integrated fluid system, sensors, scales, plc€¦ · priming minimum pump speed 3° 1200 rpm 1200...

INTEGRATED FLUID SYSTEM, SENSORS, SCALES, PLC

Quattrof low Diaphragm Pumps tap into nature i tsel f in order

to convey extremely del icate biological ly act ive molecules.

The displacement pump mimics the human heart.

The four-piston quaternary diaphragm technology generates

a gentle pumping through soft ‘heartbeats’. Each beat of

the four diaphragms is generated by an eccentr ic shaft

which is connected to the servo motor.

The evolut ionary design gently, safely and securely conveys

aqueous solut ions and biologics that are sensit ive to shear

force with minimal impact.

I t makes for the per fect model to ensure the safe, rel iable

and eff icient t ransfer of biologic mater ials .

Couple this with minimal corresponding temperature increase

and you have the ideal solut ion for cr i t ical appl icat ions

within biopharmaceutical manufactur ing. These Include:

• Tangential F low Fi l t rat ion (TFF)

• Chromatography

• Centr i fuge feed

• Virus f i l t rat ion

• Pur i f icat ion

• Inl ine di lut ion

INTR

OD

UC

ING

PUMP+DRIVE=RESULTS

BIOPROCESSDRIVING FORWARD YOUR

QUATTROFLOW QUATERNARY DIAPHRAGM PUMP FEATURING

HPNE DRIVE

Combined with the HPNE drive, you can calibrate

the pump to specific fluids and accurately measure

pressure as well as flow and other parameters.

2

TECHNICAL DATA SPECIFICATION QUATTROFLOW QF150SS QUATTROFLOW QF150SU-EZ

Flow Rate Maximum:Eccentric Shaft 3° 2.15 LPM 2.15 LPM

Eccentric Shaft 5° 3.8 LPM 3.8 LPM

Flow Rate Minimum:Eccentric Shaft 3° 0.01 LPM 0.01 LPM

Eccentric Shaft 5° 0.02 LPM 0.02 LPM

Pressure:Temperature of Fluid < 40° C (104° F) 6 Bar (87 PSI) 4 Bar (58 PSI)

Temperature of Fluid > 40° C (104° F) 4 Bar (58 PSI) 4 Bar (58 PSI)

Maximum Temperature:

Fluid 80° C (176° F) 60° C (140° F)

CIP 90° C (194° F) N/A

SIP 130° C (260° F) N/A

Autoclave 130° C (260° F) 130° C (260° F)

Pump Speed Range:RPM 10 - 3000 10 - 3000

Turndown 300:1 300:1

Suction Lift Dry @ 3000 RPM:Eccentric Shaft 3° 1-1.5 m (3.3-4.9 ft) 1-1.5 m (3.3-4.9 ft)

Eccentric Shaft 5° 2-3 m (6.6-9.8 ft) 2-3 m (6.6-9.8 ft)

Priming

Minimum Pump Speed 3° 2000 RPM 2000 RPM

Minimum Flow Rate @ Free Flow 3° 1.25 LPM 1.25 LPM

Minimum Pump Speed 5° 1000 RPM 1000 RPM

Minimum Flow Rate @ Free Flow 5° 1.25 LPM 1.25 LPM

Volume Specifications:

Approximated Volume per Revolution at

Free Output1.2 mL 1.2 mL

Filling Volume Without Connectors 15 mL 15 mL

Residual volume 1-3 mL (depends on installation position) 1-3 mL (depends on installation position)

Product Wetted Surface cm2 (inch2) 112 (17) 112 (17)

Connection Specification:

Connectors 1/4" TC ¼” TC, ¼” HB, 3/8” HB

Position of Connectors Inline Inline

Number of Flow Directions 4 4

Drive Shaft Diameter 7mm 7mm

Product Wetted Materials:

Pump Housing SS316L PP

Valve Plate SS316L PP

Diaphragms TPE TPE

Valves EPDM EPDM

O-Rings EPDM EPDM

Non-product Materials

Membrane Cover SS316L PP

Bearing Housing SS316L SS316L

Base Plate SS316L SS316L

Shroud SS316L SS316L

Certificates:Elastomers (product wetted) USP<88> Cl. VI; FDA21CFR177; BSE/TSE Safe USP<88> Cl. VI; FDA21CFR177; BSE/TSE Safe

