a sia-paciic nutrigenomics & nutrigenetics organisation ... · asia-pacific nutrigenomics &...

Asia-Pacific Nutrigenomics & Nutrigenetics Organisation

APNNO 2018BIENNIAL CONFERENCE



xii

Dec. 2nd

17:00-18:30 Registration

19:00-21:00 Dinner for Invited Speakers and Guests

Dec. 3rd


08:30-09:00 Opening RemarksFounding President and Current President

Keynote Lecture I

Chair: Young-Joon Surh (Seoul National University, South Korea)

09:00-09:30 J. Alfredo Martinez (CEI UAM-CSIC, University of Navarra and Instituto de Salud Carlos III, Spain)Precision Nutrition and Omics in Obesity

Symposium I: Obesity, Diabetes and Cardiovascular Disease

Chairs: J. Alfredo Martinez (CEI UAM-CSIC, University of Navarra and Instituto de Salud Carlos III, Spain)

Soo Wan Chae (Chonbuk National University Hospital & Medical School, South Korea)

09:30-09:50 John Cummings Mathers (Newcastle University, United Kingdom)Personalised Nutrition - Lessons from the Food4Me Study

09:50-10:10 Connie Marie Weaver (Purdue University, United States)Subgroup Differences in Mineral and Bone Metabolism in Response to Diet

10:10-10:30 Byung-Hyun Park (Chonbuk National University Medical School, South Korea)Sirtuin 6 Deacetylates XBP1 to Prevent ER Stress-induced Fat Accumulation in the Liver

SCIENTIFIC PROGRAM



xiii

10:30-11:00 PosterPresentationwithCoffee/TeaBreak

Symposium II: Neurodegenerative Diseases

Chairs: Shigeki Furuya (Kyushu University, Japan) Hiroshi Kunugi (National Center of Neurology and Psychiatry, Japan)

11:00-11:20 Lee-Yan Sheen (Institute of Food Science and Technology, Taiwan)Anti-depression Mechanism of Gastrodia elata Bl. - The Important Ingredient of Traditional Chinese Dietary Therapy

11:20-11:40 Shigeki Furuya (Kyushu University, Japan)Gene Expression Signature of Genetic Phgdh Deletion and Its Role in Pathobiology of L-serine Deficiency

11:40-12:00 Hiroshi Kunugi (National Center of Neurology and Psychiatry, Japan)Multiple Omics Approach to Human Cerebrospinal Fluid of Major Psychiatric Patients

12:00-13:10 LuncheonSymposium(HumanMetabolomeTechnologies,Inc.)

13:10-13:40 Break

Multi-Omics Workshop

Chairs: Hisanori Kato (The University of Tokyo, Japan) Lynnette Robin Ferguson (The University of Auckland, New Zealand)

13:40-14:00 TsuyoshiTsuduki(Tohoku University, Japan)Evaluation of the Health Benefits of the Japanese Diet Using Omics Analysis

14:00-14:20 Jun Nishihira (Hokkaido Information University, Japan)A Model of Personalized Nutrition Based on the Comprehensive Clinical Trial Data of Functional Foods





xiv

14:20-14:40 Lynnette Robin Ferguson (The University of Auckland, New Zealand)Why Have Inflammatory Bowel Diseases Provided an Excellent Example of Translating Precision Nutrition into Practice?


Microbiome Workshop

Chairs: Shinji Fukuda (Keio University, University of Tsukuba and KISTEC-KAST, Japan) Jia Huijuan (The University of Tokyo, Japan)

15:30-15:50 Yuji Naito (Kyoto Prefectural University of Medicine, Japan)Effects of Water Soluble Dietary Fibers on Gut Microbiome in Stress-related Gastrointestinal Dysfunction

15:50-16:10 Shinji Fukuda (Keio University, University of Tsukuba and KISTEC-KAST, Japan)A Metabologenomic Approach Reveals the Function of Gut Microbiota in Health and Disease

16:10-16:30 Jun Kunisawa (National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan)Diets and Commensal Bacteria Create Lipid Environment in the Gut for the Application to Precision Health

Early Career Scientist Presentations

Chairs: Roseline Wai Kuan Yap (Taylor's University, Malaysia) Jun Nishihira (Hokkaido Information University, Japan)

16:30-16:40 Wenqiao Wang (Zhejiang University, China)Intake of Monounsaturated Fatty Acids from Plant and Animal Sources in Relation to Mortality in China

