1590

INDEX

Volume 279, October-December, 1996

A2774 cells, effects ofendogenous TNF so-creted by, 84

Abai, A. M., see Beb#{246}k,Z., 1462Abdel-Rahman, A. A., see Mao, L., 443Abe, Y., Sekioka, K., Ishisu, R., Onishi, K.,

Ueda, Y. and Nakano, T.: Resto-ration ofischemic contractile fail-ure of indo-1-loaded guinea pigheart by a calcium sensitizer,MCI-154, 47

Abecarnil, tolerance and dependence lia-bility, in mice seizure models, 561

Abiko, Y., see Hara, A., 32Abrahams, T. P., Liu, W. and Varner, K.

J.: Blockade of alpha-2 adrener-gic receptors in the rostral ventro-lateral medulla attenuates the

sympathoinhibitory response tococaine, 967

Aceclidine, enantiomers, muscarimc re-

captor interactions, 1335Acetaminophen, toxicity

cholesteryl hemisuccinate protectionagainst, 1470

in male Wistar rats, 548Acetylcholine

-mediated vasodilation, inhibition by li-popolysaccharide, 918

release at neuromuscular junction, tet-randrine effects on, in mouse, 891

release in brain, enhancement bySA4503, in rat, 106

release in tracheal smooth muscle, ET-1effects on, in rat, 1142

Acetylcholine receptors

muscarinic

aceclidine enantiomer interactions,1335

allosteric lead structures for, 926Hml, Hm3 and Hm5, functional prop-

erties, 593-operated potassium currents, inhibi-

tion by amiodarone, 617mcotinic

agonist RJR-2403, in vitro character-ization, 1413

agonist RJR-2403, in vivo character-ization, 1422

hippocampal, mapping, 1491melatonin modulation of, in rat vas

deferens, 18N-(4-Acetyl-1-piperazinyl)-p-fluorobenz-

amidemonohydrate, see FK960AChRS, see Acetylcholine receptorsAcquired immunodeficiency syndrome,

ribavirin/ddl combination in, inmurine model, 1009

Adams, J. L., see Badger, A. M., 1453Adenosine deaminase, RBC-derived, 1250Adenosine receptors

A1, 8-butylaminoadenosine partial ago-msm at, 1439

A3, broncho8pasm induced by, in BDErats, 1148

Adenylyl cyclase

-mediated cell signaling, aging and, 478membrane-based activation assay for

beta-3 agonist potency, 214Adrenal gland, Egr-1 mRNA expression

in, neural control of, 379Adrenal medulla, catecholamine secretion

and ion channel inhibition by pro-tamine in, in bovine cells, 838

Adrenergic receptorsalpha-2

angiotensin receptor interactions, inrat nucleus reticularis gigantocel-lularis, 795

in ethanol-clonidine interactions, inrats, 443

rostral ventrolateral medullary block-ade, and cocaine sympathoinhibi-

tion, 967beta-3, agonist potency, receptor density

and, 214Adrenocorticotropic hormone, m-CPP and

DOl-induced secretion, 782w-Agatoxin-1VA, effects on motor nerve

Ca�� currents, in mouse, 1229Aging, and glucocorticoids, 478Agmatine, platelet I� binding sites, 694Agrawal, A� K. and Shapiro, B. H.: Im-

printed overinduction of hepaticCYP2B1 and 2B2 in adult ratsneonatally exposed to phenobar-bital, 991

Aguayo, L G., Tapia, J. C. and Pancetti, F.C.: Potentiation of the glycine-activated Cl current by ethanolin cultured mouse spinal neu-rons, 1116

AIDS, see Acquired immunodeficiencysyndrome

Airway musclecholinergic nerve-mediated contrac-

tions, ET-1 effects on, in rat, 1142non-neurogemc relaxation in, in canine,

813Aizeninan, E., see Boeckman, F. A., 515Akaike, T., see Noda, J., 162Akerman, E. 0., see Kukkonen, J. P., 593Albuquerque, E. X., see Alkondon, M.,

1491Albuquerque, E. X., see Marchioro, M., 143Alcohol, see EthanolAlendronate, comparison with raloxifene,

in rats, 298Ales, M. D., Wang, T., Giebisch, G., Sand-

ers, M. J., Walsh, A. H. andLopez-Anaya, A.: Model develop-ment and analysis of tenidap-induced proteinuria in the rat,1318

Alifio, S. F., see Blaya, C., 472Alkondon, M., Pereira, E. F. R. and Albu-

querque, E. X.: Mapping the loca-

tion of functional mcotinic andy-aminobutyric acidA receptorson hippocampal neurons, 1491

06-Alkylguanine DNA alkyltransferase,inactivation by triazene corn-pounds, 416

Allergic responseconjunctival itching, mediation by ke-

torolac, 137MDL 105,212 effects in, in guinea pig

model, 732Allosteric lead structures, 926�

rnethyl-1-piperazinyl)-3-hydroxy-benzyl]-N,N-diethylbenzarnide,see (±)-BW373U86

Alpert, N. M., see Christian, B. T., 325Alpert, N. M., see Fischrnan, A. J., 939American Society for Pharmacology and

Experimental Therapeutics (AS-PET), Colloquium Report, 1

�y-Arninobutyric acid, -gated chloride chan-nels, [3H]EBOB binding and in-secticide action on, 1191

-y-Aminobutyric acid receptors, agonist re-nal effects, in rat, 602

�y-Axninobutyric acidA receptorsin benzodiazepine-tolerant rats, 1092hippocampal, mapping, 1491insecticides and, in cerebellar granule

neurons, 1191stanozolol effects on, 186

(2R)-2-Amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyllpropi-onamide D-tartrate, see Re 22-9194

Arninoguanidine, pharmacokinetics andeffects on diabetes, in nonobesediabetic mice, 790

2-(2’-Amino-3’-rnethoxyphenyl)-oxanaph-thalen-4-one, see PD098059

N�-2-(4-Aminophenyl)ethyladenosine,bronchospasm induced by, inBDE rats, 1148

4-Arninopyridine, Kv4.2 blockade by, 865Arniodarone, effects on mAChR-operated

potassium currents, in guinea pigatrial cells, 617

Amrnonia, toxicity, trimethylarnine pre-ventive effects against, 194

Arnore, B. M., see Bennett, G. D., 1237Anabolic steroids, stanozolol

effects on GABAA receptor function, 186liver rnicrosorne binding site, in male

rat, 1123Analgesia, see also Antinociception

N-cyclobutylrnethyl analog of normor-phinone, 539

peripheral morphine, 502

Anderson, D. J., see Nigarn, R., 1527Anderson, D. J., see Simon, W. C., 1535Androgemc/anabolic steroids, stanozolol

effects on GABAA receptor function, 186liver microsome binding site, in male

rat, 1123Anesthesia, erythropoietin pharmacoki-

netics after, in sheep, 1205

1996 Index 1591

Angiotensin II receptors, atpha-2 adreno-ceptor interactions, 795

Angiotensin III receptors, atpha-2 adreno-ceptor interactions, 795

Angiotensin II, effects on cAMP release,114

Angiotensin I converting enzyme, single-domain, 1582

Angiotensin-converting enzyme, inhibitoreffects on bradykinin vasodepres-sor and prostacyclin responses,

703Anions, inorganic, and basolateral organic

cation transport system, in rabbitkidney proximal tubules, 1086

Antiarrhythmics, Re 22-9194, effects on

ventricular fibrillation, in dogs,877

Antibody, see atso Monoclonal antibodyantihuman anti-IgE, in monkeys, 1000-conjugated plasminogen activators,

pulmonary vasculature targeting,1026

Anticonvulsantsbenzodiazepine

effects, in direct cortical stimulationmodel, 803

receptor ligands, tolerance and depen-dence liability, 561, 573

L-701,324, proffle, 492

AntidepressantsBMS-181101, cerebral pharmacokinet-

ics, 325chronic, and 5-HT7 receptor activity, in

rat frontocortical astrocytes, 1551Antinociception, see aLso Analgesia

angiotensin-atpha-2 receptor interac-

tions in, in rat nucleus reticularisgigantocellularis, 795

f3-endorphin, pertussis toxin and, inmouse, 39

inhalation opioid, in mice, 69morphine

gender-related differences in, 767pertussis toxin and, in mouse, 39

spinal SNX-111, in rat neuropathicpain, 1243

sumatriptan, in rodents and guineapigs, 884

z�9-THC and morphine, dynorphins and,in spinal cord, 608

Antioxidantseffects on fibronectin turnover, in mes-

angial cells, 1520liver enzymes, cocaine-induced peroxi-

dative stress effects on, in rat,359

Aorta, glutathione S-transferases, glyc-eryl trinitrate biotransformationby, in rat, 1527

APNEA, see N�-2-(4-Aminophenyl)ethy-ladenosine

Apoptosisacetaminophen-induced, cholesteryl

hemisuccinate protection against,1470

induction by CoA-independent transacy-lase inhibitors, in HL-60 cells,956

lead-induced, in newborn rat, 435Aquino, A., see Prete, S. P., 1574Aracava, Y., see Marchioro, M., 143Arachidonic acid, effects on superoxide

generation in HL-60 cells, 633Archer, S., see Xu, J. Y., 539

Arends, R. H. G. P., see Hoogerkamp, A.,803

Argenzio, R. A., Armstrong, M. andRhoads, J. M.: Role of the entericnervous system in piglet crypto-sporidiosis, 1109

Armstrong, M., see Argenzio, R. A., 1109

Aromatic compounds, nitroso, pyruvatedehydrogenase complex-cata-lyzed formation of N-arylacetohy-droxamic acid from, in rat, 1282

Arrhythmiasischemia- and reperfusion-induced, Re

22-9194 effects on, in dogs, 877

proarrhythmic effects of fiecainide, 317related to delayed repolarization, 231

Arrington, S., see Bencherif, M., 1413Arthritis, antiarthritic effects of SB

203580 on, in animal models,1453

N-Arylacetohydroxamic acid, formation of,in rat, 1282

Asano, M., see Nomura, Y., 830ASPET, see American Society for Pharma-

cology and Experimental Thera-peutics

Asthma, IL-S suppression by T-440 in PB-MCs, 240

Astrocytes, chronic antidepressants and5-HT7 receptor activity in, in ratfrontal cortex, 1551

Atchison, W. D., see Xu, Y.-F., 1229Atkinson, M. A., see Bowman, M. A., 790Atochina, E. N., see Muzykantov, V. R.,

1026Atrial cells, mAChR-operated potassium

currents, inhibition by amioda-rone, in guinea pig, 617

AU1akh, C. S., see Mazzola-Pornietto, P.,782

Avenet, P., see Itier, V., 10923’-Azido-3’-dideoxythymidine, antiviral

effects, in murine cells, 1268AZT, see 3’-Azido-3’-dideoxythymidine

Babich, J. W., see Christian, B. T., 325Babich, J. W., see Fischman, A. J., 939Baclofen, renal effects, in rat, 602Baculovirus expression system, musca-

rinic ACh receptor subtypes ex-pressed in Sf� cells with, 593

Badger, A. M., Bradbeer, J. N., Votta, B.,Lee, J. C., Adams, J. L. and Gris-wold, D. E.: Pharmacological pro-file of SB 203580, a selective in-hibitor of cytokine suppressivebinding protein/p38 kinase, in an-imal models of arthritis, bone re-sorption, endotoxin shock and im-mune function, 1453

Baker, D. A., Khroyan, T. V., O’Dell, L. E.,Fuchs, R. A. and Neisewander, J.L.: Differential effects of intra-accumbens sulpiride on cocaine-induced locomotion and condi-tioned place preference, 392

Bakshi, V., see Swerdlow, N. R., 1290

Barnathan, B. S., see Muzykantov, V. R.,

1026Baron, B. M., Siegel, B. W., Harrison, B.

L., Gross, R. S., Hawes, C. andTowers, P.: [3HJMDL 105,519, ahigh-affinity radioligand for theN-Methyl-D-aspartate-associatedglycine recognition site, 62

Barone, F. C., Nelson, A. H., Ohlstein, E.H., Willette, R. N., Sealey, J. B.,Laragh, J. H., Campbell, W. G.,Jr. and Feuerstein, G. Z.: Chroniccarvedilol and propranolol re-duces mortality and renal dam-age in hypertensive stroke-pronerats, 948

Barrel field cortical neurons, cocaine sub-strates in, in rat, 582

Bartolini, A., see Ghelardim, C., 884

Bates, D. J., see Fox, J. A., 1000BDF,6153, platelet I� binding sites, 694Beanum, V. C., see Traylor, L. A., 91Beauchamp, D., see Harvie, P., 1009

Bebok, Z., Ansi, A. M., Dong, J.-Y., King,S. A., Kirk, K. L., Berta, G.,Hughes, B. W., Kraft, A. S., Bur-gess, S. W., Shaw, W., Felgner, P.L. and Sorscher, E. J.: Efficiencyof plasmid delivery and expres-sion after lipid-mediated genetransfer to human cells in vitro,1462

Bekavac, I., see Waterhouse, B. D., 582Bell, R. A., see Morita, K., 379Bernis, K., see Sato, M., 298Bencherif, M., see Lippiello, P. M., 1422Bencherif, M., Lovette, M. B., Fowler, K.

W., Arrington, S., Reeves, L.,Caldwell, W. S. and Lippiello, P.M.: RJR-2403: A nicotinic agonistwith CNS selectivity I. In vitrocharacterization, 1413

Bennett, B. M., see Nigam, R., 1527Bennett, B. M., see Simon, W. C., 1535Bennett, G. D., Amore, B. M., Finnell, R.

H., Wlodarczyk, B., Kaihorn, T.

F., Skiles, G. L., Nelson, S. D. andSlattery, J. T.: Teratogenicity ofcarbamazepine-10,1 1-epoxideand oxcarbazepine in the SWV

mouse, 1237Benyas, S., see Picker, M. J., 1130Benzodiazepines

anticonvulsant effects, in direct corticalstimulation model, 803

receptor ligands, in mice seizure models,561, 573

tolerance, GABAA receptors in, in rats,1092

1-(1,3-Benzodioxol-5-yl)-2-(methylami-no)butane, neuroendocrine phar-

macology, 1261

Bergeron, M. G., see Harvie, P., 1009

Bergman, M. R. and Holycross, B. J.:Pharmacological modulation ofmyocardial tumor necrosis factora production by phosphodiester-ase inhibitors, 247

Berta, G., see Bebok, Z., 1462Bertha, C. M., see Schetz, J. A., 1069Bevan, J. A., see Xie, H., 668Bicuculline, renal effects, in rat, 602

Bidlack, J. M., see Xu, J. Y., 539Bigelow, G. E., see Walsh, S. L., 524Biliary function, TP-680 effects on, 1404Biotransformation, see also Metabolism

diltiazem, P450 inhibition during, in ratliver, 1447

glyceryl trimtrate, by rat aortic GSTs,1527

Bladder, urinary, tachykinin NK-2 recep-tore in, in dog, 423

Blaney, B., see Higashiura, K., 1386

1592 index Vol. 279

Blaya, C., Crespo, J., Crespo, A. and Alino,S. F.: Anti-interleukin 4 antibodyand indomethacin synergistic ef-fect on B16 melanoma tumor pro-

gression, 472Blink rate, dopamine agonist effects on, in

cynomolgus monkeys, 1211

Blood, see also Peripheral blooddynorphin A (1-17) biotransformation,

human and rhesus monkey, 507Blood pressure, bradykinin response, ACE

inhibitor effects on, 703Blood-brain barrier, peptide drug delivery,

CNS effects, in rats, 77Blower, P. R., see Gr#{233}lot, L., 255

BMS-181101, cerebral pharmacokinetics,325

Boada, L. D., Fern#{225}ndez, L., Zumbado, M.,Luzardo, 0. P., Chirino, R. andDfaz-Chico, B. N.: Identificationof a specific binding site for theanabolic steroid stanozolol inmale rat liver microsomes, 1123

Boeckman, F. A. and Aizenman;E.: Phar-macological properties of ac-quired excitotoxicity in Chinese

hamster ovary cells transfected

with N-methyl-D-aspartate recep-

tor subunits, 515Bomers, A. M., see Hoogerkamp, A., 803Bonab, A. A., see Fischman, A. J., 939Bone resorption, antiarthritic effects of SB

203580 on, in animal models,1453

Bonmassar, B., see Lacal, P. M., 416Bonmassar, E., see Prete, S. P., 1574Bosche, M. C., see Nandi, J., 97Bosron, W. F., see Kamendulis, L. M., 713Boulanger, C. M., see Desta, B., 1077Bowersox, S. S., Gadbois, T., Singh, T.,

Pettus, M., Wang, Y.-X. andLuther, R. R.: Selective N-typeneuronal voltage-sensitive cal-cium channel blocker, SNX-111,produces spinal antinociceptionin rat models of acute, persistentand neuropathic pain, 1243

Bowman, M. k, Simell, 0. G., Peck, A. B.,Cornelius, J., Luchetta, R., Look,z., Maclaren, N. K. and Atkinson,M. A.: Pharmacokinetics of ami-noguanidine administration andeffects on the diabetes frequency

in nonobese diabetic mice, 790

Boyd, M. R., see Currens, M. J., 645

Boyd, M. R., see Currens, M. J., 652Boyd, M. R., see Vistica, D. T., 1018Boyle, F. M., Wheeler, H. R. and Shenfield,

G. M.: Glutamate ameliorates ex-perimental vincristine neuropa-thy, 410

Bradbeer, J. N., see Badger, A. M., 1453

Bradykinin, vasodepressor and prostacy-cm responses, ACE inhibitor ef-fects on, 703

Brain

acetyicholine release in, enhancementby SA4503, in rat, 106

CRF and CRF-R1 mRNA levels afterbinge cocaine administration, inrat, 351

dopamine neurons, NMDA currents in,in rat, 457

5-hydroxytryptamine release in, effectsofrepeated MDMA on, in rat, 277

Brain tumors, cytotoxins selective for,1018

Brauneis, U., Oz, M., Peoples, R. W.,Weight, F. F. and Zhang, L.: Dif.ferential sensitivity of recombi-nant N-methyl-D-aspartate recep-tor subunits to inhibition bydynorphin, 1063

Breimer, D. D., see Math#{244}t,R. A. A., 1439

Brenic, S., see Mayer, A. M. S., 633Bristow, L. J., Hutson, P. H., Kulagowski,

J. J., Leeson, P. D., Matheson, S.,Murray, F., Rathbone, D., Say-well, K. L, Thorn, L., Watt, A. P.and Tricklebank, M. D.: Anticon-vulsant and behavioral proffle ofL-701,324, a potent, orally activeantagonist at the glycine modula-tory site on the N-methyl-D-as-partate receptor complex, 492

Brixius, K., see Mtlller-Ehmsen, J., 1220BRL 37344, potency, receptor density and,

214N-[2-(p-Bromocinnamoylamino)ethyl]-5-

isoquinoline-sulfonamide, effects

on parietal cell function, in rab-bit, 97

Bronchiolar cytotoxicity, 1,1-dichloroeth-ylene, in adult and weanlingmice, 1484

Bronchospasm, APNEA-induced, in BDErats, 1148

Brown, N. J., Ryder, D., Gainer, J. V., Mor-row, J. D. and Nadeau, J.: Differ-ential effects of angiotensin con-verting enzyme inhibitors on thevasodepressor and prostacyclinresponses to bradykinin, 703

Browne, M. J., see Wilson, S., 214Brownfield, M. S., see Li, Q., 1261Bryant, H. U., see Sate, M., 298Brzezinski, M. R., see Kamendulis, L. M.,

