Cell Growth & Differentiation I

Instructions for AuthorsAims and ScopeCELL GROWrH & DIFFERENTiATiON aims to publ�h significant, ong-mel studies that address any aspect of the molecular biology of cellgrowth and differentiation, particularly as it relates to oncogenesis.Papers should be written as concisely as possible and should present acomplete body of work. In addition to the publication of full researchpapers, the journal also publishes reviews and minireviews that providea synopsis of recent experimental findings or meetings. Although manyare invited, proposals for reviews may be submitted to the Editor-in-Chief.

Editorial PolicyWhen a manuscript is received for consideration, the Editors assumethat no similar paper has been or will be submitted for publicationelsewhere. Further, it is understood that all authors listed on a manu-script have agreed to its submission. AACR policy requires thatauthors, reviewers, and Editorial Board members reveal tothe Editor-in-Chief any relationship that they believe could be construed ascausing a conflict of interest with regard to the manuscript submittedfor review. Upon acceptance, authors must transfer copynght to theAmerican Association for Cancer Research, Inc., the publisher andcopyright owner of thejoumal, prior to publication. Once an article isaccepted for publication in CELL GROWTH & DIFFERENTiATiON,the information therein is embargoed from reporting by the mediauntil the mail date of the issue in which the article appears.

It is understood that by publishing any work in CELL GROWTH &DIFFERENTiATiON the authors agree to make freely available toother academic researchers any of the cells, clones of cells, DNAclones, lines of genetically altered mice, antibodies, etc. that wereused in the research reported and that are not available from corn-mercial suppliers. ,�Jso, authors may be required to make primarydata available to the Editor-in-Chief in cases of dispute.

Submission of PapersAll papers should be submitted directly to the Editorial Office forconsideration (address below). The manuscript should be accompa-nied by a covering letter indicating that the paper is being submittedfor consideration for publication in CELL GROWTH & DIFFERENT!-ATiON; the name and address of the corresponding author (includetelephone and FAX numbers and an E-mail address, if available); anda statement confirming that the paper has been reviewed by allauthors and is not under consideration elsewhere. If a manuscript isclosely related to papers that are in press or have been submittedseparately, copies of these papers also should be provided. Guide-lines for the organization of manuscripts are detailed below. Fourcopies ofthe manuscript and accompanying original illustrations (notphotocopies) should be submitted. Authors may suggest appropriatereviewers (suggestions are not limited to the Editorial Board), but thecomplete mailing addresses of any suggested reviewers, includingtelephone and FAX numbers, must be provided.

Editorial office address: Dr. Joseph A. NevinsEditor-in-ChiefCell Growth & DifferentiationDuke University Medical CenterBox 3054CARL Building, Room 268Research DriveDurham, NC 27710

Organization and Preparation of ManuscriptsPapers should be written as concisely as possible in clear, gram-matical English and should not occupy more than 8-10 printedpages in thejoumai. This corresponds to approximately 32-40 dou-ble-spaced typescript pages (4 typed pages = 4 illustrations = Ijournal page). Manuscripts should be double-spaced on 8#{189}x 11-inch paper and organized in the following manner:

Title Page. A main title together with authors’ names andaffiliations and the address of the corresponding author. A run-ning title of no more than 50 characters in length should also beincluded.

Abstract. A single paragraph on a separate page of no morethan 150 words.

Introduction. A concise introduction to the body of the workwith no subheadings.

Results and Discussion. The results and discussion sectionsmay be separate or combined into a single section. Subheadingsmay be used.

Materials and Methods. Should contain sufficient detail toallow repetition of all procedures.

Acknowledgments. Should include all relevant informationwith the exception of acknowledgments of financial support,which should be indicated in a footnote.

Footnotes. On a page separate from the text. Designate foot-notes consecutively with superscript Arabic numerals.

Tables. On pages separate from the text, with descriptive titlesand legends.

Figure Legends. On pages separate from the text. Define allsymbols and include staining for halftones, where applicable.

References. Include only those articles that have been publishedor are in press. Unpublished data or personal communications mustbe cited asfootnotes to thetext. Personal communications should besubstantiated by a letter of permission.

Number references in the order of their first mention in the text.Cite only the number assigned to the reference. References must bedouble-spaced.

Sample references:

1 . Pillay, I., and Sharma, S. V. In vivo and in vitro senne/threoninephosphorylations of epidermal growth factor receptor upon entryinto the cell cycle. Cell Growth Differ., 6: 39-49, 1995.

2. Cooper, J. A. The arc-family of protein tyrosine kinases. In: B. E.Kemp (ad.), Peptides and Protein Phosphorylation, pp. 85-113.Boca Raton, FL: CRC Press, 1990.

fflus.trations

Provide four original sets of illustrations (whether line-cut drawings orhalftones). Label each figure in pencil on the reverse side with the firstauthor’s name, figure number, and an arrow indicating top of figure.Letters and numbers on illustrations should not be smaller than6-point or larger than 12-point type. All illustrations will be publishedat a width of 3#{189}inches unless the author requests a greater width.

Indicate magnifications by meansofa baron the photograph. Presentkaryotypes in the form of cardboard plates onto which chromosomesections from an original photomicrograph are pasted. Present nucleicacid sequences as glossy prints or original typesctipts.

Authors are encouraged to submit color figures. The expense ofreproducing color photographs must be offset partially by theauthors. The cost of color reproduction charged to authors is $975per color figure. Submit color illustrations on flexible backing.

ProofsPage proofs must be returned to the office of the American Associ-ation for Cancer Research within 24 hours of receipt. Return proofsby overnight mail. Proofs not received by the deadline will bepubllshed without the authors’ conectlon& Accepted manu-scripts are regarded as final copy and should not be altered sub-stantially in proof. Extensive alterations could cause publication de-lays, and authors will be charged for excessive changes in proof.

Publication Fees

A page charge of $50 per printed page will be levied on all manu-scripts accepted for publication. It is understood at the time ofsubmission that the author(s) agree to pay this charge in the event ofpublication. Under exceptional circumstances, when no other sourceof grant or other support exists, the author(s) may apply to Dr.Margaret Foti, Director of Publications, AACR Publications Depart-ment (see masthead page for address) at the time of submission fora waiver of the page charges. All such applications must be coun-tersigned by an appropriate institutional official stating that no fundsare available for the payment of page charges.

Typesetting Manuscripts from Computer Disks

CELL GROWTH & DIFFERENTiATiON requests the submission ofdisks to expedite production of accepted manuscripts. When anarticle is accepted for publication, authors will receive instructionsregarding disk submission and a form which must be completed andreturned with the disk to the MCR Publications Department within48 hours of notification of acceptance. It is the author’s responsibilityto ensure that the material on the disk matches the final acceptedversion of the manuscript.

Schedule of PublicationAuthors should expect to receive reviewers’ comments within 4 weeksof submisaion. if revisions are required, only one revised version will beconsidered. Most articles will be published within 5-7 weeks of accept-once.

BENEFITS OF MEMBERSHIP

Notification of Candidate

MarchJuly

November

Margaret Foti, Ph.D.Executive Director

AMERICAN ASSOCIATION FOR CANCER RESEARCH

GUIDELINES FOR APPLICATION FOR ACTIVE AND

CORRESPONDING MEMBERSHIP

The American Association for Cancer Research (AACR), a scientific

society of over 13,500 laboratory and clinical cancer researchers, was foundedin 1907 to facilitate communication and dissemination of knowledge amongscientists and others dedicated to the cancer problem; to foster research incancer and related biomedical sciences; to encourage the presentation and

discussion of new and important observations in the field; to foster publiceducation, science education, and training; and to advance the understandingof cancer etiology, prevention, diagnosis, and treatment throughout the world.

