INDEX

Volume 230, July-September, 1984

A23187, cutaneous vascularpermeability (guinea pigs),550

Access schedule, ethanol con-sumption patterns and (rats),658

Acetazolamide, phosphate excre-tion, prostaglandin E� effects

(dogs), 601Acetylcholine

radiolabled, release, Met-en-kephalin and (guinea pigs),493

receptor-ionic channel corn-plex, (±)-depentylperhydro-histrionicotoxin effects(frogs), 619

Acetyl-Co A:arylamine N-acetyl-transferase, induction rnodu-

lation, a’pha adrenergic drugs

(rats), 431Actin, interaction with myosin,

calcium antagonists and vas-odilators (cows), 141

Action potential, transrnernbrane,adenosine and iseprenalineeffects, heart (guinea pigs),483

Acyl glucuronide, diisopropylfluo-rophosphate and clofibricacid clearance (rabbits), 237

Adarn-Vizi, V., see Vizi, E. S., 493Adenosine, negative inotropic ef-

feet, heart (guinea pigs), 483Adenylate cyclase, beta adrenergic

receptor loss and (rats), 614Adipose tissue, bone rnarrow, free

fatty acid release (dogs), 228Adrenal gland, catecholamine in-

hibition, phenytoin (cows),171

Adrenergic nerve, norepinephrinerelease, ouabain and (dogs),527

Adrenoceptor

alpha, central cardiovasculareffects (cats), 232

a’pha and beta, antibody re-sponse and norepmephrine(rnice), 183

a4,ha and beta, a-methyl-sub-stituted phenethylamine in-teractions with (rats), 595

alpha-i and alpha-2, activationby norepinephrine, saphe-not’s vein (dogs), 699

alpha-i and alpha-2, reserve,calcium use and (rats), 587

alpha-2, dopamine release, ret-ma (rabbits), 149

aipha-2 and beta, free fatty acidrelease, bone marrow adipose

tissue (dogs), 228beta, heterogeneity, cold expo-

sure and (rats), 450

Agonista’pha adrenergic, aorta contrac-

tile response (rabbits), 162dopamine receptor, self-admin-

istration (monkeys), 678intrinsic activity, beta adrener-

gic receptor loss and (rats),614

irreversible, discriminativestimulus effects (pigeons),652

muace.rinic receptor subtypes,lower esophageal sphincter

(opossum), 284opiates and partial generaliza-

tion, fentanyl (rats), 193Abmad, A. B., Bennett, P. N. and

Rowland, M.: Influence ofroute of hepatic administra-tion on drug availability, 718

Albuquerque, E. X., see Maleque,

M. A., 619Alkali, desipramine toxicity

(rats), 12Allyl alcohol, hepatoxicity inves-

tigation, perfused liver (rats),755

Alphs, L. and Lovenberg, W.:Modulation of rat pineal ace-tyl-Co A:arylamine N-acetyl-transferase induction by at-ph�i adrenergic drugs, 431

Ambrose, J. M., see Silver, P. J.,141

Amine

biogenic, phenytoin and cats-cholamine transport, adrenalglands (cows), 171

sympathomimetic, nutrientblood flow, intestine (dogs),214

-y-Aminobutyric acidantagonism, naloxone effects

(pigeons), 40medullary mechanisms, blood

pressure regulation (rats), 34Aminoglycoside, antibiotics, kid-

ney epitheial cell line, effectsOn, 742

Amrinone, cardiovascular activi-

ties (cats, guinea pigs, rats),124

Analgesia, hot-plate, spinal andcerebral opioid receptor func-tion (mice), 341

Anaphylatoxin, C3a and C5a, iso-lated blood vessels and(guinea pigs), 749

Antagonista�pha-2, lipid mobilization

(dogs), 228beta adrenoceptor, hydralazine

and, renal hypertension (rab-bits), 205

calcium channel, a�pha adreno-

ceptor reserve and (rats), 587calcium channel, cyprohepta-

dine effects (rats, rabbits),103

calmodulin, [3Hlnitrendipinebinding, smooth and cardiac

muscle (guinea pigs, rabbits,cows), 607

muscarinic receptor subtypes,lower esophageal sphincter(opossum), 284

opiates and partial generaliza-

tion, fentanyl (rats), 193Antibiotics, aminoglycoside, ccl-

lular function effects, kidneyepithelial cell line, 742

Antibody response, beta adreno-ceptor effects on (mice), 183

Anticonvulsantscatecholamine transport inhi-

bition, adrenal glands (cows),171

gating currents, effects on(squid), 75

learning, effects on (pigeons),307

Antidepressantsbrain receptor antagonism by

(humans), 94toxicity, bicarbonate and (rats),

12Antidiuretic hormone, U-50,488

effects, kidney (dogs), 641Antigen, trachea challenged by

(guinea pigs), 534Antinociception, electroacupunc-

ture, Met�-enkephalin-Arg’-Phe7 and Met6-enkephalinmetabolism, peptidase inhib-itors and (rats), 349

Antiparkinsonian agent, (+)-4-propyl-9-hydroxynaphthoxa-

zinc (fish, mice, rats, dogs),569

Aorta, contractile response, aiphaadrenergic agonist (rabbits),162

Appel, J. B., see Cunningham,K. A., 47

AQA-39, calcium channel blocker,indirect stimulatory action(puppies), 336

Arachidonic acidmetabolites, bladder motility

and (rats), 500release, glucocorticoids and

(rats), 175AR-L57, cardiovascular activities

(cats, guinea pigs, rats), 124Asada, A., see Bowaher, D. J., 269Atenolol, hydralazine and, renal

hypertension (rabbits), 205Atkinson, A. J., Jr., see Bowsher,

D. J., 269Atrioventricular node, depres-

sion, KB-944 and (dogs), 632Atrium, beta adrenoceptor heter-

ogeneity, cold exposure(rats), 450

Atropine, AQA-39 and (puppies),336

Avram, M. J., see Bowsher, D. J.,269

Axon membrane, anticonvulsanteffects on (squid), 75

Bahouth, S.. W., Stewart, J. M.and Musacchio, J. M.: Spe-cific binding of a ThI.labeledsubstance P analog to ratsubmaxillary gland, 116

Baldwin, R. W., see Ilium, L., 733Balster, R. L., see Slifer, B. L.,

399Barbiturate, convulsant, effects

on neurons (mice), 82Barcas, P. P., see Willette, R. N.,

34Barkai, A. I., Suckow, R. F. and

Cooper, T. B.: Imipramine

and its metabolites: Relation-ship to cerebral catechol-amines in rats in viuo, 330

Baroreflex, sensitivity, dihydro-

pyridine slow channel cal-cium blocking agents (dogs),376

Baskin, E. P., see Winquist, R J.,103

Begenisich, T., see Morello, R. S.,156

Behaviordisruption, phencyclidine with-

drawal (monkeys), 399exploratory, cholecystokinin

fragments (mice), 438fixed-ratio discrimination ac-

curacy, opioid effects (mon-

keys, dogs), 541repeated acquisition, anticon-

vulsant effects on (pigeons),307

toluene anticonvulsant and an-tipunishment effects (rats),407

Belinsky, S. A., Popp, J. A., Kauf-mann, F. C. and Thurman,R. G.: Trypan blue uptake asa new method to investigate

hepatotoxicity in periportaland pericentral regions of theliverlobule: Studies with allylalcohol in the perfused liver,755

Bemis, K. G., see Rinkema, L E.,550

Bennett, P. N., see Ahmad, A. B.,718

Benowitz, N., see Pentel, P., 12Benzodiazepine

777

778 Index Vol. 230

receptor antagonist, Ro 15-1788, diazepain and tolueneanticonvulsant activity

(rats), 407receptor regulation, changes

after lesions, substantia ni-gra, globus pallidus and en-topeduncular nucleus (rats),

768

Benzomorphan, receptor (rats),110

Bepridil, calmodulin, effects on(cows, chickens, rabbits), 737

Bergstrom, K., see Hartvig, P.,250

Berlan, M., see Tran, M.-A., 228Bicarbonate, desipramine toxicity

(rats), 12Bicuculline, medullary GABA-

ergic mechanisms, bloodpressure regulation (rats), 34

Bidani, A. K., see Churchill, P. C.,302

Bladderepithelial trauma and prosta-

glandins in (rabbits), 445

motility, essential fatty aciddeprivation and (rats), 500

Blockadebeta adrenergic receptor, di-so-

talol (dogs), 519calcium, AQA-39, (puppies),

336calcium, beta adrenergic, dihy-

dropyridines (dogs), 367calcium entry, cyproheptadine

and (rats, rabbits), 103

hydralazine and, renal hyper-tension (rabbits), 205

sodium channel, phenytoin(squid), 156

Blood flowhydralazine and beta blockers,

renal hypertension (rabbits),205

nutrient, dopamine- and epi-nephrine-induced intestinal

vasodilation (dogs), 214propranolol elimination and,

liver (rats), 474regional, LY141865 effects

(dogs), 558

Blood gas, arterial concentrationsand pH, diazepam effects,methadone and (rats), 353

Blood pressuresee also Hypertension; Hypo-

tensionaipha adrenergic drugs and

(cats), 232regulation, medullary GABA

ergic mechanisms (rats), 34L-tryptophan effects (rats), 324

Blood vessel, isolated, C3a andC5a anaphylatoxin effects(guinea pigs), 749

Boder,G.B.,seeHayes,J.S., 124

B#{246}hm,M., Bruckner, R., Hack-barth, I., Haubitz, B., Lin-hart, R., Meyer, W., Schmidt,B., Schmitz, W. and Scholz,H.: Adenosine inhibition ofcatecholamine-induced in-crease in force of contraction

in guinea-pig atrial and yen-

tricular heart preparations.