16:40-16:50 Saki Shirako (Kyoto University, Japan)Administration of Pyroglutamyl-leucine Attenuates High Fat Diet-induced Dysbiosis in Rat by Affecting on Host Innate Immune System Including Antimicrobial Peptides in Ileum

16:50-17:00 NaoTakeuchi(Keio University, KISTEC-KAST and Metabologenomics, Inc., Japan)Rare Sugar, D-psicose, Suppresses High-fat Diet-induced Obesity through Gut Microbiota Alterations

17:00-17:10 Safarina G. Malik (Eijkman Institute for Molecular Biology, Indonesia)Linking Genetic Variations, Diet, and Gut Microbiota: A Study of Obesity in the Balinese



xv

17:10-17:20 Mao Lei (Zhejiang University, China)Individual Saturated Fatty Acids Intake and Risk of Overweight and Obesity: Findings from Population-based Nationwide Cohort Study

17:20-17:30 Yuan Kei Ching (Universiti Putra Malaysia, Malaysia)The Interaction of rs174547 in FADS1 Gene with Linoleic Acid and α-linolenic Acid on Metabolic Syndrome among Malaysian Vegetarians

17:30-17:40 Fei Wu (Zhejiang University School of Medicine, China)Association of Saturated Fatty Acids with the Risk of Type 2 Diabetes in China Health and Nutrition Survey

17:40-17:50 Roseline WK. Yap (Taylor's University, Malaysia)Gene-environment Interaction Effects of VEGFR-2 gene Polymorphisms with Job Stress, Mental Health and Stress Coping on Metabolic Risk Factors of Cardiovascular Disease in Chinese Malaysian Adults

17:50-18:00 Wrap Up and Synthesis

18:00-19:30 Welcome Reception

19:30-21:00 APNNO Executive Committee Meeting

Dec. 4th


Keynote Lecture II

Chair: Jun Kunisawa (National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan)

08:30-09:00 Yuji Naito (Kyoto Prefectural University of Medicine, Japan)Role of Bile Acids-microbiota Interaction in Non-alcoholic Fatty Liver Disease

Symposium III: Inflammation and Cancer

Chairs: Young-Joon Surh (Seoul National University, South Korea) Hye-Kyung Na (Sungshin Women's University, South Korea)

09:00-09:30 Young-Joon Surh (Seoul National University, South Korea)Differential Roles of SIRT1 in Colon Carcinogenesis





xvi

09:30-09:50 Hye-Kyung Na (Sungshin Women's University, South Korea)15-Hydroxyprostaglandin Dehydrogenase and Its Product 15-KetoProstaglandin E2 as Emerging Targets for Cancer Chemoprevention and Therapy

09:50-10:10 De-Xing Hou (Kagoshima University, Japan and Hunan Agriculture University, China)Protein Kinases as Molecular Targets for Cancer Chemoprevention by Dietary Polyphenols

10:10-10:30 Min-Hsiung Pan (National Taiwan University, Taiwan)Chemopreventive Effects of Bioactive Phytochemicals on Chronic Inflammation-associated Human Diseases


Symposium IV: Sarcopenia and Frailty

Chairs:Tze-PinNg(National University of Singapore, Singapore) Yasutomi Kamei (Kyoto Prefectural University, Japan)

11:00-11:20 Yasutomi Kamei (Kyoto Prefectural University, Japan)Reduced Dnmt3a Increases Gdf5 Expression with Suppressed Satellite Cell Differentiation and Impaired Skeletal Muscle Regeneration

11:20-11:40 TzePinNg(National University of Singapore, Singapore)Nutrition and Metabolic Profiling of Sarcopenia and Physical Frailty in Older Adults

11:40-12:00 Sue-Joan Chang (National Cheng Kung University, Taiwan)Therapeutic Target for Sarcopenia

12:00-13:10 LuncheonSymposium(AlmadoInc.)