Members of the AACR enjoy the following benefits:

1. the privilege of sponsoring a proffered paper (abstract) for consider-ation for presentation at the AACR annual meeting;

2. subscriptions to the Association’s high-quality journals Cancer Re-search, Clinical Cancer Research, Cell Growth & Differentiation, andCancer Epidemiology, Biomarkers & Prevention at reduced member

rates;

3. an advance copy of the Program and Proceedings of the American

Association for Cancer Research that contains over 4,000 abstracts ofproffered papers presented at the annual meeting;

4. reduced registration rates at annual meetings;

5. priority notice of small, focussed meetings in the AACR’s exciting seriesof Special Conferences in Cancer Research;

6. substantially reduced registration rates for Special Conferences;

7. opportunities for participation in AACR meetings in North America andabroad with other scientific societies around the world;

8. receipt of AACR Newsletters and other important announcements;9. early notification of and reduced rates for participation in the AACR

Employment Register;10. an up-to-date Membership Directory of over 13,500 member researchers

in the cancer field;

11. the professional benefits of the AACR’s public education activities con-

cernmg funding for cancer research and press coverage of the latestresearch findings;

12. the opportunity to participate in three Summer Workshops that fosterknowledge in the cancer field for young investigators;

13. the facilitation ofinfonnal scientific exchange with leading researchers in

the cancer field; and

14. many more ongoing benefits.

QUALWICATIONS FOR MEMBERSHIP

Active membership in the AACR is open to investigators who live in the

Americas. Individuals who have conducted two years of research resulting in

peer-reviewed publications relevant to cancer, or who have made substantialcontributions to cancer research in an administrative or educational capacity,are eligible. If a candidate has conducted research in an area of biomedical

science related to cancer, he or she will qualify for membership. Evidence ofpatents relevant to cancer research may be submitted as qualifications formembership in lieu of peer-reviewed publications.

Corresponding membership is open to persons who are not residentsof the Americas. The qualifications for corresponding membership are thesame as those indicated above for active membership. Visiting scientistsfrom outside the Americas who intend to return to their countries of originby the anticipated time of election should apply for corresponding mem-bership. All other visiting scientists should apply for active membershipand transfer to corresponding status upon leaving the Americas.

Graduate and medical students, postdoctoral fellows, and physicians intraining who do not yet meet the above qualifications for active orcorresponding membership should apply for associate membership.

Forms for associate membership are available from the AACR Office.

PROCEDURES FOR APPLICATION

There are three deadlines for the receipt of a membership application:January 1, May 1, and September 1 of each year. The MembershipCommittee will review all complete applications for active membershipthat have been received by these deadlines and will submit recommenda-tions on each candidate to the Board of Directors which formally elects all

members. The same procedure is followed by the Special MembershipsCommittee which receives applications for corresponding membership.

Candidates will be notified according to the following schedule:

Receipt of Applicationin AACR Office ______________

January 1May 1September 1

A complete application consists of the following material:

1. 6 copies ofthe form on the opposite side ofthis page, with all requestedinformation provided.

2. 5 copies of the candidate’s most current curriculum vitae and bibliog-

raphy.

3. 5 copies of a letter of recommendation from a nominator who is anactive, corresponding, emeritus, or honorary member of the AACR (atleast one copy must be a signed, original letter). This letter shoulddescribe the candidate’s achievements in laboratory research, clinical

investigations, or epidemiological research, and it should affirm thatthis research adheres to accepted ethical scientific standards. -OR- The

nominator may supply the responses requested at the bottom of theapplication form in the section entitled “STATEMENT OF SUP-PORT” (at least one copy of the form must be the signed original).

4. 5 copies of a letter of recommendation as described in Item 3 above

from a seconder who is an active, corresponding, emeritus, or honorarymember of the AACR (at least one copy must be a signed, originalletter). -OR- The seconder may supply the responses requested at thebottom of the application form in the section entitled “STATEMENT OFSUPPORT” (at least one copy of the form must be the signed original).

5. 5 reprints of each of two publications on which the candidate appears as

author. As noted above, evidence of patents developed by the candidatemay be submitted in lieu of one or both of the publications. If submittingpatents, supply patent number and year awarded.

All material should be collated into five complete sets with the originalapplication form as a covering document and sent to the address givenbelow. Questions regarding procedures for membership application may

also be directed to the following address:

Membership Services Department

American Association for Cancer ResearchPublic Ledger Building, Suite 826

150 5. Independence Mall WestPhiladelphia, PA 19106-3483

Phone: 215/440-9300FAX: 215/440-9412

E-mail: aacr@aacr.org

RESPONSIBILITIES OF MEMBERSHIP

Candidates should be aware of the following responsibilities of member-ship in the AACR. Active members must pay annual dues. In 1998 annual

dues for active members are $175, $100 of which is designated for AACRjournal subscriptions. Newly elected members of the AACR who have

already purchased subscriptions to Cancer Research, Clinical Cancer Re-

search, Cell Growth & Differentiation, or Cancer Epidemiology, Biomarkers

& Prevention at the higher, nonmember rates will receive reimbursement ofthe unused portion of those subscriptions once their first year’s membershipdues are paid in full.

Corresponding members are required to pay dues ($100 in 1998) and

may, if they wish, subscribe to Cancer Research, Clinical Cancer Re-

search, Cell Growth & Differentiation, or Cancer Epidemiology, Biomar-kers & Prevention at reduced member rates.

Applicants elected in March will be responsible for payment of thatyear’s dues; applicants elected in July and November will pay dues for the

following year. Applicants elected in March and July will be eligible tosponsor an abstract for the next annual meeting. Every effort will be madeto afford the same opportunity to applicants elected in November.

AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC.

Public Ledger Building . Suite 826 . 150 S. Independence Mall West � Philadelphia, PA 19106-3483

APPLICATION FOR ACTIVE OR CORRESPONDING MEMBERSHIP

NAME OF CANDIDATE:_____________ _____________ _____ DATE OF BIRTh:___________

LAST FIRST M.I. Month/Day/Year

PRESENT POSITIONIITLE:

INSTITUTIONAL AFFILIATION:________________________________________________________

INSTITUTIONAL ADDRESS:

(City) (State/Province) (Country) (Postal Code)

TELEPHONE NUMBER:___________________________ FAX NUMBER:________________________

E-MAIL ADDRESS:

PRIMARY FIELD OF RESEARCH (Please check only one):Biochemistry and Biophysics Biostatistics _____

_____Cellular Biology and Genetics _____Clinical Investigations EndocrinologyEpidemiology ..............Jmmunology _____Molecular Biology and GeneticsPreclinical Pharmacology and _____Virology Other:________________________________Experimental Therapeutics (Please specify)

ACADEMIC DEGREES (Including where and when granted)

EXPERIENCE SINCE HIGHEST DEGREE WAS GRANTED (Please list most recent first)

PUBLICATIONS (Reprints of two peer-reviewed articles on which the candidate appears as an author must accompany this application. For

these two articles list the authors, title, journal, volume, inclusive pages, and year. Do not submit abstracts. If submitting patents, supply patentnumber and year awarded.)

CANDIDATE IS APPLYING FOR (Check one): U ACTIVE D CORRESPONDING MEMBERSHIP

CANDIDATE CANDIDATENOMINATED BY*:__________________________ SECONDED BY*:___________________________

(Please print) (Please print)

STATEMENT OF SUPPORTInstead of submitting letters of recommendation, either the nominator or the seconder or both may complete the following section:

I acknowledge by signing this statement of support that this candidate adheres to accepted ethical scientific standards and has or will make a

long-term contribution to cancer research.

Signature of Nominator* Date Signature of Seconder* Date

See Guidelines for Application on the reverse side of this form for further instructions.