713Buckheit, R. W., Jr., see Currena, M. J.,

645Buflini, J. D., see Fox, A. W., 686Burcher, E., see Mussap, C. J., 423

Burgess, S. W., see Bebok, Z., 1462Burgmer, U., see Trankle, C., 926Burka, L. T., see Nomeir, A. A., 222Burke, see Zerrng, G., 23Burkhoff, D., see TOdaka, K., 120Burkholder, T. P., see Kudlacz, E. M., 732Burr, D. B., see Sate, M., 298Butelman, E. R., see Yu, J., 507Butelman, E. R., Lewis, J. W. and Woods,

J. H.: Methoclocinnamox: Agonist

and antagonist effects of a novellong-lasting opioid in rhesus mon-keys, 934

Butler, A. M., see Murray, M., 1447Butorphanol, discriminative stimulus ef-

fects of, 1130Butschky, M. F., see Pickworth, W. B., 4508-Butylaminoadenosine, partial agonism

at A1 receptor, 1439(±)-4-(3-t-Butylamino-2-hydroxypropoxy-

)benzimidazol-2-one, see CGP12177

[355] t-Butylbicyclophosphorothionate,GABA-stimulated binding, stano-

zolol effects on, 186(±)-BW373U86, methylether derivative,

metabolism of, 1069

Caine, G., see Lefebvre, M., 902

Calanolide AHIV inhibition by, 645HW reverse transcriptase inhibition by,

652Calcium

buffering by sarcoplasmic reticulum, inrat femoral arterial smooth mus-cle, 830

-dependent potassium channels, activa-tion, NO-synthase expressionand, 1514

effects in torsades de pointes, 231Calcium channels

L-type, cGMP effects on, in guinea pigventricular myocytes, 1274

motor nerve, w-agatoxin-IVA andw-conotoxin-MVIIC effects on, inmouse, 1229

voltage-sensitive, N-type, and spinal an-tinociception in rat neuropathicpain, 1243

Calcium sensitizerslevosimendan, effects on myocardial

contractility and oxygen con-sumption, 120

MCI-154, effects on ischemic dysfunc-tion, in guinea pig heart, 47

Calderon, S. N., see Schetz, J. A., 1069Caldwell, W. S., see Bencherif, M., 1413Calphostin-C, effects on parietal cell func-

tion, in rabbit, 97cAMP, see Cyclic adenosine monophos-

phateCampbell, W. G., Jr., see Barone, F. C., 948Cancer

CEA expression in, effects of 5-fiuorou-

racil on, 1574ovarian, effects of endogenous TNF in,

84Carbamazepine-10,11-epoxide, teratoge-

nicity, in SWV mouse, 1237Carbon dioxide, inhalation, inhibitory ef-

fects on pulmonary stretch recep-tors, in rabbit, 402

Carboxylesterase-mediated heroin metab-olism, 713

(R)-1-3-[3-(3-Carboxypyridine-2-yl)thio-2-(indol-2-yl)carbonylaminolpropio-nyl-4-diphenyl-methyl-pipera-zine, see TP-680

Carcillo, J. A., Herzer, W. A., Mi, Z.,Thomas, N. J. and Jackson, E. K.:Treatment with the type IV phos-phodiesterase inhibitor Ro 20-1724 protects renal and mesen-teric blood flow in endotoxemicrats treated with norepinephrine,1197

Carcillo, J. A., Jr., see Jackson, E. K., 1250

Carcinoembryonic antigen, expression, ef-fects of 5-fluorouracil on, in can-cer cells,1574

Cardiac hypertrophy, diuretic effects on,in spontaneously hypertensiverats, 983

Cardiac sympathetic ganglia, inhibition bydopamine receptors, in canine,

822Cardiovascular system

regulation of, angiotensin-atpha-2 re-

ceptor interactions in, 795thrombin receptor activation in vivo

and, 1365Caisson, L., Drews, L. and Duker, G.:

Rhythm anomalies related to de-

1996 Index 1593

layed repolarization in vivo. In-fluence of sarcolemmal Ca� � en-try and intracellular Ca�overload, 231

Carneiro, R. C. G., see Markus, R. P., 18Carnitine, derivatives containing trimeth-

ylamine, preventive effectsagainst ammonia toxicity andglutamate neurotoxicity, 194

Carroll, F. I., see Fleckenstein, A. B., 200Carvedilol, effects on survival in stroke-

prone spontaneously hyperten-sive rats, 948

Casida, J. E., see Huang, J., 1191Catalepsy, cholinergic neurons and, in

mouse striatum, 1430Catecholamine, secretion, inhibition by

protamine, in bovine adrenalmedullary cells, 838

Cathinone, N-methylated analog enanti-

omer effects, 1043Cations, organic, basolateral transport

system, in rabbit kidney proximaltubules, 1086

Cell death, see ApoptosisCell signaling, mediated through adenylyl

cyclase, aging and, 478Central nervous system

effects of peptide drug delivery to blood-brain barrier on, in rats, 77

-selective agonist RJR-2403

in vitro characterization, 1413in vivo characterization, 1422

CerebellumGABA-gated chloride channels in,

[3H]EBOB binding and insecti-cide action on, in granule neu-rons, 1191

lead neurotoxicity and apoptotic effectsin, in newborn rat, 435

Cerebrum

BMS-181101 pharmacokinetics, byPET, 325

thiopental kinetics, enantiomeric analy-sis in sheep, 291

CGMP, see Cyclic guanosine monophos-phate

CGP 12177, potency, receptor density and,214

Chabot-Fletcher, M., see Winkler, J. D.,956

Chait, B. T., see Yu, J., 507Chambers, J. K., see Wilson, S., 214Chan, A. W. K., see Devi, B. G., 359Chan, B. S. H., Lazzaro, V. A., Scale, J. P.

and Duggin, G. G.: Transport ofparaquat in a renal epithelial cellline LLC-PK1, 625

Chan, S. H. H., see Yang, C.-H., 795Chapman, C. G., see Wilson, S., 214Cheung, W.-M., see Damiano, B. P., 1365Chiba, K., see Kim, R. B., 4Chiba, K., see Thao, X.-J., 1327Chikkala, D. N., see Piletz, J. E., 694Chilton, F. H., see Winkler, J. D., 956Chinese hamster ovary cells, NMDA re-

ceptor subunit-transfected, ac-quired excitotoxicity in, 515

Chirino, R., see Boada, L. D., 112336Chloride, GABA-stimulated influx,

stanozolol effects on, 186Chloride channels

endothelin receptor coupling, in rat pul-monary arterial myocytes, 1053

GABA-gated, [3HIEBOB binding and in-secticide action on, in cerebellargranule neurons, 1191

glycine-activated, potentiation by etha-nol, in mouse spinal neurons,1116

7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(H)quinolone, see L-701,324

(RR,SS)-(±)-4-[(2-(2-(3-Chlorophenyl)-2-hydroxyethyl)amino)-propyl]phe-

noxyacetate, see BRL 373443�-(3-p-Chlorophenyl)tropan-2�3-carbox-

ylic acid p-isothiocyanatophenyl-ethyl ester hydrochloride, seeRTI-76

Chlorzoxazone, oral, disposition in Japa-nese and Caucasians, 4

CHO, see Chinese hamster ovary cellsCholecystokinin, mechanisms of action, in

canine GI tract, 306

Cholecystokinin receptors, antagonist TP-680, pharmacological profile,1404

Cholesteryl hemisuccinate, protectionagainst acetaminophen hepato-toxicity, 1470

Cholinederivatives containing trimethylamine,

preventive effects against ammo-nia toxicity and glutamate neuro-toxicity, 194

hepatic uptake, in rat, 774Cholinergic system

airway, ET-1 effects on, in rat trachealsmooth muscle, 1142

effects in sumatriptan antinociception,in rodents and guinea pigs, 884

neurons, and catalepsy, in mouse stria-turn, 1430

Christian, B. T., Livni, B., Babich, J. W.,Alpert, N. M., Dischino, D. D.,Ruediger, E., Salazar, D. E., Ford,

N. F. and Fischman, A. J.: Evalu-ation of cerebral pharmacokinet-ics of the novel antidepressantdrug, BMS-181101, by positronemission tomography, 325

Chu, Y., see Taguchi, H., 1514

Cicero, T. J.: Gender-related differences inthe antinociceptive properties ofmorphine, 767

Cipris, S., see Vergara, P., 306Cisplatin-induced emesis, delayed by

granisetron, in piglet, 255Claes, C., see De Ryck, M., 748

Clerico, L., see Debernardis, D., 84Clincke, G., see De Ryck, M., 748Clobazam

anticonvulsant effects, in direct corticalstimulation model, 803

tolerance and dependence liability, inmice seizure models, 561

Cloccinamox, opioid receptor blockade, 23Clonazepam

anticonvulsant effects, in direct corticalstimulation model, 803

tolerance and dependence liability, inmice seizure models, 561

Clonidine, ethanol interactions, in rats,443

Cocainebinge administration, CRF and CRF-R1

mRNA levels after, in rat brainand pituitary, 351

chronic withdrawal, CRF and CRF-R1mENA levels during, in rat brainand pituitary, 351

conditioned place preference induced by,intra-accumbens sulpiride and,177

esterase-mediated metabolism, 713

immunotoxicity, in B6C3F1 and DBAJ2mice, 3

liver toxicity, in rat, 359locomotive effects, intra-accumbens

sulpiride and, 177opioid interactions, 524plasma concentrations, arterial and ye-

nous, 1345

substrates, in rat barrel field corticalneurons, 582

sympathoinhibitory responses, blockadeby rostral ventrolateral medul-lary alpha-2 receptor, 967

Codeine, inhalation exposure, antinocicep-tire effects, in mice, 69

Coenzyme A-independent transacylase in-hibitors, apoptosis induction by,in HL-60 cells, 956

Cognition, enhancement by FK960, inrats, 1157

Coirault, C., see Joseph, T., 464Coffins, A. C., see Lippiello, P. M., 1422Collins, K. A., see Tseng, L. F., 39Colon carcinoma, CEA expression in, ef-

fects of 5-fluorouracil on, 1574Compounds, dermal application, local

deep tissue penetration of, 908

Conditioned place preferencecocaine-induced, intra-accumbens

sulpiride and, 392morphine-induced, TAN-67 effects on, in

mice, 177Cone, E. J., see Evans, S. M., 1345Conjunctival pruritus, ketorolac effects

against, 137w-Conotoxin-MVIIC, effects on motor

nerve Ca� � currents, in mouse,1229

ContractionscGMP effects on, in guinea pig ventric-

ular myocytes, 1274cholinergic nerve-mediated, ET-1 effects

on, in rat tracheal smooth muscle,1142

flow-induced, PKC effects in, 668

giant migrating, PAP-induced, duringileal inflammation, 207

myocardial, levosimendan effects on,120

Cornelius, J., see Bowman, M. A., 790Coronary artery

effects of dexfenfluramine on, porcine,1077

vasodilatory actions of mcorandil on, in

human tissue, 1220Corpus striatum

cholinergic neurons, organization, inmouse, 1430

dopamine transporter, inactivation byRTI-76, 200

GDNF functional effects in, in rat, 1181histamine release in, effects ofacute and

chronic methamphetamine on, inrat, 271

Corradetti, R., see Pugliese, A. M., 1100

Cortex

1594 Index VoL 279

chronic antidepressants and 5-HT7 re-ceptor activity in, in rat astro-cytes, 1551

cocaine substrates in, in rat, 582Corticotropin-releasing factor, mRNA 1ev-

els after binge cocaine adminis-tration, 351

Corticotropin-releasing factor receptors,type 1, mRNA levels after bingecocaine administration, 351

Crankshaw, D. J., see Senchyna, M., 262Crespo, A., see Blaya, C., 472Crespo, J., see Blaya, C., 472CRF, see Corticotropin-releasing factorCromakalim, mechano-energetic effects on

left ventricular papillary muscle,in guinea pig, 464

Cronk, D. W., see Wilson, S., 214Cryptosporidiosis, enteric nervous system

in, in piglet, 1109Currens, M. J., Gulakowski, R. J., Marl-

ncr, J. M., Moran, R. A., Buck-heit, R. W., Jr., Gustafson, K. R.,McMahon, J. B. and Boyd, M. R.:Antiviral activity and mechanismof action of calanolide A against

the human immunodeficiency vi-rus, 645

Currens, M. J., Mariner, J. M., McMahon,J. B. and Boyd, M. R.: Kineticanalysis of inhibition of humanimmunodeficiency virus reversetranscriptase by calanolide A, 652

Cu,Zn-superoxide dismutase, succinylatedkeratin fragment conjugate, ef-fects, 162

Cyclic adenosine monophosphateaccumulation, 5-HT7 receptor-mediated,

chronic antidepressants and, inrat, 1551

accumulation assay for beta-3 agonist

potency, 214release in kidney, angiotensin II effects

on, in spontaneously hyperten-sive rat, 114

Cyclic guanosine monophosphate, effectson L-type calcium current andcontractions, in guinea pig yen-tricular myocytes, 1274

N-Cyclobutylmethyl, normorphinone ana-log binding and analgesia, 539

3-(3-Cyclopropyl-5-isoxazolyl)-6-fluoro-5-morpholino-imidazo[1,5-a]quina-

zoline, see NNC 14-0185

3-(5-Cyclopropyl-1,2,4-oxadiazol-3-yl)-7-fluoro-5-(4-methyl-1-piperazinyl)-

imidazol[1 ,5-a]quinazoline, seeNNC 14-0189

Cyclo[-D-a-aspartyl-3-[(4-phenylpiperazin-1-yl)carbonyl1-L-alanyl-i�-a-aspar-tyl-D-2-(2-thienyl)glycyl-L-leucyl-D-tryptophyl]disodium salt, seeTAK-044

Cytochrome P4502B1, imprinted overinduction of, in

adult rats neonatally exposed tophenobarbital, 991

2B2, imprinted overinduction of, inadult rats neonatally exposed tophenobarbital, 991

2C19, quinine 3-hydroxylation by, inliver microsomes, 1327

2D, impipramine-induced inactivationof, in rat liver microsomes, 724

2E1, activity in Japanese and Cauca-sians, 4

3A2, inhibition during diltiazem bio-transformation, in rat liver, 1447

3A4, quinine 3-hydroxylation by, in livermicrosomes, 1327

human recombinant, quinine 3-hy-droxylation by, in liver micro-somes, 1327

Cytokine receptors, soluble, as carrier pro-teins, 340

Cytokine suppressive binding protein, in-hibitor SB 203580, pharmacolog-ical proffle, in animal models,1453

Cytotoxicitybronchiolar, 1,1-dichloroethylene, in

adult and weanling mice, 1484

indomethacin, leminoprazole protection

against, in rabbit gastric mucosalcells, 975

lipid A, nitric oxide effects in, 91Cytotoxins, brain tumor-selective, 1018

Daggett, L. P., see Varney, M. A., 367DaM, S. G., see SOUIard, C. D., 1379Dams, K., Hitzemann, B. and Hitzemann,

R.: Genetics, neuroleptic responseand the organization of cholin-ergic neurons in the mouse stria-turn, 1430

Dal Cason, T. A., see Sparago, M., 1043Damiano, B. P., Cheung, W.-M., Mitchell,

J. A. and Falotico, R.: Cardiovas-cular actions ofthrombin receptoractivation in vivo, 1365

Dan, K., see Mukai, M., 822Danhof, M., see Hoogerkamp, A., 803Danhof, M., see Math#{244}t,R. A. A., 1439Daniel, B. B., see Vergara, P., 306Danilov, S. M., see Muzykantov, V. R.,

1026D’Atri, S., see Local, P. M., 416ddl, see 2’,3’-DideoxyinosineDc Filippi, R., see Prete, S. P., 1574De Ryck, M., Keersmaekers, R.,

Duytschaever, H., Claes, C.,Clincke, G., Janssen, M. and VanReet, G.: Lubeluzole protects son-

sorimotor function and reduces

infarct size in a photochemicalstroke model in rats, 748

Dc Santis, S., see Prete, S. P., 1574De Vecchis, L., see Prete, S. P., 1574Deal, C., see Varney, M. A., 367Dean, R. A., see Kamendulis, L. M., 713Debernardis, D., Stanzione, S., Ottobom,

C., Clerico, L., Mancuso, T.,Parodi, S. and Russo, P.: Endoge-nous tumor necrosis factor en-hances topoisomerase II inhibi-tors activity in human ovariancancer cell lines, 84

Deddish, P. A., Wang, L.-X., Jackman, H.L., Michel, B., Wang, J., Skidgel,R. A. and ErdOs, E. G.: Single-domain angiotensin I convertingenzyme (kininase II): Character-ization and properties, 1582

Deitrich, R. A., see Erwin, V. G., 1310Delyani, J. A., Nossuli, T. 0., Scalia, R.,

Thomas, G., Garvey, D. S. andLefer, A. M.: S-Nitrosylated tis-sue-type plasminogen activatorprotects against myocardial iseh-

emia/reperfusion injury in cats:Role of the endothelium, 1174

Dependencebenzodiazepine receptor ligand liability,

in mice, 561, 573

ethanol, ganglioside effects against, 128morphine, substance P(1-7) effects on,

662reverse use, ofKv4.2 blockade by 4-ami-

nopyridine, 865Depoortere, H., see Itier, V., 1092L-Deprenyl, effects on excitatory synaptic

transmission, in rat hippocam-pus, 740

Dermal application of compounds, localdeep tissue penetration, 908

D#{233}sormeaux, A., see Harvie, P., 1009

Desta, B., Schultz, D., Ravel, D., Lau-dignon, N., Vanhoutte, P. M. andBoulanger, C. M.: Acute andchronic effects of dexfenfluramine

on the porcine coronary artery,1077

Devi, B. G. and Chan, A. W. K.: Cocaine-induced peroxidative stress in ratliver: Antioxidant enzymes andmitochondria, 359

Dexfenfluramine, acute and chronic ef-fects on coronary artery, porcine,1077

Diabetes, aminoguanidine effects on, innonobese diabetic mice, 790

Dfaz-Chico, B. N., see Boada, L. D., 1123Diazepam

anticonvulsant effects, in direct corticalstimulation model, 803

dependence liability, in mice seizuremodels, 561

toleranceGABAA receptors in, in rats, 1092liability, in mice seizure models, 561

Dicarboxylate, carrier, fluorescein interac-

tions, in rat kidney cortex mito-chondria, 1559

1,1-Dichioroethylene, metabolism, inadult and weanling mice, 1484

2’,3’-Dideoxyinosine, combined with riba-vim, in murine AIDS model,1009

Dilazep, effects on PALCAR-induced me-

chanical derangement, in ratheart, 32

Diltiazem, metabolismorgan-specific, in rabbits, 902P450 inhibition during, in rat liver, 1447

1-(2,5-Dimethoxy-4-iodophenyl)-2-amin-opropane, neuroendocrine effects,tolerance, 782

1-(3,4-Dimethoxyphenethyl)-4-(3-phenyl-propyl)piperazine dihydrochlo-ride, see SA4503

Dischino, D. D., see Christian, B. T., 325l4cr,14’f3-[Dithiobis[(2-oxo-2,1-ethanediy-

l)imino]]bis[7,8-dihydro-N-(cy-clobutylmethyl)-normorphinone],binding and analgesia, 539

Diuresis, effects of fedotozine vs other �c

agonists on, in rats, 1379Diuretics, effects on cardiac hypertrophy,

in spontaneously hypertensiverats, 983

DOl, see 1-(2,5-Dimethoxy4-iodophenyl)-2-aminopropane

Dombrowski, D. S., see Pugh, G., Jr., 608Dong, J.-Y., see Bebok, Z., 1462

1996 Index 1595

DopamineGDNF functional effects on, in rat stri-

atum, 1181neuron NMDA currents, in rat brain,

457transporter inactivation by intrastriatal

RTI-76, 200Dopamine receptors

agonist effects on eye blink rate, in cyno-molgus monkeys, 1211

antagonist effects on METH-inducedhistamine release, in rat stria-turn, 271

D4 antagonist U-101387, pharmacologi-cal characterization, 1392

ganglionic inhibition by, in canine car-diac sympathetic ganglia, 822

Dowsley, T. F., see Forkert, P. G., 1484Drews, L., see Carlsson, L., 231Drug delivery

peptide blood-brain barrier, CNS ef-fects, in rats, 77

solute structure and penetration, 908Drug discrimination, butorphanol, 1130Drug interactions, fluorescein, in rat kid-

ney cortex mitochondria, 1559Du Souich, P., see Lefebvre, M., 902Duckles, S. P., Krause, D. N. and Miller, V.

