introduction to renal system and hematuria
TRANSCRIPT
Introduction to Renal Systemand Hematuria
Dr. Kalpana MallaMD Pediatrics
Manipal Teaching Hospital
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Contents
• Clinical anatomy of the renal system.• Hematuria – causes, evaluation and
treatment.
Causes of Kidney Disease
Inflammatory and degenerative disease Acute glomerulonephritis Nephrotic syndrome Chronic renal failure
Damage from other diseases Hypertension, diabetes mellitus
Infection and obstruction
Causes of Kidney Disease
Damage from other agents Environmental agents Malnutrition
Genetic defects
Renal Anatomy
• Paired retroperitoneal-
• 12 thoracic & 3rd lumbar vertebra
• Covered by perinephric fat extending to hilum
• Weight- 150gm, 11 cm in length, 6 cm in width, and 3 cm thick
Source
Kidney Anatomy
• Hilum -anteromedial side of kidney (VAP-anterior to posterior)
Anatomy of kidney
• Newborn – length - 6cm, wt- 24 gms
• Cortex- glomeruli , PCT,DCT,CD
• Medulla- straight portion of tubules, loops of
Henle, vasa recta terminal collecting ducts
Nephrone
Structural and functional unit of kidney 1 million in each KidneyA. GlomerulusB. Renal tubules-Bowman’s capsule PCT Loop of Henle DCT CT Tubules
• Glomerulus–Cluster of branching capillaries–Cup-shaped membrane at the head of
each nephrone forms the Bowman’s capsule
–Filters waste products from blood
Glomerulus
• Tuft of capillaries invaginated in the Bowman’s capsule
Juxtaglomerular apparatus
• specialised muscle cells in wall of afferent arteriole + lacis cells +
macula densa – secretion of renin
Function of Kidney
Functions– Filtration of materials in blood– Filtrate includes –water, ions, urea,
glucose, amino acids,minerals, vitamins, drugs
– Reabsorption of substances - 99% of the filtrate components are reabsorbed actively or passively by tubular cells
– Secretion of hydrogen ions to maintain acid-base balance
Functions
– Water & Electrolyte balance– Excretes waste products-Urea, Uric acid,
Creatinine– Secretes erythropoietin-erythropoiesis– Renin secretion (for body water balance)– Regulates blood pressure– Excretion of drugs, various toxic substances– Vitamin D activation
Definition
Hematuria :Presence of an abnormal quantity of red blood
cells in the urine
Hematuria
Classification:A) Based on No of RBCs in urine:1. Macroscopic Hematuria -Gross Hematuria
visible to naked eye. Here RBC >106 (10 lakh) per ml of urine
2.Microscopic - >5RBCs/HPF in a sediment from 10ml of centrifuged freshly voided Urine
Microscopic hematuria without other symptoms - 2% of children
• More commonly found in girls
B) Based on site of bleeding: 1. Glomerular 2. Non glomerular
Urinary Hues
• Dark yellow – Conc urine, Bile pigment• Red- Hb, beets, blackberries, chloroquine, rifampicin, red food coloring• Dark brown /Black- Homogentisic acid, melanin
Causes of Hematuria1. Infection (UTI)- Bacterial , Viral Schistosomiasis, Tuberculosis
2. Glomerular diseases a) Recurrent gross hematuria IgA Nephropathy Benign familial idiopathic H (thin basement membrane disease)
Causes of hematuria
• Alport Syndrom b) APGNc) Membranous GNd) Secondary causes of GN – lupus
Nehpritis ,Henoch schonlein purpura, HUSe) Menbranoproloferative GNf) Rapid progressive GNg) Good Pasture DS
Causes of Hematuria3. Trauma4. Anatomical anomalies- PUJ obstruction, Polycystic Kidneys, Hydronephrosis 5. Vascular- Arteritis, Infarction, thrombosis6. Idiopathic hypercalciuria
Causes of Hematuria
7. Hematological- Coagulopathies, sickle cell Ds, Renal Vein thrombosis8. Drugs- Cyclophosphamide - Haemorrhagic
cystitis9. Acute interstitial nephritis
Glomerular vs extraglomerular hematuria:
Urinary finding Glomerular Extraglomerular
Color Red/brownCola/tea
Usually red
RBC cast Present Absent
Clots Absent May be +
Proteinuria >2 (+) Absent
Red cell morphology Dysmorphic Eumorphic
Casts in urine:
1 Physiological casts: Hyaline cast, granular cast2. Pathological casts: Lipid cast – Nephrotic syndrome RBC cast – Acute glomerulonephritis WBC cast – Pyelonephritis Crystal cast – Hypercalcemia Broad waxy cast – Chronic renal failure