*Both nominator and seconder must be active, corresponding, emeritus, or honorary members of the AACR in good standing.

(This form may be reproduced.) 1998

AMERICAN ASSOCIATION FOR CANCER RESEARCH

IGUIDELINES FOR APPLICATION FOR ASSOCIATE MEMBERSHIP

QUALIFICATIONS FOR MEMBERSHIP

Associate membership is open to graduate students, medical students,postdoctoral fellows, and physicians in training who are following a

course of study or who are working in a research program relevant to

cancer. Scientists in training who already have a substantial record of

publications may wish to apply for active or corresponding membership

which confers full benefits of membership.

BENEFITS OF MEMBERSHIP

The American Association for Cancer Research (AACR), a scientific

society consisting of laboratory and clinical cancer researchers, was

founded in 1907 to facilitate communication and dissemination of knowl-

edge among scientists and others dedicated to the cancer problem: to

foster research in cancer and related biomedical sciences; to encouragepresentation and discussion of new and important observations in the

field; to foster public education, science education, and training: and to

advance the understanding of cancer etiology, prevention, diagnosis, and

treatment throughout the world. Associate members of the AACR enjoy

the following benefits:

I . the privilege of sponsoring a proffered paper (abstract) for consider-

ation for presentation at the AACR annual meeting provided that (a)

the associate member is the presenter of the paper and (b) an active,corresponding, emeritus, or honorary member in good standing of the

AACR also signs the abstract of the paper in support of the work. (In

this instance, the member who cosigns the abstract does not lose his

or her own sponsorship privilege.);2. optional subscriptions to the Association’s high-quality journals:

Cancer Research, Clinical Cancer Research, Cell Growth & Differ-

entiation, and Cancer Epidetniologv, Biomarkers & Prevention at

reduced member rates; beginning in 1998 associate members will be

able to purchase AACR journals for half the price of a regular membersubscription:

3. the privilege of registering for the annual meeting at the low associate

member rate:4. the privilege of electing an Associate Member Council that organizes

programs benefiting associate members and that presents their con-cerns to the AACR Board of Directors:

5. the opportunity to stand for election to the Associate Member Coun-

cil;

6. preferred access to the AACR Employment Register:7. priority notification of events in the AACR’s series of special

conferences on timely subjects in the field;

8. substantially reduced registration rates at special conferences;

9. the receipt of AACR newsletters, meeting announcements, and anup-to-date Membership Directory;

10. the opportunity to participate in three Summer Workshops that fosterknowledge in the cancer field for young investigators; and

1 1. the facilitation of informal scientific exchange with leading research-ers in the cancer field.

PROCEDURES FOR APPLICATION

Persons wishing to apply for associate membership must use the

official application form on the reverse side of these instructions. Each

candidate for associate membership must be nominated by an active,

corresponding, emeritus, or honorary member in good standing of the

AACR. Three completed copies of the form should be submitted: at least

one of these copies must carry the original signatures of both the candidate

and the nominator. In addition, the candidate should submit one copy of

his or her curriculum vitae. The application form may be submitted to the

Association Office at any time.After review of applications for associate membership, the Executive

Director will notify candidates of their election or deferral within one

month of the receipt of the application form. A check for one year’s duespayment must accompany the application. Dues for 1998 are $55 for

associate members residing in the Americas and $65 for residents of other

countries. This fee will be refunded to any candidate deemed to be

ineligible for associate membership. Checks should be in U.S. currency,

made payable to AACR, Inc., and drawn on a U.S. bank. Send the three

copies of the application form and the appropriate dues payment to:

Membership Services Department

American Association for Cancer Research

Public Ledger Building. Suite 826

150 5. Independence Mall West

Philadelphia, PA 19106-3483

Phone: 215/440-9300

Fax: 215/440-9412E-mail: aacr@aacr.org

RESPONSIBILITIES OF MEMBERSHIP

Associate members must pay annual dues in an amount to be deter-

mined by the AACR Board of Directors. Dues for 1998 have been set at

$55 per year for residents of the Americas and $65 for residents of other

countries. If an application is submitted by August 3 1. the accompanying

dues payment will be credited to the current year. Candidates submitting

applications between September 1 and December 3 1 may indicate whetherthey wish their dues payments credited to the current or forthcoming year.

Candidates should be aware, however. that associate members may spon-

sor an abstract for the annual meeting only if their dues for the current year

are paid. For example, an associate member submitting an abstract in

November 1998 for the forthcoming annual meeting must have paid dues

for 1998. Any newly elected associate members of the AACR who have

already purchased subscriptions to C�ancer Research, Clinical CancerResearch, Cell Grmtth ct Differentiation. or Cancer Epidemiology. Bio-

markers & Pret’entio,i at the higher, nonmember rate will receive a refund

for the unused portion of that subscription upon receipt of their payment

for a member’s subscription.

Each Fall the AACR will send to current associate members an invoice

for dues for the ftrthcoming year. Payment of this invoice must be

accompanied by a statement signed by the associate member’s current

registrar, dean, or department head. verifying the member’s current aca-

demic status. The Association’s By-Laws state that dues are payable for

each year in advance by January 1 of the year to which they should be

applied. An individual may be an associate member for a maximum of

five years. Each year in which an individual pays dues will count as one

full year of associate membership. Thus. an associate member who pays

dues for I 998 may retain associate membership until December 3 1, 2()02.The Board of Directors may terminate the membership of an associate

member whose dues are in arrears for two years.

Margaret Foti, Ph.D.

Executive Director

AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC.

Public Ledger Building . Suite 826 . 150 S. Independence Mall West � Philadelphia, PA 19106-3483

APPLICATION FOR ASSOCIATE MEMBERSHIP

NAME OF CANDIDATE:_______________

Ml.DATE OF BIRTH:________________

INSTITUTIONAL

LAST FIRST

AFFILIATION:__________________________________________________________________

Month/Day/Year

INSTITUTIONAL ADDRESS:

(City) (State/Province) (Country) (Postal Code)

TELEPHONE NUMBER:_______________________________ FAX NUMBER:___________________________

E-MAIL ADDRESS:

PRESENT ACADEMIC STATUS/TITLE (Please check only one):

______Graduate Student ______Medical Student

Physician in Training Postdoctoral Fellow Gender: E Male � Female

PRIMARY FIELD OF RESEARCH (Please check only one):Biochemistry and Biophysics Biostatistics Carcinogenesis

______Cellular Biology and Genetics ______Clinical Investigations Endocrinology

Epidemiology Immunology _____Molecular Biology and Genetics

______Preclinical Pharmacology and Virology Other:_____________________________________

Experimental Therapeutics (Please specify)

ACADEMIC DEGREES (Please indicate degree(s) acquired to date along with the name of the academic institution and date of receipt. Provideinformation on degree currently being sought and the anticipated date of completion of this degree program.)

RELEVANT RESEARCH EXPERIENCE NOT RELATED TO COURSE WORK (Please list most recent first.)

PUBLICATIONS (List the authors. title, journal, volume, inclusive pages, and year of any article in a peer-reviewed journal on which the

candidate appears as an author. Do not list abstracts. Continue on a separate sheet, if necessary.)

CANDIDATE NOMINATED BY*:_____________________________________________________________

(Please print)

SIGNATURES

I hereby apply for associate membership in the American Association for Cancer Research. I have read the instructions on the reverse side ofthis form, and I understand the privileges and responsibilities of this class of membership. I certify that the statements on this application are

true.

Signature of Candidate:______________________________________________________________________ Date:_____________________

I recommend this candidate for associate membership in the American Association for Cancer Research. To the best of my knowledge, the

candidate is qualified for this class of membership, and the statements on this application are true.