M.: Effects of gonadal steroids onvascular function, 1

Ducros, L., see Joseph, T., 464Duggin, G. G., see Chan, B. S. H., 625Duker, G., see Carlsson, L., 231Dusserre, N., see Harvie, P., 1009

Dutton, P. L., see Johansson, J. S., 56Duytschaever, H., see De Ryck, M., 748Dynorphin

NMDA receptor sensitivity, 1063and i�#{176}-THCcombined with morphine,

in spinal cord, 608Dynorphin A (1-17), biotransformation,

human and rhesus monkey blood,507

Eaton, M. J., see Merchant, K. M., 1392Ebert, U., see Loscher, W., 561Ebert, U., see Loscher, W., 573[3H]EBOB, see [3H]Ethynylbicycloortho-

benzoateEckhardt, U., see Kontaxi, M., 1507Egr-1, neural control of, in rat adrenal

gland, 379Ehlert, F. J., Griffin, M. T. and Glidden,

P.: The interaction of the enanti-omers of aceclidine with subtypesof the muscariic receptor, 1335

Elfas, M. M., see Monasterolo, L. A., 602Elfas, M. M., see Trumper, L., 548Ellipticines, quaternized, accumulation by

human tumor cells, 1018Elmaleh, D. R., see Fischman, A. J., 939Emesis, delayed, by repeated granisetron,

in piglet, 255Endoh, T., see Suzuki, T., 177

13-Endorphin, antinociceptive effects, per-tussis toxin and, in mouse, 39

Endothelin-1effects on airway cholinergic nerves, in

rat, 1142electrophysiological effects, in rat pul-

monary arterial myocytes, 1053Endothelin receptors, potassium and chlo-

ride channel coupling, in rat pul-monary arterial myocytes, 1053

EndothelinA receptor, antagonism byTA.K-044, 675

Endothelin5 receptor, antagonism byTAK-044, 675

Endotoxemia, norepinephnne combinedwith Re 20-1724 treatment, inrat, 1197

Endotoxin shock, antiarthritic effects ofSB 203580 on, in animal models,1453

Ensinger, H. A., see Meade, C. J., 1148

Enteric nervous system, in cryptosporidi-osis, in piglet, 1109

Enterocyte microsomes, riuabutin disposi-tion and metabolism by, in rats,1300

Erd#{246}s,E. G., see Deddish, P. A., 1582Ens, T., see Winkler, J. D., 956Erwin, V. G. and Deitrich, R. A.: Genetic

selection and characterization of

mouse lines for acute functionaltolerance to ethanol, 1310

Erythrocytes, injured, adenosine deami-nase release by, 1250

Erythropoietin, pharmacokinetics, insheep, 1205

Esterase-mediated heroin metabolism,713

Estrogen, comparison with raloxifene, inrats, 298

ET, see EndothelinEthanol

clonidine interactions, in rats, 443dependence, ganglioside effects against,

128glycine receptor potentiation by, in

mouse spinal neurons, 1116tolerance, genetic selection for, in mouse

lines, 1310[3H]Ethynylbicycboorthobenzoate, binding

on GABA-gated chloride channel,in cerebellar granule neurons,1191

ET-18-O-CH3, see 1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocho-line

Evans, H. L., see Oberto, A., 435Evans, S. M., Cone, E. J. and Henning-

field, J. E.: Arterial and venouscocaine plasma concentrations inhumans: Relationship to route ofadministration, cardiovasculareffects and subjective effects,1345

Excitation, decrease by felbamate, in CAlrat hippocampal slices, 1100

Excitatory synaptic transmission, L-depre-nyl effects on, in rat hippocam-pus, 740

Excitotoxicity, acquired, in NMDA recep-tor subunit-transfected CHOcells, 515

Eye blink rate, dopamine agonist effectson, in cynomolgus monkeys, 1211

Falotico, R., see Damiano, B. P., 1365Fant, R. V., see Pickworth, W. B., 450Faraci, F. M., see Taguchi, H., 1514Fariss, M. W., see Ray, S. D., 1470Fedotozine, effects on diuresis, in rats,

1379Felbamate, excitation decrease by, in CAl

rat hippocampal slices, 1100Felgner, P. L., see Bebok, Z., 1462Felipo, V., see Mi#{241}na, M.-D., 194Female-dominant sulfotransferases, on-

togeny and hormonal basis, in ratliver, 386

Femoral arterial smooth muscle, sarco-plasmic reticulum calcium buffer-ing action in, in rat, 830

Fentanyl, inhalation exposure, antinoci-ceptive effects, in mice, 69

Fernandes, L. B., see Knott, P. G., 1142Fern#{225}ndez,L., see Boada, L. D., 1123Fernandez-Botran, R., see Ma, V., 340Ferrier, G. R., 317Feuerstein, G. Z., see Barone, F. C., 948Fibrinolytics, lung targeting, 1026Fibronectin, turnover, silibinin effects on,

in mesangial cells, 1520Figini, M., see Ghelardini, C., 884Finnell, R. H., see Bennett, G. D., 1237Fischman, A. J., see Christian, B. T., 325Fischman, A. J., Bonab, A. A., Babich, J.

W., Alpert, N. M., Rauch, S. L.,Elmaleh, D. R., Shoup, T. M., Wil-hams, S. A. and Rubin, R. H.:Positron emission tomographicanalysis ofcentral 5-hydroxytryp-tamine2 receptor occupancy inhealthy volunteers treated withthe novel antipsychotic agent, zi-prasidone, 939

Fisher, A. B., see Muzykantov, V. R., 1026FK960, cognitive enhancement by, in rats,

1157Flecainide, proarrhythmic effects, 317Fleckenstein, A. E., Pogun, S., Carroll, F.

I. and Kuhar, M. J.: Recovery ofdopamine transporter bindingand function after intrastriataladministration of the irreversibleinhibitor RTI-76 {3�3-(3-p-chloro-phenyl)tropan-213-carboxylic acidp-isothiocyanatophenylethyl es-ter hydrochloride), 200

Flow-induced contraction, PKC effects in,

668

Flunitrazepam, anticonvulsant effects, indirect cortical stimulation model,803

Fluorescein, dicarboxylate carrier interac-tions, in rat kidney cortex mite-

chondria, 15594-(4-Fluorophenyl)-2-(4-methylsulfinyl-

phenyl)-5-(4-pyridyl)imidazole,see SB 203580

5-Fluorouracil, effects on CEA expression,in cancer cells, 1574

Fluoxetine, chronic, desensitization of

5�1A receptors by, 1035Ford, N. F., see Christian, B. T., 325Forkert, P. G., Dowsley, T. F., Lee, R. P.,

Hong, J.-Y. and Ulreich, J. B.:Differential formation of 1,1-dichloroethylene-metabolites inthe lungs of adult and weanlingmale and female mice: Correla-tion with severities of bronchiolarcytotoxicity, 1484

Fossati, G., see Patrini, G., 172Fowler, K. W., see Bencherif, M., 1413Fox, A. W., Sullivan, B. W., Buffini, J. D.,

Neichin, M. L., Nicora,R.,Hoehier, F. K., O�Rourke, R. andStoltz, R. R.: Reduction of serumlactate by sodium dichloroac-etate, and human pharmacoki-netic-pharmacodynamic relation-ships, 686

Fox, J. A., Hotaling, T. E., Struble, C.,Ruppel, J., Bates, D. J., and

1596 Index VoL 279

Schoenhoff, M. B.: Tissue distri-bution and complex formationwith IgE of an anti-IgE antibodyafter intravenous administrationin cynomolgus monkeys, 1000

Fox-Threlkeld, J. E. T., see Vergara, P.,306

Free radicals, effects on K� channels innon-neurogenic relaxation, in ca-nine airway muscle, 813

Friedlaender, M. H., see Woodward, D. F.,

137Frontal cortex, chronic antidepressants

and 5-HT7 receptor activity in, inrat astrocytes, 1551

Fuchs, R. A., see Baker, D. A., 392Fujisawa, Y., see Masuda, Y., 675Furosemide, effects on cardiac hypertro-

phy, in spontaneously hyperten-sive rats, 983

Furukawa, T., see Mukai, M., 822

Gadbois, T., see Bowersox, S. S., 1243Gainer, J. V., see Brown, N. J., 703Galeotti, N., see Ghelardii, C., 884Gallagher, M. J., see Lynch, D. R., 154Ganglia, sympathetic, inhibition by dopa-

mine receptors, in canine heart,822

Gangliosides, effects against ethanol do-pendence, 128

Garner, J. E., see Walsh, S. L., 524Gartside, S. E., McQuade, R. and Sharp,

T.: Effects of repeated admiis-tration of 3,4-methyl-enedioxymethamphetamine on5-hydroxytryptamine neuronalactivity and release in the ratbrain in vivo, 277

Garvey, D. S., see Delyani, J. A., 1174Gastric acid secretion

inhibition by secretin, in canine, 718TP-680 effects on, 1404

Gastric mucosa, leminoprazole cytoprotec-tion in, in rabbit, 975

Gastrointestinal tract, cholecystokininmechanisms of action in, in ca-nine, 306

GDNF, see Glial cell-line derived neurotro-phic factor

Gender-related differences, in morphineantinociception, 767

Gene transfer, lipid-mediated, plasmid de-livery efficiency after, 1462

Genescardiac, diuretic effects on, in spontane-

ously hypertensive rats, 983PNMT, and Egr-l mRNA expression, in

rat adrenal gland, 379prostaglandin G/H synthase-2, thymo-

cyte expression, in rats, 1566selection for ethanol tolerance, in mouse

lines, 1310and striatal cholinergic neurons, in

mouse, 1430Gerber, J. G. and Payne, N. A.: Secretin

inhibits canine gastric acid secre-tion in response to pentagastrinby modulating gastric histaminerelease, 718

Gerber, N., see Koudriakova, T., 1300Gerhardt, G. A., see Hebert, M., 1181Gessa, G. L., see Ghelardii, C., 884

Geyer, M. A., see Swerdlow, N. R., 1290

Ghanayem, B. I., see Nomeir, A. A., 222

Ghelardini, C., Galeotti, N., Figii, M., Im-perato, A., Nicolodi, M., Sicuteri,F., Gessa, G. L and Bartolini, A.:The central cholinergic systemhas a role in the antinociceptioninduced in rodents and guineapigs by the antimigraine drugsumatriptan, 884

Giant migrating contractions, PAF-in-duced, during ileal inflammation,207

Giebisch, G., see Aleo, M. D., 1318Gill, G. S., see Merchant, K. M., 1392

Giuliani, A., see Prete, S. P., 1574Glaser, K. B., see Mayer, A. M. S., 633Glial cell-line derived neurotrophic factor,

functional effects, in rat striatum,1181

Glidden, P., see Ehlert, F. J., 1335Glucocorticoids, aging and, 478Glucose, high, fibronectin turnover effects,

silibinin and antioxidants and,1520

Glutamateneurotoxicity

lubeluzole protective effects against,759

trimethylamine preventive effectsagainst, 194

and vincristine neuropathy, 410Glutathione S-transferase

glyceryl trinitrate biotransformation by,in rat aorta, 1527

inhibition, glyceryl trinitrate actionsand, 1535

Glyceryl trinitrate

biotransformation by rat aortic GSTs,1527

pharmacological actions after GST inhi-bition, 1535

Glycine receptorsantagonist L-701,324, behavioral pro-

ifie, 492[3H]MDL 105,519 site, 62potentiation by ethanol, in mouse spinal

neurons, 1116Goldie, R. G., see Knott, P. G., 1142Gonadal steroids, vascular effects, 1Gori, E., see Patrii, G., 172Gotzsch, U., see Wiegand, H., 891Gould, E. M., see Waterhouse, B. D., 582Gourde, P., see Harvie, P., 1009

Granger, P., see Itier, V., 1092Granisetron, repeated, delayed emesis by,

in piglet, 255Grant, C., see Mather, L. B., 291Gray, E., see Mather, L. E., 291Gray, J. A., see Lippiello, P. M., 1422Graziani, G., see Local, P. M., 416Graziani, G., see Prete, S. P., 1574Greiner, J. W., see Prete, S. P., 1574Gr#{233}lot,L., Le Stunff, H., Milano, S.,

Blower, P. R. and Remain, D.: Re-peated administration of the5-HT3 receptor antagonist granis-etron reduces the incidence of do-layed cisplatin-induced emesis inthe piglet, 255

Greven, J., see Hohage, H., 1086Griffin, M. T., see Ehiert, F. J., 1335Griffin, R. J., see Nomeir, A. A., 222Grigoryan, G., see Lippiello, P. M., 1422Grisoll, S., see Mifina, M.-D., 194Griswold, D. E., see Badger, A. M., 1453Gross, R. S., see Baron, B. M., 62

GST, see glutathione S-transferase

Guengerich, F. P., see Kim, R. B., 4Guerif, S., see Soulard, C. D., 1379Guidotti, A., see Oberto, A., 435Gulakowski, R. J., see Currens, M. J., 645Gustafson, K. R., see Currens, M. J., 645

H-7, see 1(5-Isoquinolinesulfonyl)-2methyl piperazine

H-8, see N-[(Methylamine)ethyl]-5-iso-quinoline sulfonamide

H-89, see N-[2-(p-Bromocinnamoylamin-o)ethyl]-5-isoquinoline-sulfon-amide

HA-1004, see N-(2-Quindinoethyl)-5-iso-quinoline sulfonamide

Hadac, E. M., see Holtmann, M. H., 555Hagenbuch, B., see Kontaxi, M., 1507

Haloperidol, inhibition ofNMDA receptorsby, 154

Halothane, tetra-a-helix-bundle proteinbinding, 56

Halushka, P. V., see Higashiura, K., 1386Hamaguchi, A., see Kim, S., 983Hara, A., Hashizume, H. and Abiko, Y.:

Dilazep and its derivative,K-7259, attenuate mechanical de-rangement induced by palmitoyl-L-carnitine in the isolated, per-fused rat heart, 32

Hara, Y., see Watanabe, Y., 617

Harris, D. W., see Merchant, K. M., 1392Harrison, B. L., see Baron, B. M., 62Harvie, P., Omar, R. F., Dusserre, N.,

Lansac, N., D#{233}sormeaux, A.,Gourde, P., Simard, M., Trem-blay, M., Beauchamp, D. andBergeron, M. G.: Ribavirin poten-tiates the efficacy and toxicity of

2’,3’-dideoxyinosine in the mu-rime acquired immunodeficiencysyndrome model, 1009

Hashida, M., see Sawai, K., 284Hashizume, H., see Hara, A., 32Hatzidimitriou, G., see Sparago, M., 1043Hawes, C., see Baron, B. M., 62Heart

PALCAR-induced mechanical derange-

ment, dilazep and K-7259 effectson, in rat heart, 32

sympathetic ganglia, inhibition by dopa-mine receptors, in canine, 822

Hebert, M., Van Home, C. G., Hoffer, B. J.and Gerhardt, G. A.: Functionaleffects of GDNF in normal ratstriatum: Presynaptic studies us-ing in vivo electrochemistry and

microdialysis, 1181Heisler, B. E. and Ferrier, G. R.: Proar-

rhythmic actions of flecainide inan isolated tissue model of isch-emia and reperfusion, 317

Heisted, D. D, see Taguchi, H., 1514Helterbrand, J., see Sato, M., 298Henningfield, J. B., see Evans, S. M., 1345Henningfield, J. B., see Pickworth, W. B.,

450Henry, P. J., see Knott, P. G., 1142Hepatectomy, erythropoietin pharmacoki-

netics after, in sheep, 1205Hepatotoxicity, acetaminophen, cho-

lesteryl hemisuccinate protection

against, 1470Hermenegildo, C., see Minna, M.-D., 194Heroin

esterase-mediated metabolism, 713

1996 Index 1597

inhalation exposure, antinociceptive ef-fects, in mice, 69

Herzer, W. A., see Carcillo, J. A., 1197Herzer W. A., see Jackson, E. K., 1250Hess, S. D., see Varney, M. A., 367Higashiura, K., Blaney, B., Morgan, E.,

Mathur, R. S. and Halushka, P.V.: Inhibition of testosterone 5a-reductase: Evidence for tissue-specific regulation of thrombox-ane A� receptors, 1386

Higgs, R., see Sato, M., 298Hippocampus

CAl region, excitation decrease by fel-bamate in, in rat, 1100

excitatory synaptic transmission, L-

deprenyl effects on, in rat, 740GABAA receptors

in benzodiazepine-tolerant rats, 1092mapping, 1491

nicotinic receptors, mapping, 1491NMDA receptors, lead effects on, in rat,

143Histamine

gastric release, modulation by secretin,in canine, 718

striatal release, effects of acute andchronic methamphetamine on, inrat, 271

Hitzemann, B., see Dams, K., 1430Hitzemann, R., see Dams, K., 1430HN, see Human immunodeficiency virusHL-60 cells

apoptosis induction by CoA-independenttransacylase inhibitors, 956

superoxide generation, 633Ho, A., see Zhou, Y., 351Hodges, H., see Lippiello, P. M., 1422Hoehler, F. K., see Fox, A. W., 686Hoffer, B. J., see Hebert, M., 1181Hoffman, P. L., see Snell, L. D., 128Hohage, H., Querl, I. U., M#{246}rth,D. M. and

Greven, J.: The basolateral or-ganic cation transport system ofrabbit kidney proximal tubules.Influence of anorganic anions,1086

Hoischen, S., see Mttller-Ehmsen, J., 1220Holsapple, M. P., see Matulka, R. A., 3Holtmann, M. H., Hadac, E. M., Ulrich, C.