Stainless Steel Parts (product wetted) 3.1; Surface Roughness; Ferrite Content N/A

HP

NE

FLO

WM

AX

X R

AN

GE

4.0

3.0

2.0

1.0

0.00 533 1067 1600 2133 2667 3200

QF150 FLOW RATE VERSUS RPM

No Back Pressure (Pulsat ing Flow)1 Bar Back Pressure (Pulsat ing Flow)

2 Bar Back Pressure (Pulsat ing Flow)

No Back Pressure (No pulsat ion)

1 Bar Back Pressure (No pulsat ion)

2 Bar Back Pressure (No pulsat ion)

RPM

Flo

w R

ate

s (L

PM)

4

HP

NE

FLO

WM

AX

X R

AN

GE

TECHNICAL DATA SPECIFICATION QUATTROFLOW QF1200SS QUATTROFLOW QF1200SU-M QUATTROFLOW QF1200SU-EZ

Flow Rate Maximum:Eccentric Shaft 3° 12.38 LPM 12.38 LPM 12.38 LPM

Eccentric Shaft 5° 27.4 LPM 27.4 LPM 27.4 LPM

Flow Rate Minimum:Eccentric Shaft 3° 0.32 LPM 0.32 LPM 0.32 LPM


Pressure:

Temperature of Fluid

< 40° C (104° F)6 Bar (87 PSI) 4 Bar (58 PSI) 4 Bar (58 PSI)


> 40° C (104° F)4 Bar (58 PSI) 4 Bar (58 PSI) 4 Bar (58 PSI)


Fluid 80° C (176° F) 50° C (122° F) 60° C (140° F)

CIP 90° C (194° F) N/A N/A

SIP 130° C (260° F) N/A N/A

Autoclave 130° C (260° F) N/A 130° C (260° F)

Pump Speed Range:RPM 10 - 2400 10 - 2400 10 - 2400

Turndown 240:1 240:1 240:1

Suction Lift Dry @ 1800 RPM:Eccentric Shaft 3°

Eccentric Shaft 5° 4 - 4.5 m (13.1 - 14.7 ft.) 4 - 4.5 m (13.1 - 14.7 ft.) 4 - 4.5 m (13.1 - 14.7 ft.)

Priming

Minimum Pump Speed 3° 1200 RPM 1200 RPM 1200 RPM

Minimum Flow Rate @ Free

Flow 3°7.2 LPM 7.2 LPM 7.2 LPM



Flow 5°5 LPM 5 LPM 5 LPM


Approximated Volume per

Revolution at Free Output 3°5.8 ml 5.8 ml 5.8 ml


Revolution at Free Output 5°9.6 ml 9.6 ml 9.6 ml

Filling Volume Without

Connectors75 mL 75 mL 75 mL

Residual volume8-26 mL (depends on

installation position)

8-26 mL (depends on


8-26 mL (depends on


Product Wetted Surface cm2 (inch2) 367 (57) 367 (57) 367 (57)


Connectors 1/2" TC, 3/4" TC 3/8" HB, 1/2" HB, 3/4" TC, 90° 3/4" TC 3/8" HB, 1/2" HB, 3/4" HB, 3/4" TC

Position of Connectors Inline Front Inline

Number of Flow Directions 4 4 4

Drive Shaft Diameter 14 mm 14 mm 14 mm


Pump Housing SS316L PE (injection molded) PP

Valve Plate SS316L PE (injection molded) PP

Diaphragms TPE TPE TPE

Valves EPDM EPDM EPDM

O-Rings EPDM EPDM EPDM


Membrane Cover SS316L PP PP

Bearing Housing SS316L SS316L SS316L

Base Plate SS316L SS316L SS316L

Shroud SS316L SS316L SS316L

Certificates:

Elastomers (product wetted)USP<88> Cl. VI; FDA21CFR177;

BSE/TSE Safe

USP <88> Cl. VI; FDA21CFR177;

BSE/TSE Safe


BSE/TSE Safe

Stainless Steel Parts (product

wetted)

3.1; Surface Roughness; Ferrite

ContentN/A N/A

No Back Pressure

1 Bar Back Pressure

2 Bar Back Pressure


30.0

22.5

5.0

7.5

0.00 533 1067 1600 2133 2667 3200

RPM

Flo

w R

ate

s (L

PM)

6

HP

NE

FLO

WM

AX

X R

AN

GE

TECHNICAL DATA SPECIFICATIONQUATTROFLOW QF4400SS (SS

VALVE PLATE)

