CASE STUDIES IN IMMUNOLOGY:A CLINICAL COMPANIONSIXTH EDITION

Raif Geha, Harvard Medical SchoolLuigi D. Notarangelo, Harvard Medical School

November 2011 400 pages • 200 illustrations Paperback • 978-0-8153-4441-4 • £35.00

Case Studies in Immunology, Sixth Edition, presentsmajor topics of immunology through a selection ofclinical cases that reinforce and extend the basicscience. The case histories illustrate essential pointsabout the mechanisms of immunity and describeimmunological problems seen in the clinic. This new edition vividly illustrates the importance of an understanding of immunology in diagnosis and therapy. Case Studies in Immunology highlights major common disorders of immunity, including hypersensitivity types I-IV, immune deficiencies, and autoimmune disorders. Each case history is preceded by basic scientific facts essential to understanding the immunology behind the specific disorders. An end-of-case summary, questions, and discussion points conclude each case.

Case Studies in Immunology can be used as a stand-alone book, or as a clinical companion alongside Janeway’s Immunobiology, Eighth Edition. A marginal icon in Janeway’s Immunobiology provides the reader with a link to the relevant Case Study, where the science is applied in a clinical setting.

The book includes a total of 53 cases. The Sixth Edition is extensively revised and updated and includesTEN NEW CASES:

• DiGeorge Syndrome• Hemophagocytic Lymphohistiocytosis• Chediak-Higashi Syndrome• Hyper IgE Syndrome• Ataxia Telangiectasia

• Warts, Hypogammaglobulinemia, Infections,and Myelokathexis (WHIM) Syndrome• Severe Congenital Neutropenia• Recurrent Herpes Simplex Encephalitis• Systemic Onset Juvenile Idiopathic Arthritis• Crohn’s Disease

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“…this is an excellent overview of immunology placed in a biological context….both the style of writing and the use of figures mean that complicated concepts are put across very well indeed…” —IMMUNOLOGY NEWS

“The authors of the seventh edition of Janeway’s Immunobiology have maintainedCharles Janeway’s signature approach to teaching immunology—integration….oneof the strongest aspects of this volume is the use of visual aides….this textbook willbe an outstanding learning tool.” —THE QUARTERLY REVIEW OF BIOLOGY

“This is one of the best basic immunology textbooks available. Materials are wellorganized and clearly presented. It is a must-have… The chapters are well orderedand the language is clear and succinct. Ample, well-designed diagrams and tablesillustrate complex ideas.” —DOODY REVIEWS

“Each aspect of immunology is covered in great depth and detail. In addition, a greatsummarizing paragraph can be found at the end of each chapter to help you obtain a general overview. Supported by simple and clear illustrations, tables and interactive materials…it contains all you need to know in immunology.” —GKT GAZETTE

RESOURCESFOR INSTRUCTORS• Animations and Videos For instructors and students we offer over 40 original immunological animations based on figures in the book and videos selected from visually compelling experiments. The animations have been revised and updated for this edition, and there are five new animations covering NALP3 Inflammasome, Isotype Switching, CD28, Crohn’s Disease, and NFAT Activation and Cyclosporin. All the animations and videos are accompanied by a voice-over narration.• The Art of Immunobiology: The figures and tables from the book are available preloaded into PowerPoint® presentations and as JPEGs.• Lecture Outlines in PowerPoint®

FOR STUDENTS• Animations and Videos• Online Searchable Glossary• Interactive Flashcards

NEW IN THE 8TH EDITION• INNATE IMMUNITY has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (for example, TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes).

• The section on COMPLEMENT has been reworked and reconceived—explaining the lectin pathway first—making it easier to teach by placing it into the context of innate recognition.

• EVOLUTION is now incorporated throughout the text, helping students see similar strategies used by different organisms.

• The text and figures of Chapter 7 SIGNALING THROUGH IMMUNE SYSTEM RECEPTORS have been revised to present a cohesive synthesis of SIGNALING for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book.

• Updated chapter on B-CELL IMMUNE RESPONSES (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (for example, lymph nodes) and the locations at which they encounter antigen.

• Chapter 12, MUCOSAL IMMUNOLOGY, has been revised, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria.

• Chapter 13, FAILURES OF HOST DEFENSE MECHANISMS, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways.

• Chapter 16, MANIPULATION OF THE IMMUNE RESPONSE, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines.

• MANY NEW AND REVISED FIGURES illustrate the processes and mechanisms underlying the concepts presented in the text.