Signature of Nominator*:_____________________________________________________________________ Date:_____________________

Submit three copies of this form. At least one copy must contain the original signatures of the candidate and the nominator. In addition, submit

one copy of your curriculum vitae. Enclose a check in U.S. funds. made payable to AACR, Inc., and drawn on a U.S. bank for one year’s dues.

For 1998, dues are $55 for associate members residing in the Americas and $65 for residents of other countries.

Check one of the ftllowing boxes only if this form is being submitted between September 1 and December 3 1:

The enclosed dues payment should be applied to the fl current fl forthcoming calendar year.

(NOTE: Ifdues are applied to the forthcoming year, membership will take effect on January 1, but the candidate will not be eligible to sponsor

an abstract for presentation at the annual meeting in March or April of that year.) See Guidelines for Application on the reverse side of this

form for further instructions.

*Nomjnator must be active. corresponding. emeritus. or honorary member of the AACR in good standing.

(This form may be reproduced.) 1998

Guidelines for Submitting Disksto

American Association for Cancer Research Publications

The word processing packages that we prefer are as follows:

MacWrite WordPerfect (DOS, Windows,Microsoft Word (DOS, Windows, and Macintosh)

and Macintosh) XyWrite (DOS and Windows)

Also acceptable:

Ability Mass 1 1 SoloWriterAmiPro MS Windows Write SprintAM S-T�X MS Works StxAppleworks MS Works WP Mac SunWritekborT�X Multimate SymphonyArborText Multimate Advantage TEXClarisWorks WP Nibia T�X78CPT 8000 Nisus (to ASCII file) Text EXecutiveCTOS Notewriter TexturesDiablo Obun Total WordDisplayWrite OfficeWriter TroffDuet PC Write �T�XEinstein PFS First Choice VolkswriterEnable Professional Write VuWnterEXP Q&A Write Wang 015Final Word Quark XPress Wang WPSFullWrite RagTime MS Works Wang WriterGemWord Plus (to ASCII file) Window WorksIBM Writing Assistant Rich Text Format Windows WriteInterleaf RSG (to ASCII file) WiziWordLATEX Signature WordstarLatex SLITEX Wordstar 2000Leading Edge SmartWhere WriteNowLotus Manuscript SmartWnte II XeroxLotus Write

Software packages that we are unable to translate:

FrameMaker Ready, Set, GoPageMaker Scientific Writer

Disks produced on IBM or IBM-compatible computers are preferred, but those produced on some Apple orWang computers can also be converted. Because of the file structures and internal coding, we cannot acceptdisks created on desktop publishing systems or those created on proprietary typesetting systems. We alsocannot guarantee that all special characters can be translated. Tabular and mathematical material, such asequations, will not be captured from the disk but will be rekeyed.

To expedite work and for your own security, we do require that you submit a hard copy printout of the diskfile. The tables and equations will be keyed from this hard copy. We also need to know the name of the fileto be converted, the type of hardware (e.g., IBM PC) on which the files were created, the operating system(e.g., DOS 3.3), and the version of the software (e.g., WordPerfect 5.1) used to create the file.

PLEASE FILL OUT ALL INFORMATiON ON REVERSE SIDE AND SUBMIT THIS FORM WITH YOUR DISK.DISKS WILL NOT BE PROCESSED WITHOUT THIS INFORMATION.

DISK SUBMISSION FORM

AACR journals are now using personal computers to copyedit manuscnpts accepted for publication. Whensubmitting a revised manuscript, authors are encouraged to submit an electronic disk of the paper along withthe required four hard copy printouts. Disks will ultimately be returned to the authors.

I See reverse for the word processing packages that can be accepted.

File preparation

Please be sure that the file you send is the most recent version of the manuscript and that it matches the mostrecently submitted printed copy. The file should contain all the parts of the manuscript in one file. Mathe-matical and tabular material, however, will be processed in the traditional manner and may be excluded fromthe disk file.

Note: AACR does not assume responsibility for errors in conversion of customized software, newly releasedsoftware, or special characters.

Please label the outside of the disk with the journal name, the first author’s name, a partial title of themanuscript, and the name of the computer file used to access the manuscript on disk. To process your diskefficiently, we need the following information. Please be sure to provide ALL the information.

Name used to access paper on disk: ____________________

Name of computer used (e.g., IBM/PS2):

Operating system and version (e.g., DOS 3.3):

Word processing program and version (e.g., WordPerfect 5.0):

[See reverse for acceptable programs.]

Manuscript number: ________________________________

First author� _____________________________________Corresponding author (if different from first author):Telephone/FAX numbers: ___________________________

This form (both sides) may be reproduced.

P

BY PHONE: When paying your deposit by credit card, youmay phone your request to the AACR Housing Bureau.

Written, detailed confirmations will be sent at the completion

of your call.

Call the AACR Housing Bureau, Monday through Friday, from

8:00 am. to 5:00 p.m. Central Time. The hotels will not

accept reservations directly.

General Information:

Please read this page before making your reservation.

Deposits:. A $150.00 deposit is required in order to reserve a

room. The deposit may be made in the form of credit card or

check. Your credit card will be charged immediately.Acceptable credit cards are: VISA, MasterCard, American

Express, Diners Club, and Discover. Make checks payable to

AACR Housing Bureau, 108 Wilmot Road, Deerfield, IL

60015.

Confirmations:

. Your hotel confirmation will be sent from the Housing

Bureau. This is the only confirmation which you will receive.

You will not receive a confirmation from the hotel. Each hotel

will honor the Housing Bureau confirmation.

Room Tax/Rates:

. Rates do not include an 1 1% state and local tax as well as

a $1 to $3 per night occupancy tax. Some hotels may charge

additional fees for rooms with more than two occupants.

Instructions:

To arrange hotel accommodations for the AACR Annual

Meeting, utilize one of the following options:

BY MAIL: Simply complete the Hotel Reservation Form

and return it to the AACR Housing Bureau with a $ 150 per

room deposit by check or credit card. All arrangements will

be confirmed in writing for your approval. Return the form

with a check or credit card number to:

Tell the operator you are calling for AACR Annual Meetinghotel reservations. Please have the following information

name as it

BY FAX: For convenience, when payment is by credit card,

you may complete the Hotel Reservation Form and FAX it to

the AACR Housing Bureau. The AACR Housing Bureau will

confirm all arrangements, in writing, for your approval.

1-800-521-6017 Toll free - United States and Canada1-847-940-1364 International

Refund of Deposit:. Cancellations made prior to February 23, 1998, will receive

a full refund. Cancellations made after February 23, 1998,will be assessed a $14.00 processing fee. Your deposit will be

forfeited entirely if you do not cancel prior to 72 hours before

your arrival date.

Changes/Cancellations:

. Changes to reservations can be made in writing or by

calling the AACR Housing Bureau at (800) 424-5250 or (847)

940-2153 until February 25, 1998. After that date, please

contact your assigned hotel directly.

HOTEL RESERVATIONS I89TH ANNUAL MEETINGMarch 28-April 1, 1998

f �j � � American Association for

New Orleans, Louisiana I4kCEK W�

Cancer Research

or�RESERVE EARLY! DEADLINE - FEBRUARY 23, 1998

S Registrants in the United States and Canada

Telephone Number 1-800-424-5250

S International Registrants

Telephone Number 1-847-940-2153

ready:

1 . Hotel preference ( 1st, 2nd, and 3rd choices)

2. Arrival and departure dates and times

(indicate if arrival will be after 6:00 p.m.)

3. Number of rooms required

4. Accommodations desired:

Single

Double ( 1 bed, 2 people)

Twin (2 beds, 2 people)

5. Number of people in party

6. Credit card name, account number,

appears on card, and expiration date

7. Names of all occupants of room(s)

8. Mailing Address

9. Daytime telephone number with area code

10. FAX number with area code

1 1 . Special requests (disability,

smoking I nonsmoking, king-size bed, etc.)

