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INTRODUCTION OF PRESIDENT TIMOTHY P. YOSHINOAuthor(s): Mike MoserSource: Journal of Parasitology, 92(6):1127-1128. 2006.Published By: American Society of ParasitologistsDOI: http://dx.doi.org/10.1645/GE-1069.1URL: http://www.bioone.org/doi/full/10.1645/GE-1069.1

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J. Parasitol., 92(6), 2006, pp. 1127–1128� American Society of Parasitologists 2006

INTRODUCTION OF PRESIDENT TIMOTHY P. YOSHINO

Mike MoserDepartment of Integrative Biology, University of California-Berkeley, Berkeley, California 94720. e-mail: mmoser@berkeley.edu

When Tim Yoshino was elected to be president, it was notby a hanging chad. It was to honor him for his amazing achieve-ments in research and education, his contribution to our society,and to bring his leadership experience to the presidency. He hasbeen the right person at the right time.

His research efforts have produced, in total, more than 100peer-reviewed articles, chapters in books, and published sym-posia. This work has been funded, in part, by more than 7million dollars in extramural grants and fellowships. During thepast 25 yr, he has served as an ad hoc reviewer and in studysections for NIH, NSF, TMP, NIAID, USDA, and Sea Grant.Tim has made a considerable contribution to his professionalorganizations and societies. For ASP, he has served on morethan a dozen different committees and organizing chair posi-tions. In addition to being an associate editor for the Journalof Parasitology, he has served as associate editor on the edi-torial board of five other journals. He also has served as anexternal examiner for students in 4 foreign countries.

Tim’s commitment to education is equally as impressive. Hislaboratories have been fruitful, and his students have continuedto be productive. To date, he has mentored 6 M.S. and 10 Ph.D.students and 9 postdoctoral scholars. Tim also has a strongcommitment to the recruitment and training of underrepresentedminority students into the sciences. He is active in the researchprograms at the University of Wisconsin-Madison (UW) forundergraduates and high school students. Tim is currently di-rector and principle investigator for the NIH Cellular & Mo-lecular Parasitological Training Grant Program and chair, De-partment of Animal Health and Biomedical Sciences, UW.

In recognition of his excellence in teaching, research, andservice to his profession, Tim has received numerous awards:Henry Baldwin Medal, ASP; Pfizer Award for Research Ex-cellence; Walter F. Rank Distinguished Professor Award, Vet &Med School, UW, Career Development Awards, NIH andNIAID and various Research and Teaching Awards from theUniversity of Oklahoma-Norman.

I believe that Tim’s impressive research success is due, inlarge part, to his continued commitment to cross disciplineboundaries, becoming familiar with that literature, and applyingnew approaches and techniques to the questions he is asking.This requires an enormous amount of self-discipline and hardwork, which can be seen in the development of Tim’s career.He received his B.A. at the University of California, Santa Bar-bara in 1970, his M.A. in 1971, and Ph.D. in1975. His master’sthesis was based on a survey of the helminth parasites of thePacific killifish. From this survey, he became interested in theecological interactions among parasites and their hosts. HisPh.D. dissertation was on the host–parasite interaction betweenthe mud snail Cerithidea californica and its larval digeneans.

During this work, he began thinking about the invertebratehost’s immune responses to their metazoan parasites. To studythese responses, he learned to use the electron microscope andto run immune assays. However, to peruse this aspect of com-parative immunology further, he felt he needed to move into a

more experimental system capable of manipulation. This op-portunity came in the mid-1970s when he moved to ThomasCheng’s laboratory at Leigh University for his postdoctoralwork. He had become interested in the resistant strains of Biom-phalaria glabrata to Schistosoma mansoni. During this time,Tim became familiar with the biochemical approaches to study-ing the immune interactions at the host–parasite interface. Thiswork led to questions of how parasites escape or avoid theimmune reactions in snails. Using Biomphalaria-Schistosomaas a model, he studied the recognition receptors on hemocytesand the carbohydrates expressed on the surface of the larvaldigeneans. When Tim moved to the University of Oklahoma,the groundwork was set for the direction of his research for thenext 30 yr. In 1978, he obtained his first NIH grant to studythe immunobiology of schistosome–mollusc interactions. In the1980s, Tim used lectins and then newly developed techniqueof monoclonal antibodies to identify molecular differences atthe surface of hemocytes that may account for the differentialability of these cells to encapsulate larval stages. He also beganlooking at how larval schistosomes may be modulating thisresponse by molecular mimicry or through larval excretory-secretory products. Tim continued this work when he moved toUW where he has been for the past 2 decades. At UW, heinitiated work with a cell line, the B. glabrata embryonic cellline, originally established by Eda Hansen in the 1970s. Findingthat it shared a number of cellular and molecular properties withhemocytes, he showed that it could serve as a model for schis-tosome–snail hemocyte interactions. His laboratory has subse-quently combined cellular, biochemical, and molecular appli-cations to exploit this model. Although Tim continues to studythe immune system in snails, he has recently branched out intoa new area of research to look at changes in gene expressionduring the in vitro development of the parasite’s larval stages,especially during the critical period of transition from the free-living miracidium to the parasitic mother sporocysts. To helpachieve his goal, he is now using microarray analysis and real-time quantitative polymerase chain reaction to analyze globalchanges in gene expression. He has also pioneered the use ofRNA interference in larval schistosomes as a functional gen-omics approach to help identify the possible role genes of in-terest may play during early larval development.

Tim’s career has come a long way in 35 yr since I watchedhim smash about 3,000 snails during his Ph.D. work. But allthis did not happen in a vacuum. Tim was born in Livingston,a rural farming community in central California, which wasfounded by Japanese immigrants at the beginning of the lastcentury. I believe that this background influenced his devel-opment. His parents, Bill and Reiko, stressed to their childrenthe value of hard work, education, self-reliance, dignity, andcommunity service. His career and personal life reflect thesequalities. Although Tim has received many professional acco-lades during his career, I know the thing he is the most proudof is his wife Laureen and daughters Lyndsey and Julia.

Tim and I were present in 1980 at the ASP meeting in Berke-

1128 THE JOURNAL OF PARASITOLOGY, VOL. 92, NO. 6, DECEMBER 2006

ley, California, when Elmer Noble introduced Norman Levineas president. Elmer had been Levine’s graduate teaching in-structor in parasitology at UC-Berkeley in the 1930s. Elmerbegan his introduction by saying, ‘‘I knew young Norman whenwe both had hair.’’ I remember that Tim and I looked at eachother and commented that this was just another of Elmer’s ‘‘old

guy’’ jokes (but we didn’t say ‘‘old guy’’). In presenting myintroduction, I am well aware that there probably are graduatestudents in the audience thinking the same thing. Fair enough.However, I remind you that you also are going to get old andI encourage you to do it in a great place like the AmericanSociety of Parasitologists, among really good friends.