparoscopic cholecystectomy. Ann Surg 234: 33-40, 2001
Laparoscopic US as a good alternative to Laparoscopic US as a good alternative to intraoperative cholangiography (IOC) during intraoperative cholangiography (IOC) during laparoscopic cholecystectomy: results of laparoscopic cholecystectomy: results of prospective study.prospective study.
685 IOC (35 cannot canulate cystic duct) 269 LUS (2 steatosis)IOC detected 4.5% common bile duct stones; LUS 6%IOC sensitivity 96.9%, specificity 99.2%LUS sensitivity 100%, specificity 99.6%
Results:In this prospective study, LUS has been certainly as effective as IOC as a primary imaging technique for bile duct. It permitted to detect CBDS with a high specificity and sensitivity, and was not followed by an increase in CBDI.
Hublet A et al Laparoscopic US as a good alternative to intraoperative cholangiography during lap chole: results of prospective study Acta Chir Belg. 2009 May-Jun Belgique.
Indocyanine Green (ICG) Indocyanine Green (ICG) Injection:Injection:Shows the confluence between right and left hepatic
ducts during hepatectomy.
Enables identification of the cystic duct and CBD
before dissection of Calot’s triangle during
Cholecystectomy.
Ishizawa T, et al. Intraoperative Fluorescent Cholangiography Using Indocyanine Green: A Biliary Road Map for Safe Surgery. JACS 2009; 208(1):e1-e4
Indocyanine Green Injection (ICG)Indocyanine Green Injection (ICG) AdvantagesAdvantages
No need for dissection of Calot’s triangle
No need for insertion of trans-cystic tube
No exposure to radiation
No space-occupying C-arm machine required
Simple and convenient procedure
Allergic reactions
Ishizawa T, et al. Intraoperative Fluorescent Cholangiography Using Indocyanine Green: A Biliary Road Map for Safe Surgery. JACS 2009;208(1): e1-e4
Combined Laparoscopy Combined Laparoscopy and ERCP: Single Step – and ERCP: Single Step – TreatmentTreatment 45 pts underwent lap chole with intra-op cholangiogram
33 pts had succesful intra-op ERCP with extraction of common bile duct stones
No post-op complications related to procedure (i.e. pancreatitis, bleeding, perforation)
Mean hospital stay: 2.55+0.89 days
No pts with signs or symptoms of retained CBD stones during mean post-op follow-up of 9+4.07 months
Ghazal AH, Sorour MA, El-Riwini M, El-Bahrawy H. Single-step treatment of gallbladder and bile duct stones: a combined endoscopic-laparoscopic technique. Int J Surg 2009;7(4):338-46
Current TrendsCurrent Trends
National Hospital Discharge Survey database 1979 to 2001: Frequency of ERCP vs CBDE Beginning of study: 47,000 CBDE’s per year End of study: 7,000 CBDE vs 43,000 ERCP Complication rates from CBDE
3.4% at beginning of study 17.4% at end of study
“ERCP has replaced the need for most but not all CBDE”
“Both choledocholithiasis treatment algorithms and clinical training paradigms need to account for the rarity of CBDE and high complication rates associated with it, by incorporation of training modules in surgical residencies and advocating referral to centers having expertise in biliary tract operations from surgeons with little CBDE experience”
Livingston EH, Rege RV. Technical Complications are Rising as Common Duct Exploration is Becoming Rare. JACS 2005;201(3):426-433
Public Health Problem #1:
Laparoscopy in Bariatric Laparoscopy in Bariatric SurgerySurgery
OBESITY
Derived from Center for Disease Control and Prevention website www.cdc.gov
Percent of Obese (BMI ≥ 30) in US AdultsPercent of Obese (BMI ≥ 30) in US Adults
Derived from Center for Disease Control and Prevention website www.cdc.gov
Percent of Obese (BMI ≥ 30) in US AdultsPercent of Obese (BMI ≥ 30) in US Adults
County-level Estimates of Obesity among Adults County-level Estimates of Obesity among Adults aged ≥ 20 years: United States aged ≥ 20 years: United States
Trocars - placed high, close Trocars - placed high, close to to
the costal margin.the costal margin.Trocar A - liver retraction. Trocar A - liver retraction. Trocar D - can be enlarged to Trocar D - can be enlarged to allow for placement of a port.allow for placement of a port.Trocar C - placed left of the Trocar C - placed left of the midline for correct view ofmidline for correct view ofAngle of His.Angle of His.
LAP-BANDLAP-BAND
C D
EB
A
Laparoscopic RYGBLaparoscopic RYGB
Multicenter, prospective, risk-adjusted Multicenter, prospective, risk-adjusted data show that laparoscopic gastric data show that laparoscopic gastric bypass is safer than open gastric bypass is safer than open gastric bypass, with respect to 30-day bypass, with respect to 30-day complication rate.complication rate.
LRYGB has become the standard of LRYGB has become the standard of carecare
Hutter et al. Ann Surg. May 2006Hutter et al. Ann Surg. May 2006 Massachusetts General Hospital, BostonMassachusetts General Hospital, Boston..
Current ProceduresCurrent Procedures
Period or Decades Incidence of Surgery Reason for Change
Late 1970’s Early 1980’s
25,000 procedures per year
Innovative procedures• gastroplasty• loop GBP• jejuno-ileal bypass
Late 1980’s1990’s
5,000 procedures per year
Multifactorial:• High M&M• Ineffective long-term• Perceived failure• Surgeon experience
2000’s80,000 to 110,000 procedures per year
Multifactorial:• Laparoscopy• Long-term data• Centers of Excellence
1.National Hospital Discharge Survey Public-use data file and documentation. Multi-year data CD-ROM. National Center for Health Statistics, 1979-1996.
2.Nguyen et al. Accelerated growth of bariatric surgery with the introduction of minimally invasive surgery. Arch Surg 2005; 140: 1198-202.
3.Griffen et al. The decline and fall of the jejunoileal bypass. Surg Gynecol Obstet 1983; 157: 301-8.4.Shirmer et al. Bariatric Surgery Training: Getting Your Ticket Punched. J Gastrointest Surg 2007;11: 807-12.
Popularity of Surgical Management
The first case of laparoscopic adrenalectomy was reported by Gagner The first case of laparoscopic adrenalectomy was reported by Gagner
in 1992.in 1992.
Laparoscopic Adrenalectomy
Less blood lossLess blood loss
LessLess operative time!! operative time!!
Less hospital stay Less hospital stay
Less post operative painLess post operative pain
Tiberio et al.Tiberio et al.
Prospective RCTProspective RCT
Surg Endosc. Jun 2008Surg Endosc. Jun 2008
Laparoscopic adrenalectomy
Unilateral adrenalectomy Bilateral adrenalectomy
Hyperfunctioning tumors Aldosteronoma
Cortisol-producing adenoma
Virilizing tumors
Pheochromocytoma
Failed treatment of ACTH-dependent
Cushing’s syndrome
Nonfunctioning cortical adenomaa Cushing’s syndrome from primary
adrenal hyperplasia
Malignant tumors Adrenocortical carcinoma
Malignant pheochromocytoma
Adrenal metastasis (solitary without
other metastatic
disease)
Bilateral pheochromocytoma
symptomatic or enlarging adrenal
myelolipomas, ganglioneuroma
ACTH: adrenocorticotrophic hormone
Indications for AdrenalectomyIndications for Adrenalectomy
Local tumor invasiveness
Regional lymph node involvement
Large tumor size larger than 10 to 12 cma
Prior nephrectomy, splenectomy, or liver resection on the side of the adrenal lesiona
a Relative contraindications
Contraindications for Contraindications for Laparoscopic AdrenalectomyLaparoscopic Adrenalectomy
Laparoscopic Splenectomy-Laparoscopic Splenectomy-IndicationsIndications
Idiopathic thrombocytopenic purpura
ITP/HIV +
Thrombotic thrombocytopenic purpura
Hereditary spherocytosis
Auto-immune hemolytic anemia
Splenic cysts
Evan’s syndrome
Felty’s syndrome
Hypersplenism (portal hypertension)
Non Hodgkin’s lymphoma
Hodgkin’s lymphoma
Lymphocytic leukemia
Myelocytic leukemia
Tricholeukocytic leukemia
Myelocytic splenomegaly
Splenic tumor
SPLENECTOMYSPLENECTOMY
Laparoscopic splenectomyLaparoscopic splenectomy
Significantly less pulmonary, wound, and infectious complications.Significantly less pulmonary, wound, and infectious complications. Longer operative times Longer operative times Winslow (meta-analysis). Surgery. 2003 Oct;134(4):647-Winslow (meta-analysis). Surgery. 2003 Oct;134(4):647-
5353
Laparoscopic ProceduresLaparoscopic Procedureswith equivalencewith equivalence
Laparoscopic hernia repairLaparoscopic hernia repair
Laparoscopic appendectomyLaparoscopic appendectomy
Laparoscopic fundoplicationLaparoscopic fundoplication
Laparoscopic Inguinal Laparoscopic Inguinal Hernia RepairHernia Repair
The Ebers Papyrus 1550 BC, Entitled The Ebers Papyrus 1550 BC, Entitled “Beginning of the Secret of the “Beginning of the Secret of the
Physician” Physician”
Heat application was one of the methods to reduce a strangulated Heat application was one of the methods to reduce a strangulated hernia. hernia.