12:00-13:10 Break



xvii

Nutrigenetics Micronutrient Genomics Project (MGP) Workshop

Chairs: Yasuo Kagawa (Kagawa Nutrition University, Japan) Hitoshi Shirakawa (Tohoku University, Japan)

13:40-14:00 Yasuo Kagawa (Kagawa Nutrition University, Japan)Nutrigenomics of the Impact of Westernization in Asia: Ethnic Difference in Osteoporosis

14:00-14:20 Jildau Bouwman (TNO (The Netherlands Organization for Applied Scientific Research), The Netherlands)Proposed Guidelines to Evaluate Scientific Validity and Evidence for Genotype-based Dietary Advice

14:20-14:40 Jusheng Zheng (Westlake University, China)Effect of n-3 PUFA Supplementation on Blood Lipids Interaction with CD36, NOS3 and PPARG: A Double-blind Randomized Controlled Trial


Epigenetics Workshop

Chairs: Michael Fenech (University of South Australia, Australia) Yasutomi Kamei (Kyoto Prefectural University, Japan)

15:30-16:10 Michael Fenech (University of South Australia, Australia)What We Know and Don't Know about the Epigenetic Effects of Micronutrients

16:10-16:30 Nobuaki Shiraki (Tokyo Institute of Technology, Japan)Methionine Metabolism Regulates ESCs/iPSCs Differentiation

Startups and Translation into Practice

Chair: Hisanori Kato (The University of Tokyo, Japan)

16:30-16:50 ShokoTakahashi(Genequest Inc., Japan)Nutrigenomics Research through Personal Genome Service Genequest





xviii

16:50-17:10

Wan-Ching Chang (H2 Ltd., Japan) Shusaku Yusa (H2 Ltd., Japan)

Transforming Diabetes Care through Data-driven Analytics Platform Plus Food Auto-recognition (Deep Learning) Technology

Presidential Lecture

Chair: Hisanori Kato (The University of Tokyo, Japan)

17:10-17:40 Young-joon Surh (Seoul National University, South Korea)Anti-inflammatory, Proresolving and Cancer Chemopreventive Natural Products

17:40-18:10 Closi ng Ceremony Awarding of Prizes Closing Remarks

Founding President, Current President, President-Elect

18:10-19:00 FreeTime

19:00-21:00 Conference Gala Dinner



xix

POSTER

P-1 Physical Activity Could Mitigate the Deleterious Effects of FTO rs3751812Yi-Ching Liaw1,Yung-PoLiaw2,Tsuo-HungLan3

1Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, 2Department of Public Health and Institute of Public Health, Taichung, Taiwan, 3Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan

P-2 Identification of 12q24 Locus Associated with Fish Intake Frequency by Genome-wide Meta-analysis in Japanese PopulationsMaki Igarashi1,2,ShunNogawa3,KaoruKawafune3,TsuyoshiHachiya4,3,ShokoTakahashi3,Kenji Saito2,3,HuijuanJia2,HisanoriKato1

1Department of Applied Biological Chemistry,The University of Tokyo, Tokyo, Japan, 2Department of Molecular Endocrinology, National Research Institute for Child Health and Development, Tokyo, Japan, 3Genome Analytics Japan Inc., Tokyo, Japan, 4Genome Analysis Japan Co., Tokyo, Japan

P-3 Polymorphisms in Vitamin D Synthesis and Transport Genes; Potential Novel Factors in Interethnic Differences in Vitamin D Production Patrice Jones 1,MarkLucock1,MartinVeysey2,EmmaBeckett1,31School of Environmental & Life Sciences, University of Newcastle, Ourimbah, Australia, 2Hull-York Medical School, University of York, Heslington, United Kingdom, 3School of Medicine and Public Health, University of Newcastle, Ourimbah, Australia

P-4 A Potential Association between Bitter Taste Genetics and Risk for Adenomatous Colorectal Polyps: A Pilot Study Emma L Beckett1,2,AlexandriaTurner1,PatriceJones2,3,MarkDLucock3,MartinVeysey4

1School of Medicine & Public Health, The University of Newcastle, Newcastle, Australia, 2Hunter Medical Research Institute, Newcastle, Australia, 3School of Environmental & Life Sciences, The University of Newcastle, Newcastle, Australia, 4Hull-York Medical School, University of York, York, United Kingdom

P-5 Association between Fat Intake and DNA Methylation at CDH13 Promoter (cg02263260) in Taiwanese AdultsDislineManliTantoh1,Wen-YuLu1,OswaldNdiNfor1,Guo-ChengHe1,Kuan-JungLee1,Pei-Hsin Chien1,Yung-PoLiaw1,2

1Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung, Taiwan, 2Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