AACR Housing Bureau

108 Wilmot Road

Deerfield, IL 60015

HOTELS IN NEW ORLEANS, LOUISIANARESERVING ROOMS FOR AACR REGISTRANTS

MapNumber Hotel Name Single Double

1 New Orleans Hilton Riverside Standard $143 $163

(Headquarters Hotel) Executive $158 $178

Towers $179 $199

2 Ambassador Hotel $145 $145

3 Bienville House $135 $155

4 Bourbon Orleans Hotel $149 $149

Townhouse Suite $189

5 Chateau Sonesta Hotel $145 $165

6 Crowne Plaza $147 $162

7 Doubletree Hotel New Orleans $149 $159

8 Embassy Suites Hotel New Orleans $155 $170

9 Hampton Inn $125 $135

10 Holiday Inn Chateau LeMoyne $145 $155

11 Holiday Inn French Quarter $140 $150

12 Holiday Inn Select Standard $ 149 $169Deluxe $169 $189

13 Hotel Inter-Continental $145 $160

14 Hotel Monteleone $143 $168

15 New Orleans Marriott $164 $184

16 Omni Royal Orleans $170 $170

17 Radisson Hotel New Orleans $132 $132

18 Sheraton New Orleans $162 $185

19 Windsor Court Hotel $205 $205

Junior Suite $250 $250

FullSuite $275 $275

20 Wyndham Riverfront Hotel $ 1 65 $185

ALL RATES ARE SUBJECT TO AN 11% STATE AND LOCAL TAX AS WELL AS A $1 TO $3 PER

NIGHT OCCUPANCY TAX.

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THIRD CHOICE:_

FOURTH CHOICE:

NONSMOKING ROOM

HOTEL RESERVATION FORM I89TH ANNUAL MEETING

March 28-April 1, 1998

New Orleans, Louisiana

American

‘�-

\4�)

Association for Cancer Research

DEADLINE FOR RESERVATIONS:

FEBRUARY 23, 1998MAIL to: AACR Housing Bureau

108 Wilmot Road

Deerfield, IL 60015(DO NOT MAIL IF PREVIOUSLY FAXED OR TELEPHONED)

OR

FAX to: 800-521-6017 ToIl free inside United States and Canada

847-940-1364 International

OR

CALL: 800-424-5250 Toll free inside United States and Canada (between the hours of 8:00 a.m. and 5:00 p.m. Central time Mon. through Fri.)

847-940-2153 International

NAME OF PERSON REQUESTING ROOM

I � NUMBER

0 Please FAX Confirmation

HOTEL PREFERENCE:

FIRST CHOICE: _________

SECOND CHOICE: _______

OCCUPANTS’ NAME(S):

ROOM TYPE:

LI SINGLE OCCUPANCY/ONE PERSON

1111 DOUBLE OCCUPANCYTI’WO PERSONS (KING BED)

LII TWIN OCCtJPANCY/TWO PERSONS (TWO BEDS)

LI SPECIAL NEEDS ______________________

Please Specify

ARRIVAL DAY/DATE

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(Note: Your credit card will be charged immediately.)

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VISA; _ MASTERCARD; AMERICAN EXPRESS; DISCOVER; DINER’S CLUB

CARDHOLDER NAME CREDIT CARD NUMBER

CARDHOLDER SIGNATURE EXPIRATION DATE

LI $150 DEPOSIT BY CHECK PAYABLE TO AACR HOUSING BUREAU (US. FUNDS DRAWN ON U.S. BANK)

HOTEL DESCRIPTIONS

(Descriptions Provided by Individual Hotels)

1. NEW ORLEANS HILTON RIVERSIDE (Headquarters)Located at the foot of the busy Poydras Street corridor, right on the

river, the New Orleans Hilton Riverside is a step from the fabledFrench Quarter and only two blocks from the Central BusinessDistrict. The Hilton is an easy two block walk to the Ernest N.

Morial Convention Center and just one block from the Aquarium ofthe Americas. All rooms have direct dial phones and video messages,as well as numerous other amenities. The Hilton boasts ninerestaurants, plenty of nearby parking, two outdoor swimming pools,and the Rivercenter racquet and health club. Just steps away is theRiverwalk Festival Marketplace where you will find plenty of

shopping and dining.Poydras at the MississippiRiver #{149}� (504) 561-0500Rates: Standard Executive Towers

$143 $158 $179 Single

$163 $178 $199 Double

2. AMBASSADOR HOTEL

Ambassador Hotel New Orleans offers meticulously appointed guestrooms featuring the uniqueness, character, charm, and history of OldNew Orleans, with all oftoday’s modem conveniences. Many guestrooms offer a view ofthe Historic Riverfront District and downtownNew Orleans. Within walking distance to the Ernest N. Morial

Convention Center, French Quarter, Central Business District,

Riverwalk Marketplace, and Canal Place shopping, you will enjoymodem luxury with old world charm. Rooms have in-room safes,cable television, wrought iron beds, executive writing desk, hardwoodfloors, high ceilings, 24-hour parking, data compatible phones,business center, as well as restaurant and bar facilities.535 Tchoupitoulas Street #{149}� (504) 527-5271

Rates: Single/Double $145

3. BIENVILLE HOUSE

Closest French Quarter Hotel to the Convention Center. IntimateEuropean style hotel located in the French Quarter Riverfront, only

steps away from House of Blues, Jackson Square, Bourbon Street,Riverfront Streetcar, AquariumandlMAXTheater, SaksFifth Avenue

and many more attractions. Complimentary continental breakfastdaily.320 Decatur Street #{149}� (504) 529-2345

Rates: Single $135Double $155

4. BOURBON ORLEANS HOTELThe Bourbon Orleans Hotel, ideally located in the very heart of theFrench Quarter, features 216 custom-designed luxurious guest rooms,

including 50 distinctive townhouse suites. The decor combines themost modem conveniences with 17th-century French Country Houseromantic atmosphere. All guest rooms feature mini-bars, hair dryers,

coffee makers, and telephone equipped with voice mail and dataportcapabilities. Outdoor pool in French style courtyard and just stepsfrom Jackson Square.Bourbon and Orleans #{149}� (504) 523-2322

Rates: Single/Double $149Townhouse Suite $189

5. CHATEAU SONESTA HOTELThe Chateau Sonesta Hotel is located at the site of the former D.H.Holmes Canal Street Department Store which was constructed in 1849

and occupied until its closing in 1989. Situated on Iberville Street in

the French Quarter and with direct access to Canal Street, the hotel is

steps away from the Central Business District and one block awayfrom the Royal Sonesta Hotel. Many rooms with balconiesoverlooking Bourbon Street, Dauphine Street, and interior pool andcourtyard areas. Outdoor pool and exercise room on property. La

Chatelaine Restaurant and The Clock Bar open daily. Room serviceavailable.800 Iberville Street . � (504) 586-0800

Rates: Single $145Double $165

6. CROWNE PLAZAThe Crowne Plaza New Orleans features 439 beautifully furnishedguest rooms and suites, and Creole flavored restaurants and lounges -all within the sights, the sounds, and tastes that make the city sodistinctive in the fabric of America. Ideally located alongside theFrench Quarter, within a short walk are the Ernest N. MorialConvention Center, Mississippi Riverwalk, Canal Place, theSuperdome and a host of places to see and things to do.333 Poydras Street #{149}� (504) 525-9444

Rates: Single $147Double $162

7. DOUBLETREE HOTEL NEW ORLEANSLocated on Canal Street overlooking the Mississippi River and thecity’s major business and entertainment districts. Across the street

from the world famous French Quarter and within walking distanceto hundreds of shops and restaurants. The Ernest N. Morial