The mummy of Meren-Ptah (19th dynasty) shows a sign of an open The mummy of Meren-Ptah (19th dynasty) shows a sign of an open wound resulting from surgical interference.wound resulting from surgical interference.
If thou examinst a swelling of the covering If thou examinst a swelling of the covering of his belly’s horns above his pudenda (sex of his belly’s horns above his pudenda (sex organs) then thou shalt place thy finger on organs) then thou shalt place thy finger on it and examine his belly and knock on the it and examine his belly and knock on the fingers (percuss) if thou examinst his that fingers (percuss) if thou examinst his that has come out and has arisen by his cough. has come out and has arisen by his cough. Then thou shalt say concerning it: it is a Then thou shalt say concerning it: it is a swelling of the covering of his belly. It is a swelling of the covering of his belly. It is a disease which I will treat”.disease which I will treat”.
Hernia - Historic PerspectiveHernia - Historic Perspective
Galen of Pergamum (AC 129-179) who was a Galen of Pergamum (AC 129-179) who was a
surgeon to the gladiators practiced ligation of the sac surgeon to the gladiators practiced ligation of the sac
and cord with amputation of the testicle. and cord with amputation of the testicle.
Guy de Chauliac (AC 1300-1368) in his book Guy de Chauliac (AC 1300-1368) in his book
Chirurgia Magna: laxatives, hang patient from his Chirurgia Magna: laxatives, hang patient from his
legs, bed rest for 50 days.legs, bed rest for 50 days.
Trocar placement:Trocar placement:
TransabdominalTransabdominal
Preperitoneal (TAPP)Preperitoneal (TAPP)
TotallyExtraperitoneal
(TEP)
Additional
trocar
INGUINAL INGUINAL HERNIA REPAIRHERNIA REPAIR
Inguinal Hernia RepairInguinal Hernia Repair
What are indications for What are indications for laparoscopic inguinal hernia laparoscopic inguinal hernia
repair?repair?Recurrent herniaRecurrent hernia
• Avoids scar tissueAvoids scar tissue
• Visualizes occult hernia Visualizes occult hernia
Bilateral herniaBilateral hernia
• Decreased pain Decreased pain
• Earlier return to workEarlier return to work
• No difference in recurrence or complicationNo difference in recurrence or complication
Obese / Athletic patientsObese / Athletic patients
• Definitive diagnosisDefinitive diagnosis
• Reduced infection in susceptible populationReduced infection in susceptible population
• Gilmore’s groinGilmore’s groin
Patients with contralateral injury to vas deferensPatients with contralateral injury to vas deferens
• Less chance to injure other vasLess chance to injure other vas
Are there contraindications to Are there contraindications to lap. inguinal hernia repair?lap. inguinal hernia repair?
ContraindicationsContraindications• Patients for whom general anesthesia and Patients for whom general anesthesia and
pneumoperitoneum are risks (cardiac, pulmonary pneumoperitoneum are risks (cardiac, pulmonary disease)disease)
Relative ContraindicationsRelative Contraindications• Prior pre-peritoneal surgery (prostate, hernia, vascular, Prior pre-peritoneal surgery (prostate, hernia, vascular,
kidney transplant)kidney transplant)• Prior laparotomyPrior laparotomy• AscitesAscites• Strangulated herniaStrangulated hernia• Giant scrotal herniaGiant scrotal hernia• Anticipated bleeding (patients on anti-coagulation)Anticipated bleeding (patients on anti-coagulation)
Management of recurrent Management of recurrent inguinal herniasinguinal hernias
Kamal MF Itani MDKamal MF Itani MD11, Robert Fitzgibbon Jr MD, Robert Fitzgibbon Jr MD22, Samir S Awad MD, Samir S Awad MD33, Quan-Yang Duh MD, Quan-Yang Duh MD44, George S. Ferzli , George S. Ferzli MD5MD5
1 Boston VA Health Care System and Boston University, Boston MA1 Boston VA Health Care System and Boston University, Boston MA2 Creighton University, Omaha NE2 Creighton University, Omaha NE3 Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX3 Michael E DeBakey VA Medical Center and Baylor College of Medicine, Houston, TX4 San Francisco VA Medical Center and University of California San Francisco, San Francisco CA4 San Francisco VA Medical Center and University of California San Francisco, San Francisco CA5 SUNY Downstate Medical Center and Lutheran Medical Center, Brooklyn NY5 SUNY Downstate Medical Center and Lutheran Medical Center, Brooklyn NY
Role of the Patient in Role of the Patient in RecurrenceRecurrence
Characteristics Points
Gender Male 3
Female 1
Age ? 50 3
< 50 1
Hernia Primary inguinal 2
Recurrent ingui ( nal first recurrence) 4
(Recurrent inguinal> 1 recurrence) 8
Primary incisional 3
Recurrent incisional 8
Femoral hernia 8
Size ? 3cm 3
< 3cm 1
Localization Multilocular 4
Unilocular 1
Smoking Yes 2
No 1
Family Occurrence of hernias in? 2 first- grade relatives 3
Occurrence of hernias in< 2 first- grade relatives 1
Collagen Disorders (Proven alteration in collagen metabolism Ehlers-, , Danlos Marfan syndrome Osteogenesis
, )imperfecta AAA
5
No evidence of alteration in collagen metabolism 1
Total
HEAD ScoreHEAD Score::
Hernia of the Adult Hernia of the Adult
Disease ScoreDisease Score
Attempt to Attempt to
individualize treatment individualize treatment
based on 8 factors.based on 8 factors.
Courtesy of Dr. Christian PeiperCourtesy of Dr. Christian Peiper
2. Do we have an answer for
groin pain after hernia repair?
Nerves prone to injury Nerves prone to injury anterior and posterioranterior and posterior
Author # of Pts Pain* Pain Severe Outcome of Pain
A. S. Poobalan 2001 226 30% > 3 mo
Morten Bay-Nielsen 2001 1166 28.7% > year 3%
S. Kumar 2002 454 30% >21 mo
C. A. Courtney 2002 4062 > 3 mo 3% > 2.5 yrs 71% have painSevere in 22% Mild in 45%
Marcello Picchio 2004 593 25% > 1 yr 6%>1 yr
A. M. Grant 2004 928 9.7%>1 yr 1.8% > 5 yrs
Jrg Kninger 2004 208 36% (Shouldice) 31% (Lichtenstein)15% (TAPP)> 52 mo
Ulf Fränneby 2006 2456 31% >24 to 36 mo
Sergio Alfieri 2006 973 9.7% > 6 mo 2.1 %> 6 mo Mild 4.1% > 1yr Severe 0.5% > 1yr
E. K. Aasvang 2006 210 34.3% >1year Less pain 75.8%Same pain 16.7%More severe 7.5%> 6.5 years
* Groin pain or discomfort lasting more than 3 months after groin hernia repair.Intern. Assn. for the Study of Pain. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. Prepared by the International Association for the Study of Pain, Subcommittee on Taxonomy. Pain. 1986; 3 (suppl): 1–226.