P-6 Genetic Polymorphism of Human Bitter Taste Receptors in the Defense System against CancersMichiko Yamaki1,2,HirokiSaito2,KunioIsono2,ShizukoSatoh-Kuriwada3,NoriakiShoji3,TomokoGoto2,HitoshiShirakawa2,MichioKomai21Tohoku Seikatsu Bunka University, Sendai, Japan, 2Graduate School of Agricultural Science, Tohoku University, Sendai, Japan, 3Tohoku University Graduate School of Dentistry, Sendai, Japan





xx

P-7 Evaluation of the Correlation between Bitterness Sensitivities to PTC / PROP (TAS2R38 SNP) and to Grapefruit Genotype (TAS2R19 SNP)Hiroki Saito1,MichikoYamaki2,1,YukikoNumakura1,MaikoIribe1,AsumiIshikura1,KunioIsono1,TomokoGoto1,HitoshiShirakawa1,MichioKomai11Graduate School of Agricultural Science, Tohoku University, Sendai, Japan, 2Department of Home Economics, Tohoku Seikatsu Bunka University, Sendai, Japan

P-8 Epidemiological Nutrimetabolomics Approach for the Dietary Biomarkers of Fish IntakeEriko Shibutami1,ToruTakebayashi1,21Graduate School of Health Management, Keio University, Fujisawa, Japan, 2Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan

P-9 The Interaction between UCP2 Gene Variation and Vitamin B Intake on Changes in Adiposity in Healthy Indonesian Adults: Report from 2 Years CohortHarry F.L. Muhammad1,DianCSulistyoningrum1,EmyHuriyati1,YiYLee2,Wan Abdul M Wan Muda3

1Universitas Gadjah Mada, Yogyakarta, Indonesia, 2United Nation University, Kuala Lumpur, Malaysia, 3Kyoto University, Kyoto, Japan

P-10 Cancelled

P-11 Cancelled

P-12 Cancelled

P-13 The Effect of the 1975 Type Japanese Diet Intake on the Overweight SubjectsMasaki Asano,MamoruKushida,TsuyoshiTsudukiGraduate School of Agriculture Science Tohoku University, Sendai, Japan

P-14 Survey of Knowledge and Awareness for Foods with Health ClaimsYuusuke Sekiguchi1,SanaeYamada2,MasahiroWada3,YasukoSannoumaru3

1Faculty of Pharmaceutical Sciences / Josai University, Saitama, Japan, 2Faculty of Life and Environmental Science, Mukogawa Women's University, Hyogo, Japan, 3Graduate School of Pharmaceutical Sciences, Josai University, Saitama, Japan

P-15 Innovative Nutrition Education-board GameShu-Jen WuChina Medical University Hospital, Taichung, Taiwan

P-16 Self-rated Health Status and Sarcopenia Index among Elderly Population in TaiwanLai Kuan Ching1,2,CunCenXuan1,WuMingGuo31Department of Nutrition/Hsinchu Cathay General Hospital, Hsinchu, Taiwan, 2Department of Food and Beverage Management / Yuanpei University of Medical Technology, Hsinchu, Taiwan, 3Department of Administration, Hsinchu Cathay General Hospital, Hsinchu, Taiwan



xxi

P-17 Effect of Tempeh on Related Signaling of Cognitive ImpairmentYin-Ching Chan1,Ming-FuWang1,Sih-TingLuo1,Sue-JoanChang2

1Department of Food and Nutrition/Providence University, Taichung, Taiwan, 2Department of Life Sciences/Cheng Kung University, Tainan, Taiwan

P-18 Effect of Pu-erh and Oolong Mixed Tea on Obesity and Gut Microbiota in Mice Fed a High Fat DietShogo Itakura1,KoutaShimokawa1,HiroakiYamamoto2,TakehiroOguri2,ShizukaHirai1,Yukari Egashira1

1Graduate School of Horticalture, Chiba University, Chiba, Japan, 2Asahi Soft Drinks Co, Ltd., Moriya, Japan

P-19 Ghrelin Sensitivity Decreases in Both Aged and Young Mice a Fed Protein-free DietYukihiroTakekuma,ShinIguchi,JunyaNakato,KousakuOhinataGraduate School of Agriculture, Kyoto University, Kyoto, Japan

P-20 Effects of Long-term Physical Exercise on Skeletal Muscles in Senescence-accelerated Mice (SAMP8)KahoTakigawa,RintaroMatsuda,RanUchitomi,TakumiOnishi,YukinoHatazawa,YasutomiKameiKyoto Prefectural University, Graduate School of Life and Environmental Sciences, Kyoto, Japan