Convention Center is within walking distance. All rooms provide aspacious, comfortable setting to spread out and work or just relax.Each room is equipped with color TV, in-room movies, phones withdataports, coffee makers, iron and ironing boards. The ChicoryRotisserie and Grill adds a new turn to fine dining while the ChicoryLounge provides an intimate meeting place for New Orleans stylerefreshments. The Sweet Dreams Caf#{233}is a great alternative for thoseon the run. All guests receive complimentary chocolate chip cookiesupon check-in.300 Canal Street #{149}� (504) 581-1300Rates: Single $149

Double $159

8. EMBASSY SUITES HOTEL NEW ORLEANS

Embassy Suites has a distinctive flair for making conventioneers feelwelcome in more than 90 cities in over 34 states, but especially in oneof America’s favorite cities...New Orleans! Located in the heart ofthe Arts and Warehouse District, only two short blocks away from theErnest N. Morial Convention Center and a short distance from theFrench Quarter, the Embassy Suites blends the old with the new. Inaddition to having all suite accommodations, Embassy Suites offerscomplimentary cooked-to-order breakfast and a two-hour Manager’sreception daily to all guests. It’s the Embassy Way.315 Julia Street #{149}� (504) 525-1993

Rates: Single $155Double $170

9. HAMPTON INNJust steps from world-famous Bourbon Street and the French Quarteryou will find the outstanding quality and service you have come to

expect from Hampton Inn. Located within an historic, turn-of-the-

century building, the Hampton Inn - Downtown/French Quarter Areafeatures I 86 newly constructed, oversized guest rooms. Included atno extra charge is a daily continental breakfast buffet, all local phonecalls, incoming faxes, and use of the state-of-the-art fitness facility.Secured valet parking, laundry services, and a variety oftours leavingfrom the hotel daily are also available at an additional charge.226 Carondelet #{149}� (504) 529-9990Rates: Single $125

Double $135

$162$185

SingleDouble

$143

$168

10. HOLIDAY INN CHATEAU LeMOYNEUnique 150-year-old townhouses and suites. Four lush tropical

courtyards, iron lacework balconies and heated pool with sun deck.Located in the Historic French Quarter within strolling distance oflegendary Bourbon Street andjust minutes from New Orleans’ world

famous shopping, restaurants, and nightspots.301 Rue Dauphine #{149}� (504) 581-1303

Rates: Single $145

Double $155

11. HOLIDAY INN FRENCH QUARTERWith guest rooms overlooking the Mississippi River, the Holiday Inn

French Quarter is situated in the center ofthe historic French Quarter.Just strolling distance from legendary Bourbon Street and minutesaway from any of New Orleans’ world famous restaurants. Indoorheated poo1 with exercise facility.124 Royal Street #{149}� (504) 529-7211

Rates: Single $140

Double $150

12. HOLIDAY INN SELECTThis deluxe property recently opened directly across the street fromthe Ernest N. Morial Convention Center. The hotel features Ray T’sLounge, Atrium Restaurant with room service, fitness center, valetparking, laundry, and business services. The plush, spacious roomsare richly appointed with a large executive desk, coffee makers, hairdryer, iron and ironing board, and three phones (desk, bed, bathroom)with data ports.881 ConventIon Center Boulevard#{149} � (504) 524-1881Rates: Standard Executive

$149 $169 Single$169 $189 Double

13. HOTEL INTER-CONTINENTALIn the heart ofthe financial district, only three blocks from the French

Quarter, Aquarium, and other major areas of shopping and

entertainment. Each elegantly appointed room features a mini-bar andrefrigerator, television, hair dryer, and 24-hour room service.Parking, fitness center and pool are available.444 St. Charles Avenue #{149}� (504) 525-5566

Rates: Single $145

Double $160

14. HOTEL MONTELEONEOwned and operated by the Monteleone family since 1886, thisproperty located in the heart ofthe French Quarter, hasjust completeda $20 million dollar renovation returning to its position as one of thepremier hotels in New Orleans. Three restaurants, two cocktaillounges, full service business center, data posts in every guest room,iron and ironing board in every room, complimentary coffee eachmorning, heated pool and rooftop fitness center are available. TheMonteleone is the closest French Quarter hotel to the ConventionCenter. New Orleans begins in the lobby of the Monteleone.

214 Royal Street #{149}� (504) 523-3341

Rates:

15. NEW ORLEANS MARRIOTT

Our back door leads to the famous French Quarter. Out the frontdoor, you may catch a streetcar ride or walk to many nearbyattractions, Aquarium of the Americas, Riverboat Cruises, or theRiverwalk Shopping Mall.555 Canal Street . � (504) 581-1000

Rates: Single $164Double $184

16. OMNI ROYAL ORLEANS

Located in the heart of the French Quarter on the corner of St. Louisand Royal Streets is the Omni Royal Orleans, an AAA 4-Diamondhotel. The Royal Orleans features four restaurants, beauty salon,barber and florist shops, covered valet parking, fitness center, rooftoppool, full bath amenities, direct dial telephone with voice mail, faxand computer hookup as well as specialty rooms with balconies orjacuzzis.Royal and St. Louis Streets #{149}� (504) 529-5333

Rates: Single/Double $170

17. RADISSON HOTEL NEW ORLEANS

The Radisson Hotel New Orleans is conveniently located downtownin the Central Business District and has recently completed a $10million renovation to all guest rooms, meeting facilities, and publicareas. This New Orleans landmark is listed on the National Registerof Historic Places and features a tour desk and gift shop at the lobbylevel, voice mail message service and computer dataport in all guestrooms, scenic rooftop pool, hot tub deck, fitness center, valet parking,guest business center, and free shuttle to the French Quarter. Diningis available at Praline’s Restaurant, LaSalle’s Food and Spirits, andPizza Hut.1500 Canal Street #{149}� (504) 522-4500Rates: SinglefDouble $132

18. SHERATON NEW ORLEANS

The beautifully renovated Sheraton New Orleans Hotel featuresexquisitemahogany furniture, nchjewel-tone colored fabncsand wallcoverings, fine marble, and wrought iron detailing reminiscent of anhistoric New Orleans home. The hotel also features a fine dining

restaurant, quality coffee shop, high-end gift shop, convenientbusiness center, full-service fitness center with pool (complete withprofessional trainers), therapists, spa amenities, valet, and an award-winning concierge service. The Hotel is conveniently located in the

heart of the Central Business District, bordering the historic FrenchQuarter, and just blocks from the Mississippi River.500 Canal Street #{149}� (504) 525-2500Rates: Single

Double

19. WINDSOR COURT HOTELThe Windsor Court Hotel is recognized as one ofthe world’s premierhotels. Abundant suites, a multi-million dollar art collection, andlegendary cuisine complement the hotel’s incomparable convenienceto the Ernest N. Morial Convention Center, the French Quarter, andthe MississippiRiverfront. Selected by both the Zagat Survey and thereaders of Cond#{233}Nast Traveler Magazine as one of the “Top Three”domestic hotels and the only AAA “Five Diamond” rating in the DeepSouth.300 Gravier Street #{149}� (504) 523-6000

Rates: Single/Double $205Junior Suite $250Full Suite $275

20. WYNDHAM RIVERFRONT HOTEL

New Orleans’ newest luxury hotel, the Wyndham Riverfront, islocated just across the street from the Ernest N. Monal ConventionCenter and only steps away from the French Quarter. The deluxeguest rooms feature the finest attention to detail and amenitiesincluding in-room coffee makers with complimentary coffee, hair

dryer, and iron and ironing board. The hotel also offers computermodem telephones, valet parking and complimentary usage of thefully equipped exercise room. E’s Caf#{233}and lounge offers traditionalcontinental cuisine and Creole specialties.