Groin Pain IncidenceGroin Pain Incidence
Quality of LifeQuality of Life
Author Pts Pain affects the quality of life
Morten Bay-Nielsen 2001 1166 16.6%
S Kumar 2002 454 18.1%
Jrg Kninger 2004 208 14% (Shouldice)
13% (Lichtenstein)
2.4% (TAPP)
Ulf Fränneby 2006 2456 6%
EK Aasvang 2006 210 Nb
24.8%
6% after 6.5 years
Sergio Alfieri 2006 973 11.3% to 14.2%
Causes and Risk Factors Causes and Risk Factors of Groin Painof Groin Pain
Anatomical Variation Innervation symmetry - 40.6%
Normal distribution - 20.3%
“Normal” anatomic pattern - 56.3%
Mesh repair No clear correlation between use of mesh and chronic pain
Age Studies disagree on correlation between older age and post-herniorrhaphy pain
Pre-operative pain Pain associated with hernia before repair is associated with post-operative pain
BMI No correlation found between elevated BMI and post-operative pain
Post-operative complications
Postoperative complications linked to an increased risk for long term pain
Recurrent hernia
Day case surgery
Open versus laparoscopic
Recurrence associated with recurrent pain
The probability of developing chronic pain is 2.5 times higher in day-case patients, controlling for age
Open repair strongly correlated with post-operative pain compared to laparoscopic repair
What are recommendations for prevention of chronic pain?
ConclusionsLevel 1B• Material reduced meshes have some advantages with respect to longterm discomfort and foreign body sensation in open hernia repair (when only considering chronic pain).Level 2A• Prophylactic resection of the ilioinguinal nerve does not reduce the risk of chronic pain after hernia surgery.Level 2B• Identification of all inguinal nerves during open hernia surgery may reduce the risk of nerve damage and postoperative chronic groin pain.
Treatment of chronic painLevel 3• A multidisciplinary approach at a pain clinic is an option for the treatment of chronic post herniorrhaphy pain.• Surgical treatment of specific causes of chronic post herniorrhapy pain can be beneficial, such as resection of entrapped nerves, mesh removal in mesh-related pain, removal of endoscopic staples or fixating sutures.
European Hernia Society Guidelines: Treatment of Inguinal Hernia in Adult Patients
Laparoscopic Ventral Hernia:Is the Abdomen a Laparoscopic Ventral Hernia:Is the Abdomen a Weakness in the Human Race ?Weakness in the Human Race ?
Laparoscopic Ventral Hernia:Is the Abdomen a Laparoscopic Ventral Hernia:Is the Abdomen a Weakness in the Human Race ?Weakness in the Human Race ?
Incidence of Ventral HerniasIncidence of Ventral HerniasIncidence of Ventral HerniasIncidence of Ventral Hernias
Around 10% of all laparotomies will generate incisional hernias. Around 10% of all laparotomies will generate incisional hernias.
The bigger the incision, the higher the risk.The bigger the incision, the higher the risk.~77% are median hernias~77% are median hernias~17% are lateral hernias~17% are lateral hernias~6% are iliac hernias~6% are iliac hernias
Direct closure have a high recurrences incidence (50%). The rateDirect closure have a high recurrences incidence (50%). The rate increases (58%) with repair of recurrent hernias.increases (58%) with repair of recurrent hernias.
Significant reduction in recurrences is achieved when meshes are used.Significant reduction in recurrences is achieved when meshes are used.
LuijendijkLuijendijk RW, et al. A Comparison of Suture Repair with Mesh Repair for Incisional RW, et al. A Comparison of Suture Repair with Mesh Repair for Incisional HerniaHernia.NEJM .NEJM 2000; 343:392-398 2000; 343:392-398
Factors Influencing Factors Influencing Ventral Hernia OccurrenceVentral Hernia Occurrence
The most important functions of the abdominal wall are protection, The most important functions of the abdominal wall are protection, compression and retention of the abdominal contents, flexion and rotationcompression and retention of the abdominal contents, flexion and rotation of the trunk and forced expiration.of the trunk and forced expiration.
EndogenEndogen ExogeneExogene OthersOthers
Age > 45Age > 45 SuturesSutures EmergencyEmergency BMI > 25BMI > 25 Length of incisionLength of incision Intra-abdominal Intra-abdominal Previous operationPrevious operation ContaminationContamination pressurepressure AnemiaAnemia MedicationMedication ShockShock Type of incisionType of incision SmokerSmoker CorticoïdsCorticoïds Aneurysm/MarfanAneurysm/Marfan (+30% risks)(+30% risks)
Hypothesis:Hypothesis: In midline incisions closed with a single layer running suture, theIn midline incisions closed with a single layer running suture, therate of wound complications is lower when a suture length to wound lengthrate of wound complications is lower when a suture length to wound lengthratio of at least 4 is accomplished with a short stitch length rather than with aratio of at least 4 is accomplished with a short stitch length rather than with along one.long one.
Surgical site infection occurred in 35 of 343 patients (10.2%) in the long stitchSurgical site infection occurred in 35 of 343 patients (10.2%) in the long stitchgroup and in 17 of 326 (5.2%) in the short stitch group (P=0.2). Igroup and in 17 of 326 (5.2%) in the short stitch group (P=0.2). Incisionalncisionalhernia was present in 49 of 272 patients (18.0%) in the long stitch group andhernia was present in 49 of 272 patients (18.0%) in the long stitch group andin 14 of 250 (5.6%) in the short stitch group (P<.001).in 14 of 250 (5.6%) in the short stitch group (P<.001).
Conclusion:Conclusion: In midline incisions closed with a running suture and having aIn midline incisions closed with a running suture and having asuture length to wound length ratio of at least 4, current recommendations ofsuture length to wound length ratio of at least 4, current recommendations ofplacing stitches at least 10mm from the wound edge should be changed toplacing stitches at least 10mm from the wound edge should be changed toavoid patient suffering and costly wound complications.avoid patient suffering and costly wound complications.
Effect of Stitch Length on Wound Complications After Closure of Midline Incisions; A Randomized Controlled StudyDaniel Millbourn, MD; Yucel Cengiz, MD, PhD; Leif A. Israelsson, MD, PhD
Effect of Stitch Length on Wound Complications After Closure of Midline Incisions; A Randomized Controlled Study, Millbourn, D MD; Cengiz, Y MD, PhD; Israelsson, L MD, PhD Arch Surg/vol 144 (No. 11), Nov 2009 www.archsurg.com
Significant predictors of surgical site infection and incisional herniaa
Effect of Stitch Length on Wound Complications After Closure of Midline Incisions; A Randomized Controlled Study, Millbourn, D MD; Cengiz, Y MD, PhD; Israelsson, L MD, PhD Arch Surg/vol 144 (No. 11), Nov 2009 www.archsurg.com
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); CI, confidence interval; OR odds ratio; SL, suture length; WL wound length
A Results of logistic regression analysis. All recorded variables were included in the model and removed by a backward reduction strategy if nonsignificant.
Predictor Regression Coefficient (SE) OR (95%CI)
Surgical site infection
Wound contamination 1.03 (0.48) 2.81 (1.09-7.25)
Being diabetic 1.01 (0.38) 2.73 (1.30-5.72)
Long stitch length 0.77 (0.31) 2.15 (1.17-3.96)
Incisional hernia
Male sex 0.76 (0.34) 2.14 (1.10-4.15)
Higher BMI 0.05 (0.02) 1.05 (1.01-1.10)
Longer operation time 0.005 (0.002) 1.01 (1.002-1.01)
Surgical site infection 1.16 (0.40) 3.18 (1.44-7.02)
SL to WL ratio <4 1.32 (0.52) 3.73 (1.36-10.26)
Long stitch length 1.44 (0.34) 4.24 (2.19-8.23)
Prospective Clinical Trial of Factors Predicting the Prospective Clinical Trial of Factors Predicting the Early Development of Incisional Hernia after Midline Early Development of Incisional Hernia after Midline
LaparotomyLaparotomy
6 months analysis after operation of numerous demographic, clinical, treatment and outcomes-6 months analysis after operation of numerous demographic, clinical, treatment and outcomes-related peri-operative factors to determine statistical association with development of incisional related peri-operative factors to determine statistical association with development of incisional hernia.hernia.