QUATTROFLOW QF4400SS (PP

VALVE PLATE)QUATTROFLOW QF4400SU

Flow Rate Maximum:Eccentric Shaft 3° 57.9 LPM 57.9 LPM 57.9 LPM

Eccentric Shaft 6° 128 LPM 128 LPM 128 LPM

Flow Rate Minimum:Eccentric Shaft 3° 2.4 LPM 2.4 LPM 2.4 LPM


Pressure:


< 40° C (104° F)6 Bar (87 PSI) 6 Bar (87 PSI) 4 Bar (58 PSI)


> 40° C (104° F)4 Bar (58 PSI) 4 Bar (58 PSI) 4 Bar (58 PSI)


Fluid 80° C (176° F) 80° C (176° F) 60° C (140° F)

CIP 90° C (194° F) 90° C (194° F) N/A

SIP 130° C (260° F) N/A N/A

Autoclave 130° C (260° F) N/A 130° C (260° F)

Pump Speed Range:RPM 20 - 1200 RPM 20 - 1200 RPM 20 - 1200 RPM

Turndown 60:1 60:1 60:1

Suction Lift Dry @ 1200 RPM:Eccentric Shaft 3° 2.5-3 m (8.2-9.8 ft) 2.5-3 m (8.2-9.8 ft) 2.5-3 m (8.2-9.8 ft)

Eccentric Shaft 6° 4-4.5 m (13.1-14.7 ft) 4-4.5 m (13.1-14.7 ft) 4-4.5 m (13.1-14.7 ft)

Priming



Flow 3°37.5 LPM 37.5 LPM 37.5 LPM



Flow 6°53.3 LPM 53.3 LPM 53.3 LPM



Revolution at Free Output 3°52 ml 52 ml 52 ml


Revolution at Free Output 6°95 ml 95 ml 95 ml

Filling Volume Without

Connectors820 ml 820 ml 820 ml

Residual volume 80 ml 80 ml 80 ml

Product Wetted Surface cm2 (inch2) 1669 (259) 1669 (259) 1669 (259)


Connectors 1" TC, 1.5" TC 1" TC, 1.5" TC 3/4" HB, 1" TC, 1.5" TC

Position of Connectors Front Front Front

Number of Flow Directions 4 4 4

Drive Shaft Diameter 28 mm 28 mm 28 mm


Pump Housing SS316L SS316L PP

Valve Plate SS316L PP PP

Diaphragms TPE TPE TPE

Valves EPDM EPDM EPDM

O-Rings EPDM EPDM EPDM


Membrane Cover SS316L PP PP

Bearing Housing SS316L SS316L SS316L

Base Plate SS316L SS316L SS316L

Shroud SS316L SS316L SS316L

Certificates:

Elastomers (product wetted)USP<88> Cl. VI; FDA21CFR177;

BSE/TSE Safe


BSE/TSE Safe


BSE/TSE Safe

Stainless Steel Parts (product

wetted)


Content


ContentN/A


RPM

Flo

w R

ate

s (L

PM)

140.0

105.0

70.0

35.0

0.00 533 1067 1600 2133 2667 3200

No Back Pressure

1 Bar Back Pressure

2 Bar Back Pressure

8

HOW TO USEThe technology is used in conjunction with aqueous-based f lu ids that are typical ly

handled in research, pi lot plant, and/or production faci l i t ies of the pharmaceutical

and biotech industr ies.

EXAMPLES OF PRODUCT USE:

FEATURES BENEFITS

Solut ions containing proteins (albumin, IgG, clott ing factors,

monoclonal ant ibodies, enzymes, vaccines)

Solut ions of polymers or suspensions (s i l icon, latex,

chromatographic media)

Cel l suspensions (bacter ia, yeast, algae, fungi, mammalian cel ls)

Col loidal solut ions

Suspensions of v i ruses or phage

Minimal maintenance

Minimal downtime

Low pulsat ion

Superior containment

Variable wide f low

Capable of dry run

Self-pr iming

Cleanable outer sur face

Linear turndown

Compact design

Pressure shut-off

Low heat generat ion

High pur i ty

Minimum part icle shedding

Quiet operat ion

Lower l i fe cycle cost

Ease of use

Quick start-up

Scaleable

No cel l damage

Low shear

Walk away operat ion

10

PUMPAPPLICATIONSFeed pump for centr i fuges or separators? Feed pump for homogenizers? Feed pump for

f i l l ing machines? Quattrof low pumps can be found in al l areas of biologic manufactur ing.