Evidence against a cyclicAMP- and cyclic GMP-de-pendent effect, 483

Bohn, D. L., see Winquist, R. J.,103

Bolt, G. R. and Saxena, P. R.:Interaction of atenolol withthe systemic and regional he-modynamic effects of hydral-azine in conscious renal hy-pertensive rabbits, 205

Bombesin, scratching induced by,benzomorphan receptors(rats), 110

Bone marrow, adipose tissue, freefatty acid release (dogs), 228

Bookstaff, R. C., see Katz, L. B.,670

Botulinum, type C2 toxin, molec-ular pharmacology (mice),665

Bousquet, P., Feldman, J. andSchwartz, J.: Central cardio-vascular effects of alpha ad-renergic drugs: Differences

between catecholamines andimidazolines, 232

Bovermann, K., see Seizinger,B. R., 455

Bowling, H. N., see Hayes, J. S.,124

Bowsher, D. J., Avram, M. J.,Frederiksen, M. C., Asada, A.and Atkinson, A. J., Jr.: Ureadistribution kinetics ana-lyzed by simultaneous injec-tion of urea and inulin: Dem-

onstration that transcapil-lary exchange is rate limiting,269

Bradykinin, capsaicin and, sub-

stance P-ergic responses(rabbits), 469

Brain“C-labeled opiates (monkeys),

250catecholomines, imipramine

and (rats), 330neurotransmitter receptors, an-

tidepressants and (humans),94

Brainstem, aipha adrenergic

drugs and (cats), 232Branch, R. A. see KUpfer, A., 28

Briston, C., see Schaeffer, R. C.,Jr., 393

Bromobenzene metabolite, 2-bro-mohydroquinone, nephrotox-icity (rats), 360

2-Bromohydroquinone, nephro-toxicity induced by (rats),360

Brooks, H. L., see Warltier, D. C.,367, 376

Brossi, A., see Maleque, M. A.,619

Brown, D. M., see Knodell, R. G.,256

Bruckner, R., see B#{246}hm,M., 483Buckner, C. K., see Fishleder,

R. I., 534Buprenorphine,

bombesin-induced scratchingand (rats), 110

discriminative stimulus effects(pigeons), 652

fixed-ratio discrimination ac-curacy and (monkeys, dogs),541

Burks, T. F., see Porreca, F., 341

Caffeine, muscle excitation, sa-licylate effects on (frogs,toads), 478

Calciumantagonist, coronary arteries

and myocardium (humans),514

antagonist, KB-944, cardiacelectrophysiology (dogs), 632

antagonist, vasodilators and,myosin phosphorylation

(cows), 141contractile responses depend-

ent on, inhibition by leuko-trienes, myocardium (guineapigs), 646

entry blocker, cyproheptadineand (rats, rabbits), 103

influx and release, alphaadrenoceptors, artery (rats),413

radiolabeled, 2-nicotinamido-ethyl nitrate and vascularsmooth muscle (rabbits), 462

renal handling, prostaglandin-vasopressin interactions

(rats), 295Calcium channel

antagonist, a’pha adrenoceptorreserve and (rats), 587

blocker, AQA-39 (puppies), 336blocker, cyproheptadine effects

(rats, rabbits), 103blocker, dihydropyridine

(dogs), 367, 376Callahan, P. M., see Cunningham,

K. A., 47Callia, M. L. and de Moraes, S.:

Heterogeneity of beta adre-noceptors in right atria iso-lated from cold-exposed rats,450

Calmodulinantagonists, [3H]nitrendipine

binding, smooth and cardiacmuscle (guinea pigs, rabbits,cows), 607

bepridil effects on (cows, chick-ens, rabbits), 737

vasodilators and myosin phos-phorylation (cows), 141

cAMP, see Cyclic AMPCapsaicin, bradykinin and, sub-

stance P-ergic responses(rabbits), 469

Cardiomyocyte, amrinone andAR-L57 effects (cats, guineapigs, rats), 124

Cardiovascular system

dihydropyridine slow channelcalcium blocking agents,(dogs), 367, 376

vasodilators and myosin phos-phorylation (cows), 141

Carlson, R. W., see Schaeffer,R. C., Jr., 393

Carrageenan, edema responseto, 2,3,7,8-tetrachlorodi-benzo-p-dioxin treatment

and (rats), 670

Carter, R. B. and Leander, J. D.:

Comparison of the effects ofnaloxone and picrotoxin on

schedule-controlled respond-ing in the pigeon: PossibleGABA-antagonistic effects ofnaloxone, 40

Casteels, R., see Kajiwara, M., 462Catatonia, amine-ketamine, pin-

ealectomy and hypophysec-tomy (chicks, rats), 69

Catecholamine,atpha-2 agonists and antago-

fists, dopamine release, ret-ma (rabbits), 149

cerebral, imipramine relation-ship to (rats), 330

imidazoline us. , central cardio-vascular effects (cats), 232

ketamine catatonia (chicks,rats), 69

neuron development, propyl-thiouracil effects (rats), 53

response, erythrosin B effects,ganglia (frogs, bullfrogs), 221

transport inhibition, pheny-tom, adrenal glands (cows),171

Cation, [3H]nitrendipine bindingregulatedby, smooth and car-disc muscle (guinea pigs, rab-bits, cows), 607

Catto, B. A., see Valencia, C. I.,133

Cauvin, C. and Malik, S.: Induc-tion of Ca�� influx and intra-cellular Ca� release in iso-lated rat aorta and mesen-teric resistance vessels bynorepinephrine activation ofatpha-1 receptors, 413

Cerebral cortex, alpha-i receptorsand inositol (rats), 317

Cerebrospinal fluid, phenobarbi-tel in, kidney dysfunctionand (rats), 627

Channel blocker, open, (±)-

depentylperhythohistrionico-toxin on mcotinic receptor-ion channel (frogs), 619

Childers, S. R.: Interaction of opi-ate receptor binding sites andguanine nucleotide regula-tory sites: Selective protec-

tion from N-ethylmaleimide,684

Chilton, S.-M., see Schaeffer, R.C., Jr., 393

2-Chloroadenosine, renal effects(rats), 302

Cholecystokinin, C- and N-tsr-minal fragments, analysis(mice), 438

Chou, J., Tang, J., Del Rio, J.,Yang, H.-Y. T. and Costa,E.: Action of peptidase in-hibitors on methionine5-en-kephalin-arginine6-phenyl-alanine7 (YGGFMRF) andmethionine5 - enkephalin(YGGFM) metabolism andon electroacupuncture anti-nociception, 349

Chromaffin granule, catechol-amine inhibition, phenytoinadrenal glands (cows), 171

Chromatography, gel filtration,

1984 Index 779

venom fraction coagulopathy(dogs), 393

Churchill, M. C. see Churchill, P.C., 302

Churchill, P. C., Bidani, A. K.,Churchill, M. C. and Prada,J.: Renal effects of 2-chlo-roadenosine in the two-kid-ney Goldblatt rat, 302

Cirazoline, central cardiovascular

effects (cats), 232Clineschmidt, B. V., see Martin,

G. E., 569Clofibric acid, clearance, diisopro-

pylfluorophosphate (rabbits),237

Clonazepam, learning, effects on(pigeons), 307

Clonidinecentral cardiovascular effects

(cats), 232free fatty acid release, bone

marrow adipose tissue (dogs),228

Clostridium botulinum, type C2toxin, molecular pharmacol-ogy (mice), 665

Coagulopathy, venom fractions

(dogs), 393Codeine, “C-labeled, kinetics,

brain (monkeys), 250Coleman, J. B., see Wood, R. W.,

407Colpaert, F. C. and Janssen, P. A.