Four covariates independently predictive of incisional hernia were studied: Four covariates independently predictive of incisional hernia were studied: Body mass index Body mass index (BMI) > 24.4kg/m2(BMI) > 24.4kg/m2; ; fascial suture to incision ratio (SIR) < 4.2fascial suture to incision ratio (SIR) < 4.2 ; ; deep surgical site, deep space, or deep surgical site, deep space, or organ infection (SSIorgan infection (SSI); and ); and time to suture removal or complete epithelialization >16 days time to suture removal or complete epithelialization >16 days (TIME).(TIME).
Conclusion: The hernia risk scoring system equation [p(%) = 32(SIR) + 30(SSI) + 9(TIME) + Conclusion: The hernia risk scoring system equation [p(%) = 32(SIR) + 30(SSI) + 9(TIME) + 2(BMI)] provided accurate estimates of incisional hernia according to stratified risk groups based 2(BMI)] provided accurate estimates of incisional hernia according to stratified risk groups based on total score: on total score: low (0 to 5 points), 1.0%; moderate (6 to 15 points), 9.7%; increased (16 to 50 low (0 to 5 points), 1.0%; moderate (6 to 15 points), 9.7%; increased (16 to 50 points), 30.2%; and markedly increased (>50 points), 73.1%points), 30.2%; and markedly increased (>50 points), 73.1%
JACS, Volume 210, Issue 2, pp 210-219.JACS, Volume 210, Issue 2, pp 210-219.
Radovan Veljkovic, MD, PhDa, Mladjan Protic, MDa, Aleksandar Gluhovic, MDa, Radovan Veljkovic, MD, PhDa, Mladjan Protic, MDa, Aleksandar Gluhovic, MDa, Zoran Potic, MSb, Zoran Milosevic, MD, PhDa, Alexander Stojadinovic, MD, Zoran Potic, MSb, Zoran Milosevic, MD, PhDa, Alexander Stojadinovic, MD, FACScdFACScd
Laparoscopic Repair of Laparoscopic Repair of Incisional HerniasIncisional Hernias
wound complicationswound complications
recurrence raterecurrence rate
LOSLOS
painpain
coverage of “Swiss cheese” coverage of “Swiss cheese” abdomenabdomen
Ventral Hernia Defect
Mesh used to patch defect
Secure periphery Secure periphery
of mesh with tackerof mesh with tacker
Approximately 1cm Approximately 1cm
apartapart
Completed repair
Potential Mesh-Related Potential Mesh-Related Complications:Complications:
InfectionInfection
Intestinal adhesionsIntestinal adhesions
Bowel obstructionsBowel obstructions
Erosion of the prosthesis into the adjacent hollow Erosion of the prosthesis into the adjacent hollow viscousviscous
Contraction of prosthesisContraction of prosthesis
BiomeshesBiomeshes
Biomesh Type Products, Manufacturers
Human acellular dermis AlloDermØ, LifeCell
Flex HDTM, J&J
AlloMaxTM, Davol
Xenogenic acellular dermis PermacolTM (porcine), Tissue Science Laboratories
SurgiMendTM (bovine,calf), TEI Biosciences
CollaMendTM, (porcine) Davol
XenMatriXØ (porcine), Brennen Medical LLC;Brennenmed.com
StratticeTM, LifeCell
Porcine small intestinesubmucosa
SurgisisØ, Cook Medical
FortaGenØ, Organogenesis
Processing of BiomaterialsProcessing of Biomaterials
Cadaveric, Bovine, Porcine, Equine: removal of all live cells Cadaveric, Bovine, Porcine, Equine: removal of all live cells
and removal of all nuclear tissue to prevent rejection by and removal of all nuclear tissue to prevent rejection by
the hostthe host..
Cross-linking: serve to form either an intermolecular or an Cross-linking: serve to form either an intermolecular or an
intramolecular cross-link between two aminoacids along intramolecular cross-link between two aminoacids along
protein structure (HDMI and EDC are in common use)protein structure (HDMI and EDC are in common use)..
Crosslinked products are more resistant to collagenase Crosslinked products are more resistant to collagenase
degradation degradation (more stable in infected fields where (more stable in infected fields where
collagenases are secreted by bacteria).collagenases are secreted by bacteria).Rapid dissolution Rapid dissolution
in the presence of enteric contents (fistulas)in the presence of enteric contents (fistulas)..
Must be placed in direct contact with healthy tissue, under Must be placed in direct contact with healthy tissue, under
no tension and should not be usedto bridge the defect.no tension and should not be usedto bridge the defect.
Alloderm Bulge Alloderm Translucency
Gaertner, W et al. Experimental Evaluation of Four Biologic Prostheses for Ventral Hernia Repair. J Gastrointest Surg July 2007
Comparison of Biologic Grafts – Comparison of Biologic Grafts – Overview of Gaertner StudyOverview of Gaertner Study
• Thickness at the defect area diminished significantly at 6 months with both Veritas and AlloDerm (P<0.05), so much so that they became translucent.• Permacol and Peri-Guard, the mean defect area and thickness were virtually identical to when they were originally installed 6months earlier. • Tensile strength of the material itself after 6 months was significantly reduced for the non-cross-linked prostheses (Veritas and AlloDerm) compared to the cross-linked prostheses (Peri-Guard and Permacol). • Stretching, bulging, and translucency were routine with AlloDerm.
Leve
l of C
ompl
exity
Grade 1Low risk of infection
Low risk of complications
Grade 2Smoker
Immunosuppressed
Obese
Diabetic
Grade 4Active infection
Infected meshGrade 3
Contamination risk
Stoma present
Violation of bowel wall
Previous Wound infection
Grade 5Traumatic fascia loss
Extensive fascia loss
Percent Performed Open
Patients with co-morbid conditions have up to 4x increase in wound-infection rates
Open incisional hernias are 10x more likely to have infection than a clean surgical case
Infected mesh commonly results in a 2nd procedure for removal
Synthetic
Biologic
Massive Incisional HerniasMassive Incisional Hernias
Material Functions for Soft Tissue Material Functions for Soft Tissue RepairRepair
Synthetics Autografts
•Good mechanical properties
•Low cost
•High foreign body reaction
•Infection up to 8%1
•Can cause pain
•Native Tissue
•Good Mechanical Properties
•Donor Site Morbidity
•Many patients unqualified
•Strong reinforcement
•Biocompatible
•Supports ingrowth
•Ease of handling
•Ability to vascularize
Xeno/Allo graft
Components SeparationComponents SeparationComponents SeparationComponents Separation
Developed by Dr. Ramirez in the late 80’sDeveloped by Dr. Ramirez in the late 80’s
Employs the use of autologous myofascial tissue to effect abdominal Employs the use of autologous myofascial tissue to effect abdominal wall closurewall closure
Bilateral relaxation incisions 2cm lateral to the external oblique from Bilateral relaxation incisions 2cm lateral to the external oblique from costal margin to level of symphasis pubiscostal margin to level of symphasis pubis
Blunt separation of external oblique layer from underlying internal Blunt separation of external oblique layer from underlying internal oblique layer taking care not to interrupt vascular/nerve supplyoblique layer taking care not to interrupt vascular/nerve supply
May employ undermining of one or both posterior rectus sheaths to May employ undermining of one or both posterior rectus sheaths to achieve further medial advancementachieve further medial advancement
**Provides dynamic support of the abdominal girdle****Provides dynamic support of the abdominal girdle**
Ventral Hernia: AnatomyVentral Hernia: AnatomyVentral Hernia: AnatomyVentral Hernia: Anatomy
Components SeparationComponents Separation
Grevious MA. Cohen M. Shah SR. Rodriguez P. Structural and functional anatomy of the abdominal wall. Clinics in Plastic Surgery. 33(2):169-79, v, 2006 Apr.