D. and Miller, L. J.: Molecular ba-515 and species specificity of highaffinity binding of vasoactive in-testinal polypeptide by the rat so-cretin receptor, 555

Holycross, B. J., see Bergman, M. R., 247H#{246}nack,D., see Loscher, W., 561H#{246}nack,D., see Loscher, W., 573Hong, J.-Y., see Forkert, P. G., 1484

Hoogerkamp, A., Arends, R. H. G. P.,Bomers, A. M., Mandema, J. W.,Voskuy, R. A�, and Danhof, M.:

Pharmacokinetic/pharmacody-namic relationship of benzodiaz-epines in the direct cortical stim-ulation model of anticonvulsanteffect, 803

Horie, T., see Masubuchi, Y., 724Hormones, regulation of female-dominant

sulfotransferases by, in rat liver,386

Horwitz, J. A., see Picker, M. J., 1130Hotaling, T. E., see Fox, J. A., 1000

Hsu, K.-S., Huang, C.-C., Su, M.-T. andTsai, J.-J.: L-Deprenyl (selegiline)

decreases excitatory synaptictransmission in the rat hip-pocampus via a dopaminergicmechanism, 740

5-HT, see 5-Hydroxytryptamine

HT-29 cells, CEA expression, effects of5-fluorouracil on, 1574

Huang, C.-C., see Hsu, K.-S., 740Huang, J. and Casida, J. B.: Characteriza-

tion of [3H]ethynylbicycloortho-benzoate ([3H]EBOB) bindingand the action of insecticides onthe -y-aminobutyric acid-gatedchloride channel in cultured cere-bellar granule neurons, 1191

Huang, J. L., see Mather, L. E., 291Huang, S.-J., see Mazzola-Pomietto, P.,

782Huff, R. M., see Merchant, K. M., 1392Hughes, B. W., see Bebok, Z., 1462

Human immunodeficiency virusinhibition by calanolide A, 645reverse transcriptase, inhibition by cal-

anolide A, 652Hursey, M., see Vistica, D. T., 1018Hurst, H. E., see Ma, V., 340Hutson, P. H., see Bristow, L. J., 492Hydrogen, secretion of, modulation by

PKC, in rabbit parietal cells, 97Hydromorphone, cocaine interactions, in

humans, 5243-Hydroxylation, quinine, by cytochrome

P450 isoforms, in liver, 13275-Hydroxytryptamine

function, effects of repeated MDMA on,in rat, 277

mitogen-activated protein kinase activa-tion by, in vascular smooth mus-cle, 1541

release in brain, effects of repeatedMDMA on, in rat, 277

releasers, neuroendocrine pharmacol-ogy, 1261

5-Hydroxytryptamine� receptors, desen-sitization by chronic fluoxetine,1035

5-Hydroxytryptamine3 receptors, antago-nist granisetron, delayed emesisby, in piglet, 255

5-Hydroxytryptamine7 receptors, chronicantidepressants and, in rat fron-tocortical astrocytes, 1551

5-Hydroxytryptamine2 receptors, ziprasi-done and, PET analysis, 939

Hypertension, spontaneousangiotensin II effects on renal cAMP re-

lease in, in rat, 114carvedilol effects on survival in, in

stroke-prone rats, 948effects of diuretics on cardiac hypertro-

phy in, in rats, 983Hypertrophy, cardiac, diuretic effects on,

in spontaneously hypertensiverats, 983

Hypothalamus, CRF and CRF-Rl mRNAlevels after binge cocaine admin-istration, in rat, 351

Hypothermia, early neuroprotective ef-fects against metabolic stress,332

Iatsimirskaia, E., see Koudriakova, T.,1300

Igarashi, S., see Masubuchi, Y., 724IGROV-l cells, effects ofendogenous TNF

secreted by, 84

Ijzerman, A. P., see MathSt, R. A. A., 1439Ikezawa, K., see Kaminuma, 0., 240IL, see Interleukinileal inflammation, PAl contractile effects

during, 207Imaizumi, Y., see Nomura, Y., 830Imidazoline, platelet binding sites, 694Imidazoquinazolines, NNC 14-0185 and

NNC 14-0189, tolerance and de-pendence liability, in mice seizuremodels, 573

Imipramine, inactivation of CYP2D by, inrat liver microsomes, 724

Immune cells, opioid receptor density,morphine and methadone effectson, on murine splenocytes, 172

Immune function, antiarthritic effects ofSB 203580 on, in animal models,1453

Immunodeficiency, see Acquired iminuno-deficiency syndrome; Human im-munodeficiency virus

Immunoglobulin E, antthuman anti-IgEantibody, in monkeys, 1000

Immunotoxicity, cocaine, in B6C3F1 andDBA/2 mice, 3

Imperato, A., see Ghelardini, C., 884

Indomethacincombined with anti-1L4, effect on tumor

metastasis, 472cytotoxicity, leminoprazole protection

against, in rabbit gastric mucosalcells, 975

Infarcts, size, lubeluzole effects on, in ratphotochemical stroke model, 748

Inflammation, ileal, PAY contractile ef-fects during, 207

Inhalationcarbon dioxide, inhibitory effects on pul-

monary stretch receptors, in rat>bit, 402

opioid, antinociceptive effects, in mice,69

Injuryischemia/reperfusion

focal, lubeluzole neuroprotection in, in

rat photochemical stroke model,748

-induced arrhythmias, Re 22-9194 ef-fects on, in dogs, 877

mesenteric, norepinephrmne combinedwith Re 20-1724 and, in endotox-emic rats, 1197

myocardial, MCI-154 effects on, inguinea pig heart, 47

myocardial, NO-tPA effects against,in cats, 1174

proarrhythmic effects of flecainide in,in tissue model, 317

red blood cells, adenosine deaminase re-lease by, 1250

Insecticides, action on GABA-gated chlo-ride channel, in cerebellar gran-ule neurons, 1191

Insulin-dependent diabetes, aminoguani-

dine effects on, in nonobese dia-betic mice, 790

Interferon-gamma, in met-enkephalin an-

tiviral effects, in murine cells,1268

Interleukin-4anti-HA effect on tumor metastasis, 472pharmacokinetics, effects ofsoluble IL-4

receptors on, in mouse, 340

1598 Index Vol. 279

soluble, receptors effects on murine IL-4pharmacokinetics, 340

Interleukin-5, suppression by T-440, inPBMCs, 240

Ion channels, inhibition by protamine, inbovine adrenal medullary cells,838

Ischemia/reperfusion injuryarrhythmias, Re 22-9194 effects on, in

dogs, 877

focal, lubeluzole neuroprotection in, in

rat photochemical stroke model,748

mesenteric, norepinephrine combinedwith Re 20-1724 and, in endotox-emic rats, 1197

myocardialMCI-154 effects on, in guinea pig

heart, 47NO-tPA effects against, in cats, 1174

proarrhythmic effects offlecainide in, intissue model, 317

Ishisu, R., see Abe, Y., 47Ishizaki, T., see Kim, R. B., 4Ishizaki, T., see Thao, X.-J., 1327S(-)-4-{-[2-(Isochroman-1-yl)ethyl]pipera-

zin-lyl)benzenesulfonamide, seeU-101387

Isoquinoline sulfonamides, effects on pan-etal cell function, in rabbit, 97

l(5-Isoquinolinesulfonyl)-2 methyl pipera-zine, effects on parietal cell func-tion, in rabbit, 97

Itching, allergic conjunctival, mediationby ketorolac, 137

Itier, V., Granger, P., Perrault, G., Depoor-tore, H., Scatton, B. and Avenet,P.: Protracted treatment with di-azepam reduces benzodiazepine1receptor-mediated potentiation of

‘y-aminobutyric acid-induced cur-rents in dissociated rat hippocam-pal neurons, 1092

Ito, C., Onodera, K., Sakurai, E., Sato, M.and Watanabe, T.: Effects of do-

pamine antagonists on neuronalhistamine release in the striatumof rats subjected to acute andchronic treatments with metham-phetamine, 271

Ito, K., see Nomura, Y., 830Itoh, Y., see Masuda, Y., 675Iversen, P., see Sato, M., 298Iwao, H., see Kim, S., 983Izumi, F., see Minami, K., 838

Jachec, C., see Varney, M. A., 367Jackman, H. L., see Deddish, P. A., 1582Jackson, B. K., see Carcfflo, J. A., 1197Jackson, E. K., see Vyas, S. J., 114Jackson, B. K., Mi, Z., Koehler, M. T., Car-

cillo, J. A., Jr. and Herzer W. A.:Injured erythrocytes releaseadenosine deaminase into the cir-culation, 1250

Jan, 5., see Kolesnikov, Y. A., 502Janssen, L. J. and Wattie, J.: Non-neuro-

genic electrically evoked relax-ation in canine airway muscle in-volves action of free radicals onK’ channels, 813

Janssen, M., see De Ryck, M., 748

Jiang, M., see Tseng, G.-N., 865Johansson, J. S., Rabanal, F. and Dutton,

P. L: Binding of the volatile an-esthetic halothane to the hydro-

phobic core of a tetra-a-helix-bundle protein, 56

Johnson, E. C., see Varney, M. A., 367Johnson, S. W., see Wu, Y.-N., 457Jordan, S. see Matulka, IL A., 3Joseph, T., Coirault, C., Ducros, L., and

Lecarpentier, Y.: Mechanical andenergetic effects of cromakalim

on guinea pigleft ventricular pap-illary muscle, 464

Jou#{235}t,P. and Sarna, S. K.: Platelet-activating factor (PAY) stimu-lates giant migrating contrac-tions during ileal inflammation,207

K-7259, effects on PALCAR-induced me-chanical derangement, in ratheart, 32

Kathorn, T. see Bennett, G. D., 1237Kallender, H., see Wilson, S., 214Kamendulis, L M., Brzezinski, M. R., Pin-

del, E. V., Bosron, W. F. andDean, R. A.: Metabolism of co-caine and heroin is catalyzed bythe same human liver carboxyles-terases, 713

Kaminuma, 0., Mori, A., Suko, M.,Kikkewa, H., Ikezawa, K. andOkudaira, H.: Interleukin-5 pro-duction by peripheral bloodmononuclear cells of asthmaticpatients is suppressed by T-440:Relation to phosphodiesterase in-hibition, 240

Kanagawa, K., see Tachibana, I., 1404Kanazawa, T., see Murakami, M., 877Kato, Y., see Kim, S., 983

Katz, see Sparago, M., 1043Kawata, A., see Masuda, Y., 675

Keersmaekers, R., see De Ryck, M., 748

Kenney, S., see Vistica, D. T., 1018Keratin, succinylated fragment, SOD con-

jugate, effects, 162Ketorolac, antipruritic effects, 137Khroyan, T. V., see Baker, D. A., 392Kidney, see also under Renal

cAMP release, angiotensin II effects on,in spontaneously hypertensiverat, 114

GABA agonist effects on, in rat, 602oligonucleotide disposition, in rat, 284paraquat transport, in LLC-PK1 cells,

625proximal tubules

basolateral organic cation transportsystem, in rabbit, 1086

nitric oxide generation by, 91Kidney cortex, dicarboxylate carrier, flue-

rescein interactions, in rat mite-chondria, 1559

Kidney damage, carvedilol effects on, instroke-prone spontaneously hy-pertensive rats, 948

Kidney failure, in endotoxemia, norepi-nephrine combined with Re 20-1724 treatment, in rats, 1197

Kikkewa, H., see Kaminuma, 0., 240Kikuchi, T., see Masuda, Y., 675Kim, R. B., Yamazaki, H., Chiba, K.,

O’Shea, D., Mimura, M.,Guengerich, F. P., Ishizaki, T.,

Shimada, T. and Wilkinson, G.R.: In vivo and in vitro character-ization ofCYP2E1 activity in Jap-

anese and Caucasians, 4

Kim, S., Hamaguchi, A., Shinkawa, T.,Kato, Y., Tsuchiya, N., Miura, K.,

Ohta, K. and Iwao, H.: Moleculareffects of M17055, furosemideand thiazide on cardiac hypertro-phy of spontaneously hyperten-sive rats, 983

Kinaseinhibitor effects on superoxide genera-

tion in HL-60 cells, 633inhibitor SB 203580, pharmacological

proffle, in animal models, 1453mitogen-activated protein, activation by

serotonin, in vascular smoothmuscle, 1541

King, S. A., see Bebok, Z., 1462Kininase II, characterization and proper-

ties, 1582Kinukawa, M., see Murakami, M., 877Kirk, K. L., see Beb#{246}k,Z., 1462

Kistard, J. A., see Widness, J. A., 1205Klaassen, C. D., see Liu, L., 386Kleven, M. S. and Kook, W.: Differential

effects ofdirect and indirect dopa-mine agonists on eye blink rate in

cynomolgus monkeys, 1211Knecht, M., see Todaka, K., 120Knippenberg, R. W., see Kudlacz, E. M.,

732Knott, P. G., Fernandes, L. B., Henry, P. J.

and Goldie, R. G.: Influence of en-dothelin-1 on cholinergic nerve-mediated contractions and acetyl-choline release in rat isolatedtracheal smooth muscle, 1142

Kobayashi, T., Matsuno, K., Nakata, K.and Mita, S.: Enhancement ofacetylcholine release by SA4503,a novel o� receptor agonist, in therat brain, 106

Koehler, M. T., see Jackson, E. K., 1250

Koek, W., see Kleven, M. S., 1211Kolesnikov, Y. A., Jam, S., Wilson, R. and

Pasternak, G. W.: Peripheralmorphine analgesia: Synergywith central sites and a target ofmorphine tolerance, 502

Kontaxi, M., Eckhardt, U., Hagenbuch, B.,Stieger, B., Meier, P. J. and Petz-inger, E.: Uptake of the myco-toxin ochratoxin A in liver cellsoccurs via the cloned organic an-ion transporting polypeptide,1507

Kostenis, E., see Tranlde, C., 926Koudriakova, T., Iatsimirskaia, E., Thle-

baev, S., Spetie, D., Utkin, I.,Mullet, D., Thompson, T., Vouros,

P. and Gerber, N.: In vivo dispo-sition and metabolism by liverand enterocyte microsomes of theantitubercular drug rifabutin inrats, 1300

Kozlowski, R. Z., see Salter, K. J., 1053Kraft, A. S., see Bebok, Z., 1462Kramer, U., see Wiegand, H., 891Krause, D. N., see Duckles, S. P., 1Kreeger, J. S. and Larson, A. A.: The sub-

stance P amino-terminal metabo-lite substance P(l-7), adminis-tered peripherally, prevents thedevelopment of acute morphinetolerance and attenuates the ex-pression of withdrawal in mice,662

1996 Index 1599

Kreek, M. J., see Yu, J., 507Kreek, M. J., see Zhou, Y., 351Kudlacz, E. M., Knippenberg, R. W., Lo-

gan, D. E. and Burkholder, T. P.:Effect ofMDL 105,212, a nonpep-tide NK-1/NK-2 receptor antago-nist in an allergic guinea pigmodel, 732

Kuhar, M. J., see Fleckenstein, A. E., 200

Kukkonen, J. P., Nasman, J., Ojala, P.,Oker-Blom, C. and Akerman, E.0.: Functional properties of mus-carinic receptor subtypes Hml,Hm3 and Hm5 expressed in Sf9

cells using the baculovirus ex-pression system, 593

Kulagowski, J. J., see Bristow, L. J., 492Kuo, A., see Muzykantov, V. R., 1026Kurl, R. N., see Olnes, M. J., 1566Kushiku, K., see Mukai, M., 822Kv4.2, blockade by 4-aminopyridine, 865Kvl.2, quiidine effects on, 844

Kwon, V., Lee, R. D. and Morris, M. E.:Hepatic uptake of choline in ratliver basolateral and canalicularmembrane vesicle preparations,774

L-701,324, anticonvulsant and behavioral

profile, 492L929 cells, effects of endogenous TNF

against, 84Lacal, P. M., D’Atri, S., Orlando, L., Bon-

massar, E. and Graziarn, G.: Invitro inactivation of human O�-alkylguanine DNA alkyltrans-ferase by antitumor triazene com-pounds, 416

Lactate, serum, reduction by sodium di-chioroacetate, 686

Ladurner, A., see Wilson, S., 214LaForge, K. S., see Zhou, Y., 351Laker, I., see Xie, H., 668Lansac, N., see Harvie, P., 1009Laragh, J. H., see Barone, F. C., 948Larson, A. A., see Kreeger, J. S., 662Laser desorption/ionization mass spec-

trometry, matrix-assisted, dynor-phin A (1-17) biotransformation,human and rhesus monkey blood,507

Laudignon, N., see Desta, B., 1077Lazzaro, V. A., see Chan, B. S. H., 625Le Stunif, H., see Gr#{233}lot,L., 255Lead

allosteric structures, 926neurotoxicity and apoptotic effects, in

newborn rat, 435NMDA receptor effects, in rat hippocam-

pal neurons, 143Lecarpentier, Y., see Joseph, T., 464Lee, J. C., see Badger, A. M., 1453Lee, R. D., see Kwon, Y., 774Lee, R. P., see Forkert, P. G., 1484

Lee, S-F., see Nigam, R., 1527Leeson, P. D., see Bristow, L. J., 492Lefebvre, M., Caille, G. and Du Souich, P.:

Organ-specific pattern of inhibi-tion of diltiazem metabolism atsteady state in rabbits, 902

Lefer, A. M., see Delyani, J. A., 1174Left ventricular papillary muscle,

mechano-energetic effects of cro-

makalim on, in guinea pig, 464Lemaire, M., see Yamada, T., 1357

Leminoprazole, cytoprotective effects, inrabbit gastric mucosal cells, 975

Leon, I., see Meade, C. J., 1148

Lesage, A. S., Peeters, L. and Leysen, J.E.: Lubeluzole, a novel long-termneuroprotectant, inhibits the glu-tamate-activated nitric oxide syn-thase pathway, 759

Levine, R. A., see Nandi, J., 97Levosimendan, effects on myocardial con-

tractility and oxygen consump-tion, 120

Levy,A. D.,seeLi,Q., 1261Lewis, J. W., see Butelman, B. R., 934

Lewis, J. W., see Zernig, G., 23Lewis, S. J., see Peters, T. S., 918Leysen, J. E., see Lesage, A. S., 759Li, Q., Muma, N. A. and Van De Kar, L. D.:

Chronic fluoxetine induces agradual desensitization of 5-HT�receptors: Reductions in hypotha-lamic and midbrain G. and G0proteins and in neuroendocrineresponses to a 5-HT1A agonist,1035

Li, Q., Murakami, I., Stall, S., Levy, A. D.,Brownfield, M. S., Nichols, D. E.and Van de Kar, L. D.: Neuroen-docrine pharmacology ofthree se-rotonin releasers: 1-(l,3-Benzodi-oxol-5-yl)-2-(methylamino)butane(MBDB), 5-methoxy-6-methyl-2-aminoindan (MMAI) and p-meth-ylthioamphetamine (MTA), 1261

Lichtman, A. H., Meng, Y. and Martin, B.R.: Inhalation exposure to volatil-ized opioids produces antinocicep-tion in mice, 69

Ling, S., see Tseng, G.-N., 844Lipid-mediated gene transfer, plasmid do-

livery efficiency after, 1462Lipid A, cytotoxicity, nitric oxide effects in,

91Lipopolysaccharide, inhibition of ACh-

and NO-mediated vasodilationby, 918

Liposome-mediated gene transfer, plas-mid delivery efficiency after, 1462

Lippiello, P. M., see Bencherif, M., 1413Lippiello, P. M., Bencherif, M., Gray, J. A.,

Peters, S., Grigoryan, G., Hodges,H. and Collins, A. C.: RJR-2403:A nicotinic agonist with CNS so-lectivity II. In vivo characteriza-tion, 1422

Liu, L. and Klaassen, C. D.: Ontogeny andhormonal basis of female-domi-nant rat hepatic sulfotrans-ferases, 386

Liu, W., see Abrahams, T. P., 967Liver

acetaminophen toxicity, cholesterylhemisuccinate protection against,1470

choline uptake, in rat basolateral mem-brane vesicles and canalicularmembrane vesicles, 774

cocaine toxicity, in rat, 359cytochrome P450

inhibition during diltiazem biotrans-formation, in rat, 1447

isoforms in quinine metabolism, 1327cytochrome P450 2D inactivation, impi-

pramine-induced, in rat micro-somes, 724

heroin metabolism, carboxylesterase-mediated, 713

membrane vesicles, choline uptake, inrat, 774

microsomesquinine metabolism, cytochrome P450

isoforms in, 1327stanozolol binding site, in male rat,

1123ochratoxin A uptake, 1507rifabutin metabolism, in rats, 1300sulfotransferases, female-dominant, on-

togeny and hormonal basis, 386Livni, E., see Christian, B. T., 325Llansola, M., see Mi#{241}na, M.-D., 194LLC-PK1 cells, paraquat transport by, 625Locomotion, cocaine-induced, intra-ac-

cumbens sulpiride and, 392

Logan, D. E., see Kudlacz, E. M., 732Look, Z., see Bowman, M. A., 790Lookingland, K., see Merchant, K. M.,