701 ConventIon Center Boulevard #{149}� (504) 524-8200

Rates: Single $165Double $185

ADVANCE REGISTRATION FORM

AMERICAN ASSOCIATION FOR CANCER RESEARCH89TH ANNUAL MEETING - NEW ORLEANS, LOUISIANA - March 28-April 1, 1998

Return to

American Association for Cancer Research #{149}Public Ledger Building, Suite 826150 S. Independence Mall West #{149}Philadelphia, PA 19106-3483 #{149}FAX: 215-440-7228

DEADLINES: #{149}February 2, 1998 for reduced rates and to ensure receipt of meeting materials by mail in March

. February 23, 1998 for all registration by mail (Registration forms received after this date will not be accepted.

Registration will be conducted at the Morial Convention Center in New Orleans from March 28-April 1, 1998.)

. March 20, 1998 to cancel registration and receive refund less cancellation fee of $35

(Please print)

NAME: __________________________________ ____________________________ _______________Last First/Middle Initial AACR Member Number

TITLE: _________________________ ADDRESS: _____________________________________________Instituti#{248}n

Street, Building. or Post Office Box

City State or Province Zip/Postal Code Country (if not U.S.)

TELEPHONE NO.: _________________ FAX NO.: _________________ E-Mail: _______________________

0 Check this box if you have a physical disability and have special requirements for transportation, hotel accommodations, or other facilities in connection

with the meeting. A member of the Association Staff will contact you.

WHAT IS YOUR PRIMARY FIELD OF RESEARCH? (Please check only one):

0 1Biochemistry/Biophysics 0 �Carcinogenesis 0 3Cellular Biology and Genetics 0 ��ini� Investigations

0 �Endocrinology/Signal Transduction 0 6Epidemiology 0 ‘Experimental Therapeutics o 8Ii���unology o 9Molecular Biology and Genetics

0 ‘#{176}Prevention � “Radiobiology/Radiation Oncology 0 12Vimlogy 0 t3Other (please specify): ____________________________________

ARE YOU THE PRESENTER OF AN ABSTRACT SUBMITI’ED FOR THE 1998 AACR MEETING? 0 Yes 0 No

ON WHICH DAYS WILL YOU ATI’END THE 1998 AACR ANNUAL MEETING (Check all that apply)?

0 � March 28 � Sunday, March 29 o Monday, March 30 o Tuesday, March 3 1 0 Wednesday, April 1

0 Check this box if you are a high school or undergraduate student. This information will be used for the organization of a special educational event duringthe annual meeting for students interested in pursuing careen in science. The program, to be organized by the AACR Science Education Committee, willinclude presentations as well as a panel discussion by cancer experts. Further information will be sent to you under separate cover.

PAYMENT OF REGISTRATION

Fees may be paid by check or with a VISA, MasteiCard, or American Express credit card. All payments must be made in U.S. currency, and all checks must bedrawn on a U.S. bank. Payment must accompany this form; purchase orders will not be accepted as payment.

On or Before AfterFebruary 2 February 2 METHOD OF PAYMENT

$160 $200 0 Check payable to AACR, Inc. in U.S. currency, drawn on a

$310 $370 U.S. bank

$55 $55

0 Active/Corresponding Member Rate

0 Nonmember Rate

(includes copy of AACR Proceedings)

0 Emeritus Member Rate

0 Associate Member/Predoctoral

Student Rate $ 85 $ 95

0 Honorary Member Rate $ 0 $ 00 AACR Proceedings” $ 35 Members $ 35 Members

$ 45 Nonmembers $ 45 Nonmembers

0 Optional Overseas Surcharge’ $ 25 NA.

TOTAL ENCLOSED OR CHARGED $________ $_______

Person/Institutio n Issuing Check Check No.

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Expiration DateCard Number

Signature

‘An application for Associate Membership may accompany this form, but these should be submiued by February 16. 1998, as review of the Associate Membership application may delayregistration. Students must enclose a statement, signed by the registrar, dean, or department head of their university or college on official letterhead, confirming their status. Postdoctoralfellows or physicians in training do not qualify for the student registration rate. Persons wishing to register at the associate member rate in New Orleans must submit applicationsno later than March 6, 1998, to ensure time for review of their applications.bActive, corresponding, and associate members of the AACR who have paid dues for 1998 and registrants who pay the nonmember fee receive the Proceeding.s automatically. If these

members or nonmembers check this box and pay the fee, they will receive an additional copy of the Proceedings.

Optional payment for registrants outside of the U.S. and Canada only. Registrants paying this surcharge will receive meeting publications via airmail before the annual meeting. This servicewill not be available after February 2, 1998.

AACR members in good standing, i.e., dues paid for 1998, will receive copies of the Program and Proceedings prior to the meeting. Nonmember and student registrants who meet theFebruary 2 deadline will also receive the Program and (if they have purchased it) the Proceedings prior to the meeting. Nonmembers and students who do not meet the deadline mustpick up publications at the meeting site.

REFUND POLICYRefunds on registration fees will be granted on written request received in the AACR Office by March 20, 1998. Requests received after this date will not be honored. Receipts and badges(if they have been mailed) must be returned to the AACR Office with the refund request. A cancellation fee of $35 will be deducted from all refunds to cover administrative costs.

LATE-BREAKING RESEARCH SESSION� 4� � AT THE AACR ANNUAL MEETING

� Tuesday, March 31, 1998“I,

Time has been set aside for the presentation ofa few definitive reports ofhighly significant

and timely findings in the field. Criteria for the selection ofthese presentations and

instructions for submission ofabstracts are as follows:

INSTRUCTIONS FOR SUBMISSION OF LATE-BREAKING ABSTRACTS

1. The work to be presented must be ofmajor novelty and significance, e.g. , the

characterization of a new gene in familial cancer or the discovery of a new diagnosticmarker, and should not have been previously published in a peer-reviewed scientific journalor presented at a national meeting.

2. The abstract must be sponsored by an AACR member in good standing (dues paid for

1998).

3. Each member in good standing may sponsor only one abstract for this session whether

or not he or she sponsored an abstract last October for the regular annual meeting program.If an associate member is the sponsor, the abstract must also be endorsed by an active or

corresponding member in good standing. In this case, the endorser does not forfeit the

opportunity to sponsor a late-breaking abstract.

4. Abstracts must be typed on one side ofone sheet ofwhite paper.

5. All text on the page must fit within an area 6 1/2” wide and 9” high (16.5 cm X 22.9 cm)with margins of at least 1” (2.5 cm) on the top, bottom, and sides of the page.

6. Each abstract must be accompanied by a covering letter from the sponsor explaining

why the work is novel and significant enough to be considered for this late-breaking

research session and certifying that the findings became available after the annual

meeting abstract deadline of October 28, 1997. This letter must contain the sponsor’s

complete mailing address, FAX number, and E-mail address (if available) so that we can

communicate the scheduling decision of the Program Committee.

7. Abstracts and covering letters must be received in the AACR Office by 5:00 p.m. Eastern

Time on February 27, 1998. FAX transmissions are not acceptable. Carrying envelopes

should be clearly marked “Late-Breaking Abstract,” and should be addressed to AmericanAssociation for Cancer Research, Public Ledger Building, SUite 826, 150 SouthIndependence Mall West, Philadelphia, PA 19106-3483. Ifyou wish to receiveacknowledgment of receipt of your abstract, enclose a self-addressed post card withappropriate postage affixed. Accepted abstracts will not be published since they will be

received after the Proceedings ofthe American Association for Cancer Research has been

printed; however, they will be distributed at the session in New Orleans.