External oblique
Internal oblique
Transversus abdominis
Rectus abdominis
Components SeparationComponents Separation
Case ReportCase Report
Laparoscopic AppendectomyLaparoscopic Appendectomy
Laparoscopic Appendectomy
Endo-loop
APPENDECTOMYAPPENDECTOMYAlternatively, an appendectomy can be Alternatively, an appendectomy can be performed through a trocar in the performed through a trocar in the umbilicus and two trocars in the umbilicus and two trocars in the suprapubic area medial to the epigastric suprapubic area medial to the epigastric
vesselsvesselsfor a superb cosmetic result (if an extended for a superb cosmetic result (if an extended right hemicolectomy is to be performed, the right hemicolectomy is to be performed, the hepatic flexure positioning is preferred.)hepatic flexure positioning is preferred.)
Laparoscopic Appendectomy Laparoscopic Appendectomy Evidence-based MedicineEvidence-based Medicine
Clear advantage in children*Clear advantage in children*
- Less wound infection, LOS, ileus- Less wound infection, LOS, ileus
- More OR time, intra-abdominal abscess- More OR time, intra-abdominal abscess
Controversies in adultsControversies in adults
- Cost, obese patients, severe appendicitis- Cost, obese patients, severe appendicitis
*Aziz et al. *Aziz et al. Ann SurgAnn Surg 2006 2006
- Prelude to NOTES
LAPAROSCOPIC PROCEDURES
WITH CLEAR ADVANTAGES.
Laparoscopic Heller’s Laparoscopic Heller’s CardiomyotomyCardiomyotomy
Technically feasible
Short recovery time
Less overall complication
rates
Anti-reflux surgeryAnti-reflux surgery
1945 to present1945 to presentMultiple methods and techniques:Multiple methods and techniques:Nissen fundoplicationNissen fundoplicationDor wrapDor wrapHill gastropexy ….Hill gastropexy ….
Different approaches:Different approaches:Laparotomy vs laparoscopyLaparotomy vs laparoscopyThoracotomy vs thoracoscopyThoracotomy vs thoracoscopy
Rudolph Nissen, MD
INFLUENTIAL PEOPLE:
Lortat-Jacob, MD
AndreToupet, MD
Jacques Dor, MD
Ernst Heller, MD
Rudolph Nissen MD
Ivor Lewis, MD
J. Leigh Collis, MD
K. Alvin Merendino, MD
Lucius Hill, MD
Ronald Belsey, MD
Alan Thal, MD
Nissen’s FundoplicationNissen’s Fundoplication
Technique
Nissen FundoplicationNissen Fundoplication
Esophageal HiatusEsophageal Hiatus
LiverLiver
EsophagusEsophagus
Left crusLeft crus
Right crusRight crus
AortaAorta
Hiatal DefectHiatal Defect
Chest cavityChest cavity
StomachStomach
Left crusLeft crus
Mesh RepairMesh Repair
Polypropylene mesh
Esophagus
• Do not use metal tacks
• Biologic mesh? dual mesh?
• No mesh at all? (remember original Toupet repair)
Mesh
Wrap
Circular mesh
Fundoplication
Laparoscopic Surgery Laparoscopic Surgery in Colorectal Diseasesin Colorectal Diseases
Port Site RecurrencePort Site Recurrence
NOTENOTE::
If proximal divided end of colon can reach through If proximal divided end of colon can reach through the skin there has been sufficient dissection of the skin there has been sufficient dissection of splenic flexure providing a tension-free anastomosis.splenic flexure providing a tension-free anastomosis.
HEPATIC HEPATIC FLEXURE FLEXURE COLON COLON
RESECTION RESECTION
ABTension-free anastomosis
The ileum is more mobile than the The ileum is more mobile than the transverse colon, which can still be transverse colon, which can still be delivered adequately at this level.delivered adequately at this level.
Trocar C is used for GIA divisionof distal ileum and midtransverse colon (site is enlarged to retrieve specimen and for extracorporeal anastomosis).
C
LAPAROSCOPIC LAPAROSCOPIC SIGMOID RESECTIONSIGMOID RESECTION
(lateral decubiti (lateral decubiti position)position)
LateralSupine
Laparoscopic colorectal Laparoscopic colorectal surgerysurgery
Cochrane Systematic review of short term outcomes in 25 RCTs showed that Cochrane Systematic review of short term outcomes in 25 RCTs showed that laparoscopic colorectal surgery had:laparoscopic colorectal surgery had:
Longer operative time Longer operative time Less intraoperative blood lossLess intraoperative blood loss Less postoperative painLess postoperative pain less postoperative ileusless postoperative ileus Better postoperative pulmonary functionBetter postoperative pulmonary function Less total and local morbidityLess total and local morbidity Less postoperative hospital stay Less postoperative hospital stay Similar general morbidity and mortalitySimilar general morbidity and mortality Better quality of life (within 30 days) Better quality of life (within 30 days)
Schwenk et al. 2005 Jul 20;(3):Cochrane Database 003145Schwenk et al. 2005 Jul 20;(3):Cochrane Database 003145
Cochrane Systematic review of long term outcomes showed:Cochrane Systematic review of long term outcomes showed: Similar port-site metastases and wound recurrencesSimilar port-site metastases and wound recurrences Similar cancer-related mortality at maximum follow-upSimilar cancer-related mortality at maximum follow-up Similar tumor recurrenceSimilar tumor recurrence Similar overall mortality Similar overall mortality
Kuhry et al. Cancer Treat Rev. Oct 2008Kuhry et al. Cancer Treat Rev. Oct 2008
Consensus Review of Optimal Perioperative Care in Colorectal Consensus Review of Optimal Perioperative Care in Colorectal Surgery, Enhanced Recovery After Surgery (ERAS) Group Surgery, Enhanced Recovery After Surgery (ERAS) Group
RecommendationsRecommendations
Fast-track ProtocolFast-track Protocol No oral bowel preparationNo oral bowel preparation Pre operative fasting of 2 Pre operative fasting of 2
hours for liquids and 6 hours hours for liquids and 6 hours for solids. Carbohydrate for solids. Carbohydrate loadingloading
Single dose antibiotic Single dose antibiotic prophylaxis.prophylaxis.
No routine use of nasogastric No routine use of nasogastric tubes.tubes.
Use of drains not advisable.Use of drains not advisable. Oral diet at will after surgery.Oral diet at will after surgery.
Conventional ProtocolConventional Protocol
Oral bowel preparationOral bowel preparation
Pre operative fasting of 6 Pre operative fasting of 6
hourshours
Prolonged antibiotic use.Prolonged antibiotic use.
Nasogastric tubes used Nasogastric tubes used
routinely.routinely.
Drains routinely used.Drains routinely used.
Delayed oral intake.Delayed oral intake.
Less frequent Laparoscopic Less frequent Laparoscopic proceduresprocedures
Liver SurgeryLiver Surgery
Pancreas SurgeryPancreas Surgery
Laparoscopic hepatectomyLaparoscopic hepatectomy
First performed 1994 First performed 1994 by Huscher et alby Huscher et al
A safe procedure in A safe procedure in experienced handsexperienced hands
Resection devices:Resection devices: StaplersStaplers Bipolar vessel sealing Bipolar vessel sealing
(Ligasure)(Ligasure) Radiofrequency Radiofrequency U/S dissectorU/S dissector Nd-YAG laserNd-YAG laser
Laparoscopic left hemihepatectomy (resection of segments 2, 3, and 4). (A) Intraoperative view showing ischemic delineation of the left liver. Note the vascular endoscopic stapler encircling the left Glissonian pedicle. (B) Schematic view. The stapler is closed, and ischemic delineation of the left liver is obtained. (C) Intraoperative view. The stapler is fired, and the left main Glissonian pedicle is transected (arrows). (D) Schematic view. The stapler is fired
Pulitanò C and Aldrighetti L Nat Clin Pract Gastroenterol Hepatol (2008)
Outcomes of laparoscopic hepatectomy
Laparoscopic pancreatectomyLaparoscopic pancreatectomy
Pancreaticoduodenectomy Pancreaticoduodenectomy Total splenopancreatectomyTotal splenopancreatectomy Spleen-preserving total Spleen-preserving total
pancreatectomypancreatectomy Distal splenopancreatectomyDistal splenopancreatectomy Spleen-preserving distal Spleen-preserving distal
pancreatectomypancreatectomy Central pancreatectomyCentral pancreatectomy Enucleation Enucleation
Procedures are technically Procedures are technically challengingchallenging
Long learning curveLong learning curve High volume center improves High volume center improves
clinical outcomeclinical outcome
DISTAL PANCREATECTOMYDISTAL PANCREATECTOMY
DE
C
B
A
• Trocars “A” and “B” divide gastrocolic ligament• GIA is introduced through “D”
Laparoscopic pancreatectomy Laparoscopic pancreatectomy Vs. openVs. open
Finan et al. Am Surg. Aug 2009 Finan et al. Am Surg. Aug 2009 Laparoscopic and open distal Laparoscopic and open distal pancreatectomy: a comparison of pancreatectomy: a comparison of outcomes.outcomes.