1392Lopez-Anaya, A., see Aleo, M. D., 1318Loscher, W., Rundfeldt, C., H#{246}nack, D.

and Ebert, U.: Long-term studieson anticonvulsant tolerance andwithdrawal characteristics ofbenzodiazepine receptor ligandsin different seizure models inmice. I. Comparison of diazepam,clonazepam, clobazam and abe-

carnil, 561Loscher, W., Rundfeldt, C., H#{246}nack, D.

and Ebert, U.: Long-term studieson anticonvulsant tolerance andwithdrawal characteristics ofbenzodiazepine receptor ligandsin different seizure models inmice. II. The novel imidazoquina-zolines NNC 14-0185 and NNC

14-0189, 573Lovette, M. E., see Bencherif, M., 1413

Lowe, L. S., see Widness, J. A., 1205Lubeluzole, neuroprotective effects

in focal ischemia, in rat photochemicalstroke model, 748

against glutamate toxicity, 759Luchetta, R., see Bowman, M. A., 790Ludbrook, G. L., see Mather, L. E., 291Lung

arterial myocytes, endothelin receptorcoupling to potassium and chlo-ride channels in, in rat, 1053

1,1-dichloroethylene metabolism, inadult and weanling mice, 1484

fibrinolytic targeting to, 1026stretch receptors, inhibitory effects of

CO2 inhalation on, in rabbit, 402vasculature, antibody-conjugated plas-

minogen activator targeting to,1026

Luther, R. R., see Bowersox, S. S., 1243Lutzke, B. S., see Merchant, K. M., 1392

Luzardo, 0. P., see Boada, L. D., 1123Lynch, D. R. and Gallagher, M. J.: Inhibi-

tion of N-methyl-D-aspartate re-ceptors by haloperidol: Develop-mental and pharmacologicalcharacterization in native and re-combinant receptors, 154

M17055, effects on cardiac hypertrophy, inspontaneously hypertensive rats,983

Ma, Y., Hurst, H. E. and Fernandez-Botran, R.: Soluble cytokine re-

1600 Index

ceptors as carrier proteins: Ef-fects of soluble interleukin-4receptors on the pharmacokinet-ics of murine interleukin-4, 340

Maclaren, N. K., see Bowman, M. A., 790Maeda, H., see Noda, J., 162Maeda, N., see Yamazaki, M., 1157Maggos, C. E., see Thou, Y., 351Mahato, R. I., see Sawai, K., 284Mancuso, T., see Debernardis, D., 84Mandema, J. W., see Hoogerkamp, A., 803Mao, L. and Abdel-Rahman, A. A.: Syner-

gistic behavioral interaction be-tween ethanol and clonidine inrats: Rele of alpha-2 adrenocep-tors, 443

MAPK, see Mitogen-activated protein ki-nase

Marchioro, M., Swanson, K. L., Aracava,Y. and Albuquerque, E. X.: Gly-cine- and calcium-dependent ef-fects oflead on N-methyl-D-aspar-tate receptor function in rathippocampal neurons, 143

Mariner, J. M., see Currens, M. J., 645Mariner, J. M., see Currens, M. J., 652Markham, P., see Nomeir, A. A., 222Marks, N., see Oberto, A., 435Markus, R. P., Zago, W. M. and Carneiro,

R. C. G.: Melatonin modulation ofpresynaptic nicotinic acetylcho-line receptors in the rat vas defer-ens, 18

Martin, B. R., see Lichtman, A. H., 69Maruyama, K., see Murakami, M., 877Masci, G., see Prete, S. P., 1574Masereeuw, R., Saleming, W. C., Miller, D.

S. and Russel, F. G. M.: Interac-tion of fluorescein with the dicer-boxylate carrier in rat kidney cor-tex mitochondria, 1559

Masonis, A. B. T. and McCarthy, M. P.:Effects ofthe androgenic/anabolicsteroid stanozolol on GABAA re-ceptor function: GABA-stimu-lated 36C1 influx and [355] TBPSbinding, 186

Mass spectrometry, matrix-assisted laserdesorption/ionization, dynorphinA (1-17) biotransformation, hu-man and rhesus monkey blood,507

Massi, P., see Patrii, G., 172Masubuchi, Y., Igarashi, S., Suzuki, T.,

Hone, T. and Narimatsu, S.: Imi-pramine-induced inactivation of acytochrome P450 2D enzyme inrat liver microsomes: In relationto covalent binding of its reactiveintermediate, 724

Masuda, Y., Sugo, T., Kikuchi, T., Kawata,A., Satoh, M., Fu.jisawa, Y., Itoh,Y., Wakimasu, M. and Ohtaki, T.:Receptor binding and antagonistproperties of a novel endothelinreceptor antagonist, TAK-044 {cy-clo[-D-a-aspartyl-3-[(4-phe-nylpiperazin-1-yl)carbonyll-L-ala-

nyl-L-a-aspartyl-D-2-(2-thienyl)glycyl-L-leucyl-D-tryptophyl]disodium salt), inhuman endothelinA and endo-thelin9 receptors, 675

Mather, L. E., Upton, R. N., Huang, J. L.,Ludbrook, G. L., Gray, E. and

Grant, C.: The systemic and cere-bra! kinetics of thiopental insheep: Enantiomeric analysis,291

Matheson, S., see Bristow, L. J., 492Mathewson, C., see Picker, M. J., 1130Math#{244}t,R. A. A., Van der Wenden, B. M.,

Soudijn, W., Breimer, D. D., Ijz-erman, A. P. and Danhof, M.: Par-tial agonism of the nonselectiveadenosine receptor agonist 8-bu-tylaminoadenosine at the A1 ro-ceptor in vivo, 1439

Mathur, R. S., see Higashiura, K., 1386Matrix-assisted laser desorption/ioniza-

tion mass spectrometry, dynor-phin A (1-17) biotransformation,human and rhesus monkey blood,507

Matsumoto, S., Okamura, H., Suzuki, K.,Sugai, N. and Shiniizu, T.: Inhib-itory mechanism of CO2 inhala-tion on slowly adapting pulmo-nary stretch receptors in theanesthetized rabbit, 402

Matsuno, K., see Kobayashi, T., 106

Matsuoka, N., see Yamazaki, M., 1157Matuilca, R. A., Jordan, S. D., Stanulis, E.

D. and Holsapple, M. P.: Evalua-tion of sex- and strain-depen-dency of cocaine-induced immu-nosuppression in B6C3F1 andDBA/2 mice, 3

Mayer, A. M. S., Brenic, S. and Glaser, K.B.: Pharmacological targeting ofsignaling pathways in protein ki-nase C-stimulated superoxidegeneration in neutrophil-likeHL-60 cells: Effect of phorbol es-ter, arachidonic acid and inhibi-tors of kinase(s), phosphatase(s)and phospholipase A�, 633

Mayer, R. J., see Winkler, J. D., 956Mayeux, P. R., see Traylor, L. A., 91Mazzola-Pomietto, P., Aulakh, C. S.,

Huang, S.-J. and Murphy, D. L.:Repeated administration of meta-chiorophenylpiperazine or 1-(2,5-dimethoxy-4-iodophenyl)-2-amin-opropane produces tolerance toits stimulatory effect on adreno-corticotropin hormone but notprolactin or corticosterone secre-tion in rats, 782

Mazzone, A., see Patrini, G., 172Mazzuccheffi, I., see Patrini, G., 172MBDB, see 1-(1,3-Benzodioxol-5-yl)-2-

(methylamino)butaneMcCall, R. B., see Merchant, K. M., 1392McCarthy, M. P., see Masonis, A. E. T., 186

McCook, C., see Slotkin, T. A., 478MCI-154, effects on ischemic dysfunction,

in guinea pig heart, 47McIntosh, L. J., see Wiegand, H., 891McMahon, J. B., see Currens, M. J., 645McMahon, J. B., see Currens, M. J., 652m-CPP, see Meta-chiorophenylpiperazineMcQuade, R., see Gartside, S. B., 277MDL 105,212, effects in allergic response,

in guinea pig model, 732MDL 105,519, NMDA receptor-glycine

site, 62MDMA, see 3,4-Methylenedioxymetham-

phetamine

Vol. 279

Meade, C. J., Mierau, J., Leon, I. and Ens-inger, H. A.: In vivo role of theadenosine A3 receptor: N#{176}-2-(4-Aminophenyl)ethyladenosine in-duces bronchospasm in BDE ratsby mast-like cell-mediated andneurally mediated mechanisms,1148

Meier, P. J., see Kontaxi, M., 1507Melanoma, B16 tumor progression, anti-

IL4 effect on, 472Melatonin, modulation of nAChRS by, in

rat vas deferens, 18Memory, enhancement by FK960, in rats,

1157Meng, Y., see Lichtman, A. H., 69Meperidine, inhalation exposure, antinoci-

ceptive effects, in mice, 69Merchant, K. M., Gifi, G. S., Harris, D. W.,

Huff, R. M., Eaton, M. J., Look-ingland, K., Lutzke, B. S., Mc-Call, R. B., Piercey, M. F.,Schreur, P. J. K. D., Sethy, V. H.,Smith, M. W., Svensson, K. A.,Tang, A. H., Vonvoigtlander, P. F.and Tenbrink, R E.: Pharmaco-logical characterization ofU-101387, a dopamine D4 recep-tor selective antagonist, 1392

Mesangial cells, fibronectin turnover, sill-binin effects on, 1520

Mesenteric blood flow, in endotoxemia,norepinephrine combined with Re20-1724 and, in rats, 1197

Messenger RNA

CRF and CRF-Rl, levels after binge co-

caine administration, in rat, 351Egr-1, neural control of, in rat adrenal

gland, 379Metabolic stress, hypothermia and neuro-

protection against, 332Metabolism

diltiazemorgan-specific, in rabbits, 902P450 inhibition during, in rat liver,

1447

glyceryl trinitrate, by rat aortic GSTs,1527

heroin, esteraso-mediated, 713methylether derivative of (±)-

BW373U86, 1069

nalidixic acid, species differences in, 222quinine, by cytochrome P450 isoforms,

in liver, 1327rifabutin, in rats, 1300

Meta-chlorophenylpiperazine, neuroendo-crine effects, tolerance, 782

Metastasis, tumor, anti-IL4 effect on, 472Met-enkephalin, see Methionine enkepha-

lin

METH, see MethamphetamineMethadone, combined with morphine, opi-

old receptors and, on murinesplenocytes, 172

Methamphetamine, acute and chronic, ef-fects on neuronal histamine ro-lease, in rat striatum, 271

Methcathinone, enantiomer effects, 1043Methionine enkephalin, antiviral effects,

in murmne cells, 1268

Methoclocinnamox, agonist and antago-nist effects, in rhesus monkeys,934

5-Methoxy-6-methyl-2-aminoindan, neu-roendocrine pharmacology, 1261

1996 Index 1601

N-[(Methylamine)ethyl]-5-isoquinolinesulfonamide, effects on parietalcell function, in rabbit, 97

N-Methyl-D-aspartate, currents in dopa-mine neurons, in rat brain, 457

N-Methyl-D-aspartate receptorsantagonist L-701,324, behavioral pro-

file,492inhibition by dynorphin, 1063inhibition by haloperidol, 154[3H]MDL 105,519-glycine site, 62modulation by lead, in rat hippocampal

neurons, 143recombinant human subtypes

NMDAR1A/2A and NMDAR1A/

2B, in mammalian cells, 367subunit-transfected CHO cells, acquired

excitotoxicity in, 5153,4-Methylenedioxymethamphetamine,

repeated, effects on 5-HT func-

tion, in rat brain, 277O6-Methylguanine-DNA methyifrans-

ferase, see 0#{176}-Alkylguanine DNAalkyltransferase

2-Methyl-4aa-(3-hydroxyphenyl)-1,2,3,4,4a,5,l2,l2aa-octahydro-quinolino [2,3,3,-g] isoquinoline,see TAN-67

(E)-N-Methyl-4-(3-pyridinyl)-3-butene-l-amine, see RJR-2403

p-Methylthioamphetamine, neuroendo-crime pharmacology, 1261

Meyer, E. R., see Cicero, T. J., 767Mi, Z., see Carcillo, J. A., 1197Mi, Z., see Jackson, E. K., 1250Mi, Z., see Vyas, S. J., 114Michel, B., see Deddish, P. A., 1582Microsomes

impipramine-induced inactivation ofCYP2D in, in rat liver, 724

quinine metabolism, cytochrome P450isoforms in, 1327

stanozolol binding site, in male rat liver,1123

Midazolam, anticonvulsant effects, in di-rect cortical stimulation model,803

Mierau, J., see Meade, C. J., 1148

Migrating contractions, giant, PAY-in-duced, during ileal inflammation,207

Milano, S., see Gr#{233}lot,L., 255Miller, D. S., see Masereeuw, R., 1559Miller, L. J., see Holtmann, M. H., 555Miller, V. M., see Duckles, S. P., 1Mimura, M., see Kim, R. B., 4Minami, K., Yanagihara, N., Segawa, K.,

Sata, T., Tsutsui, M., Shige-matsu, A. and Izumi, F.: Inhibi-tion by protamine of catechol-amine secretion and ion influxes

in bovine adrenal medullary cellsin culture, 838

Mifina, M.-D., Hermenegildo, C., Llansola,M., Montoliu, C., Grisoli, S. andFelipo, V.: Carnitine and cholinederivatives containing a trimeth-

ylamine group prevent ammoniatoxicity in mice and glutamatetoxicity in primary cultures ofneurons, 194

Misawa, M., see Suzuki, T., 177Mite, S., see Kobayashi, T., 106Mitchell, J. A., see Damiano, B. P., 1365Mitochondria

cocaine-induced peroxidative stress ef-fects on, in rat liver, 359

dicarboxylate carrier, fluorescein inter-actions, in rat kidney cortex, 1559

Mitogen-activated protein kinaseactivation by serotonin, in vascular

smooth muscle, 1541effects on superoxide generation in

HL-60 cells, 633

Miura, K., see Kim, S., 983Miyagi, M., see Murakami, M., 877Miyata, H., see MUrakami, M., 877MMAI, see 5-Methoxy-6-methyl-2-amin-

oindanMohr, K., see Trankle, C., 926Monasterolo, L. A., see Trumper, L., 548

Monasterolo, L. A., Trumper, L., andElfas, M. M.: Effects of ‘y-ami-nobutyric acid agonists on the iso-lated perfused rat kidney, 602

Monoamine oxidase B inhibitors, i..-depre-nyl, effects on excitatory synaptictransmission, in rat hippocam-pus, 740

Monoclonal antibody, anti-IL4, effect ontumor metastasis, 472

Mononuclear cells, peripheral blood, IL-5suppression by T-440 in, 240

Montoliu, C., see Mifina, M.-D., 194Moran, R. A., see Currens, M. J., 645Moran, T., see Varney, M. A., 367Morgan, E., see Higashiura, K., 1386Mori, A., see Kaminuma, 0., 240Mori, T., see Suzuki, T., 177Morita, K., Bell, R. A., Siddall, B. J. and

Wong, D. L.: Neural stimulationof Egr-1 messenger RNA expres-sion in rat adrenal gland: Possi-ble relation to phenylethano-lamine N-methyltransferase generegulation, 379

Morphineacute, tolerance, substance P(1-7) ef-

fects on, 662

antinociceptive effectsgender-related differences in, 767pertussis toxin and, in mouse, 39

combined with methadone, opioid recep-tors and, on murine splenocytes,172

combined with �9-THC, dynorphinsand, in spinal cord, 608

dependence, substance P(1-7) effects on,662

inhalation exposure, antinociceptive ef-fects, in mice, 69

peripheral analgesia, 502place preference induced by, TAN-67 ef-

fects on, in mice, 177Morris, M. E., see Kwon, Y., 774Morrison, J. H., see Varney, M. A., 367Morrow, J. D., see Brown, N. J., 703Mortality, carvedilol effects on, in stroko-

prone spontaneously hyperten-sive rats, 948

Morth, D. M., see Hohage, H., 1086

Motor nerve terminals, calcium channelsin, w-agatoxin-WA and w-cono-toxin-MVIIC effects on, in mouse,1229

Moxonidine, platelet I� binding sites, 694MTA, see p-MethylthioamphetamineMucosa, gastric, leminoprazole cytoprotec-

tion in, in rabbit, 975

Mukai, M., Kushiku, K., Yamada, H.,Yamada, K., Dan, K. and Fu-rukawa, T.: The inhibition of gan-glionic transmission via presyn-aptic dopamine DA1 andpostsynaptic DA� receptor activa-tion in the canine cardiac sympa-thetic ganglia, 822

Muller-Ehmsen, J., Brixius, K., Hoischen,S., and Schwinger, R. H. G.: Ino-tropic and coronary vasodilatoryactions of the K-adenosinetriphosphate channel modulatornicorandil in human tissue, 1220

Mullet, D., see Koudriakova, T., 1300Muma, N. A., see Li, Q., 1035Mumaw, V. R., see Ray, S. D., 1470Murakami, I., see Li, Q., 1261Murakami, M., Kinukawa, M., Kanazawa,

T., Maruyama, K., Miyagi, M.,Miyata, H. and Ujiie, A.: Effectsofthe new class I antiarrhythmicagent Re 22-9194, (2R)-2-amino-N-(2,6-dimethylphenyl)-N-[3-(3-pyridyl)propyllpropionamide D-tartrate, on ischemia- andreperfusion-induced arrhythmiasin dogs: Involvement of throm-boxane A2 synthase inhibitory ac-tivity, 877

Murphy, D. L., see Mazzola-Pomietto, P.,782

Murphy, G. J., see Wilson, S., 214Murray, F., see Bristow, L. J., 492Murray, M. and Butler, A. M.: Enhanced

inhibition of microsomal cyto-chrome P450 3A2 in rat liver dur-ing diltiazem biotransformation,1447

Muscarinic receptorsaceclidine enantiomer interactions,

1335allosteric lead structures for, 926Hml, Hm3 and Hm5, functional proper-

ties, in Sf9 cells, 593-operated potassium currents, inhibi-

tion by amiodarone, 617Muscimol, renal effects, in rat, 602Muscle, see also Smooth muscle

airway, non-neurogenic relaxation in, incanine, 813

left ventricular papillary, mechano-energetic effects of cromakalimon, in guinea pig, 464

Mussap, C. J., Stamatakos, C. andBurcher, E.: Radioligand binding,autoradiographic and functionalstudies demonstrate tachykininneurokinin-2 receptors in dog urn-nary bladder, 423

Muzykantov, V. R., Barnathan, E. S.,Atochina, E. N., Kuo, A., Danilov,S. M. and Fisher, A. B.: Targetingof antibody-conjugated plasmino-gen activators to the pulmonaryvasculature, 1026

Mycotoxins, ochratoxin A, hepatocellulartransport, 1507

Myocardial ischemia/reperfusion injuryMCI-154 effects on, in guinea pig heart,

47NO-tPA effects against, in cats, 1174

Myocardiumcontractility, levosimendan effects on,

120

1602 Index Vol. 279

function, MCI-l54 effects on, in guineapig heart, 47

oxygen consumption, levosimendan ef-fects on, 120

TNF-a production in, modulation byPDE inhibitors, 247

Myocytes

pulmonary arterial, endothelin receptorcoupling to potassium and chlo-ride channels in, in rat, 1053

ventricular, cGMP effects on L-type cal-cium current and contractions in,in guinea pig, 1274