J.: Agonist and antagonist ef-fects of prototype opiatedrugs in rats discriminating

fent.anyl from saline: Char-acteristics of partial general-ization, 193

Complement, activation, anaphy-latoxin effects, isolated blood

vessels (guinea pigs), 749Cone, E. J., see Vaupel, D. B., 20Cooke, J. P., see Flavahan, N. A.,

699Cooper, T. B., see Barkai, A. I.,

330Coronary artery

contractile activity, nifedipineand (humans), 514

PO2 and beta adrenergic respon-siveness (cows, pigs), 692

Cory, R. N., Osman, R. and Maay-

ani, S.: Kinetic characteriza-tion of the rabbit aorta con-tractile response to an alphaadrenergic agonist, 162

Costa, E., see Chou, J., 349Coutinho, S., see Suarez-Kurtz,

G., 478Cowan, A., see Gmerek, D. E., 110

Cox, C., see Wood, R. W., 407Crawley, J. N., St-Pierre, S. and

Gaudreau, P.: Analysis of thebehavioral activity of C- andN-terminal fragments of cho-lecystokinin octapeptide, 438

Crews, F. T., see Heiman, A. S.,175

Crowley, P., see Shiverick, K. T.,

761Cunningham, K. A., Callahan, P.

M. and Appel, J. B.: Discrim-inative stimulus properties oflergotrile, 47

Cyclazocine, fixed-ratio discrimi-nation accuracy and (mon-keys, dogs), 541

Cyclic AMP, adenosine and iso-prenaline antagonism, heart(guinea pigs), 483

Cyclic GMP, adenosine and iso-

prenaline antagonism, heart(guinea pigs), 483

Cyclic nucleotide phosphodester-am, calmodulin antagonisticactivity of bepridil (cows,chickens, rabbits), 737

Cyproheptadine, cardiovascularactions (rats, rabbits), 103

Dachiw, J., see Silver, P. J., 141da Costa, M. J. B., see Suarez-

Kurtz, G., 478Danhof, M., Kisaoka, M. and

Levy, G.: Kinetics of drug ac-tion in disease states. II. Ef-fect of experimental renaldysfunction on phenobarbi-tal concentrations in rats atonset of loss of righting re-flex, 627

Davies, S., see Lauterburg, B. H.,7

Davis, S. S., see Illum, L., 733Del Rio, J., see Chou, J., 349de Moraes, S., see Callia, M. L.,

450(±) - Depentylperhydrohistrioni -

cotoxin, nicotinic receptor-ion channel, effects on

(frogs), 619Desipramine

catecholamine uptake, ganglia(frogs, bullfrogs), 221

toxicity, bicarbonate and (rats),12

Deupree, J. D., Downs, D. A., La-posky, J. E. and Hitchcock,J. J.: Inhibition of catechol-amine transport into chro-maffin granule ghosts iso-lated from bovine adrenal

glands by phenytoin, 171

Dextran, edema response to,2,3,7,8-tetrachlorodibenzo-p-

dioxin treatment and (rats),670

Diabetesautonomic receptors, heart

(rats), 242hepatic drug metabolism

(mice), 256Diazepam

anticonvulsant activity rever-sal, Ro 15-1788 (rats), 407

arterial blood gas concentra-tions and pH, methadone(rats), 353

Dihydropyridineslow channel calcium blocking

agents, baroreflex sensitivity(dogs), 376

slow channel calcium block-ing agents, hemodynamics(dogs), 367

Diisopropylfluorophosphate, do-fibric acid clearance, futilecycle (rabbits), 237

Diltiazem, cardiovascular actions(rats, rabbits), 103

Diureticindacrinone enantiomer, renal

tubular effects (rats), 62water, U-50,488, kidney (rats),

641

Dobutamine, norepinephrine and,antibody response (mice),183

Dombro, K.-R., see Smith, P. A.,221

Dominguez, J. H., see Pitts, T. 0.,601

Dopamine,

agonist, (+)-4-propyl-9-hy-droxynaphthoxazine (fish,mice, rats, dogs), 569

alpha and beta adrenoceptors

and, interaction (rats), 595antagonism, lergotrile (rats), 47erythrosin B effects, ganglia

(frogs, bullfrogs), 221intestinal vasodilation induced

by, nutrient blood flow(dogs), 214

receptor, antidepressant antag-onism (humans), 94

receptor agonist, LY141865,

blood flow and (dogs), 558receptor agonist, self-adminis-

tration (monkeys), 678release, retina, (rabbits), 149

Downie, J. W. and Karmazyn, M.:

Mechanical trauma to blad-der epithelium liberates pros-tanoids which modulate neu-rotransmission in rabbit de-trusor muscle, 445

Downs, D. A., see Deupree, J. D.,171

Droogmans, G., see Kajiwara, M.,462

Drug availability, route of adniin-istration and, liver (rats), 718

Dubocovich, M. L.: Alpha-2 adre-noceptors modulate [3HJdo-pamine release from rabbitretina, 149

Duncalf, D., see Vizi, E. 5, 493Dynorphin, fragment, receptor se-

lectivity, vas deferens (mice),200

Ear artery, 2-nicotinamidoethyl

nitrate, vascular smoothmuscle (rabbits), 462

Edema, carrageenan and dextran,

2,3,7,8-tetrachlorodibenzo-p-dioxin treatment and (rats),670

Electrolyte, transport, loop ofHenle, distal tubule (rats), 62

Electrophoresis, sodium dodecylsulfate-polyacrylamide gel,venom fraction coagulopathy

(dogs), 393Endocrine system, ethanol and $-

endorphinergic system acti-

vation (rats), 455�9-Endorphin, ethanol effects

(rats), 455Endotoxin, paraquat toxicity and

(mice), 284Endplate current, noise analysis,

(±)-depentylperhydrohistri-

onicotoxin on acetylcholinereceptors (frogs), 619

Enkephalin, cyclic, spinal andcerebral opioid receptor func-tion (mice), 341

Entopeduncular nuclens, benzo-diazepine receptor changes,lesions and (rats), 768

Epinephrinealpha and beta adrenoceptors

and, interaction (rats), 595

erythrosin B effects, ganglia

(frogs, bullfrogs), 221free fatty acid release, bone

marrow adipose tissue (dogs),228

intestinal vasodilation inducedby, nutrient blood flow(dogs), 214

norepinephrine metabolismregulation, brain (rats), 577

Ergot, derivative, lergotrile, stim-ulus effects (rats), 47

Erythrosin B, catecholamine re-sponses and, ganglia (frogs,bullfrogs), 221

Esterase, inhibition, acyl glucu-ronide, diisopropylfluoro-phosphate (rabbits), 237

Ethanolj3-endorphinergic system,

chronic effects (rats), 455glutathione suppression, liver

(rats), 7

periodic availability (rats), 658Ethosuximide

ionic channel effects (squid), 75learning, effects on (pigeons),

307Ethylketocyclazocine, bombesin-

induced scratching and

(rats), 110Ethylketazocine, fixed-ratio dis-

crimination accuracy and(monkeys, dogs), 541

N-Ethylmaleimide, opiate recep-tsr binding site and guaninenucleotide regulatory site in-teraction (rats), 684

Evangelists, S., see Maggi, C. A.,500

Excitatory junction potential, 2-nicotinamidoethyl nitrate ef-

fects, vascular smooth mus-dc (rabbits), 462

Fairchild, E. H., see Valencia, C.I., 133

Fatty acid, free, release, epineph-rine, bone marrow adiposetissue (dogs), 228

Feldman, J., see Bousquet, P., 232Fentanyl, discrimination from sa-

line, agonist and antagonistopiate effects (rats), 193

Field, M. J., Fowler, N. and Gie-bisch, G. H.: Effects of en-antiomers and indacrinone

(MK-196) on cation trans-port by the loop of Henle anddistal tubule studied by mi-croperfusion in uiuo, 62

Finet, M., see Godfraind, T., 514Fishleder, R. I. and Buckner, C.