There was no significant difference in the There was no significant difference in the incidence of postoperative morbidity or incidence of postoperative morbidity or mortalitymortality
There was no significant difference in the rate There was no significant difference in the rate
of all pancreatic fistula formation or clinically of all pancreatic fistula formation or clinically significant leaks significant leaks
Lparoscopic technique had decreased: Lparoscopic technique had decreased: operative timeoperative time blood lossblood loss length of stay in the lap group. length of stay in the lap group.
ConclusionConclusion Lap and open distal pancreatectomy are Lap and open distal pancreatectomy are
performed safely at high-volume performed safely at high-volume pancreatic surgery centers. pancreatic surgery centers.
Laparoscopic Urologic Laparoscopic Urologic proceduresprocedures
Undescended testisUndescended testis
VaricocelectomyVaricocelectomy
Retroperitoneal fibrosisRetroperitoneal fibrosis
Lymph node dissectionLymph node dissection
Bladder neck suspensionBladder neck suspension
Bladder diverticulumBladder diverticulum
Patent urachusPatent urachus
NephrectomyNephrectomy
ProstatectomyProstatectomy
RT. KIDNEY RESECTIONRT. KIDNEY RESECTION• Subxiphoid port (D) - liver retraction
• Trocar A - parallel to vena cava (perpendicular approach to rt. renal vessels and rt. adrenal vein –additional trocar E may be placed more laterally and posterior to trocar A if needed.)
B
C
D
AE
PROSTATECTOMPROSTATECTOMYY
AB
C
Trocars – added as needed along semicircular line. i.e., during a prostatectomy, another trocar is added between A and B.Another trocar may be added between B and C allowing the surgeon and assistant surgeonon the opposite side to each use both hands.
Minimally invasive neck surgery
Minimally invasive neck surgery
Endoscopic
Central
Lateral
“Other” (transaxillary, transpectoral, transoral)
Minimally invasive MIVAT (min. invasive video assisted thyroidectomy)
MIVAP (min. invasive video assisted parathyroidectomy)
Robotic assisted
Inferior parathyroid release in Minimally invasive thyroidectomy
Cosmetic resultsCosmetic results
Open surgery scar Minimally invasive / endoscopic scars
ConclusionsConclusions
MIVAT and MIVAP yield equivalent endocrine results as
open procedure
Oncologic result is equivalent in selected patients
Equivalent safety profile as open procedures
Postop pain is decreased
Patient satisfaction with procedure and cosmetic result
is significantly increased
(Miccoli et al., RCT, Surgery. 2001)
Yet:
What about large masses?!
It is not a ‘niche surgery’!
Emerging TechnologiesEmerging Technologies
RoboticsRobotics
SILSSILS
NOTESNOTES
Trocarless laparoscopyTrocarless laparoscopy
ENDOBARRIERENDOBARRIER
History of RoboticsHistory of Robotics
Leonardo da Vinci Leonardo da Vinci
developed one of the developed one of the
first robots in 1495 – an first robots in 1495 – an
armored knight for the armored knight for the
purposes of purposes of
entertaining royalty.entertaining royalty.
What Robotics Aimed to Improve in Laparoscopy
Surgeon operates from a 2D imageSurgeon operates from a 2D image
Straight, rigid instruments (limited range of motion)Straight, rigid instruments (limited range of motion)
Instrument tips controlled at a distance Instrument tips controlled at a distance
Reduced dexterity, precision & controlReduced dexterity, precision & control
Unsteady camera controlled by assistantUnsteady camera controlled by assistant
Dependent on assistant for surgical support through accessory portDependent on assistant for surgical support through accessory port
Greater surgeon fatigueGreater surgeon fatigue
Makes complex operations more difficultMakes complex operations more difficult
Surgical RobotsSurgical Robots
AESOPAESOP (Automated Endoscopic System for Optimal (Automated Endoscopic System for Optimal
Positioning)Positioning)
- Voice activated mechanical arm- Voice activated mechanical arm
- Steadier than human, never tires- Steadier than human, never tires
da Vincida Vinci®®
- FDA approval in 2002- FDA approval in 2002
- Laparoscopic instrumentation controlled by the - Laparoscopic instrumentation controlled by the
surgeon, positioned remotely at a consolesurgeon, positioned remotely at a console
Development of Development of da Vincida Vinci®®
Defense Advanced Research Projects Agency (DARPA) Defense Advanced Research Projects Agency (DARPA)
for for
military research of remote battlefield surgerymilitary research of remote battlefield surgery
Cholecystectomy performed remotely via telesurgery from 300 miles Cholecystectomy performed remotely via telesurgery from 300 miles
awayaway
Intuitive surgical created in 1999 after acquiring patent rights from Intuitive surgical created in 1999 after acquiring patent rights from
militarymilitary
First robotic prostatectomy performed in 2001First robotic prostatectomy performed in 2001
da Vincida Vinci®® Surgical System U.S. Surgical System U.S. Installed Base 1999 – 2006Installed Base 1999 – 2006
What is the What is the da Vincida Vinci®® Surgical Surgical System?System?
State-of-the-art robotic State-of-the-art robotic technologytechnology
Surgeon in controlSurgeon in control
Assistant has direct accessAssistant has direct access
Surgeon directs precise Surgeon directs precise
movements of instruments in movements of instruments in
the slave unit using console the slave unit using console
controls.controls.
What is the What is the da Vincida Vinci®® Surgical System?Surgical System?
Robotic Scrub NurseRobotic Scrub Nurse“Penelope”“Penelope”
Laparoscopic instruments Laparoscopic instruments
are rigid with no wristsare rigid with no wrists
EndoWristEndoWrist®® Instrument tips Instrument tips
move like a human wrist move like a human wrist
Allows surgeon to operate Allows surgeon to operate
with increased dexterity & with increased dexterity &
precision. No tremorprecision. No tremor
Wrist and Finger MovementWrist and Finger Movement
Disadvantages of Disadvantages of da Vincida Vinci®® RobotRobot
ExpensiveExpensive
- $1.4 million cost for machine- $1.4 million cost for machine
- $120,000 annual maintenance contract- $120,000 annual maintenance contract
- Disposable instruments $2000/case- Disposable instruments $2000/case
- Hospital reimbursement same DRG- Hospital reimbursement same DRG
Steep surgical learning curveSteep surgical learning curve
Loss of tactile feedbackLoss of tactile feedback
Increased staff training/competenceIncreased staff training/competence
Increased OR set-up/turnover time!!Increased OR set-up/turnover time!!
Past Present
SILSSILSSingle Incision Laparoscopic SurgerySingle Incision Laparoscopic Surgery
SILS – Single Incision Laparoscopic Surgery
SSA – Single Site Access
SPA – Single Port Access
SAS – Single Access Site
SPL – Single Port Laparoscopy
LESS – Laparo Endoscopic Single Site Surgery
TUES – Trans Umbilical Endoscopic Surgery
What does that stand for ?
SILSSILS
UrologyUrology
Renal transplantRenal transplant
CholecystectomyCholecystectomy
Gastric band surgeryGastric band surgery
ColectomyColectomy
TechniqueTechnique
SILSSILS
SILSSILS
Ergonomically difficult ?!
Training !
Port Site Hernia !!Port Site Hernia !!
N.O.T.E.S.