Myometrium, TP receptors in, 262

Nadeau, J., see Brown, N. J., 703Nagase, H., see Suzuki, T., 177Nakano, T., see Abe, Y., 47Nakata, K., see Kobayashi, T., 106Nakaya, H., see Watanabe, Y., 617Nalidixic acid, disposition and metabolism

of, species differences in, 222Naltrexone, effects on cocaine/opioid inter-

actions, in humans, 524Nandi, J., Bosche, M. C. and Levine, R. A.:

Effects of a phorbol ester and iso-quinoline sulfonamides on rabbitparietal cell function, 97

Naphazoline, platelet I� binding sites, 694Nanmatsu, S., see Masubuchi, Y., 724N#{228}sman, J., see Kukkonen, J. P., 593N-CPM-TAMO, see l4a,14’�3-[Dithiobis[(2-

oxo-2, 1-ethanediyl)imino-]]bis[7,8-dihydro-N-(cyclobutylm-

ethyl)-normorphinone]Necrosis, acetaminophen-induced, cho-

lesteryl hemisuccinate protectionagainst, 1470

Neichin, M. L., see Fox, A. W., 686Neisewander, J. L., see Baker, D. A., 392Nelson, A. H., see Barone, F. C., 948Nelson, S. D., see Bennett, G. D., 1237Neonates

exposed to phenobarbital, imprintedoverinduction of CYP2B1 and2B2 in, in adult rats, 991

lead neurotoxicity and apoptotic effectsin, in rat, 435

Nephrectomy, erythropoietin pharmacoki-netics after, in sheep, 1205

Nephrotoxicity, acetaminophen, in maleWistar rats, 548

Nervous systemcentral

effects of peptide drug delivery toblood-brain barrier on, in rats, 77

-selective agonist RJR-2403, in vitrocharacterization, 1413

-selective agonist RJR-2403, in vivocharacterization, 1422

enteric, in cryptosporidiosis, in piglet,1109

peripheral, morphine analgesia, 502sympathetic

inhibition by cocaine, blockade by ros-tral ventrolateral medullary al-pha-2 receptor, 967

inhibition by dopamine receptors, incanine heart, 822

Neurokinin receptorsNK-1INK-2 antagonist MDL 105,212, ef-

fects in allergic response, inguinea pig model, 732

NK-2, in dog urinary bladder, 423Neuroleptic response, cholinergic neurons

and, in mouse striatum, 1430

Neuromuscular junction, acetylcholine re-lease at, tetrandrine effects on, inmouse, 891

Neuronscholinergic, and catalepsy, in mouse

striatum, 1430dopamine, NMDA currents, in rat brain,

457Neuropathy

pain, SNX-111 spinal antinociception in,in rat models, 1243

vincristine, glutamate effects on, 410Neuroprotection

early hypothermic, against metabolicstress, 332

lubeluzole

in focal ischemia, in rat photochemicalstroke model, 748

against glutamate toxicity, 759Neurotoxicity

glutamatelubeluzole protective effects against,

759trimethylamine preventive effects

against, 194lead, in newborn rat, 435methcathinone enantiomers, 1043vincristine, glutamate effects on, 410

Neurotrophic factor, glial cell-line derived,functional effects, in rat striatum,1181

Newborns, see NeonatesNichols, D. E., see Li, Q., 1261Nicklas, W. J., see Zeevalk, G. D., 332Nicolodi, M., see Ghelardini, C., 884

Nicora, R., see Fox, A. W., 686Nicorandil, inotropic and coronary vasodi-

latory actions, in human tissue,1220

Nicotine, acute withdrawal, transdermalnicotine and, 450

Nicotinic receptorsagonist RJR-2403

in vitro characterization, 1413in vivo characterization, 1422

hippocampal, mapping, 1491melatonin modulation of, in rat vas do-

ferens, 18Nieves, A. L., see Woodward, D. F., 137Nigam, R., Anderson, D. J., Lee, S.-F. and

Bennett, B. M.: Isoform-specificbiotransformation of glyceryltrinitrate by rat aortic glutathi-one S-transferases, 1527

Niinuma, K., see Yamada, T., 1357Nishida, A., see Shimizu, M., 1551Nitric oxide

and cholecystokinin mechanisms of ac-tion, in canine GI tract, 306

generation by proximal tubules, 91-mediated vasodilation, inhibition by li-

popolysaccharide, 918-tissue-type plasminogen activator, pro-

tective effects against myocardialischemia/reperfusion injury, incats, 1174

Nitric oxide synthaseglutamate-activated pathway, inhibi-

tion by lubeluzole, 759inducible, vascular expression, and K�

channel activation, 1514Nitroso aromatic compounds, pyruvate do-

hydrogenase complex-catalyzedformation of N-arylacetohydrox-amic acid from, in rat, 1282

NK, see NeurokininNMDA, see N-Methyl-D-aspartateNNC 14-0185, tolerance and dependence

liability, in mice seizure models,573

NNC 14-0189, tolerance and dependenceliability, in mice seizure models,573

Nock, B., see Cicero, T. J., 767Noda, J., Otagiri, M., Akaike, T. and

Maeda, H.: Pharmacological ad-vantages of conjugation of Cu,Zn-superoxide dismutase with succi-nylated keratin fragment:Improvement ofbiological proper-ties and resistance to oxidativedamage, 162

Nomeir, A. A., Markham, P., Burka, L. T.,Griffin, R. J. and Ghanayem, B.I.: Species differences in the dis-position and metabolism of nali-dixic acid, 222

Nomura, Y., Asano, M., Ito, K., Uyama, Y.,Imaizumi, Y. and Watanabe, M.:Superficial sarcoplasmic reticu-lum calcium buffering of resting,voltage-dependent, Ca� � influxin rat femoral arterial smoothmuscle, 830

Norepinephnne, combined with Re 20-1724, treatment for endotoxemia,in rats, 1197

Normorphinone, N-cyclobutylmethyl ana-log binding and analgesia, 539

Nossuli, T. 0., see Delyani, J. A., 1174Nucleus reticularis gigantocellularis, an-

giotensin-alpha-2 receptor inter-actions, in rat, 795

Oberto, A., Marks, N., Evans, H. L. andGuidotti, A.: Lead (Pb�) pro-motes apoptosis in newborn ratcerebella neurons: Pathologicalimplications, 435

Ochratoxin A, hepatocellular transport,1507

1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine, apoptosis induc-tion by, in HL-60 cells, 956

Octreotide, tissue distribution and biliaryexcretion mechanism, 1357

O’Dell, L. B., see Baker, D. A., 392OGAT, see O6-Alkylguanine DNA alkyl-

transferaseOhkubo, Y., see Yamazaki, M., 1157Ohlstein, E. H., see Barone, F. C., 948Ohno, H., see Yoshioka, T., 1282Ohta, K., see Kim, S., 983Ohtaki, T., see Masuda, V., 675Ojala, P., see Kukkonen, J. P., 593Oka, Y., see Sawai, K., 284Okabe, S., see Takahashi, S., 975Okamura, H., see Matsumoto, S., 402Oker-Blom, C., see Kukkonen, J. P., 593Okudaira, H., see Kaminuma, 0., 240Oligonucleotides, renal disposition, in rat,

284Olnes, M. J., Verma, M. and Kurl, R. N.:

2,3,7,8-Tetrachlorodibenzo-p-di-oxin modulates expression of theprostaglandin G/H synthase-2gene in rat thymocytes, 1566

Omar, R. F., see Harvie, P., 1009

Onishi, K., see Abe, Y., 47Onodera, K., see Ito, C., 271

1996 Index 1603

Ontogeny, female-dominant sulfotrans-ferase, in rat liver, 386

Ooboshi, H., see Taguchi, H., 1514Opioid receptors

blockade by cloccinamox, 23delta

agonist effects on butorphanol dis-crimination, 1130

agonist TAN-67 effects on morphine-induced place preference, in mice,177

inhalation exposure, antinociceptive ef-fects, in mice, 69

kappaagonist effects on butorphanol dis-

crimination, 1130agonist effects on diuresis, in rats,

1379mu

agonist effects on butorphanol dis-crimination, 1130

N-CPM-TAMO antagonism, 539

N-CPM-TAMO agomsm, 539

splenocyte density, morphine and meth-adone effects on, in mouse, 172

Opioidscocaine interactions, 524methoclocinnainox, agonist and antago-

nist effects, in rhesus monkeys,

934and �9-THC combined with morphine,

in spinal cord, 608Organic cations, basolateral transport sys-

tem, in rabbit kidney proximal tu-bules, 1086

Orlando, L., see Lacal, P. M., 416; Prete, S.P., 1574

O’Reurke, R., see Fox, A. W., 686O’Shea, D., see Kim, R. B., 4Otagiri, M., see Noda, J., 162Otsuki, M., see Tachibana, I., 1404

Ottoboni, C., see Debernardis, D., 84Ovarian cancer, effects of endogenous

TNF in, 84OVCAR-8 cells, effects ofendogenous TNF

secreted by, 84Owan, I., see Sate, M., 298Oxazepam, anticonvulsant effects, in di-

rect cortical stimulation model,803

Oxcarbazepine, teratogenicity, in SWV

mouse, 1237Oxygen consumption, myocardial, levosi-

mendan effects on, 120Oz, M., see Brauneis, U., 1063

p38 kinase, inhibitor SB 203580, pharma-cological profile, in animal mod-els, 1453

Packer, M., see Todaka, K., 120Pain, neuropathic, SNX-lll spinal antino-

ciception in, in rat models, 1243PALCAR, see Palmitoyl-L-carnitine

Palmitoyl-L-carnitine, mechanical de-rangement induced by, dilazepand K-7259 effects on, in ratheart, 32

Pancetti, F. C., see Aguayo, L. G., 1116Pancreas, function, TP-680 effects on,

1404Papillary muscle, left ventricular,

mechano-energetic effects of cm-

makalim on, in guinea pig, 464

Pappano, A. J., see Shirayama, T., 1274Paraquat, renal transport, in LLC-PK1

cells, 625

Pardridge, W. M., see Wu, D., 77Panetal cells, H� secretion in, modulation

by PKC, in rabbit, 97Park, J. E., see Wilson, S., 214Parodi, S., see Debernardis, D., 84Parolaro, D., see Patrini, G., 172Passanil, M. B., see Pugliese, A. M., 1100Pasternak, G. W., see Kolesnikov, V. A.,

502Patch, nicotine, and acute nicotine with-

drawal, 450Patrii, G., Massi, P., Ricevuti, G., Maz-

zone, A., Fossati, G., Mazzucch-elli, I., Gori, E. and Parolaro, D.:Changes in opioid receptor den-sity on murine splenocytes in-duced by in vivo treatment withmorphine and methadone, 172

Payne, A., see Soulard, C. D., 1379Payne, N. A., see Gerber, J. G., 718PBMCs, see Peripheral blood mononuclear

cellsPCP, see PhencycidinePD098059, and serotonin activation of

MAPK, in vascular smooth mus-cle, 1541

Peck, A. B., see Bowman, M. A., 790Peeters, L., see Lesage, A. S., 759Pentagastrin, gastric acid secretion re-

sponse, inhibition by secretin, incanine, 718

Peoples, R. W., see Brauneis, U., 1063Pepeu, G., see Pugliese, A. M., 1100Peptide, blood-brain barrier drug delivery,

CNS effects, in rats, 77Pereira, E. F. R., see Alkondon, M., 1491Peripheral blood mononuclear cells, IL-S

suppression by T-440 in, 240Peripheral morphine analgesia, 502Peroxidative stress, cocaine-induced, in

rat liver, 359Perrault, G., see Itier, V., 1092Pertussis toxin, effects in morphine and

13-endorphin antinociception, inmouse, 39

PET, see Positron emission tomographyPeters, C., see Widness, J. A., 1205Peters, see Lippiello, P. M., 1422Peters, T. S. and Lewis, S. J.: Lipopolysac-

charide inhibits acetylcholine-and nitric oxide-mediated vasodi-lation in vivo, 918

Pettus, M., see Bowersox, S. S., 1243

Petzinger, B., see Kontaxi, M., 1507Phencyclidine, prepulse inhibition disrup-

tion, seroquel effects on, in rats,1290

Phenobarbital, neonatal exposure, im-printed overinduction of CYP2B1and 2B2 after, in adult rats, 991

(E)-3-(2-Phenyl-2-carboxyethenyl)-4,6-dichloro-1H-indole-2-carboxylicacid, see [3H]MDL 105,519

Phenylethanolamine N-methyltrans-ferase, gene regulation, and Egr-1mRNA expression, in rat adrenalgland, 379

Phorbol estereffects on parietal cell function, in rat>

bit, 97effects on superoxide generation in

HL-60 cells, 633Phosphatase, effects on superoxide gener-

ation in HL-60 cells, 633Phosphodiesterase inhibitors

modulation ofmyocardial TNF-a by, 247T-440, IL-S suppression by, in PBMCs,

240type N, Re 20-1724, for endotoxemia, in

rats, 1197Phospholipase A�, effects on superoxide

generation in HL-60 cells, 633Picker, M. J., Benyas, S., Horwitz, J. A.,

Thompson, K., Mathewson, C.and Smith, M. A.: Discriminativestimulus effects of butorphanol:Influence of training dose on thesubstitution patterns producedby mu, kappa and delta opioidagonists, 1130

Pickworth, W. B., Fant, R. V., Butschky,M. F. and Henningfield, J. E.: Ef-fects of transdermal nicotine do-livery on measures of acute nice-tine withdrawal, 450

Piercey, M. F., see Merchant, K. M., 1392Piletz, J. E., Thu, H. and Chikkala, D. N.:

Comparison of ligand binding aS-finities at human I1-imidazolinebinding sites and the high affinitystate of alpha-2 adrenoceptorsubtypes, 694

Pindel, E. V., see Kamendulis, L. M., 713Pituitary gland, CRF and CRF-Rl mRNA

levels after binge cocaine admin-istration, in rat, 351

Place preferencecocaine-induced, intra-accumbens

sulpiride and, 392morphine-induced, TAN-67 effects on, in

mice, 177Plasma cocaine, arterial and venous con-

centrations, 1345Plasmid delivery, efficiency after lipid-

mediated gene transfer, 1462Plasminogen activators

antibody-conjugated, targeting to pul-monary vasculature, 1026

S-nitrosylated tissuo-type, protective ef-fects against myocardial isch-emia/reperfusion injury, in cats,1174

Platelet-activating factor, contractile ef-

fects, during ileal inflammation,207

Platelets, imidazoline binding sites, 694PNMT, see Phenylethanolamine N-meth-

yltransferasePogun, S., see Fleckenstein, A. E., 200Porreca, F., see Schetz, J. A., 1069Positron emission tomography

cerebral BMS-181101 pharmacokineticsby, 325

of ziprasidone and 5�’F2 receptors, 939Potassium channels

activation, NO-synthase expressionand, 1514

Ca � k-activated, w-agatoxin-IVA andw-conotoxin-MVIIC effects on, inmouse motor nerve terminals,1229

endothelin receptor coupling, in rat pul-

monary arterial myocytes, 1053free radical effects on, in non-neurogenic

relaxation, in canine airway mus-cle, 813

Kvl.2 clone, quiidine effects on, 844Kv4.2 clone, blockade by 4-aminopyri-

dine, 865

1604 Index Vol. 279

mAChR-operated, inhibition by amioda-rone, in guinea pig atrial cells,617

slow delayed rectifier, blockade by quin-idine, 856

Potassium-ATP channel openers, nicoran-di!, inotropic and coronary vase-dilatory actions, 1220

Prepulse inhibition, disruption by phen-cycidine, seroquel effects on, inrats, 1290

Preston, K. L., see Walsh, S. L., 524Prete, S. P., Aquino, A., Masci, G., Or-

lando, L., Giuliani, A., De Santis,S., De Vecchis, L., De Filippi, R.,Greiner, J. W., Bonmassar, E.and Graziani, G.: Drug-inducedchanges of carcinoembryonic an-tigen expression in human cancercells: Effect of 5-fluorouracil,1574

Proksch, J. W., see Traylor, L. A., 91Propranolol, effects on survival in stroke-

prone spontaneously hyperten-sive rats, 948

Prostacyclin, bradykinin response, ACEinhibitor effects on, 703

Prostaglandin D2 receptors, effects inprostanoid-induced conjunctivalpruritus, 137

Prostaglandin E2 receptors, effects inprostanoid-induced conjunctival

pruritus, 137Prostaglandin G/H synthase-2, gene ex-

pression, in rat thymocytes, 1566

Prostaglandin 12mediation by enteric nerves, in piglet

cryptosporidiosis, 1109receptor effects in prostanoid-induced

conjunctival pruritus, 137Prostaglandins, pruritogenic, 137Prostanoids, TP receptors, in human non-

pregnant myometrium, 262Protamine, catecholamine secretion and

ion channel inhibition by, in ho-vine adrenal medullary cells, 838

Protein kinase Ceffects on superoxide generation in

HL-60 cells, 633in flow-induced contraction, 668modulation ofW secretion by, in rabbit

parietal cells, 97Protein serine-threonine phosphatase 1,

effects on superoxide generationin HL-60 cells, 633

Protein serine-threonine phosphatase 2a,effects on superoxide generationin HL-60 cells, 633

Protein tyrosine phosphatase, effects onsuperoxide generation in HL-60cells, 633

Proteinsmitogen-activated, kinase activation by

serotonin, in vascular smoothmuscle, 1541

tetra-a-helix-bundle, halothane binding,56

Proteinuria, tenidap-induced, rat model,1318

Proximal tubulesbasolateral organic cation transport sys-

tom, in rabbit, 1086nitric oxide generation by, 91

Pruritogenic prostaglandins, 137

Pruritus, conjunctival, ketorolac effectsagainst, 137

Pugh, G., Jr., Smith, P. B., Dombrowski,D. S. and Welch, S. P.: The role ofendogenous opioids in enhancingthe antinociception produced bythe combination of i�”-tetrahydro-cannabinol and morphine in thespinal cord, 608

Pugliese, A. M., Passanil, M. B., Pepeu, G.and Corradetti, R.: Felbamate do-creases synaptic transmission inthe CAl region of the rat hip-pocampal slices, 1100

Pulmonary arterial myocytes, endothelinreceptor coupling to potassiumand chloride channels in, in rat,1053

Pulmonary stretch receptors, inhibitoryeffects of CO2 inhalation on, inrabbit, 402

Pulmonary vasculature, antibody-conju-gated plasminogen activator tar-geting to, 1026

Pyruvate dehydrogenase complex, -cata-lyzed formation of N-arylacetohy-droxamic acid, in rat, 1282

Quaternized ellipticines, accumulation byhuman tumor cells, 1018

Querl, I. U., see Hohage, H., 1086N-(2-Quindinoethyl)-5-isoquinoline sul-

fonamide, effects on parietal cellfunction, in rabbit, 97

QuinidineKvl.2 effects, 844slow delayed rectifier potassium chan-

nel blockade by, 856Quinine, 3-hydroxylation by cytochrome

P450 isoforms, in liver, 1327

Rabanal, F., see Johansson, J. S., 56Raje, R. R., see Ray, S. D., 1470Raloxiuene, comparison with alendronate

and estrogen, in rats, 298Rathbone, D., see Bristow, L. J., 492Rauch, S. L., see Fischman, A. J., 939Ravel, D., see Desta, B., 1077Ray, S. D., Mumaw, V. R., Raje, R. R. and

Fariss, M. W.: Protection of acet-aminophen-induced hepatocellu-lar apoptosis and necrosis by cho-lesteryl hemisuccinatepretreatment, 1470