P-21 Identification of Anti-muscle-atrophic Compounds that Suppress FOXO1 Transcriptional ActivityRintaro Matsuda,TakumiOnishi,YumaHirose,YukinoHatazawa,YasutomiKameiKyoto Prefectural University,Graduate School of Life and Environment, Kyoto, Japan

P-22 Genistein, Daidzein, and Resveratrols Stimulate PGC-1β-mediated Gene RegulationShiho Nakai1,RanUchitomi1,RintaroMatsuda1,TakumiOnishi1,ShinjiMiura2,YukinoHatazawa1,Yasutomi Kamei1

1Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan, 2Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan

P-23 Metabolomic Analysis of Skeletal Muscles in Aged MiceRan Uchitomi,YukinoHatazawa,YasutomiKameiKyoto Prefectural University, Graduate School of Life and Environmental Sciences, Kyoto, Japan

P-24 Mechanism of Soy-deprestatin, an Orally Active Decapeptide Acting via Gut-brain CommunicationSaho Asakura,YukihaMori,JunyaNakato,KousakuOhinataGraduate School of Agriculture, Kyoto University, Kyoto, Japan

P-25 Mechanisms of Obesity in Female CRTC1KO MiceFuka Ishikawa,ShigenobuMatsumura,KousakuOhinata,KazuoInoueGraduate school of Agriculture, Kyoto University, Kyoto, Japan

P-26 Hepatic KLF15 Modulates Lipogenesis via Inhibition of LXR Activity by Recruiting Corepressor RIP140 on SREBP-1c Promoter during FastingYoshinoriTakeuchi1,2,NaoyaYahagi1,2,3,YuichiAita1,2,YukiMurayama1,2,ZahraMehrazadSaber1,2,Nobuhiro Wada1,3,EnXuLi1,3,HuyanYiren1,3,YukariMasuda1,3,YoshihikoIzumida1,3,HitoshiShimano2

1Nutrigenomics Research Group, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 2Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, 3Department of Internal Medicine, the University of Tokyo, Tokyo, Japan





xxii

P-27 Confined Condition, Netakiri, Itself Induced Liver Injury and Abnormality of Lipid Metabolism in RatsHiroaki OdaLaboratory of Nutritional Biochemistry, Nagoya University, Nagoya, Japan

P-28 Caulerpa Lentillifera Ameliorated Inflammation and Modulated Gut Microbiota in Rats with Alcoholic Liver DiseaseKuan-Yu Lin1,Jiun-RongChen1,Hsin-Yi Yang2

1School of Nutrition and Health Sciences, Taipei Medical University, Taipei City, Taiwan, 2Department of Nutrition, I-Shou University, Kaohsiung, Taiwan

P-29 The Novel Effect of Glossogyne Tenuifolia on Differentiation of MacrophagesLi-Wen Fang1,Jer-YiingHoung1,Hsin-JenTsai21Department of Nutrition, I-Shou University, Kaohsiung, Taiwan, 2Department of Health Management, I-Shou University, Kaohsiung, Taiwan

P-30 The Green Tea Polyphenol Epigallocatechin-3-gallate Attenuates Age-associated Muscle Atrophy via Regulation of miR-486/PTEN/AKT AxisShu-Hui HuDepartment of Medical Laboratory Science and Biotechnology Kaohsiung Medical University, Kaohsiung, Taiwan

P-31 Beneficial Metabolic Effects by Dietary Short-chain Fatty AcidsSatsukiTaira1,HidenoriShimizu1,2,RyujiOhue1,3,IkuoKimura1,31Department of Applied Biological Science, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan, 2Nitto Pharmaceutical Industries, Ltd., Kyoto, Japan, 3AMED-CREST, Japan Agency for Medical Research and Development, Tokyo, Japan

P-32 Studies on Lipid Metabolism-related miRNAs in a Mouse Model of Non-alcoholic Steatohepatitis Ayana Ikeda1,NanaIshikura2,KyoulHan2,RinoAbiru2,TakahiroWatanabe2,AtsushiMiura1,Yori Ozaki-Masuzawa2,TakashiHosono1,2,TaiichiroSeki1,21Department of Applied Life Sciences, Nihon University Graduate School of Bioresource Sciences, Fujisawa, Japan, 2Department of Chemistry and Life Science, Nihon University College of Bioresource Sciences, Fujisawa, Japan