Natural Orifice Transluminal Endoscopic Surgery
NOTES - instrumentNOTES - instrument
A Recent History of“New Minimal Access” Surgery
2000 Flexible endoscopic endoluminal therapy for GERD
2003 Kalloo et al transgastric peritoneoscopy with flexible
endoscope
2004 Rao and Reddy reported on transgastric
cholecystectomy and appendectomy in patients
2006 summit meeting: NOSCAR (Natural Orifice Surgery
Consortium for Assessment and Research) formed
Alleged NOTES Benefits
No surface incision
Reduced surgical site infection
Reduced visible scarring
Reduction in pain analgesics
Quicker recovery time
Reduction in hernias, adhesions
Advantages in the morbidly obese
Scarless surgery!Scarless surgery!
Notes- TransvaginalNotes- Transvaginal
Video-endoscope entering through the posterior vaginal fornix
NOTES - Transgastric
Courtesy of N Reddy, Hyperbad India 2005
NOTES - AppendectomyNOTES - Appendectomy
NOTES – Obesity SurgeryNOTES – Obesity Surgery
Trocarless LaparoscopyTrocarless Laparoscopy
The development of magnetically controlled and anchored, The development of magnetically controlled and anchored, intracorporeal surgical instruments and camera introduced intracorporeal surgical instruments and camera introduced
through a single trocar.through a single trocar.
A. Schematic representation of conventional transabdominal trocar A. Schematic representation of conventional transabdominal trocar and instrument (left) and proposed magnetically anchored and and instrument (left) and proposed magnetically anchored and guided instrument/camera (right). guided instrument/camera (right).
B. Schematic representation of typical multitrocar laparoscopic B. Schematic representation of typical multitrocar laparoscopic surgery (left) and proposed single trocar surgery through which surgery (left) and proposed single trocar surgery through which multiple MAGS instruments are introduced and deployed. multiple MAGS instruments are introduced and deployed.
The novel use of The novel use of
‘Light’ trocar‘Light’ trocar
A. Schematic representation of A. Schematic representation of
prototype internal camera prototype internal camera
fully deployed. fully deployed.
B. Internal view of camera fully B. Internal view of camera fully
deployed. deployed.
A. Schematic representation A. Schematic representation
of prototype paddle-type of prototype paddle-type
retractor fully deployed. retractor fully deployed.
B. Internal view of prototype B. Internal view of prototype
elevating porcine spleen. elevating porcine spleen.
EndobarrierEndobarrier
EndobarrierEndobarrier
The EndoBarrier The EndoBarrier
gastrointestinal liner works by gastrointestinal liner works by
creating a physical barrier creating a physical barrier
between ingested food and the between ingested food and the
intestinal wall. intestinal wall.
Food bypasses the duodenum Food bypasses the duodenum
and proximal jejunum as it does and proximal jejunum as it does
in a Roux-en-Y gastric bypass. in a Roux-en-Y gastric bypass.
Endo-BarrierEndo-Barrier
Benefits include:Benefits include:
Weight loss Weight loss
ADA: glycemic control in Type 2 diabetes ADA: glycemic control in Type 2 diabetes
Safe alternative to gastric bypass Safe alternative to gastric bypass
Non-invasive procedure Non-invasive procedure
Rapid recovery Rapid recovery
Lower costs Lower costs
Feb 2010: Feb 2010: SchoutenSchouten
Objective:Objective: To determine the safety and efficacy of To determine the safety and efficacy of
EndoBarrier Gastrointestinal Liner EndoBarrier Gastrointestinal Liner
Duodenal-jejunal bypass sleeveDuodenal-jejunal bypass sleeve
Designed to achieve weight loss in Designed to achieve weight loss in
morbidly obese patients. morbidly obese patients.
First European experience First European experience 41 patients included 41 patients included
30 underwent sleeve implantation.30 underwent sleeve implantation.
11 - diet control group. 11 - diet control group.
All followed the same low-calorie diet All followed the same low-calorie diet
during the study period.during the study period.
2010: Schouten et al. Role of 2010: Schouten et al. Role of EndoBarrierEndoBarrier
26 devices were successfully implanted 26 devices were successfully implanted
Mean procedure time -35 min (range: 12–102 Mean procedure time -35 min (range: 12–102
min) min)
No procedure related adverse events. No procedure related adverse events.
Mean excess weight loss after 3 monthsMean excess weight loss after 3 months
19.0% device vs 6.9% for control (19.0% device vs 6.9% for control (PP < 0.002) < 0.002)
Type 2 diabetes mellitusType 2 diabetes mellitus
8 pts with baseline Type 2 diabetes mellitus 8 pts with baseline Type 2 diabetes mellitus
Improvement in 7 patients during the study Improvement in 7 patients during the study
period period
Schouten et al. A multicenter, randomized efficacy study of the EndoBarrier Gastrointestinal Liner for presurgical weight loss prior to bariatric surgery. Ann Surg. 2010 Feb;251(2):236-43.
2010: Schouten et al. Role of 2010: Schouten et al. Role of EndoBarrier EndoBarrier
The EndoBarrier Gastrointestinal Liner The EndoBarrier Gastrointestinal Liner Feasible and safe noninvasive device Feasible and safe noninvasive device
Excellent short-term weight loss results. Excellent short-term weight loss results.
Type 2 DM Type 2 DM Significant positive effect Significant positive effect
Long-term randomized and sham studies Long-term randomized and sham studies
necessarynecessary
Schouten et al. A multicenter, randomized efficacy study of the EndoBarrier Gastrointestinal Liner for presurgical weight loss prior to bariatric surgery. Ann Surg. 2010 Feb;251(2):236-43.
Surgery for DiabetesSurgery for Diabetes
DiabetesDiabetes
Considered major public health problem – emerging as a world Considered major public health problem – emerging as a world
wide pandemic. In 1995 ~ 135 million people worldwidewide pandemic. In 1995 ~ 135 million people worldwide
Currently 240 million, expected to rise to close to 380 million by Currently 240 million, expected to rise to close to 380 million by
2025 2025
ComplicationsComplications Peripheral vascular disease (PVD) accounts for 20-30% Peripheral vascular disease (PVD) accounts for 20-30%
10% of cerebral vascular accident 10% of cerebral vascular accident
Cardiovascular disease accounts for 50% of total mortality Cardiovascular disease accounts for 50% of total mortality 1. Venkat et al Diabetes–a common, growing, serious, costly, and potentially preventable public health
problem. Diabetes ResClin Pract. 2000; 5 (Suppl2): S77–S784.2. H. King et Global burden of diabetes, 1995-2025: prevalence, numerical estimates and projections.
Diabetes Care 21 (1998)1414-1431.3. Annals of Surgery. Volume 251, Number 3, March 2010
Prevalence of Diabetes
• From 1980 through 2006, the number of Americans with diabetes tripled (from 5.6 million to 16.8 million).
• ~24 million in 2009.
CDC. National Diabetes Fact Sheet, 2007.Source: 2003–2006 National Health and Nutrition Examination Survey estimates of total prevalence (both diagnosed and undiagnosed) were projected to year 2007.
Metabolic Syndrome
Also Known as:1. Syndrome “X”
2. Insulin Resistance Syndrome
3. Reaven’s Syndrome
4. Deadly Quartet
5. CHAOSCoronary Artery DiseaseHypertensionAdult Onset DiabetesObesityStroke
Obesity Associated Conditions
Diabetes
Hypertension
Sleep apnea
Congestive heart failure
Hyperlipidemia
Stroke
Coronary artery disease
Osteoarthritis
Gastroesophageal reflux disease
Non-alcoholic fatty liver
Psychological disturbances
MorbidityMorbidity
Studies Type and Size Effect on Weight Effect on Comorbidities
Buchwald et al.Meta-analysisn = 22,094 pts
Mean excess weight loss: 61%
Resolution of: n Diabetes: 70% HTN: 62% Sleep apnea: 86%
Swedish Obese Subject trial (SOS)
Prospective matched cohortn = 4,047 pts
At 10 years: Med: 1.6% gainSurg: 16% loss
Improved by surgery: Diabetes Lipid profile HTN Hyperuricemia
1. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004; 292: 1724-37.
2. Sjostrom L, Lindros AK, Peltonem M, Torgerson J, Bouchard C, Carlsson B, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 2004; 351: 2683-93.