RBC, see Red blood cellsReceptors

adenosine A3, bronchospasm inducedby, in BDE rats, 1148

adenosine A1, 8-butylaminoadenosinepartial agonism at, 1439

adrenergic

alpha-2, angiotensin receptor interac-tions, 795

alpha-2, in ethanol-clonidine interac-tions, in rats, 443

alpha-2, rostral ventrolateral medul-lary blockade, and cocaine sym-pathoinhibition, 967

beta-3 agonist potency, receptor den-sity and, 214

angiotensin, alpha-2 adrenoceptor in-teractions, 795

benzodiazepine, ligands, in mice seizure

models, 561, 573cholecystokinin, antagonist TP-680,

pharmacological profile, 1404

corticotropin-releasing factor, type 1,mRNA levels after binge cocaineadministration, 351

cytokine, soluble, as carrier proteins,340

dopamineagonist effects on eye blink rate, in

cynomolgus monkeys, 1211antagonist effects on METH-induced

histamine release, in rat stria-tum, 271

ganglionic inhibition by, in canine car-diac sympathetic gangia, 822

dopamine D4, antagonist U-l0l387,pharmacological characteriza-tion, 1392

endothelin, potassium and chloridechannel coupling, in rat pulmo-nary arterial myocytes, 1053

endothelinA, antagonism by TAK-044,675

endothelinB, antagonism by TAK-044,675

GABA, agonist renal effects, in rat, 602GABAA

in benzodiazepine-tolerant rats, 1092

hippocampal, mapping, 1491insecticides and, in cerebellar granule

neurons, 1191

stanozolol effects on, 186glycine

antagonist L-70l,324, behavioral pro-file, 492

[3HIMDL 105,519 site, 62potentiation by ethanol, in mouse spi-

nal neurons, 1116

5�”�1A’ desensitization by chronic flu-oxetine, 1035

5-HT2, ziprasidone and, PET analysis,939

5-HT3, antagonist granisetron, delayedemesis by, in piglet, 255

5-HT7, chronic antidepressants and, inrat frontocortical astrocytes, 1551

IL-4, soluble, effects on murine IL-4pharmacokinetics, 340

imidazoline, platelet binding sites, 694muscarinic

aceclidine enantiomer interactions,1335

allosteric lead structures for, 926Hml, Hm3 and HmS, functional prop-

erties, 593-operated potassium currents, inhibi-

tion by amiodarone, 617neurokinin NK-1INK-2 antagonist MDL

105,212 effects in allergic re-sponse, in guinea pig model, 732

neurokinin NK-2, in dog urinary blad-der, 423

nicotiicagonist RJR-2403, in vitro character-

ization, 1413agonist EJR-2403, in vivo character-

ization, 1422hippocampal, mapping, 1491melatonin modulation of, in rat vas

deferens, 18NMDA

antagonist L-701,324, behavioral pro-ifie, 492

[3H]MDL 105,519-glycine site, 62inhibition by dynorphin, 1063inhibition by haloperidol, 154

1996 Index 1605

modulation by lead, in rat hippocam-pal neurons, 143

recombinant human subtypesNMDAR1A/2A and NMDAR1A/2B, in mammalian cells, 367

subunit-transfected CHO cells, ac-quired excitotoxicity in, 515

opioidblockade by cloccinamox, 23delta, agonist effects on butorphanol

discrimination, 1130delta, agonist TAN-67 effects on mor-

phine-induced place preference,in mice, 177

inhalation exposure, antinociceptiveeffects, in mice, 69

kappa, agonist effects on butorphanoldiscrimination, 1130

kappa, agonist effects on diuresis, inrats, 1379

methoclocinnamox agonist and antag-onist effects, in rhesus monkeys,934

mu, agonist effects on butorphanoldiscrimination, 1130

mu, N-CPM-TAMO antagonism, 539N-CPM-TAMO agonism, 539splenocyte density, morphine and

methadone effects on, in mouse,172

prostaglandin D2 effects in prostanoid-induced conjunctival pruritus,137

prostaglandin E2, effects in prostanoid-induced conjunctival pruritus,137

prostaglandin ‘2, effects in prostanoid-induced conjunctival pruritus,137

pulmonary stretch, inhibitory effects ofCO2 inhalation on, in rabbit, 402

scavenger, effects in renal oligonucleo-tide disposition, in rat, 284

secretin, VIP specificity, in rat, 55501, agonist SA4503, enhancement of

acetylcholine release by, in ratbrain, 106

soluble cytokine, as carrier proteins, 340soluble IL-4, effects on murine IL-4

pharmacokinetics, 340tachykinin, in dog urinary bladder, 423thrombin, activation in vivo, cardiovas-

cular effects of, 1365thromboxane A�, regulation by testos-

terone 5a-reductase, 1386TP, in human nonpregnant myome-

trium, 262

Red blood cells, injured, adenosine deami-nase release by, 1250

Reeves, L., see Bencherif, M., 1413Relaxation, see also Vasodilation

non-neurogenic, in canine airway mus-cle, 813

Renal cortex, dicarboxylate carrier, flue-rescein interactions, in rat mito-chondria, 1559

Renal damage, carvedilol effects on, instroke-prone spontaneously hy-pertensive rats, 948

Renal failure, in endotoxemia, norepi-nephrine combined with Re 20-1724 treatment, in rats, 1197

Renal proximal tubulesbasolateral organic cation transport sys-

tem, in rabbit, 1086

nitric oxide generation by, 91Reperfusion injury

arrhythmias, Re 22-9194 effects on, indogs, 877

NO-tPA effects against, in cats, 1174proarrhythmic effects offlecainide in, in

tissue model, 317Repolarization, delayed, rhythm anoma-

lies related to, 231

Reproductive tissues, long-term effects ofraloxifene vs alendronate or es-trogen on, in rats, 298

Reverse transcriptase, HN, inhibition bycalanolide A, 652

Reward, morphine, TAN-67 effects on, inmice, 177

Rhoads, J. M., see Argenzio, R. A., 1109Rhythm anomalies, related to delayed re-

polarization, 231Ribavirin, combined with 2’,3’-dideoxyi-

nosine, in murine AIDS model,1009

Ricaurte, G., see Sparago, M., 1043Rice, K., see Schetz, J. A., 1069Ricevuti, G., see Patrini, G., 172Rifabutin, disposition and metabolism by

liver, in rats, 1300Rios, C. D., see Taguchi, H., 1514RJR-2403

in vitro characterization, 1413in vivo characterization, 1422

RNA, see Messenger RNARo 20-1724, for endotoxemia, in rats,

1197Re 22-9194, and ventricular fibrillation,

in dogs, 877Reberts, M. S., see Singh, P., 908Remain, D., see Gr#{233}lot,L., 255Rostral ventrolateral medulla, alpha-2 re-

ceptor blockade in, and cocainesympathoinhibition, 967

RTI-76, intrastriatal, dopamine trans-porter inactivation by, 200

Rubin, R. H., see Fischman, A. J., 939Ruediger, B., see Christian, B. T., 325Rundfeldt, C., see Loscher, W., 561Rundfeldt, C., see Loscher, W., 573Ruppel, J., see Fox, J. A., 1000

Russel, F. G. M., see Masereeuw, R., 1559Russo, P., see Debernardis, D., 84Ryder, D., see Brown, N. J., 703

SA4503, enhancement of acetylcholine re-lease by, in rat brain, 106

Sakurai, B., see Ito, C., 271Salazar, D. E., see Christian, B. T., 325Saleh, J. L., see Slotkin, T. A., 478Saleming, W. C., see Masereeuw, R., 1559Salter, K. J. and Kozlowski, R. Z.: Endo-

thelin receptor coupling to potas-sium and chloride channels in iso-

lated rat pulmonary arterialmyocytes, 1053

Sanders, M. J., see Aleo, M. D., 1318Sarcolemma, Ca� � entry and intracellular

overload, effects in torsades depointes, 231

Sarcoplasmic reticulum, calcium bufferingaction of, in rat femoral arterialsmooth muscle, 830

Sarna, S. K., see Jou#{235}t,P., 207Sata, T., see Minami, K., 838Sato, M., see Ito, C., 271Sate, M., Bryant, H. U., Iversen, P., Hel-

terbrand, J., Smietana, F., Bemis,K., Higgs, R., Turner, C. H.,

Owan, I., Takano, Y. and Burr, D.B.: Advantages of raloxifene overalendronate or estrogen on nonre-productive and reproductive tis-sues in the long-term dosing ofovariectomized rats, 298

Satoh, M., see Masuda, Y., 675Sawai, K., Mahato, R. I., Oka, Y.,

Takakura, V. and Hashida, M.:Disposition of oligonucleotides inisolated perfused rat kidney: In-volvement of scavenger receptorsin their renal uptake, 284

Saywell, K. L., see Bristow, L. J., 492SB 203580, pharmacological profile, in an-

imal models, 1453Scalia, R., see Delyani, J. A., 1174Scatton, B., see Itier, V., 1092Scavenger receptors, effects in renal oligo-

nucleotide disposition, in rat, 284Schetz, J. A., Calderon, S. N., Bertha, C.

M., Rice, K. and Porreca, F.:Rapid in vivo metabolism of amethylether derivative of (±)-

BW373U86: The metabolic fate of[3H]SNC121 in rats, 1069

Schmidt, R. L., see Widness, J. A., 1205Schoenhoff, M. B., see Fox, J. A., 1000Schreur, P. J. K. D., see Merchant, K. M.,

1392Schultz, D., see Desta, B., 1077Schwinger, R. H. G., see M#{252}ller-Ehmsen,

J., 1220Seale, J. P., see Chan, B. S. H., 625Sealey, J. E., see Barone, F. C., 948Secretin, gastric histamine release modu-

lation by, in canine, 718Secretin receptors, VIP specificity, in rat,

555Segawa, K., see Minami, K., 838Seidler, F. J., see Slotkin, T. A., 478Seizures, benzodiazepine receptor ligands

in, in mice models, 561, 573Sekioka, K., see Abe, Y., 47Selegiline, see L-DeprenylSenchyna, M. and Crankshaw, D. J.: Char-

acterization of the prostanoid TPreceptor population in humannonpregnant myometrium, 262

Sensitivity, dynorphin, to NMDA recep-tors, 1063

Sensorimotor gating, seroquel effects on,in PCP-treated rats, 1290

Seroquel, effects in PCP-treated rats, 1290Serotonin, see 5-Hydroxytryptamine

Serum lactate, reduction by sodium di-chloroacetate, 686

Sethy, V. H., see Merchant, K. M., 1392Sex

and cocaine immunotoxicity, in B6C3F1and DBA/2 mice, 3

differences in morphine antinociception,767

Seyed-Mozaffari, A., see Xu, J. Y., 539Sf9 cells, muscarinic receptor subtypes

functional properties, 593Shapiro, B. H., see Agrawal, A. K., 991Sharp, T., see Gartside, S. E., 277Shaw, W., see Bebok, Z., 1462Shenfield, G. M., see Boyle, F. M., 410Shigematsu, A., see Minami, K., 838Shimada, T., see Kim, R. B., 4Shimizu, M., Nishida, A., Zensho, H. and

Yamawaki, S.: Chronic antide-pressant exposure enhances

1606 Index Vol. 279

S-Hydroxytryptamine7 receptor-mediated cyclic adenosine mono-phosphate accumulation in ratfrontocortical astrocytes, 1551

Shimizu, T., see Matsumoto, S., 402Shinkawa, T., see Kim, S., 983Shirayama, T. and Pappano, A. J.: Bipha-

sic effects of intrapipette cyclicguanosine monophosphate on L-type calcium current and contrac-tion of guinea pig ventricularmyocytes, 1274

Shock, endotoxin, antiarthritic effects ofSB 203580 on, in animal models,1453

Shoup, T. M., see Fisckman, A. J., 939Shyr, M.-H., see Yang, C.-H., 795Sicuteri, F., see Ghelardini, C., 884

Siddall, B. J., see Morita, K., 379Siegel, B. W., see Baron, B. M., 62U1 receptors, agonist SA4SO3, enhance-

ment of acetylcholine release by,in rat brain, 106

Silibinin, effects on fibronectin turnover,in mesangial cells, 1520

Simard, M., see Harvie, P., 1009

Simell, 0. G., see Bowman, M. A., 790

Simon, W. C., Anderson, D. J. and Ben-nett, B. M.: Inhibition ofthe phar-macological actions of glyceryltrinitrate after the electroporeticdelivery of a glutathione S-trans-ferase inhibitor, 1535

Sin, J.-I. and Specter, S.: The role of inter-feron-gamma in antiretroviral ac-tivity of methionine enkephalinand AZT in a murine cell culture,1268

Singh, P. and Reberts, M. S.: Local deeptissue penetration of compoundsafter dermal application: Struc-ture-tissue penetration relation-ships, 908

Singh, T., see Bowersox, S. S., 1243Skidgel, R. A., see Deddish, P. A., 1582Skiles, G. L., see Bennett, G. D., 1237Skvoretz, R., see Varney, M. A., 367Slattery, J. T., see Bennett, G. D., 1237Slotkin, T. A., Thai, L., McCook, C., Saleh,

J. L., Zhang, J. and Seidler, F. J.:Aging and glucocorticoids: Effectson cell signaling mediatedthrough adenylyl cyclase, 478

Slowly adapting pulmonary stretch recep-tors, inhibitory effects of CO2 in-halation on, in rabbit, 402

Smietana, F., see Sate, M., 298Smith, M. A., see Picker, M. J., 1130Smith, M. W., see Merchant, K. M., 1392Smith, P. B., see Pugh, G., Jr., 608

Smooth musclefemoral arterial, sarcoplasmic reticulum

calcium buffering action in, inrat, 830

tracheal, cholinergic nerve-mediatedcontractions, ET-1 effects on, inrat, 1142

vascular, mitogen-activated protein ki-nase activation by serotonin in,1541

[3H]SNC121, metabolic fate, in rats, 1069Snell, L. D., Szab#{243},G., Tabakoff, B. and

Hoffman, P. L.: Gangliosides re-

duce the development of ethanol

dependence without affecting eth-anol tolerance, 128

SNX-l11, spinal antinociceptive effects, inrat neuropathic pain, 1243

SOD, see Superoxide dismutaseSodium dichloroacetate, serum lactate re-

duction by, 686

Solutes, structure and penetration, 908

Somatosensory-evoked discharges, co-caine-induced enhancement of,

substrates of, in rat barrel fieldcortical neurons, 582

Soose, M., see Wenzel, S., 1520Sorscher, E. J., see Bebok, Z., 1462Soudijn, W., see MathSt, R. A. A., 1439Soulard, C. D., Guerif, S., Payne, A. and

Dahi, S. G.: Differential effects offedotozine compared to other scagonists on diuresis in rats, 1379

Spangler, R., see Thou, Y., 351Sparago, M., Wios, J., Yuan, J., Hatzidimi-

triou, G., Tolliver, J., Dal Cason,T. A., Katz, J. and Ricaurte, G.:Neurotoxic and pharmacologicstudies on enantiomers of the N-methylated analog of cathinone(methcathinone): A new drug ofabuse, 1043

Species differences, in nalidixic acid me-

tabolism, 222Specter, S., see Sin, J.-I., 1268

Spetie, D., see Koudriakova, T., 1300Spinal antinociception, SNX-lll, in rat

neuropathic pain, 1243

Spinal cord, dynorphins and combined �

THC and morphine in, 608Spinal neurons, glycine receptor potentia-

tion by ethanol in, in mouse, 1116Splenocytes, opioid receptor density, mor-

phine and methadone effects on,in mouse, 172

Spontaneous hypertensionangiotensin II effects on renal cAMP re-

lease in, in rat, 114carvedilol effects on survival in, in

stroke-prone rats, 948effects of diuretics on cardiac hypertro-

phy in, in rats, 983Stall, S., see Li, Q., 1261Stamatakos, C., see Mussap, C. J., 423Stanozolol

effects on GABAA receptor function, 186liver microsome binding site, in male

rat, 1123Stanulis, E. D., see Matulka, R. A., 3Stanzione, S., see Debernardis, D., 84

Stennett, R., see TOdaka, K., 120Steroids

gonadal, vascular effects, 1stanozolol

effects on GABAA receptor function,186

liver microsome binding site, in malerat, 1123

Stieger, B., see Kontaxi, M., 1507Stolte, H., see Wenzel, S., 1520Stoltz, R. R., see Fox, A. W., 686

Stomachgastric acid secretion

inhibition by secretin, in canine, 718TP-680 effects on, 1404

gastric mucosa, leminoprazole cytopro-tection in, in rabbit, 975

H� secretion, modulation by PKC, inrabbit parietal cells, 97

histamine release, modulation by secre-tin, in canine, 718

Stressmetabolic, hypothermia and neuropro-

tection against, 332peroxidative, cocaine-induced, in rat

liver, 359Stroke

lubeluzole neuroprotective effects in, inrat photochemical model, 748

-prone spontaneously hypertensive rats,carvedilol effects on survival in,948

Struble, C., see Fox, J. A., 1000

Su, M.-T., see Hsu, K.-S., 740Substance P(l-7), effects on morphine tel-

erance and dependence, 662Succinylated keratin fragment, SOD con-

jugate, effects, 162Sugai, N., see Matsumoto, S., 402Sugiyama, Y., see Yamada, T., 1357Sugo, T., see Masuda, Y., 675Suko, M., see Kaminuma, 0., 240Sulfotransferases, female-dominant, on-

togeny and hormonal basis, in ratliver, 386

Sullivan, B. W., see Fox, A. W., 686Sullivan, J. T., see Walsh, S. L., 524Sulpiride, intra-accumbens, effects on co-

caine-induced locomotion andconditioned place preference, 392

Sumatriptan, antinociception, in rodentsand guinea pigs, 884

Sung, C.-H., see Winkler, J. D., 956Superoxide, generation in HL-60 cells, 633Superoxide dismutase, succinylated kera-

tin fragment conjugate, effects,162

Surette, M. E., see Winkler, J. D., 956Suzuki, K., see Matsumoto, S., 402Suzuki, T., see Masubuchi, Y., 724Suzuki, T., Tsuji, M., Mori, T., Misawa, M.,

Endoh, T. and Nagase, H.: Effectof the highly selective and non-peptide 8 opioid receptor agonistTAN-67 on the morphine-inducedplace preference in mice, 177

Svensson, K. A., see Merchant, K. M., 1392SW626 cells, effects of endogenous TNF

secreted by, 84Swanson, K. L., see Marchioro, M., 143Swerdlow, N. R., Bakshi, V. and Geyer, M.