P-33 Insulin Receptor Substrate-2 Knockout Rats Generated by CRISPR/Cas9-mediated Genome Editing Exhibit Growth RetardationYukaToyoshima1,KatsuyukiNakamura2,ReikoTokita1,YusukeTaguchi1,NaomiTeramoto2,Hidetoshi Sugihara2,HisanoriKato3,KeitaroYamanouchi2,ShiroMinami11Department of Bioregulation, Institute for Advanced Medical Sciences, Nippon Medical School, Kanagawa, Japan, 2Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan, 3Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

P-34 Suppressive Effect on Blood-ethanol Elevation by Shiitake Extract Containing Lentinic AcidAyaka Sakurai1,YusukeUeno1,YusukeYamaguchi1,MakotoAkao1,HarumiKondo1,TakeshiSaito2,Hitomi Kumagai1

1College of Bioresource Sciences, Nihon University, Kanagawa, Japan, 2ACERA Food R&D Center, ACERA Co.,Ltd., Kanagawa, Japan



xxiii

P-35 Deamidation of Water-soluble Wheat Gliadin by Cation-exchange Resins and Its Functional PropertiesHanae Nakamura1,ShigenobuIna1,RinaTonoshima1,YusukeYamaguchi1,MakotoAkao1,Hitoshi Kumagai2,HitomiKumagai11College of Bioresource Sciences, Nihon University, Kanagawa, Japan, 2Faculty of Home Economics, Kyoritsu Women's University, Tokyo, Japan

P-36 Postprandial Metabolome Analysis on Breakfast and Dinner in Healthy Male AdultsHiroyuki Sasaki1,2,MasakiTakahashi3,MamihoOzaki1,Moon-IlKang4,MayukoFukazawa1,TamaoIwakami1,LimJeanPei3,Hyeon-KiKim5,ShinyaAoyama5,ShigenobuShibata6

1Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan, 2AIST-Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), Tokyo, Japan, 3Waseda Bioscience Research Institute in Singapore, Singapore, 4Human Metabolome Technologies Inc., Tokyo, Japan, 5Organization for University Research Initiatives, Waseda University, Tokyo, Japan, 6Faculty of Science and Engineering, Waseda University, Tokyo, Japan

P-37 Rice Bran-derived Fibers Ameliorate Colonic Inflammation through Gut Microbiota Modulation and FermentationKazukiTanaka1,2,WanpingAw1,KentaSuzuki3,NozomuObana4,MasaruTomita1,ShinjiFukuda1,2,51Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan, 2Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki, Japan, 3National Institute for Environmental Studies, Tsukuba, Japan, 4Transborder Medical Research Center, University of Tsukuba, Tsukuba, Japan, 5Metabologenomics, Inc., Tsuruoka, Japan

P-38 Pilot Trial of Human Circadian Transcriptome Using Hair Follicle Cells in Young MaleShinya Aoyama1,2,TakeruShimoda2,Hyeon-KiKim1,2,MasakiTakahashi3,TsudoiToyoda4,Shinji Okada4,KeikoAbe4,ShigenobuShibata2

1Organization for University Research Initiatives/Waseda University, Tokyo, Japan, 2Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Tokyo, Japan, 3Waseda Bioscience Research Institute in Singapore, Waseda University, Singapore, Singapore, 4Graduate School of Agricultural and Life Sciences/The University of Tokyo, Tokyo, Japan

P-39 Effects of Maternal Protein Restriction during Pregnancy on Renal Gene Expression in Young SHRSP OffspringMoe Miyoshi,MasayukiSato,KenjiSaito,LilaOtani,HuijuanJia,HisanoriKatoGraduate School of Agricultural and Life Sciences, the University of Tokyo / Health Nutrition, Tokyo, Japan

P-40 Findings of Potentially Cancer-preventive Foods Using Drosophila Cell Competition ModelKaz Nagaosa,YujiNakaiInstitute of Regional Innovation, Hirosaki University, Aomori, Japan

P-41 Effects of Gynura bicolor on Lipid Regulation in HamsterLan-Chi Hsieh1,Li-Jung Wang2,Ya-TingChen2,Chih-ChungWu3,Shu-LingHsieh2