K.: Studies on the relation-ship between contraction andmediator release produced byovalbumin in superfused tra-

780 Index Vol. 230

chea isolated from the ac-tively sensitized guinea pigs,534

Flavahan, N. A., Rimele, T. J.,Cooke, J. P. and Vanhoutte,P. M.: Characterization ofpostjunctional alpha-i andalpha-2 adrenoceptors acti-vated by exogenous or nerve-released norepinephrine inthe canine saphenous vein,699

Fleisch, J. H., see Rinkema, L. E.,550

Fohlmeister, J. F., Adelman, W.J., Jr. and Brennan, J. J.: Ex-citable channel currents andgating times in the presenceof anticonvulsants ethosux-imide and valproate, 75

F#{246}ldes,F. F., see Vizi, E. S., 493Fostedil, KB-944, cardiac electro-

physiology (dogs), 632Fowler, N., see Field, M. J., 62

France, C. P., Jacobson, A. E. andWoods, J. H.: Discriminativestimulus effects of reversibleand irreversible opiate antag-onists: Morphine, oxymor-phazone and buprenorphine,652

Frederiksen, M. C., see Bowsher,D. J., 269

Fuhrman-Lane, C., see Shiverick,K. T., 761

Fujiwara, M., see Murarnatsu, I.,469

Furosemide, interaction with pro-benecid (chinchillas), 706

Ganglia, sympathetic, erythrosinon catecholamine response(frogs, bullfrogs), 221

Gastrointestinal tract, transit,

spinal and cerebral opioid re-ceptor function (mice), 341

Gaudreau, P., see Crawley, J. N.,438

Gentamicin, kidney epithelial cellline, effects on, 742

George, C. F., see Strong, H. A.,726

Giebisch, G. H., see Field, M. J.,62

Gilbert, R., Rattan, S. and Goyal,R. K.: Pharmacologic identi-fication, activation and an-tagonism of two muscarine

receptor subtypes in thelower esophageal sphincter,284

Gillette, J. R., see Lau, S. S., 360Ginos, J. Z., see Woolverton,

W. L., 678Giolitti, A., see Maggi, C. A., 500

Giraud, G. D. and MacCannell, K.L.: Decreased nutrient bloodflow during dopamine- andepinephrine-induced intes-tinal vasodilation, 214

Gland, see specific glandGlobus pallidus, benzodiazepine

receptor changes, lesions and(rats), 768

Glucocorticoid, immunoglobulin,histamine and arachidonic

acid, effects on (rats), 175Glutathione,

depletion, renal and hepatic(rats), 360

synthesis, ethanol suppressionof, liver (rats), 7

Gmerek, D. E. and Cowan, A.: Invivo evidence for benzomor-

phan-selective receptors inrats, 110

Godfraind, T., Finet, M., Lima, J.S. and Miller, R. C.: Contrac-tile activity of human coro-nary arteries and humanmyocardiuni in vitro andtheir sensitivity to calcium

entry blockade by nifedipine,514

Goldberg, L. I., see Woolverton,W. L., 678

Goldberg, M. R, see Ruffolo, R.R., Jr., 595

Goyal, R K., see Gilbert, R, 284

Green, T. P., see Rybak, L. P., 706

Grimaldi, G., see Maggi, C. A., 500Gross, G. J., see Warltier, D. C.,

367, 376Guanidine, alkyl derivatives, nor-

epinephrine release and(rats), 710

Guanine nucleotide

regulatory protein, muscarinicreceptor affinity, heart (rats),424

regulatory sites, opiate receptorbinding site interaction with(rats), 684

Guanine 5’-triphosphate, opiatereceptor regulation (rats),684

Guchhait, R. B., see Stolk, J. M.,577

Hackbarth, I., see B#{246}hm, M., 483

Hahn, R. A. and MacDonald, B.R.: Systemic hemodynamicand regional blood flow ef-fects ofLY141865, a selectivedopamine receptor agonist,558

Handwerger, B. S., see Knodell,

R. G., 256Harden, T. K., see Martin, M. W.,

424Harmon, J. R., see Miska, S. P.,

419Hartvig, P., Bergstrom, K., Lind-

berg, B., Lundberg, P. 0.,Lundqvist, H., L#{224}ngstrom,B., Sv#{228}rd,H. and Rane, A.:Kinetics of “C-labeled opi-ates in the brain of rhesusmonkeys, 250

Hattori, Y. and Levi, R.: Negative

inotropic effect of leuko-trienes: Leukotrienes C4 andD4 inhibit calcium-dependentcontractile responses in po-tassium-depolarized guinea-pig myocardium, 646

Haubitz, B., see B#{246}hm,M., 483Hayashi, S. and Park, M. K.: Neu-

rogenic and myogenic con-tractile responses of dog mes-enteric arteries to reduced K’concentration and their in-

teractions with ouabain, 527Hayes, J. S., Bowling, H. N.,

Boder, G. B. and Kauffman,R.: Molecular basis for thecardiovascular activities of

amrinone and AR-L57, 124Heart

adenosine and isoprenaline an-tagonism (guinea pigs), 483

autonomic receptors, diabetes(rats), 242

KB-944 actions on (dogs), 632

muscarinic receptor affinity(rats), 424

ornithine decarboxylase ontog-eny (rats), 419

rate, medullary GABAergicmechanisms (rats), 34

Heiman, A. S. and Crews, F. T.:Inhibition of immunoglobu-

lin, but not polypeptide base-stimulated release of hista-mine and arachidonic acid byanti-inflammatory steroids,175

Hepatic artery, portal vein us.,

drug availability (rats), 718Hepatotoxicity, investigation

method, trypan blue uptake(rats), 755

Heroin, “C-labeled, kinetics,brain (monkeys), 250

Hers, A., see Schulz, R., 200Hers, A., see Seizinger, B. R, 4552,4,5,2’,4’,5’ -Hexachlorobi-

phenyl, redistribution, preg-nancy (rats), 263

Hidaka, H., see Itoh, H., 737

Hirsch, J. A.: Structure-activityrelationship between guani-

dine alkyl derivatives andnorepinephrine release:

Site(s) and mechanism(s) ofaction, 710

Hisaoka, M., see Danhof, M., 627Histamine

cutaneous vascular permeabil-

ity (guinea pigs), 550receptor, antidepressant antag-

onism (humans), 94release, glucocorticoids and

(rats), 175

Histrionicotoxin analog, (±)-de-pentylperhydrohistrionico-toxin, nicotinic receptor-ionchannel (frogs), 619

Hitchcock, J. J., see Deupree, J.D., 171

Hollinger, M. A.: Potentiation ofparaquat lethality in mice bybacterial lipopolysaccharidepretreatment, 292

H#{246}llt,V., see Seizinger, B. R., 455

Hom, G. J. and Jandhyala, B. S.:Effects of cerebroventricularadministration of ouabain onrenal hemodynamics in anes-

thetized dogs: Evidence for

the participation of renal do-paminergic vasodilator fi-hers, 275

Hori, R., Yamamoto, K., Saito,H., Kohno, M. and Inui,K.-I.: Effect of aminoglyco-side antibiotics on cellularfunctions of kidney epitheial

cell line (LLC-PK,): A modelsystem for aminoglycoside

nephrotoxicity, 742Hormone, see specific hormoneHruby, V. J., see Porreca, F., 341

Hugh, T. E., see Marceau, F., 749Hurst, R., see Porreca, F., 341

Hydantoin, comparative metabo-ham (humans), 28

Hydralazine, beta blockers and,renal hypertension (rabbits),205

Hydrocortisone, immunoglobulin,histamine and arachidonic

acid, effects on (rats), 1755-Hydroxyindoleacetic acid, L-

tryptophan and blood pres-sure (rats), 324

4-Hydroxyniridazole, Schisto-

some japonicum infection(humans), 133

Hydroxyphenobarbital, hypnoticeffect (rats), 627

Hyperglycemia, insulin and, he-

patic drug metabolism, dia-betes (mice), 256

Hyperpolarization, catechol-amine-induced, ganglia

(frogs, bullfrogs), 221Hypertension

alpha-2 adrenoceptors and,phenoxybenzamine (rats),387

renal, hydralazine and betablockade (rabbits), 205

L-tryptophan effects (rats), 324

Hypocalcemia, calcium and mag-nesium handling, prostaglan-

din-vasopressin interactions,kidney (rats), 295

Hypokalemia, ouabain and, mes-enteric artery (rats), 527

Hypophysectomy, amine-keta-mine catatonia (chicks), 69

Hypotensionarterial, LY141865 effects

(dogs), 558venom fraction coagulopathy

and (dogs), 393Hypothyroidism, propylthioura-

cil-induced, catecholamineneuron development (rats),53

Ileostomy, sulfinpyrazone reduc-

tion (humans), 726

Illuin, L., Jones, P. D. E., Bald-win, R. W. and Davis, S. S.:Tissue distribution of poly-(hexyl 2-cyanoacrylate) nan-oparticles coated with mono-clonal antibodies in micebearing human tumor xeno-grafts, 733

Imidazoline, catecholamine us.,central cardiovascular effects(cats), 232

Imipramine, cerebral catechol-

ainines and (rats), 330Immune response, norepineph-

tine and, beta adrenoceptor

mediation (mice), 183

Immunoglobulin, inhibition, glu-cocorticoids (rats), 175

Immunomodulation, antibody re-

sponse, norepinephrine ef-

1984 Index 781

fects (mice), 183Immunoregulation, antibody re-

sponse, norepinephrine ef-fects (mice), 183

Indacrinone, enantiomers, renaltubular effects (rats), 62

Indolamine, pineal, ketamine ca-tatonia (chicks, rats), 69

Inflammation, neurogenic, cap-saicin and bradykinin, irissphincter muscle (rabbits),469