• History• Physical examination • Lab tests
Presentation:
May present in one of three ways1 Onset as gross hematuria2 Onset with urinary or other symptoms3. Incidental finding during a health
evaluation
Approach:
• Age: Preschool age- Wilm’s tumor School age – PIGN• Sex: Females- lupus nephritis Males – Alport syndrome• Race: Blacks- Sickle cell disease Caucasians- Hypercalciuria
History:
• H/O passage of clots- extraglomerular cause• Fever, dysuria, abdominal pain, recent
enuresis, frquency- UTI• Recent trauma to abdomen- hydronephrosis• Early morning periorbital puffiness, weight
gain, oliguria, dark-coloured urine, edema and hypertension- glomerular cause
History:• Painless hematuria- glomerular• Recent h/o skin or sore throat infection- PSGN• Prolonged fever, joint pain, skin rashes-
connective tissue disease• Anemia – SLE or bleeding disorder• Skin rash and arthritis- HSP, SLE• Similar family history- SLE, Alport syndrome,
urolithiasis, Polycystic kidney disease
History:• Timing of the hematuria Initial (urethral bleeding)
Terminal (bladder)Throughout (no localizing value)
• Also important- h/o passage of calculi per urethra, exercise, ingestion of drugs or toxic agents, menstruation, recent bladder catheterisation
Physical examination:
• Edema- periorbital and pedal• Blood pressure, weight• Skin- purpura• Abdomen- palpable kidneys (Wilm’s tumor,
hydronephrosis)• Genitalia
Lab Tests
Step 1- Must be done in all Patients• CBC• Urine R/E, Urine C/S• S. Creatinine, B. Urea• C3 Level• USG Or IVP
Confirmation of Hematuria:
Urinalysis: • Uncentrifuged (fresh) urine specimen- >5
RBCs/ cu.mm
• Centrifuged sample -> 5 RBCs/HPF RBC casts- glomerulotubular origin WBC/ WBC casts- UTI
Red cell morphology: Look for presence of “dysmorphic RBCs” in
fresh urine specimen by light or phase contrast microscopy
- > 60-80% dysmorphic RBCs indicates glomerular cause
- Eumorphic RBCs indicate origin in renal pelvis or lower urinary tract
Phase-contrast microscopy:
Non-glomerular /Eumorphic RBCs
Confirmation of hematuria-
Dipstick test :Test is negative when “red urine” is due to
beeturia and drugs (rifampicin, phenazopyridine)
Pseudoperoxidase activity of Haemoglobin or myoglobin catalyzes a reaction between hydrogen peroxide and tetramethyl benzidine - to produce an oxidized chromogen having green-blue colour
- Detects 5-10 intact RBCs per cu.mm (~ 2-5 RBCs per HPF)
Step 2
• ASO titre / anti-DNAse B Titre• Throat C/S• ANA, ds-DN• Urine Electrolytes• Coagulation studies• MCU
Step 2
Hb electrophoresis (HbS)Urinary calcium excretion (> 4 mg/kg/day or urinary
calcium to creatinine ratio > 0.21)Urine Calcium Excretion (normal <4 mg/kg/day) Urine Calcium to Creatinine ratio (normal <0.2-0.25) Urinalysis of a Family Member
Step 2 - Imaging tests:
• USG (KUB region) • Spiral CT scan- Urolithiasis, Wilm’s tumor,
polycystic kidney disease• Voiding cystourethrogram• Radionuclide studies- calculi• IVP
Step 3
Renal Biopsy• Persistent High grade microscopic hematuria• Microscopic Hematuria + decre R.function• ,, ,, +Protenuria +++• ,, ,, + Hypertension• Second episode of gross hematuriaCystocopy
Referral Criteria
• Concurrent systemic signs – Hypertension, edema, Arthritis
• Abnormal RFT , ↓C3 • Significant Proteinuria • Episodes of Gross Hematuria• Persistant hematuria > 1yr • Hypercalciuria • Parental anxiety
Referral Criteria
• Evidence of nephrolithiasis• F/H/O hereditary nephritis• RBC cast on microscopic urine examination
Spectrum of Anomalies
• Renal disorders • Horseshoe Kidney• Renal Agenesis and Dysplasia• Polycystic Kidneys• Prune Belly
• Urinary Tract Obstructions• Antenatal Renal Pelvi-caliceal Dilatation• VUR• PUJO, VUJO• Posterior Urethral Valves• Ureterocoeles, Megaureter• Calculi
VUR
PUJO, VUJO
Posterior Urethral Valves
Ureterocoeles
• Abnormalities of Genitalia • Phimosis, Paraphimosis, Circumcision• Labial Fusion• Abnormalities of Bladder • Voiding dysfunction and Wetting • Neurogenic• Sacral Agenesis and Neural Tube Defects
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