The tech ensures safety, eff ic iency and rel iabi l i ty when handl ing biologics such as

plasma products, therapeutic proteins, monoclonal ant ibodies, vaccines, and other

high value products.

F ILTRATION TECHNOLOGY:

CHROMATOGRAPHY:

To recirculate feed/retentate (e.g. membrane cassettes, hol low f iber, spi ral

wound, ceramic elements)

Feed pump for f i l ter cartr idges or depth f i l ters

Packing of chromatography columns

Chromatography pur i f icat ion

Feed pump to mix gradients

F i l l f in ish

In- l ine di lut ion mix ing

HPNE Quattrof low pumps can also be outf i t ted with a s ingle-use head which enables them to meet st r ict speed-to-market manufactur ing demands.

DIDYOUKNOW?

12

TORQUE SPECS (NM) QF150 QF1200 QF4400 QF20K

Pressure Plate SU 3 8 25 35

Pump Chamber SU Cover Membrane Housing 0.8 0.8 0.8

Clamp Ring0.6 PP 5 PP 20 1-piece

2 SST 6 SST 18 SST 15 2-piece

Stainless Steel Pumps 4 10 28 30

Stainless Steel Pump Cover Membrane Housing 2 5 6 25

TORQUESPECS

14

MEET HIGH PURITYNEW ENGLAND

WHO WE ARE

Under the auspices of ISO 9001

2015, High Pur i ty New England

designs, tests , val idates,

manufactures and dist r ibutes:

• S ingle-use products

• Connectors

• Tubing

• Components and systems

• Designs Systems

to the biopharma and pharmaceutical industr ies

S ingle-use assembl ies have fast-become an economic and

logical necess i ty. Meet HPNE - your t rusted and approved

vendor. HPConnexx is our own ISO-Cert i f ied, custom, s ingle-

use assembly service.

We work with you to design and optimize an assembly with

any commercial components that you specify and that you

are comfortable with. Our technical background enables

us to provide valuable feedback for process improvements

and avoid cost ly mistakes.

SINGLE-USE, MANY BENEFITS

Single Use Fluid Path Assemblies...

High PurityDesign Assembly

Supply

16

5 REASONS TO CHOOSE HPNE:

TWOReduce cost of

bui lding, maintaining

inventory and labor by

outsourcing assembly

production

THREEReduce costs and

downtime for cleaning,

cleaning val idat ion,

ster i l i zat ion and process

engineer ing

ONEMonitor & provide

detai led guidance to

inform extractable

and leachable

test ing

ASSESS DESIGN IMPROVEI f we don’t get you,

how can we get results?

That’s why the team

gets things underway by

assess ing your current

operat ion.

With ins ights generated,

the team fuses i ts

expert ise with best of

breed process solut ions

in designing systems to

your needs.

HPNE is hands-on.

Reactiv i ty makes way

for proactiv i ty. We’l l

monitor your act iv i ty,

assess ing exist ing and

new needs.

IMPLEMENT OVERSEEYou’l l judge us on the

results . And r ight ly

so. Custom parts are

therefore assembled

and implemented with

pinpoint precis ion.

The team wi l l seek

out, recommend &

implement continuous

improvements. This

ensures you maximize

eff ic iency & productiv i ty.

ADDED IN THE BIOPROCESSFrom buffer solut ions to cel l cultures, your needs are unique. HPNE secures a return on your investment by way of a 5 step process.

FOUR FIVEIntegrate stainless steel

with s ingle-use for hybr id

operat ion

ISO 9001:

2015 Cert i f ied products

and services

18

GETTING CONNECTED WITH BETTER PROCESSESHigh Pur i ty New England Inc, 25 Thurber Boulevard,

Unit #4, Smithf ield, RI 02917

GOT A QUESTION?GET AN ANSWER!

Ready to get connected with a hol ist ic start-to-f in ish service which optimizes

your in-process supply chain? Great. HPNE is standing by to discuss your needs.

Cal l : 401-349-4477|Emai l : [email protected]

Vis i t : www.hp-ne.com

integrated fluid system, sensors, scales, plc€¦ · priming minimum pump speed 3° 1200 rpm 1200...

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