Inotropic agents, amrinone andAR-L57 (cats, guinea pigs,rats), 124

Insulin, hyperglycemia and, he-patic drug metabolism, dia-betes (mice), 256

Intestinemicroflora, sulfinpyrazone re-

duction (humans), 726

nutrient blood flow, dopamine-and epinephrine-inducedvasodilation (dogs), 214

Inui, K., see Hori, R., 742Inulin, urea distribution, trans-

capillary exchange effects(dogs), 269

lonophore, A23187, cutaneous

vascular permeability (gum-ea pigs), 550

Ischemia, intestinal, nutrient flowand vasodilation (dogs), 214

Ishikawa, T., see Itoh, H., 737Isoprenaline, positive inotropic

effect, heart (guinea pigs),483

Isoproterenol, cold exposure and,atria (rats), 450

Itoh, H., Ishikawa, T. and Hidaka,H.: Effects on calmodulinof bepridil, an antianginalagent, 737

Itzhak, Y. and Simon, E. J.: Anovel phencycidine analoginteracts selectively with muopioid receptors, 383

Jacobson, A. E., see France, C. P.,652

Jandhyala, B. S., see Hom, G. J.,275

Janis, R. A., see Luchowski, E. M.,607

Janssen, P. A. J., see Colpaert, F.C., 193

Johnson, R. D., see Minneman,K. P., 317

Jones, J. H., see Martin, G. E.,569

Jones, P. D. E., see Ilium, L., 733Juhn, S. K., see Rybak, L. P., 706

Kajiwara, M., Droogmans, G. andCasteels, R.: Effects of 2-ni-cotinamidoethyl nitrate (Ni-

corandil) on excitation-con-traction coupling in thesmooth muscle cells of rabbitear artery, 462

Karmazyn, M., see Downie, J. W.,445

Katz, L. B., Theobald, H. M.,Bookstaff, R C. and Peter-son, R E.: Characterizationof the enhanced paw edema

response to carrageenan anddextran in 2,3,7,8-tetrachlo-

rodibenzo-p-dioxin-treatedrats, 670

Kauffman, F. C., see Belinsky, S.A., 755

Kauffman, R., see Hayes, J. S.,124

KB-944, calcium antagonist, car-diac electrophysiology (dogs),632

Keiding, S. and Steiness, E.: Flowdependence of propranololelimination in perfused ratliver, 474

Ketamine, catatonia induced by,pinealectomy and hypophy-sectomy (chicks, rats), 69

4-Ketoniridazole, Schistosoma ja-

ponicum infection (humans),133

Kidneyaipha-2 adrenoceptors, phen-

oxybenzamine (rats), 3872-chloroadenosine effects

(rats), 302dysfunction, phenobarbital in

(rats), 627epithelial cell line, aminoglyco-

side antibiotic effects, 742function, U-50,488 effects

(dogs), 641

hypertension, hydralazine andbeta blockade (rabbits), 205

necrosis, bromobenzene metab-olites (rats), 360

tubules, indacrinone enantio-mere and cation transport(rats), 62

tubules, prostaglandin-vaso-

pressin and divalent ion cx-cretion (rats), 295

vasodilator fibers, ouabain ef-fects (dogs), 275

Kimmel, G. L., see Miska, S. P.,419

Knodell, R. G., Handwerger, B.S., Morley, J. E., Levine, A.S. and Brown, D. M.: Sepa-rate influences of insulin andhyperglycemia on hepatic

drug metabolism in mice with

genetic and chemically in-duced diabetes mellitus, 256

Kohno, M., see Hori, R., 742Krieger, A. J., see Willette, R. N.,

34Kuhn, D. M., see Wolf, W. A., 324Kupfer, A., Patwardhan, R,

Ward, S., Schenker, S., Prei-sig, R. and Branch, R. A.:Stereoselective metabolismand pharmacogenetic controlof 5-phenyl-5-ethylhydan-tom (nivranol) in humans, 28

Lac, D. T., see Tran, M.-A., 228Lactation, 2,4,5,2’,4’,5’-hexa-

chlorobiphenyl redistribu-tion (rats), 263

Lafontan, M., see Tran, M.-A.,228

Lakin, M. L., see Winters, W. D.,69

Lang, C. M., see McCormick, G.

Y., 353

L#{226}ngstr#{246}m,B., see Hartvig, P.,250

Laposky, J. E., see Deupree, J. D.,171

Latifpour, J. and McNeill, J. H.:Cardiac autonomic receptors:Effect of long-term experi-mental diabetes, 242

Lau, S. S., Monks, T. J. and Gil-lette, J. R.: Identification of2-bromohydroquinone as ametabolite of bromobenzeneand o-bromophenol: 1mph-cations for bromobenzene-in-duced nephrotoxicity, 360

Lauterburg, B. H., Davies, S. andMitchell, J. R.: Ethanol sup-presses hepatic ghutathionesynthesis in rats in uiuo, 7

Leander, J. D., see Carter, R. B.,40

Learning, anticonvulsant effectsOn (pigeons), 307

Lechene, C., see Roman, R. J., 295Lergotrile, stimulus effects of

(rats), 47

Leukotrienecutaneous vascular permeabil-

ity and (guinea pigs), 550myocardial Ca� influx inhibi-

tion (guinea pigs), 646Levi, R., see Hattori, Y., 646Levine, A. S., see Knodehi, R. G.,

256Levy, G., see Danhof, M., 627Lidocaine, route of administra-

tion, drug availability andliver, (rats), 718

Lima, J. S., see Godfraind, T., 514Lindberg, B., see Hartvig P., 250Linhart, R., see B#{246}hm,M., 483Lipolysis, a4,ha-2 and beta recep-

tars, bone marrow, adiposetissue (dogs), 228

Lipopolysaccharide, endotoxin

pretreatment, paraquat tox-icity and (mice), 284

Lipoprotein, 2,4,5,2’,4’,5’-hexa-chlorobiphenyl distribution,pregnancy (rats), 263

Livercirculation, propranohol ehimi-

nation (rats), 474drug metabolism, insulin and

hyperglycemia effects, diabe-tes (mice), 256

glutathione depletion, bromo-benzene metabohite (rats),

360ghutathione synthesis, ethanol

suppression of (rats), 7route of administration, drug

availability and (rats), 718salicyhamide kinetics (dogs), 89

LLC-PK,, kidney epithehial cellline, aminoglycoside anti-biotic effects on, 742

Loop of Henhe, cation transport,indacrinone enantiomer ef-fects (rats), 62

Lovenberg, W., see Alphs, L., 431Lucchesi, B. R., see Patterson, E.,

519, 632Luchowski, E. M., Yousif, F.,

Triggle, D. J., Maurer, S. C.,Sarmiento, J. G. and Janis,

R. A.: Effects of metal cationsand calmodulin antagonistson [3Hjnitrendipine bindingin smooth and cardiac mus-dc, 607

Ludens, J. H., see Shizgi, G. R.,

641

Lundberg, P. 0., see Hartvig, P.,250

Lundqvist, H., see Hartvig, P., 250LY134046, phenylethanolamine

N-methyltransferase inhibi-tion, central effects ofchronic treatment (rats), 577

LY141865, dopamine receptoragonist, blood flow effects(dogs), 558

Lynch, J. J., see Patterson, E.,519, 632

Maayani, S., see Cozy, R. N., 162

MacCannell, K. L., see Giraud,G.D.,214

MacDonald, B. R., see Hahn, R.A., 558

Macdonald, R. L., see Skerritt, J.H., 82

MacDonall, J. S., see Marcucella,

H., 658Maggi, C. A., Evangelists, S., Gri-

maldi, G., Santiciohi, P., Giol-itti, A. and Mcli, A.: Evidencefor the involvement of arach-idonic acid metabohites inspontaneous and drug-in-duced contractions of rat uri-nary bladder, 500

Magnesium, renal handling, pros-

taglandin-vasopressin inter-actions (rats), 295

Magnesium adenosine triphos-

phate, catecholamine trans-port inhibition, phenytoinand (cows), 171

Maleque, M. A., Takahashi, K.,Witkop, B., Brossi, A. andAlbuquerque, E. X.: A studyof the novel synthetic analog(±)-depentyiperhydrohistri-

onicotoxin on the nicotinicreceptor-ion channel, 619

Mahik, S., see Cauvin, C., 413Maramba, N. C., see Valencia,

C. I., 133Marceau, F. and Hugh, T. E.: Ef-

fect of C3a and C5a anaphy-latoxins on guinea-pig iso-hated blood vessels, 749

Marcucella, H., Munro, I. andMacDonahl, J. S.: Patterns ofethanol consumption as afunction of the schedule ofethanol access, 658

Martin, G. E., Williams, M., Pet-tibone, D. J., Yarbrough, G.G., Chineschmidt, B. V. andJones, J. H.: Pharmaco-logic profile of a novel po-

tent direct-acting dopamineagonist, (+)-4-propyl-9-hy-droxynaphthoxazine [(+)-PHNO], 569

