introduction to nutrigenetics by geneobe
TRANSCRIPT
Introduction to Nutrigenetics & Personalised Nutrition
Presented by Janani Tamilvanan, Founder, Geneobe Wellness
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THE ENVIRONMENT YOUR GENES YOUR HEALTH
http://www.niehs.nih.gov/health/topics/science/gene-env/
The Diet- Gene Interaction
NATURE VS NURTURE
Genetic information serves as an additional tool for assessment for dietetic professionals
Diet
Physical activity
Anthropometric data
Biomedical data
Genetic data
Nutri +genetics = (the study of interaction between nutrients & genes)
• AIMS TO UNRAVEL THE INTERACTIONS BETWEEN NUTRIENTS AND GENES.
• IT IS MORE SPECIFIC IN NATURE. INDIVIDUALS VARY IN THEIR NUTRIENT METABOLISM AND RESPONSE TO DIET.
• IT HOLDS THE POTENTIAL TO PROVIDE BETTER NUTRITIONAL ADVICE TO PREVENT OR TO OVERCOME DISEASE RISKS.
The Personalised Nutrition ApproachIn this personalised nutrition approach:
• We analyse genetic variations found in human DNA called single nucleotide polymorphisms (SNPs). Almost all of DNA are the same (99.9%) and 0.1% is different and that is due to these SNPs.
• These SNPs are common genetic variations, some of these variations have no effect while others are known to be very important for health status and disease risk.
• The variations can affect gene function, altering the way nutrients are metabolised. This can have a detrimental effect on the body, influencing human phenotype – the observable, physical characteristic of a person.
Personalised nutrition approach One size fit’s all approach is not effective
ADIPOQ gene:
AA genotype carriers do not benefit by consuming MUFA rich foods and they are at increased risk of obesity, when they consume more than ( >13% of the total calories) from MUFA.
CC genotype carriers benefit by consuming MUFA rich foods. Based on the type of genetic variation, dietary recommendations are designed.
A vitamin deficiency can be caused by either insufficient intake, or by the body’s ability to metabolise it because of a genetic variation – via the action of an SNP.
For example, vitamin B12 deficiency is highly prevalent among Indians. By knowing their genetic make up, more specific recommendations can be given.
Personalised nutrition approach:Helps to get thorough understanding of the gene-diet interactions.
Personalised Nutrition Approach: Is based on genetic makeup and not on generalised population-based data
North Indians are more lactose tolerant than western & South Indians. Differences are seen even within same ethnicity/ population.
“One Size fit all” approach is helpful but not effective to combat chronic lifestyle diseases