1Department of Dietetics Kaohsiung Municipal United Hospital, Kaohsiung, Taiwan, 2Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan, 3Department of Food and Nutrition, Providence University, Taichung, Taiwan





xxiv

P-42 Effect of Oral Ingestion of Vitamin K2 on the Gene Expression of Drug-metabolism and Bile Acid Synthesis in Humanized PXR MiceHalimaSultana,KimikaWatanabe,MichioKomai,Hitoshi ShirakawaLaboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

P-43 Nostoc Commune Ethanol Extract (NEE) Regulates Expression of Genes Involved in Lipid Metabolism of Obese RatsSheng-ChiehTsai1,Jyh-JyeWang2,Chih-ChungWu3,Shu-LingHsieh4,Sue-JoanChang1

1Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan, 2Department of Nutrition and Health Science, Fooyin University, Kaohsiung, Taiwan, 3Department of Nutrition and Health Science, Providence University, Taichung, Taiwan, 4Department of Seafood Science, National Kaohsiung University of Science and Technology, Kaohsiung, Taiwan

P-44 The Development of High Throughput Screening System for Alzheimer's Disease-preventive Foods Using DrosophilaYuji Nakai,KazNagaosaInstitute of Regional Innovation, Hirosaki University, Aomori, Japan

P-45 Mechanism of Fatty Liver Induction in Rats Fed Low Arginine DietsKyoko Nakazawa,YutaAkasaka,LilaOtani,HisanoriKatoGraduate School of Agricultural and Life Sciences, the University of Tokyo / Health Nutrition, Tokyo, Japan

P-46 Squalene Oxidation Mechanisms in Skin Surface Lipids and Its Prevention by AntioxidantsNaoki Shimizu1,JunyaIto1,ShunjiKato2,TomomiAyasu3,TakahiroEitsuka1,TeruoMiyazawa1,4,Kiyotaka Nakagawa1

1Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan, 2Tokai University School of Medicine, Kanagawa, Japan, 3Sunstar Inc., Osaka, Japan, 4New Industry Creation Hatchery Center, Tohoku University, Miyagi, Japan

P-47 Physiological Effects and Organ Distribution of Microbial 1-Deoxynojirimycin in C57BL/6J MiceIsabella Supardi Parida1,SooTakasu1,JunyaIto1,RyoichiIkeda2,KenjiYamagishi3,ToshiyukiKimura3,TeruoMiyazawa1,4,TakahiroEitsuka1,KiyotakaNakagawa1

1Graduate School of Agricultural Science, Tohoku University, Miyagi, Japan, 2Food Research Laboratory, Asahimatsu Foods Co., Ltd., Nagano, Japan, 3Food Research Institute (NFRI), National Agriculture and Food Research Organization (NARO), Tsukuba, Japan, 4New Industry Creation Hatchery Center, Tohoku University, Miyagi, Japan

P-48 Proteomic Study Revealed the Preventive Effects of Coriander (Coriandrum sativum L.) on Gastrocnemius Muscle Disorders during Pre-cachexia in Rheumatoid Arthritis Rat ModelYa Wen,HisanoriKato,HuijuanJiaGraduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan



xxv

P-49 The Role of FGF21 Upregulation Induced by Protein Malnutrition in Hepatic SteatosisHiroki Kosaka1,KotaKawabata2,YoriOzaki-Masuzawa2,MorichikaKonishi3,NobuyukiItoh4,TakashiHosono1,2,AsakoTakenaka5,TaiichiroSeki1,21Nihon University Graduate School of Bioresource Sciences, Fujisawa, Japan, 2Nihon University College of Bioresource Sciences, Fujisawa, Japan, 3Kobe Pharmaceutical University, Kobe, Japan, 4Kyoto University Graduate School of Pharmaceutical Sciences, Kyoto, Japan, 5Meiji University School of Agriculture, Kawasaki, Japan

P-50 Eggshell Membrane Improved Lipid Metabolism in the Animal Model of High-Fat Diet-Induced ObesityYunlin Liu1,AyumuSekine1,YukioHasebe2,HuijuanJia1,HisanoriKato1

1Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan, 2ALMADO Inc., Tokyo, Japan

P-51 Coriander (Coriandrum sativum L.) Supplementation Ameliorates the Microbiota Dysbiosis in a DSS-induced Colitis Animal ModelJung Ko,HuijuanJia,HisanoriKatoGraduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan

P-52 Eggshell Menbrane Suppresses Spontaneous Colitis in Interleukin-10 Knockout MiceMasaya Kouno1,KazukiHirota1,YukioHasebe2,HuijuanJia1,HisanoriKato1

1Graduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan, 2ALMADO inc., Tokyo, Japan

P-53 Effects of Extracts from Lactobacillus plantarum TWK10 Fermented Soy Milk on the Streptozotocin and High Fat Diet Induced Dementia in Diabetic RatsLin Wan-Jyun1,Tai-YingChiou2,Tsung-YuTsai1,31Department of Food Science, Fu Jen Catholic University, New Taipei City, Taiwan, 2Division of Biotechnology and Environmental Chemistry, Graduate School of Engineering, Kitami Institute of Technology, Kitami, Japan, 3Ph.D. Program of Nutrition and Food Sciences, Fu Jen Catholic University, New Taipei City, Taiwan

P-54 The Influence of Turmeric on Dexamethasone-induced Skeletal Muscle Atrophy in vitroMarika Kousaka1,ChihiroOkahara1,YoshitakeHirayama2,HiromuTaguchi3,TakashiHirao3,Huijuan Jia1,HisanoriKato1

1Graduate School of Agricultural and Life Sciences, the University of Tokyo / Health Nutrition, Tokyo, Japan, 2House Wellness Foods Corporation, Chiba, Japan, 3House Foods Group Inc., Chiba, Japan

P-55 Analysis of the Function of Bitter Taste Receptors Tas2r in Extraoral Tissues in MiceMichio Komai1,YukaOizumi1,MichikoYamaki2,HitoshiShirakawa1

1Graduate Sch of Agricultural Sci, Tohoku University, Sendai, Japan, 2Tohoku Seikatsu Bunka University, Sendai, Japan

P-56 Zeolite-Containing Mixture Alleviates Microbial Dysbiosis in Dextran Sodium Sulfate Induced Colitis in MiceWeidaLyu,Nurul Shazini Ramli,KeLi,ChuanzongDeng,SeigoYamada,HuijuanJia,HisanoriKatoGraduate School of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan





xxvi

P-57 Low-arginine Diet Induces Hepatic Lipid Accumulation in Growing Rats by Different Mechanisms from Low-protein DietsNatsuru Ikenosako1,LilaOtani1,AyakaKoyama1,YutaAkasaka1,YusukeTaguchi2,YukaToyoshima2,Fumihiko Hakuno3,HuijuanJia1,Shin-ichiroTakahashi3,HisanoriKato1

1Faculty of Agricultural and Life Sciences, the University of Tokyo, Tokyo, Japan, 2Department of Bioregulation, Nippon Medical School, Kanagawa, Japan, 3Animal Sciences, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

P-58 Cordycepin Induced Unfolded Protein Response-Dependent Cell Death with Drug Resistance Phenomenon in MA-10 Mouse Testicular Cancer CellsMing-Min Chang1,Bo-SyongPan2,Bu-Miin Huang1

1Department of Cell Biology and Anatomy1, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 2Department of Cancer Biology2, Wake Forest University School of Medicine, Winston Salem, United States

P-59 Tea Consumption Attenuate Smoking-induced Diseases through Inhibition of the Alpha9-nicotinic-acetylcholine Receptor Expression: Breast Cancer Formation and Atherosclerosis as ExamplesLi-Ching Chen1,2,3,Chi-TangHo4,Yuan-Soon Ho5

1Breast Medical Center, Taipei Medical University Hospital, Taipei, Taiwan, 2Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan, 3Translational Cancer Research Center, Taipei Medical University, Taipei, Taiwan, 4Department of Food Science, Rutgers University, New Brunswick, United States, 5Graduate Institute of Medical Science, College of Medicine, Taipei Medical University, Taipei, Taiwan

P-60 Ameliorating Effects of Lactobacillus Paracasei Subsp. Paracasei NTU 101-fermented Skim Milk in Lipopolysaccharide-induced Periodontal Inflammation Experimental RatsTe-HuaLiu1,Meng-ChunCheng3,Tsung-YuTsai2,Tzu-MingPan1

1Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan, 2Department of Food Science, Fu Jen Catholic University, Taipei, Taiwan, 3College of Human Ecology, Fu Jen Catholic University, Taipei, Taiwan

a sia-paciic nutrigenomics & nutrigenetics organisation ... · asia-pacific nutrigenomics &...

Documents