Martin, M. W., Smith, M. M. andHarden, T. K.: Modulation ofmuscarinic chohinergic recep-tar affinity for antagonists in

782 Index Vol. 230

rat heart, 424Mastropaolo, J., see Moersch-

baecher, J. M., 541

Maurer, S. C., see Luchowski, E.M.,607

McCormick, G. Y., White, W. J.,Zagon, I. S. and Lang, C. M.:Effects of diazepam on arte-rial blood gas concentrationsand pH of adult rats acutelyand chronically exposed tomethadone, 353

McCoun, D., see Vaupel, D. B., 20McNeill, J. H., see Latifpour, J.,

242Medulla, GABAergic mecha-

nisms, blood pressure regu-lation (rats), 34

Meffin, P. J., see Rowe, B. J., 237

Mcli, A., see Maggi, C. A., 500

Membrane potentialcatecholamine transport inhi-

bition, phenytoin, adrenalglands (cows), 171

2-nicotinamidoethyl nitrate ef-fects, ear artery (rabbits), 462

Mesenteric arteryreduced K� concentration and

ouabain (dogs), 527resistance vessels, alpha adre-

noceptors and Ca� use(rats), 413

saponin-skinned, calmodulin

antagonistic activity of bepri-dil (cows, chickens, rabbits),737

Messick, K., see Ruffoho, R. R.,Jr., 587

Met-enkephalin, [‘4C)acetylcho-line release and (guinea pigs),

493Met6-enkephalin, metabolism,

peptidase inhibitors and(rats), 349

Met5-enkephahin-Ar�-Phe7, me-tabohism, peptidase inhibi-tars and (rats), 349

Methadonearterial blood gas concentra-

tions and pH, diazepam ef-

fects (rats), 353fixed-ratio discrimination ac-

curacy and (monkeys, dogs),541

3-Methylcholanthrene, steroidmetabolism, effects on, pla-cents (rats), 761

a-Methylnorepinephrine, centralcardiovascular effects (rats),

232Meyer, W., see B#{246}hm,M., 483Microperfusion, renal tubular, in-

dacrinone enantiomer effects

(rats), 62Microsphere, hydralazine and

beta blockers, renal hyper-tension (rabbits), 205

Micturition, reflex, arachidonicacid metabolites and, bladder(rats), 500

Miller, C. H., see Winters, W. D.,69

Miller, R. C., see Godfraind, T.,514

Minneman, K. P. and Johnson,

R. D.: Characterization of at-pha-1 adrenergic receptorslinked to [3Hjinositol metab-ohism in rat cerebral cortex,317

Miska, S. P., Kimmel, G. L., Har-mon, J. R. and Webb, P.: On-togeny of cardiac ornithinedecarboxylase and its betaadrenergic responsiveness inthe rat, 419

Mitchell, J. R., see Lauterburg, B.

H., 7

MK-196, renal tubular effects(rats), 62

Moerschbaecher, J. M., Mastro-paolo, J., Winsauer, P. J. andThompson, D. M.: Effects ofopioids on accuracy of afixed-ratio discrimination inmonkeys and rats, 541

Molinoff, P. B., see Pittman, R.N., 614

Monks, T. J., see Lau, S. S., 360Monoclonal antibody, nanoparti-

dc coating by, tissue distri-bution (mice), 733

Montgomery, D. G., see Patter-son, E., 632

Morello, R. S., Begenisich, T. andYeh, J. Z.: Determination ofthe active form of phenytoin,156

Morgan, E. L., see Ruffolo, R. R.,Jr., 587, 595

Morgan, G., see Winquist, R. J.,

103Morizono, T., see Rybak, L. P.,

706

Morley, J. E., see Knodell, R. G.,256

Morphine

“C-labeled, kinetics, brain

(monkeys), 250

discriminative stimulus effects(pigeons), 652

fixed-ratio discrimination ac-curacy and (monkeys, dogs),541

Mosberg, H. I., see Porreca, F.,341

Munro, I., see Marcucella, H., 658

Munson, A. E., see Sanders, V.M.,183

Muramatsu, I., see Ueda, N., 469Musacchio, J. M., see Bahouth,

S.W., 116Muscle

detrusor, prostanoids and neu-rotransmission (rabbits), 445

iris sphincter, substance P-ergic responses (rabbits), 469

skeletal, contraction, salicylateand (frogs, toads), 478

smooth, reduced K� and oua-bain, mesenteric artery(dogs), 527

smooth, vascular, vasodilatoreffects on (rabbits), 462

Myenteric plexus,

[‘4C�acetylchohine release, Met-enkephahin effects (guineapigs), 493

Myocardium

contractile activity, nifedipine

and (humans), 514potassium-depolarized, Ca�

influx inhibition by leuko-trienes (guinea pigs), 646

Myosin, phosphorylation, vasodi-

lators and (cows), 141Myosin light chain kinase, bepri-

dii effects on (cows, chickens,rabbits), 737

Naloxonephencyclidine withdrawal, ef-

fects on (monkeys), 399

picrotoxin us., schedule-con-trolled responding (pigeons),40

Naltrexone, reversible and irre-versible opiate agonists, (pi-geons), 652

fl-Naphthoflavone, steroid me-tabohism, effects on, placenta(rats), 761

Naphthoxazine, (+)-4-propyl-9-hydroxynaphthoxazine, do-pamine agonist (fish, mice,rats, dogs), 569

Narcotic, tolerance and antago-nism, discriminative stimu-

lus effects (pigeons), 652Nelson, A., see Richelson, E., 94Nephrotoxicity

aminoglycoside, kidney epithe-hal cell line, 742

2-bromohydroquinone-induced(rats), 360

Nervous system

central and sympathetic, devel-opment in hypothyroidism

(rats), 53sympathetic, neurotransmitter,

antibody response and nor-epinephrine (mice), 183

Neuromuscular transmission,electrical excitability, (±)-de-

pentylperhydrohistrionico-toxin on acetylchohine recep-tors (frogs), 619

2-nicotinamidoethyl nitrate ef-

fects, ear artery (rabbits), 462Neuron

catecholaminergic, hypothy-roidism and (rats), 53

convulsant barbiturate effects

on (mice), 82vagal inhibitory, muscarinic

transmission (opossum), 284Neurotransmission, prostanoids

modulating, epithehialtrauma and, bladder (rab-bits), 445

Neurotransmitterreceptor, antidepressants and

(humans), 94sympathetic, antibody response

and norepinephrine (mice),183

Nicorandil, excitation-contrac-

tion coupling, vascularsmooth muscle (rabbits), 462

2-Nicotinamidoethyl nitrate, cx-citation-contraction cou-phing, vascular smooth mus-dc (rabbits), 462

Nifedipinebaroreflex sensitivity altera-

tions (dogs), 376calcium entry blockade, coro-

nary arteries and myocar-dium, (humans), 514

cardiovascular actions (rats,rabbits), 103

Niridazole, metabohites, Schi,sto-soma japonicum infection(humans), 133

Nirvanol, 5-phenyl-5-ethylhy-dantoin, stereoselective me-tabohism (humans), 28

Nitrendipine, radiolabeled, cationand calmodulin antagonisteffects, smooth and cardiacmuscle (guinea pigs, rabbits,cows), 607

Nonsteroidal anti-inflammatory

drugs, arachidonic acid de-pletion and, bladder contrac-tions (rats), 500

Noradrenaline, 2-nicotinamido-ethyl nitrate effects, vascularsmooth muscle (rabbits), 462

Norepinephrine

acetyl-Co A:arylamine N-ace-tyltransferase inductionmodulation (rats), 431

alpha adrenoceptor activation,saphenous vein (dogs), 699

alpha and beta adrenoceptors

and, interaction (rats), 595alpha-i receptor activation,

(rats), 413antibody response, beta adre-

noceptor mediation (mice),183

cold exposure and, atria (rats),450

[3H]inositol metabolism and,cerebral cortex (rats), 317

release, guanidine and (rats),

710release, ouabain effects, mes-

enteric artery (dogs), 527release inhibition, LY141865

effects (dogs), 558

Oates, J., see Strong, H. A., 726Ono, K., see Vizi, E. S., 493Opiate

“C-labeled, brain (monkeys),250

fentanyl us. saline, agonist andantagonist effects (rats), 193

receptor binding sites, guaninenucleotide regulatory site in-teraction with (rats), 684

reversible and irreversible ago-nists, discriminative stimulus

effects (pigeons), 652Opioid

kappa, U-50,488, kidney (dogs),641

peptide precursors, ethanol and$-endorphinergic system ac-tivation (rats), 455

Ornithine decarboxylase, ontog-eny, cardiac (rats), 419

Ortiz, E., see Shiverick, K. T., 761Osman, R., see Cory, R. N., 162Ototoxicity, probenecid-furose-

mide interaction and (chin-chillas), 706

Ouabain

1984 Index 783

Na�,K�-exchange pump inhi-bition, mesenteric artery(dogs), 527

renal hemodynamics and(dogs), 275

Ovalbumin, contraction and me-diator release, trachea(guinea pigs), 534

Oxotremorine, receptor binding,

heart (rats), 424Oxygen tension, beta adrenergic

responsiveness and, coronaryartery (cows, pigs), 692

Oxymorphazone, discriminativestimulus effects (pigeons),652

pA2, cold exposure and beta adre-noceptors, atria (rats), 450

Pan, H. A., Penney, J. B., Jr. andYoung, A. B.: Characteriza-tion of benzodiazepine recep-tor changes in substantia ni-gra, globus pallidus and en-topeduncular nucleus afterstriatal lesions, 768