Long-term Weight Control Analysis
Schauer et al.Effect of laparoscopic Roux-en Y gastric bypass on
type 2 diabetes mellitus. Ann Surg. 2003 Oct; 238 (4): 467-84
1160 patients underwent LRYGBP 5-year period
LRYGBP resulted in significant weight loss (60% percent of excess body weight loss) and resolution (83%) of T2DM
Fasting plasma glucose and HBA1C normalized (83%) or markedly improved (17%) in all patients
Patients with the shortest duration and mildest form of T2DM had a higher rate of T2DM resolution after surgery suggesting that early surgical
intervention is warranted to increase the likelihood of rendering patients euglycemic
Rates of Remission of Diabetes
AdjustableGastric Banding
Roux-en-YGastric Bypass
BiliopancreaticDiversion
>95%(Immediate)
48%(Slow)
84%(Immediate)
“Gastric bypass and biliopancreatic diversion seem to achieve control of diabetes as a primary and
independent effect, not secondary to the treatment of overweight.”
Potential of Surgery for Curing Type 2 Diabetes Mellitus. Rubino, Francesco, MD; Gagner, Michel MD, FACS, FRCSC Annals of Surgery; 236 (5): 554-559, November 2002
2002: Antidiabetic Effect of 2002: Antidiabetic Effect of Bariatric Surgery: Direct or Indirect? Bariatric Surgery: Direct or Indirect?
Historical Perspective 1955- Friedman
3 patients with poorly control DM
3-4 days after subtotal gastrectomy all 3 pateints showed an improvement in their DM
Occurred sooner than associated weight loss
Patients later regained their weight without an associated loss of glucose control or
glycosuria
Mingrone 1977 : Case report Young, non obese woman with DM who underwent BPD for chylomicronemia
Plasma insulin and blood glucose levels normalized within 3 months
Bittner –1981- subtotal gastrectomy and gastrointestinal reconstructions that excluded duodenal passage (B2 and RYGB Lowered plasma glucose and insulin Conclusion: Plasma glucose and insulin fall rapidly post-operatively
antidiabetic medications can be reduced or stopped shortly after gastrointestinal bypass interventions
Rubino F. Bariatric Surgery:effects on glucose homeostasis. Curr. Opin. Clin. Nutr. Metab. Care 9: 497-507Bittner R. Homeostasis of glucose and gastric resection: the influence of food passage through the duodenum Z Gastroenterology 1981; 19: 698-707.Friedman NM et al. The amelioration of diabetes mellitus following subtotal gastrectomy. Surg. Gynecol. Obstetr. 1955; 100:201-204
2004: Duodenal-Jejunal Exclusion - Foregut2004: Duodenal-Jejunal Exclusion - Foregut
Slides taken from:Slides taken from:
DIABETES IS NO LONGER DIABETES IS NO LONGER A HOPELESS DISEASEA HOPELESS DISEASE
The Guilty GutThe Guilty Gut
Walter Pories, MD, FACS, Walter Pories, MD, FACS,
Chief, Metabolic Institute Chief, Metabolic Institute
East Carolina University Greenville,East Carolina University Greenville,
North CarolinaNorth Carolina
2006:
2004:2004:
“Results of our study support the hypothesis that the bypass of duodenum and jejunum can
directly control type 2 diabetes and not secondarily to weight loss or treatment of obesity.”
Effect of Duodenal-Jejunal Exclusion in a Non-obese Animal Model of Type 2 Diabetes: A New Perspective for an Old Disease. Rubino, Francesco, MD; Marescaux, Jacques MD, FRCS Annals of Surgery; 239 (1): 1-11, January 2004
Double blind study: 16 patients assigned to
LRYGBP and 16 Pts to LSG
Patients reevaluated on the 1st, 3rd, 6th,
and 12th mos
Results:
No change in ghrelin levels after LRYGBP
Significant decrease in ghrelin after
LSG (P < 0.0001)
Fasting PYY levels increased after
either surgical procedure (P <= 0.001)
Appetite decreased in both groups but to
a greater extend after LSG
Weight loss, appetite suppression, and changes in fasting and postprandial ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a prospective, double blind study.
Karamanakos et al Ann Surg. 2008 Mar; 247(3): 401-7.
“PYY levels increased similarly after either procedure.
The markedly reduced ghrelin levels in addition to increased
PYY levels after LSG, are associated with greater appetite
suppression and excess weight loss compared with LRYGBP”
March 2008: Weight loss, appetite suppression, and changes in fasting and postprandial
ghrelin and peptide-YY levels after Roux-en-Y gastric bypass and sleeve gastrectomy: a
prospective, double blind study. Karamanakos et al Ann Surg. 2008 Mar; 247(3): 401-7.
March 2008:March 2008:
2009: Ferzli et al2009: Ferzli et al
2009: Ferzli et al2009: Ferzli et al
2009: Ferzli et al. Results at 2009: Ferzli et al. Results at 12 months12 months AAll subjects consistently felt relief from fatigue, pain ll subjects consistently felt relief from fatigue, pain
and/or numbness in the extremities, polyuria, and and/or numbness in the extremities, polyuria, and polydypsia.polydypsia.
Clinical resolution was obtained for one patient, and Clinical resolution was obtained for one patient, and the preoperative diabetic medication requirements the preoperative diabetic medication requirements decreased for most of the other patients.decreased for most of the other patients.
The subjects demonstrated an overall improved The subjects demonstrated an overall improved HbA1c (from 9.4% to 8.5%) and fasting blood HbA1c (from 9.4% to 8.5%) and fasting blood glucose level (from 209 to 154 mg/dl).glucose level (from 209 to 154 mg/dl).
The Diabetes Surgery Summit Consensus Conference
Rubino et al. Annals of Surgery. Vol 251, Number3,300-405, March 2010
45% of type 2 patients with diabetes world-wide demonstrate a BMI less than 30
ADA : “ Bariatric Surgery should be considered for adults with BMI > 35Kg/m2And type 2 diabetes ,especially if the diabetes is difficult to control with lifestyle And pharmacologic therapy
The Surgeon and the Diabetologists
And it ought to be remembered that there is nothing more And it ought to be remembered that there is nothing more
difficult than to take the lead in the introduction of a new difficult than to take the lead in the introduction of a new
order of things, because the innovator has for enemies, all order of things, because the innovator has for enemies, all
those who have done well under the old conditions.those who have done well under the old conditions.
Nicolo Machiavelli (1469-1527), Nicolo Machiavelli (1469-1527), The Prince,The Prince, 1513 1513
Patient Duration of Type 2 Diabetes
Pre-Operative Medication
1 Year Medication Requirement
#1 19 Metformin 850mg One tablet daily
Metformin 850 mg half tablet daily
#2 10 30/10 Units Insulin 30/10 Units Insulin
#3 12 40/20/20/20 Units Insulin
30 Units occasionally at night
#4 12 2 Metformin 850mg daily; 40/20 Units
Insulin
1 Metformin 850mg daily; 5 Units n
occasionally#5 12 40/20 Units Insulin 5 Units Insulin three
times per week
#6 * 6 20/12 Units Insulin No Medication
#7 4 Clormin 1000mg daily; 30/20 Units
Insulin
Diaformin 500mg daily; 30/20 Units
Insulin
Clinical Evaluation of the Effect of Duodenal-Jejunal Bypass on Type 2 Diabetes (June 2007)
Clinical Evaluation of the Effect of Duodenal-Jejunal Bypass on Type 2 Diabetes (June 2007)
Mean (SEM)Pre vs post op
Correlation P value*
HBA1C Pre-op 9.371 (0.85)
-0.040 0.933HBA1C 1yr 8.500 (0.67)
FBG Pre-op 208.86 (22.50
0.74 0.057FBG 1YR 154.86 (39.9)
Cholesterol preop 183.71 (11.5)
0.632 0.128Cholesterol 1yr 186.00 (19.9)
TG pre-op 112.43 (27.7)
-0.245 0.596TG 1yr 127.29 (25.3)
Cpep pre-op 1.343 (0.29)
-0.245 0.205Cpep 3 months 1.200 (0.32)
• The mean HBA1c at pre-op and 1 year was 9.371 and 8.500 respectively• FBG at pre-op and 1 year were 208 and 154 respectively for the seven patients (p=0.057) • Lipid profiles improved with lower total cholesterol levels and triglycerides 1 year