• The ICONS used have been updated and expanded to incorporate a new emphasis on signaling pathways.

• New REFERENCES have been added throughout the text.

Janeway’s Immunobiology is a textbook that introduces the immune system in all its aspects toundergraduates, and also provides a treatment of the subject that is comprehensive enough to be useful to graduate students interested in research, and to medical students focused on clinicalapplications. The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.

Janeway’s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout—that of the host’s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way to help deliver a complete one semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.

Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.

PART I: AN INTRODUCTION TO IMMUNOBIOLOGY ANDINNATE IMMUNITY

Chapter 1: Basic Concepts in ImmunologyChapter 2: Innate Immunity: The First Lines of DefenseChapter 3: The Induced Responses of Innate Immunity

PART II: THE RECOGNITION OF ANTIGEN

Chapter 4: Antigen Recognition by B-cell and T-cell ReceptorsChapter 5: The Generation of Lymphocyte Antigen ReceptorsChapter 6: Antigen Presentation to T Lymphocytes

PART III: THE DEVELOPMENT OF MATURE LYMPHOCYTERECEPTOR REPERTOIRES

Chapter 7: Signaling Through Immune System ReceptorsChapter 8: The Development and Survival of Lymphocytes

PART IV: THE ADAPTIVE IMMUNE RESPONSE

Chapter 9: T Cell-Mediated ImmunityChapter 10: The Humoral Immune ResponseChapter 11: Dynamics of Adaptive ImmunityChapter 12: The Mucosal Immune System

PART V: THE IMMUNE SYSTEM IN HEALTH AND DISEASE

Chapter 13: Failures of Host Defense MechanismsChapter 14: Allergy and Allergic DiseasesChapter 15: Autoimmunity and TransplantationChapter 16: Manipulation of the Immune Response

To download a detailed table of contents and sample chapters,please visit: www.garlandscience.com/imm8

TABLE OF CONTENTS

n10-100

germinalcenter

afferentlymphatic

vessel

SCSmacrophage

subcapsularsinus (SCS)

folliculardentritic

cell

efferentlymphatic

vessel

T-cellarea

medullarysinus

Opsonized antigens entering lymphnodes from afferent lymphatics bindto the complement receptors on thesurface of macrophages present in

the subcapsular sinus

The low endocytic and degradative activity of

subcapsular macrophages preserves the antigens

trapped on their surfaces, allowing B cells to

encounter them

Antigen preservation by subcapsular macrophages also allows antigen to be

transported into the follicle to become localized on the

surface of follicular dendritic cells

JAN

EWAY

’S IM

MU

NO

BIO

LOG

YEI

GH

TH E

DIT

ION

i7-31

The division of thymocytes into the CD4 or CD8 lineage occurs at this CD4+CD8low

stage, where transient expression of ThPOK leads to CD4 commitment, or its

absence leads to CD8 commitment

CD4+ single positiveCD4+CD8low

CD4lowCD8low

CD4+CD8+ double positive (DP)CD4–CD8– double negative (DN)CD4lowCD8+

CD8+ single positive

CD4–CD8– (DN) thymocytes give rise to the CD4+CD8+ (DP) thymocytes that express low

levels of TCR and await positive selection

Positively selecting TCR signals initially reduce CD4 and CD8 expression (CD4lowCD8lowcells), followed by re-expression of CD4, regardless of whether the initiating signal involves MHC

class I or MHC class II ligands

CD4

CD8

CD4

CD8

CD4

CD8

PRAISE FOR THE PREVIOUS EDITION

i9-10

centrocytes

helperT cells

mantlezone

centroblasts

Darkzone

Lightzone

folliculardendriticcells

Schematic representation of a folliclewith a germinal center

CXCR5+ B cells

CXCR4+

B cells

CXCL13

CXCR12

Cyclic reentry of cells into the dark zoneis dependent on reexpression of CXCR4

on centrocytes

10.8 Opsonized antigens are captured and preserved by subcapsularsinus macrophages.

8.31 Stages in the positive selection of α:β t cells as identified by FaCS analysis.

10.11 the structure of a germinalcenter.

THE AUTHOR

Kenneth Murphy is the Eugene Opie First Centennial Professor of Pathology and immunology at Washington University School of Medicine in St. Louis and investigator at the Howard Hughes Medical Institute. He obtained his MD and PHD degrees from the Johns Hopkins University School of Medicine.

August 2011928 pages • 547 illustrationsPaperback • 978-08153-4243-4 • £48.00

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