Pang, P. K. T., see Shew, R. L., 1Parahydroxylation, stereoselec-

tive, nirvanol (humans), 28Paraquat, toxicity, endotoxin and

(mice), 284Parathyroid hormone, uterine

contractility and (rats), 1Park, M. K., see Hayashi, S., 527Patterson, E., Lynch, J. J. and

Lucchesi, B. R.: Antiar-rhythmic and antifibrillatoryactions of the beta adrenergicreceptor antagonist, dl-so-talol, 519

Patterson, E., Montgomery, D.G., Lynch, J. J. and Lucchesi,B. R.: Cardiac electrophys-iologic actions of KB-944(Fostedil), a new calcium an-tagonist, in the anesthetizeddog, 632

Patwardhan, R., see K#{252}pfer,A.,28

Paul, R. J., see Rubanyi, G., 692Penney, J. B., Jr., see Pan, H. S.,

768

Pentel, P. and Benowitz, N.: Ef-ficacy and mechanism of ac-tion of sodium bicarbonate inthe treatment of desipraminetoxicity in rats, 12

Pentylenetetrazol, toluene anti-convulsant and antipunish-ment effects (rats), 407

Peptidase, inhibitors, Met5-en-kephalin-Arg6-Phe7 andMet5-enkephalin metabolism(rats), 349

Peptide, fragments, cholecysto-kinin behavioral activity(mice), 438

Perilymph, probenecid-furose-mide interactions and (chin-chillas), 706

Perry, B. D., see Stolk, J. M., 577Peterson, R. E., see Katz, L. B.,

670Pethidine, “C-labeled, kinetics,

brain (monkeys), 250

Petit, J. P., see Winters, W. D.,69

Pettibone, D. J., see Martin, G.E., 569

Pettinger, W. A., see Smyth, D.D., 387

Phenazocine, bombesin-inducedscratching and (rats), 110

Phencyclidine

analog, mu opioid receptor in-teraction with (mice), 383

analogs and precursors (mice),20

behavioral dependence (mon-

keys), 399Phenethylamine, a-methyl-sub-

stituted, interactions with at-pha and beta adrenoceptors(rats), 595

Phenobarbitalcatecholamine inhibition, ad-

renal glands (cows), 171kidney dysfunction and (rats),

627learning, effects on (pigeons),

307

Phenoxybenzamine

acetyl-Co A:arylamine N-ace-tyltransferase induction(rats), 431

selective alpha-i blockade, kid-ney (rats), 383

Phenylephrine, [3H]inositol me-tabolism and, cerebral cortex

(rats), 317

Phenylethanolamine N-methyl-transferase, chronic inhibi-tion, norepinephrine metab-olism and (rats), 577

5-Phenyl-5-ethylhydantoin, star-eoselective metabolism (hu-mans), 28

Phenytoincatecholamine inhibition, ad-

renal glands (cows), 171learning, effects on (pigeons),

307sodium channel current block-

ing and (squid), 156Phosphatidylinositol, alpha-i ad-

renergic receptors and, cere-bral cortex (rats), 317

Phosphaturia, bicarbonate load-

ing and volume expansion,prostaglandin E2 effects(dogs), 601

Phosphodiesterase, inhibition,amrinone and AR-L57 (cats,guinea pigs, rats), 124

Phosphonic acid, derivative, KB-944, cardiac electrophysiol-ogy (dogs), 632

Phosphorylation, myosin, vasodi-

lators and (cows), 141Physalaemin, substance P recep-

tors and, salivary gland(rats), 116

Picker, M. and Poling, A.: Effectsof anticonvulsants on learn-ing Performance of pigeonsunder a repeated acquisitionprocedure when exposed tophenobarbital, clonazepam,vaiproic acid, ethosuximideand phenytoin, 307

Picrotoxin, naloxone us., sched-ule-controlled responding(pigeons), 40

Pinealectomy, amine-ketaminecatatonia (chicks, rats), 69

Pittman, R. N., Reynolds, E. E.and Molinoff, P. B.: Rela-tionship between intrinsicactivities of agonists in nor-mal and desensitized tissueand agonist-induced loss ofbeta adrenergic receptors, 614

Pitts, T. 0., Dominguez, J. H. andPuschett, J. B.: Interferenceby prostaglandin E2 with thephosphaturic effects of non-hormonal agents, 601

Pituitary gland, ethanol and fi-endorphinergic system acti-vation (rats), 455

Poling, A., see Picker, M., 307Poly(hexyl 2-cyanoacrylate) nan-

oparticles, monoclonal anti-body-coated, tissue distribu-tion (mice), 733

Popp, J. A., see Belinsky, S. A.,755

Porreca, F., Mosberg, H. I., Hurst,R., Hruby, V. J. and Burks,T. F.: Roles of mu, delta andkappa opioid receptors inspinal and supraspinal me-diation of gastrointestinaltransit effects and hot-plateanalgesia in the mouse, 341

Portal vein, hepatic, hepatic ar-tery us., drug availability(rats), 718

Potassiumdepolarized myocardium, Ca�

influx inhibition by leuko-trienes (guinea pigs), 646

permeability, 2-nicotinamido-

ethyl nitrate effects, vascularsmooth muscle (rabbits), 462

Potassium channel, currents andgating (squid), 75

Potassium ion, reduced concen-tration, ouabain and, mesen-teric artery (dogs), 527

Prada, J., see Churchill, P. C., 302Prazosin

chronic, brain catecholamine

metabolism and (rats), 577

[3H)inositol metabolism and,cerebral cortex (rats), 317

Pregnancy

2,4,2’,4’,5’-hexachlorobiphenylredistribution (rats), 263

steroid metabolism, $-naphtho-flavone and 3-methylcholan-threne effects, placenta(rats), 761

Preisig, R., see Kupfer, A., 28Pressor response, alpha adreno-

ceptor-mediated, calcium useand (rats), 587

Probenecid, interaction with fu-

rosemide (chinchillas), 706

PropranololAQA-39 and (puppies), 336elimination, hepatic blood flow

and (rats), 474(+) -4 -Propyl- 9 -hydroxynaph-

thoxazine, dopamine agonist

(fish, mice, rats, dogs), 569Propylthiouracil, hypothyroidism

and catecholamine develop-ment (rats), 53

Prostaglandindepletion, nonsteroidal anti-in-

flammatory drugs and blad-der contractions (rats), 500

epithelial trauma and, bladder(rabbits), 445

Prostaglandin E, vasopressin and,divalent ion excretion, kid-ney (rats), 295

Prostaglandin E�,, phosphaturia

inhibition by (dogs), 601Prostanoid, epithelial trauma

and, bladder (rabbits), 445Protein, phosphorylation, amri-

none and AR-L57, cardio-myocyte (cats, guinea pigs,rats), 124

Puschett, J. B., see Pitts, T. 0.,601

Quinine, muscle excitation, sali-

cylate effects on (frogs,toads), 478

Quinuclidinyl benzilate, musca-

rinic receptor affinity, heart(rats), 424

Rane, A., see Hartvig, P., 250

Rattan, S., see Gilbert, R., 284Receptor

adrenergic, I3Hlinositol metab-olism and, cerebral cortex(rats), 317

agonist, dopamine, LY141865,blood flow and (dogs), 558

alpha-i, norepinephrine acti-vation, calcium influx andrelease, artery (rats), 413

alpha adrenergic, epinephrinelevel reduction, brain (rats),577

benzodiazepine, regulation, �changes after lesions, sub-stantia nigra, globus pallidusand entopeduncular nucleus(rats), 768

benzomorphan-selective (rats),110

beta adrenergic, agonist-in-duced loss of (rats), 614

beta adrenergic, ornithine de-carboxylase ontogeny, heart(rats), 419

beta adrenergic, responsive-ness, PO2 and, coronary ar-tery (cows, pigs), 692

muscarinic, binding, diabetes(rats), 242

muscarinic and cholinergicsubtypes, lower esophageal

sphincter (opossum), 284

muscarinic guanine nucleo-tides, heart (rats), 424

muscarinic, Met-enkephalinand [‘4C)acetylcholine re-lease (guinea pigs), 493

neurotransmitter, antidepres-sant antagonism (humans),94

nicotinic, activation and desen-

sitization, (±)-depentylper-hydrohistrionicotoxin effects

Vol. 230784 Index

(frogs), 619opiate, binding sites, guanine

nucleotide regulatory site in-teraction with (rats), 684

opioid, fixed-ratio discrimina-tion accuracy and (monkeys,dogs), 541

opioid, mu, phencycidine ana-log interaction with (mice),383

opioid, spinal and cerebral, gas-trointestinal transit and hot-plate analgesia (mice), 341

substance P, salivary gland(rats), 116

Renin, 2-chloroadenosine effects(rats), 302

Renwick, A. G., see Strong, H. A.,726

Reserpine, AQA-39 and (pup-pies), 336

Respiratory system, arterial bloodgas concentrations and pH,diazepam effects, methadoneand (rats), 353