A.: Seroquel restores sensorimo-tor gating in phencyclidine-treated rats, 1290

Sympathoinhibition

cocaine, blockade by rostral ventrolat-eral medullary alpha-2 receptor,967

dopamine receptor, in canine heart, 822Synaptic transmission, decrease by fel-

bamate, in CAl rat hippocampalslices, 1100

Synthetic proteins, halothane binding, 56Szab#{243},G., see Snell, L. D., 128

T-440, IL-S suppression by, in PBMCs, 240Tabakoff, B., see Snell, L. D., 128Tachibana, I., Kanagawa, K., Yamamoto,

Y. and Otsuki, M.: Pharmacolog-ical profile of a new serine deriv-ative, the cholecystokinin recep-tor antagonist TP-680, onpancreatic, biliary and gastricfunction, 1404

1996 Index 1607

Van De Kar, L. D., see Li, Q., 1035

Tachykinin receptors, in dog urinary blad-der, 423

Taguchi, H., Heistad, D. D, Chu, Y., Bios,C. D., Ooboshi, H. and Faraci, F.M.: Vascular expression of induc-ible nitric oxide synthase is asso-ciated with activation of Ca� �-

dependent K� channels, 1514TAK-044, endothelin receptor binding and

antagonist properties, 675Takahashi, S. and Okabe, S.: The cytopro-

tective effect of leminoprazole onindomethacin-induced damage torabbit gastric mucosal cells, 975

Takakura, Y., see Sawai, K., 284Takano, Y., see Sato, M., 298Tamagawa, M., see Watanabe, Y., 617TAN-67, effects on morphine-induced

place preference, in mice, 177Tan, P. P. C., see Yang, C.-H., 795Tang, A. H., see Merchant, K. M., 1392Tapia, J. C., see Aguayo, L. G., 1116[355] TBPS, see [355] t-Butylbicyclophos-

phorothionateTenbrink, R. E., see Merchant, K. M., 1392Temdap proteinuria, rat model, 1318Terasaki, T., see Yamada, T., 1357Teratogenicity, carbamazepine-l0,l 1-

epoxide and oxcarbazepine, inSWV mouse, 1237

Testosterone Sa-reductase, regulation ofthromboxane A2 receptors by,1386

2,3,7,8-Tetrachlorodibenze-p-dioxin, pros-taglandin G/H synthase-2 geneexpression and, in rat thymo-cytes, 1566

12-O-Tetradecanoylphorbol-13-acetate, ef-fects on parietal cell function, inrabbit, 97

Tetraethylammonium, tubular transport,in rabbit, 1086

Tetra-a-helix-bundle proteins, halothanebinding, 56

i�9-Tetrahydrocannabinol, combined withmorphine, dynorphins and, in spi-nal cord, 608

Tetrandrine, effects on acetylcholine re-lease, in mouse neuromuscularjunction, 891

Thai, L., see Slotkin, T. A., 478THC, see �9-TetrahydrocannabinolThiazide, effects on cardiac hypertrophy,

in spontaneously hypertensiverats, 983

Thiopental, systemic and cerebral kinet-ics, enantiomeric analysis insheep, 291

Thomas, G., see Delyani, J. A., 1174Thomas, N. J., see Carcillo, J. A., 1197Thompson, K., see Picker, M. J., 1130Thompson, T., see Koudriakova, T., 1300Thorn, L., see Bristow, L. J., 492Thrombin receptors, activation in vivo,

cardiovascular effects of, 1365

Thromboxane A� receptors, regulation bytestosterone 5a-reductase, 1386

Thromboxane A� synthase, inhibition byRe 22-9194, in dogs, 877

Thymocytes, prostaglandin G/H syn-thase-2 genes expression in, inrats, 1566

Tissueoctreotide distribution mechanism, 1357

structure-tissue penetration relation-ships, 908

Tissue-type plasminogen activator, S-nitrosylated, protective effectsagainst myocardial ischemia/reperfusion injury, in cats, 1174

Tizanidine, platelet I� binding sites, 694TNF, see Tumor necrosis factorTobacco, see NicotineTodaka, K., Wang, J., Yi, G.-H., Stennett,

R., Knecht, M., Packer, M. andBurkhoff, D.: Effects of levosi-mendan on myocardial contractil-ity and oxygen consumption, 120

Toleranceacute ethanol, genetic selection for, in

mouse lines, 1310acute morphine, substance P(l-7) effects

on, 662benzodiazepine, GABAA receptors in, in

rats, 1092benzodiazepine receptor ligand liability,

in mice, 561, 573DOI, 782m-CPP, 782morphine, and peripheral morphine an-

algesia, 502Tolliver, J., see Sparago, M., 1043Topical application of compounds, local

deep tissue penetration of, 908Topoisomerase II, inhibitors, activity en-

hancement by endogenous TNF,in ovarian cancer cells, 84

Torsades de pointes, calcium effects in,231

Towers, P., see Baron, B. M., 62Toxicity

acetaminophencholesteryl hemisuccinate protection

against, 1470in male Wistar rats, 548

ammonia, trimethylamine preventiveeffects against, 194

cocainein B6C3F1 and DBA/2 mice, 3in rat liver, 359

1,1-dichioroethylene, in adult and wean-ling mice, 1484

excitotoxicity, acquired, in NMDA re-ceptor subunit-transfected CHOcells, 515

glutamatelubeluzole protective effects against,

759trimethylamine preventive effects

against, 194indomethacin, leminoprazole protection

against, in rabbit gastric mucosalcells, 975

lead, in newborn rat, 435lipid A, nitric oxide effects in, 91vincristine, glutamate effects on, 410

Toxinsw-agatoxin-NA, effects on motor nerve

Ca� � currents, in mouse, 1229brain tumor-selective, 1018w-conotoxin-MVIIC, effects on motor

nerve Ca� � currents, in mouse,1229

ochratoxin A, hepatocellular transport,1507

pertussis, effects in morphine and 13-en-dorphin antinociception, inmouse, 39

TP-680, pharmacological profile, 1404

TP receptors, in human nonpregnant myo-metrium, 262

Tr#{228}nkle,C., Kostenis, E., Burgmer, U. andMohr, K.: Search for lead struc-tures to develop new allostericmodulators of muscariic recep-tors, 926

Transacylase, CoA-independent, inhibi-tors, apoptosis induction by, 956

Transdermal nicotine, and acute nicotinewithdrawal, 450

Traylor, L. A., Proksch, J. W., Beanum, V.C. and Mayeux, P. R.: Nitric oxidegeneration by renal proximal tu-bules: Rele of nitric oxide in thecytotoxicity of lipid A, 91

Tremblay, M., see Harvie, P., 1009Triazene compounds, OGAT inactivation

by, 416Tricklebank, M. D., see Bristow, L. J., 492Trimethylamines, carnitine and choline

derivatives containing, preven-tive effects against ammonia tox-icity and glutamate neurotoxic-ity, 194

Trumper, L., see Monasterolo, L. A., 602Trumper, L., Monasterolo, L. A. and Elfas,

M. M.: Nephrotoxicity of acet-aminophen in male Wistar rats:Rele of hepatically derived me-tabolites, 548

Trybulski, E. J., see Yao, J.-A., 856Tsai, J.-J., see Hsu, K.-S., 740Tseng, G.-N., see Yao, J.-A., 856Tseng, G.-N., Jiang, M. and Yao, J.-A.:

Reverse use dependence of Kv4.2blockade by 4-aminopyridine, 865

Tseng, G.-N., Thu, B., Ling, S. and Yao,J.-A.: Quinidine enhances andsuppresses Kvl.2 from outsideand inside the cell, respectively,844

Tseng, L. F. and Collins, K. A.: Pretreat-ment with pertussis toxin differ-entially modulates morphine-and 13-endorphin-induced antino-ciception in the mouse, 39

Tsuchiya, N., see Kim, S., 983Tsuji, M., see Suzuki, T., 177Tsutsui, M., see Minami, K., 838Tulebaev, S., see Koudriakova, T., 1300Tumor necrosis factor a, myocardial, mod-

ulation by PDE inhibitors, 247Thmor necrosis factor, endogenous, topo II

inhibitor activity enhancementby, in ovarian cancer cells, 84

Tumorsbrain, cytotoxins selective for, 1018metastasis, anti-IL4 effect on, 472

Turner, C. H., see Sate, M., 298

U-101387, pharmacological characteriza-tion, 1392

Ueda, Y., see Abe, Y., 47Uematsu, T., see Yoshioka, T., 1282Ujiie, A., see Murakami, M., 877Ulreich, J. B., see Forkert, P. G., 1484

Ulrich, C. D., see Holtmann, M. H., 555Upton, R. N., see Mather, L. E., 291Urcan, M., see Varney, M. A., 367Urinary bladder, tachykiin NK-2 recep-

tors in, in dog, 423Utkin, I., see Koudriakova, T., 1300Uyama, Y., see Nomura, Y., 830

1608 Index VoL 279

Van de Kar, L. D., see Li, Q., 1261Van der Wenden, E. M., see MathOt, R. A.

A., 1439

Van Home, C. G., see Hebert, M., 1181Van Reet, G., see De Ryck, M., 748Vanhoutte, P. M., see Desta, B., 1077Varner, K. J., see Abrahams, T. P., 967Varney, M. A., Jachec, C., Deal, C., Hess,

S. D., Daggett, L. P., Skvoretz, R.,Urcan, M., Morrison, J. H., Mo-ran, T., Johnson, B. C. and Veli-#{231}elebi,G.: Stable expression andcharacterization of recombinanthuman heteromeric N-methyl-n-aspartate receptor subtypesNMDAR1A/2A andNMDAR1AJ2B in mammaliancells, 367

Vas deferens, melatonin modulation ofnAChRS, in rat, 18

Vascular function, gonadal steroid effectson, 1

Vascular smooth muscle, mitogen-acti-vated protein kinase activationby serotonin in, 1541

Vasculature, pulmonary, antibody-conju-gated plasminogen activator tar-geting to, 1026

Vasoactive intestinal peptide

blood-brain barrier drug delivery, CNSeffects, in rats, 77

and cholecystokinin mechanisms of ac-tion, in canine GI tract, 306

secretin receptor specificity, in rat, 555Vasodilation

ACh- and NO-mediated, inhibition bylipopolysaccharide, 918

coronary, nicorandil effects, in humantissue, 1220

Vasospasm, coronary, acute and chronicdexfenfluramine and, porcine,1077

Veli#{231}elebi, G., see Varney, M. A., 367Veng-Pedersen, P., see Widness, J. A.,

1205Ventricular fibrillation, Re 22-9194 ef-

fects on, in dogs, 877Ventricular function, levosimendan effects

on, 120Ventricular myocytes, cGMP effects on L-

type calcium current and contrac-tions in, in guinea pig, 1274

Ventricular papillary muscle, left,mechano-energetic effects of cm-makalim on, in guinea pig, 464

Vergara, P., Woskowska, Z., Cipris, S.,Fox-Threlkeld, J. E. T. andDaniel, E. E.: Mechanisms of ac-tion of cholecystokinin in the ca-nine gastrointestinal tract: Releof vasoactive intestinal peptideand nitric oxide, 306

Verma, M., see Olnes, M. J., 1566

Vincristine, neurotoxicity, glutamate ef-fects on, 410

VIP, see Vasoactive intestinal peptideViruses

HNinhibition by calanolide A, 645reverse transcriptase inhibition by

calanolide A, 652met-enkephalin and AZT effects

against, in murine cells, 1268Vistica, D. T., Kenney, S., Hursey, M. and

Boyd, M. R.: Rele of membrane

potential in the accumulation ofquaternized ellipticines by hu-man tumor cell lines, 1018

Voltage-sensitive calcium channels, N-type, and spinal antinociceptionin rat neuropathic pain, 1243

Vonvoigtlander, P. F., see Merchant, K.M., 1392

Voskuy, R. A., see Hoogerkamp, A., 803Votta, B., see Badger, A. M., 1453Vouros, P., see Koudriakova, T., 1300Vyas, S. J., Mi, Z. and Jackson, E. K.: The

inhibitory effect of angiotensin IIon stimulus-induced release ofcAMP is augmented in the genet-ically hypertensive rat kidney,114

Wakimasu, M., see Masuda, Y., 675Walsh, A. H., see AIeo, M. D., 1318Walsh, S. L, Suffivan, J. T., Preston, K. L.,

Garner, J. E. and Bigelow, G. B.:Effects of naltrexone on responseto intravenous cocaine, hydro-morphone and their combinationin humans, 524

Wang, J., see Deddish, P. A., 1582; Todaka,K., 120

Wang, L.-X., see Deddish, P. A., 1582Wang, T., see Aleo, M. D., 1318Wang, Y.-X., see Bowersox, S. S., 1243Wanwimolruk, S., see Thao, X.-J., 1327Watanabe, M., see Nomura, Y., 830

Watanabe, T., see Ito, C., 271Watanabe, Y., Ham, Y., Tamagawa, M.

and Nakaya, H.: Inhibitory effectof amiodarone on the muscarinicacetylcholine receptor-operatedpotassium current in guinea pigatrial cells, 617

Waterhouse, B. D., Gould, E. M. and Beka-vac, I.: Monoaminergic substratesunderlying cocaine-induced en-hancement of somatosensory-evoked discharges in rat barrelfield cortical neurons, 582

Watt, A. P., see Bristow, L J., 492Wattle, J., see Janssen, L. J., 813Watts, S. W.: Serotonin activates the mi-

togen-activated protein kinasepathway in vascular smooth mus-cle: Use of the mitogen-activatedprotein kinase kinase inhibitorPD098059, 1541

Weight, F. F., see Brauneis, U., 1063Welch, S. P., see Pugh, G., Jr., 608Wenzel, S., Stolte, H. and Soose, M.: Ef-

fects of siibinin and antioxidantson high glucose-induced alter-ations of fibronectin turnover inhuman mesangial cell cultures,1520

Wheeler, H. R., see Boyle, F. M., 410Widness, J. A., Veng-Pedersen, P.,

Schmidt, R. L, Lowe, L S., Kis-taM, J. A. and Peters, C.: In vivo1mI�Erythropoietin pharmacoki-netics are unchanged after anes-thesia, nephrectomy and hepato-ctomy in sheep, 1205

Wiegand, H., McIntosh, L J., Gotzsch, U.and Kramer, U.: Effects of tetran-drine on spontaneous and evokedrelease of acetylcholine at themouse neuromuscular junction,891

Wilkinson, G. R., see Kim, R. B., 4Willette, R. N., see Barone, F. C., 948Williams, S. A., see Fischman, A. J., 939Wilson, R., see Kolesnikov, Y. A., 502Wilson, S., Chambers, J. K., Park, J. E.,

Ladurner, A., Cronk, D. W.,Chapman, C. G., Kallender, H.,Browne, M. J., Murphy, G. J., andYoung, P. W.: Agonist potency atthe cloned human beta-3 adreno-

ceptor depends on receptor ex-pression level and nature of as-say, 214

Winkler, J. D., Eris, T., Sung, C.-H.,Chabot-Fletcher, M., Mayer, R.J., Surette, M. B. and Chilton, F.H.: Inhibitors of coenzyme A-in-dependent transacylase induceapoptosis in human HL-60 cells,956

Withdrawalacute nicotine, transdermal nicotine

and, 450anticonvulsant, benzodiazepine receptor

ligand characteristics, in mice,561, 573

chronic cocaine, CRF and CRF-RlmRNA levels during, in rat brainand pituitary, 351

Wlodarczyk, B., see Bennett, G. D., 1237Wlos, J., see Sparago, M., 1043Wong, D. L., see Morita, K., 379Woods, J. H., see Butelman, E. R., 934; Yu,

J., 507; Zernig, G., 23Woodward, D. F., Nieves, A. L. and Fried-

laender, M. H.: Characterizationof receptor subtypes involved inprostanoid-induced conjunctivalpruritus and their role in mediat-ing allergic conjunctival itching,137

Woskowska, Z., see Vergara, P., 306Wu, D. and Pardridge, W. M.: Central ner-

vous system pharmacologic effectin conscious rats after intrave-nous injection of a biotinylatedvasoactive intestinal peptide ana-log coupled to a blood-brain bar-rier drug delivery system, 77

Wu, Y.-N. and Johnson, S. W.: Pharmaco-logical characterization of inwardcurrent evoked by N-Methyl-D-aspartate in dopamine neurons inthe rat brain slice, 457

Xie, H., Laher, I. and Bevan, J. A.: Proteinkinase C modulates flow-initiatedcontraction, 668

Xu, J. Y., Seyed-Mozaffari, A., Archer, S.and Bidlack, J. M.: N-Cyclobutyl-methyl analog of normorphinone,14a,l4’13-[dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis[7,8-dihy-dro-N-(cyclobutylmethyl)-nor-morphinone]: A short-term opioidagonist and long-term mu-selec-tive irreversible opioid antago-nism, 539

Xu, Y.-F. and Atchison, W. D.: Effects ofw-agatoxin-NA and w-conothxin-MVIIC on perineurial Ca� andCa4 ‘-activated K� currents ofmouse motor nerve terminals,1229

Yamada, H., see Mukai, M., 822

1996 Index 1609

Yamada, K., see Mukai, M., 822Yamada, T., Niinuma, K., Lemaire, M.,

Terasaki, T. and Sugiyama, Y.:Mechanism ofthe tissue distribu-tion and biliary excretion of thecyclic peptide octreotide, 1357

Yamaguchi, I., see Yamazak.i, M., 1157Yamamoto, Y., see Tachibana, I., 1404Yamawaki, S., see Shimizu, M., 1551Yamazaki, H., see Kim, R. B., 4Yamazaki, M., Matsuoka, N., Maeda, N.,

Ohkubo, Y. and Yamaguchi, I.:N-(4-Acetyl-l-piperazinyl)-p-flu-orobenzamidemonohydrate amo-liorates the impaired memory ofrats in passive avoidance, watermaze and eight-arm radial mazetasks through a novel mechanismofaction, 1157

Yanagthara, N., see Minami, K., 838Yang, C.-H., Shyr, M.-H., Tan, P. P. C. and

Chan, S. H. H.: Participation ofAT1 and AT2 receptors in the dif-ferential interaction between an-giotensin II or III and alpha-2 ad-renoceptors in the nucleusreticularis gigantocellularis incardiovascular regulation and an-tinociception in rats, 795

Yao, J.-A., see Tseng, G.-N., 844Yao, J.-A., see Tseng, G.-N., 865

Yao, J.-A., Trybuiski, E. J. and Tseng, G.-N.: Quinidine preferentiallyblocks the slow, delayed rectifierpotassium channel in the restedstate, 856

Yi, G.-H., see Todaka, K., 120Yokoyama, H., see Thao, X.-J., 1327Yoshioka, T., Ohno, H. and Uematsu, T.:

Pyruvate dehydrogenase com-plex-catalyzed formation of N-arylacetohydroxamic acids fromnitroso aromatic compounds inrat isolated cells and perfused or-gans, 1282

Young, P. W., see Wilson, S., 214Yu, J., Butelman, E. R., Woods, J. H.,

Chait, B. T. and Kreek, M. J.: Invitro biotransformation of dynor-phin A (1-17) is similar in humanand rhesus monkey blood as stud-ied by matrix-assisted laser de-sorption/ionization mass spec-trometry, 507

Yuan, J., see Sparago, M., 1043

Zago, W. M., see Markus, R. P., 18Zeevalk, G. D. and Nicklas, W. J.: Hype-

thermia and metabolic stress:Narrowing the cellular site ofearly neuroprotection, 332

Zensho, H., see Shimizu, M., 1551

Zernig, G., Burke, T., Lewis, J. W. andWoods, J. H.: Mechanism of dc-cinamox blockade of opioid recep-tors: Evidence from in vitro andex vivo binding and behavioral as-says, 23

Zhang, J., see Slotkin, T. A., 478Zhang, L., see Brauneis, U., 1063Zhao, X.-J., Yokoyama, H., Chiba, K.,

Wanwimolruk, S. and Ishizaki,T.: Identification of human cyte-chrome P450 isoforms involved inthe 3-hydroxylation of quinine byhuman liver microsomes and ninerecombinant human cytochromesP450, 1327

Thou, Y., Spangler, R., LaForge, K. S.,Maggos, C. E., Ho, A. and Kreek,M. J.: Corticotropin-releasing fac-tor and type 1 corticotropin-releasing factor receptor messen-ger RNAs in rat brain andpituitary during “binge”-patterncocaine administration andchronic withdrawal, 351

Thu, B., see Tseng, G.-N., 844Thu, H., see Piletz, J. B., 694Ziprasidone, and � receptors, PET

analysis, 939Zumbado, M., see Boada, L. D., 1123

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