8. A special subcommittee of the Program Committee appointed by President Donald S.

Coffey will select the papers to be presented. Presenters of accepted papers will be notifiedvia FAX no later than March 16, 1998.

oftI:i� ofCancer Published by the

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AMERICAN ASSOCIATION FOR CANCER RESEARCH89th Annual Meeting

Frank J. Rauscher, ifi, Program Committee Chairperson

Morial Convention Center, New Orleans, Louisiana

March 28-April 1, 1998

Titles of Major Sessions

(Names of confirmed session organizers are in parentheses)

SPECIAL LECTURES

Presidential Address: Donald S. CoffeyClowes Award: Arnold J. LevineBurchenal Award: Bernard FisherRosenthal Award: Lee NadlerCain Award: Bruce A. ChabnerRhoads Award: Michael DeanAACR-ACS AwardGoodman Lecture

PLENARY SESSIONNew Horizons in Cancer Research (Frank J.

Rauscher, III)

SYMPOSIAMolecular Determinants of Cellular and

Tumor Responses to Radiation (MichaelB. Kastan)

The Promise of Oncogene-based DrugTargeting (Alex Matter)

Cancer Gene Therapy: New Concepts and

Clinical Applications (Jack A. Roth)Reconstruction of Human Tumorigenesis

and Progression: Cancer Genetics InModel Organisms (Anthony Wynshaw-Boris)

Tumor Angiogenesis and Microcirculation:An Integrated Approach (Rakesh K. Jam)

Signaling by wnt-l, �3-catenin, and the APCTumor Suppressor in Cancer (PaulPolakis)

Prostate Cancer: Basic Science and ClinicalAspects (Leland W.K. Chung)

The Molecular Basis of ImmuneRecognition: Basic Concepts withTherapeutic Implications (GiorgioTrinchieri)

The bcl-2 Family: Death Agonists and

Antagonists (Stanley J. Korsmeyer)Telomerase and Telomeres in Normal and

Neoplastic Cells (Ronald A. DePinho)Inherited Cancer Susceptibility Syndromes:

Genetics, Genes, and Function (DanielA. Haber)

New Concepts in Chemotherapeutics andDrug Resistance (Susan Band Horwitz)

Cell Death Signaling Pathways: Caspase

Cascades and Effectors/Initiators ofApoptosis (Douglas R. Green)

p73/p53: An Emerging Gene Family(William G. Kaelin)

Breast Cancer: Basic Science and Clinical

Aspects (Sofia D. Merajver)Molecular Targets and Endpoints for

Chemoprevention (Waun Ki Hong)Cancer Biology in Context: Stromal-

Epithelial, Cell-Cell, and Cell-ECMInteractions in Normal Development andCancer (Mina J. Bissell)

Gastrointestinal Cancer: Basic Science andClinical Aspects (Kenneth W. Kinzler)

Tumor Virology: Molecular Biology andEtiology (Karl MOnger)

Advances in Cancer Vaccine Development(Dorothee Herlyn)

Molecular Diversity-based Approaches toAnti-Cancer Drug Design (Jack D.Keene)

New Mechanisms of Action of Viral andCellular Oncogenes (Elizabeth Moran)

Genetic Approaches to Diagnosis: TheImpact of Molecular Medicine on EarlyDetection and Diagnosis (DavidSidransky)

Tobacco and Lung Carcinogenesis:Genetics, Biology, and Epidemiology(Adi F. Gazdar)

Transcriptional Regulation of the NeoplasticPhenotype (Frank J. Rauscher, III)

Restoring Drug Sensitivity to Tumors: NewConcepts from Tumor Biology andPhysiology (William N. Hamt)

Emerging Issues for Individual CancerSusceptibility and Risk Assessment (FredF. Kadlubar)

Epigenetics and Cancer (Stephen B. Baylinand Peter A. Jones)

CONTROVERSY SESSIONSHave We Improved the Treatment of

Cancer?Environmental Estrogens and Cancer

(Nancy E. Davidson)Will Multidrug Resistance Modulators Be

Effective in the Clinic?

METHODS WORKSHOPS ANDEDUCATIONAL SESSIONS

To Be Announced

“MEET-THE-EXPERT’SUNRISE SESSIONS

Cancer Genome Anatomy Project (CGAP):Update and Potential (Paul S. Meltzer)

JAKs, STATs, and src Kinases: ObligatePartners in Cytokine Signaling(E. Premkumar Reddy)

Histone Acetylation and TranscriptionalRegulation (Tony Kouzarides)

Molecular Genetics of Brain Tumors(Sandra H. Bigner)

Genetic Analysis of Tumor Suppression byCOX-2 Inhibitors (Makoto M. Taketo)

Sequence-specific Gene Regulation:Application of Ribozymes in PreclinicalModels of Cancer (Thale Jarvis)

Gene Transfer to Hematopoietic Progenitors(Fulvio Mavilio)

Genetic Testing for Breast CancerSusceptibility: Psychosocial and ClinicalResearch Update (Caryn E. Lerman)

Nuclear Hormone Receptors in

Development and Disease (VincentGigu#{232}re)

B-Cell Lymphomas: Genetics and Biology(Riccardo Dalla-Favera)

Hormonal Regulation of Cell Proliferationand Differentiation (Lorraine J. Gudas)

Alterations of Cell Cycle Controls in Cancer(Giulio Draetta)

Proteases in Cancer: Clinical Significanceand Mechanisms in Metastasis (HenriRochefort)

Inherited Cancers of the Kidney: FamilyStudies, Genes, and Biochemistry (W.Marston Linehan)

Strategies for Combining Chemotherapy andBiotherapy (Antonio C. Buzaid)

Antimetabolites: New Insights into CellDeath/Signal Transduction Pathways as

. Determinants of Drug Sensitivity (StevenGrant)

Interleukin-l2: Biological and ClinicalDevelopments (Giorgio Trinchieri)

Chemoprevention Trials: Progress andPromise (Scott M. Lippman)

Growth Factor Signaling: The IGF-l, IGF-2 System in Cancer (Haim Werner)

Pathogenesis of Acute PromyelocyticLeukemia (Pier Pellici)

Radiation Sensitization: Basic and ClinicalAspects (Rupert Schmidt-Ullrich)

Advances in Mechanisms of Drug

Resistance: Basic Science and ClinicalImplications (Susan E. Bates)

Harnessing the Immune System in TumorTherapy: Manipulation, Stimulatory andInhibitory Signals in T Cell Activation(James P. Allison)

Integrin Signaling and Cell Growth Control:Consensus and Controversies (RudolphL. Juliano)

Issues and Applications in MolecularEpidemiology (Barbara S. Hulka)

Familial Cancer Syndromes: Genetic Testsand Clinical Approaches (KenYamaguchi)

Relevance of DNA Damage and Repair forInitiation and Progression of Carcino-

gens: Recent Advances (Jan H. J.Hoeijmakers)

Chromosomal Translocations: Genetics,Biology, and Protein Function (James R.Downing)

Advances in the Mechanisms of Invasionand Metastasis (Isaiah J. Fidler)

From Slave to Master: The BiologicalEvents During Melanoma Development

and Progression (Meenhard Herlyn)Farnesyl Transferase Inhibitors (Ivan D.

Horak)

Topoisomerases: Structure and Function(James Wang)

Progress in Antibody Therapy of HumanCancer (Nancy Hynes)

Animal Models for Chemoprevention(Michael N. Gould)

Further Information: AACR Office . PublicLedger Building . Suite 826 . 150 5.Independence Mall West . Philadelphia, PA19106-3483 . TELEPHONE: (215) 440-9300 . FAX: (215) 440-9313Email: meetings@aacr.org . For uD-to-dateinformation visit the AACR Website athttp://www.aacr.org