Retina, dopamine release (rab-bits), 149

Reynolds, E. E., see Pittman, R.N., 614

Richelson, E. and Nelson, A.: An-tagonism by antidepressantsof neurotransmitter recep-tom of normal human brainin uitro, 94

Righting reflex, loss, phenobarbi-tal-induced, kidney dysfunc-tion and (rats), 627

Rimele, T. J., see Flavahan, N. A.,

699Rinkema, L E., Bemis, K. G. and

Fleisch, J. H.: Productionand antagonism of cutaneousvascular permeability in theguinea pig in response to his-tamine, leuokotrienes andA23187, 550

Roman, R. J., Skelton, M. andLechene, C.: Prostaglandin-vasopression interactions onthe renal handling of calciumand magnesium, 295

Rowe, B. J. and Meffin, P. J.:Diisopropylfluorophosphateincreases clofibric acid clear-ance: Supporting evidencefor a futile cycle, 237

Rowland, M., see Ahmad, A. B.,718

Rubanyi, G. and Paul R. J.: 02-sensitivity of beta adrenergicresponsiveness in isolatedbovine and porcine coronaryarteries, 692

Ruffolo, R R., Jr., Goldberg, M.R and Morgan, E. L.: Inter-actions of epinephrine, nor-epinephrine, dopamine andtheir corresponding a-meth-yl-substituted derivativeswith alpha and beta adreno-ceptors in the pithed rat, 595

Ruffolo, R R., Jr., Morgan, E. L.and Messick, K.: Possible re-lationship between receptorreserve and the differential

antagonism of alpha-i andalpha-2 adrenoceptor-medi-ated pressor responses by cal-cium channel antagonists inthe pithed rat, 587

Rybak, L. P., Green, T. P., Juhn,S. K. and Morizono, T.: Pro-benecid reduces cochlear ef-fects and perilymph penetra-tion of furosemide in chin-chilla, 706

St-Pierre, S., see Crawley, J. N.,438

Saito, H., see Hori, R., 742Salicylamide, dose-dependent ki-

netics (dogs), 89Salicylate, muscle contraction

and (frogs, toads), 478Salivary gland, substance P re-

ceptor (rats), 116Sanders, V. M. and Munson, A.

E.: Beta adrenoceptor media-

tion of the enhancing effectof norepinephrine on the mu-rine primary antibody re-sponse in uitro, 183

Santicioli, P., see Maggi, C. A.,500

Saphenous vein, alpha adrenocep-tore, activation by norepi-nephrine (dogs), 699

Saponin, skinned mesenteric ar-tery, calmodulin antagonisticactivity of bepridil (cows,

chickens, rabbits), 737Sapru, H. N., see Willette, R N.,

34Sarcoplasmic reticulum, calcium

sequestration, salicylate ef-

fects (frogs, toads), 478Sarmiento, J. G., see Luchowski,

E. M., 607

Saxena, P. R., see Bolt, G. R., 205Schaeffer, R. C., Jr., Briston, C.,

Chilton, S.-M. and Carlson,R. W.: Hypotensive and he-mostatic properties of rat-tlesnake (Crotalus uiridis hel-Len) venom and venom frac-tions in dogs, 393

Schenker, S., see Kupfer, A., 28Schistosoma japonicum, nirida-

sole, serum metabolites (hu-mans), 133

Schmidt, B., see B#{246}hm,M., 483Schmitz, W., see B#{246}hm,M., 483Scholz, H., see B#{246}hm,M., 483Schuler, R., see Wood, R. W., 407Schulz, R., W#{252}ster,M. and Hers,

A.: Receptor preference ofdynorphin A fragments in themouse vas deferens deter-mined by different tech-niques, 200

Schwartz, J., see Bousquet, P., 232Seizinger, B. R., Bovermann, K.,

H#{246}llt,V. and Hers, A.: En-hanced activity of the �9-en-dorphinergic system in theanterior and neurointerme-diate lobe of the rat pituitaryafter chronic treatment withethanol liquid diet, 455

Sembi, J., see Strong, H. A., 726Serotonin

antagonism, lergotrile (rats), 47L-tryptophan effects, blood

pressure and (rats), 324Shew, R. L., Yes, J. A. and Pang,

P. K. T.: Direct effect ofparathyroid hormone on ratuterine contraction, 1

Shiverick, K. T., Ortiz, E., Fuhr-man-Lane, C. and Crowley,P.: Effects of �-naphthofla-vone and 3-methylcholan-threne administered to preg-

nant rats on steroid metabo-lism in the isolated basalzone of the placenta, 761

Siegl, P. K. S., see Winquist, R.J., 103

Silver, P. J., Dachiw, J. and Am-brose, J. M.: Effects of cal-cium antagonists and vaso-dilators on arterial myosinphosphorylation and actin-myosin interactions, 141

Simon, E. J., see Itzhak, Y., 383Simpson, L. L.: Molecular basis

for the pharmacological ac-tions of Clostridium botu-

linum type C2 toxin, 665Skelton, M., see Roman, R. J., 295Skerritt, J. H. and Macdonald, R.

L.: Multiple actions of con-vulsant barbiturates onmouse neurons in cell cul-ture, 82

SKF 10,047, fixed-ratio discrimi-nation accuracy and (mon.keys, dogs), 541

SK&F 64139, phenylethanola-mine N-methyltransferaseinhibition, central effects ofchronic treatment (rats), 577

SK&F 29661, chronic, brain cats-cholamine metabolism and

(rats), 577Skin, vascular permeability, his-

tamine, leukotrienes andA23187 (guinea pigs), 550

Slepetis, R. J., see Slotkin, T. A.,53

Slifer, B. L., Balster, R. L. andWoolverton, W. L.: Behav-ioral dependence produced bycontinuous phencyclidine in-fusion in rhesus monkeys,399

Slizgi, G. R., Taylor, C. J. andLudens, J. H.: Effects of thehighly selective kappa opioid,U-50,488, on renal functionin the anesthetized dog, 641

Slotkin, T. A. and Slepetis, R. J.:Obligatory role of thyroid

hormones in development ofperipheral sympathetic and

central nervous system ca-techolaminergic neurons: Ef-fects of propylthiouracil-in-duced hypothyroidism ontransmitter levels, turnoverand release, 53

Smith, M. M., see Martin, M. W.,424

Smith, P. A., Dombro, K.-R and

Zidichouksi, J.: Effect oferythrosin B on hyperpolar-izing responses to catechol-amines in amphibian sympa-thetic ganglia, 221

Smyth, D. D., Umemura, S. andPettinger, W. A.: Alpha-i ad-renoceptor selectivity ofphenoxybenzamine in the rat

kidney, 387

Sodium bicarbonate, desipramine

toxicity (rats), 12Sodium channel

blockade, phenytoin effects(squid), 156

currenta and gating (squid), 75

Sodium pump, erythrosin B inhi-bition, ganglia (frogs, bull-frogs), 221

dl-Sotalol, antiarrhythmic andantifibrillatory actions(dogs), 519

Sphincter, lower esophageal, mus-carinic receptor subtypes in(opussum), 284

Spindler-Vomachka, M. and Vod-icnik, M. J.: Distribution of2,4,5,2’,4’,5’ - hexachlorobi-phenyl among lipoproteinsduring pregnancy and lacta-tion in the rat, 263

Steiness, E., see Keiding S., 474Steroid

anti-inflammatory, histamine

and arachidonic acid (rats),175

metabolism, �9-naphthoflavoneand 3-methylcholanthreneeffects, placenta (rats), 761

Stewart, J. M., see Bahouth, S.W., 116

Stolk, J. M., Vantini, G., Perry,B. D., Guchhait, R. B. andU’Prichard, D. C.: Assess-ment of the functional role ofbrain adrenergic neurons:Chronic effects of phenyleth-anolamine N - methyltrans-ferase inhibitors and alphaadrenergic receptor antago-fists on brain norepineph-rine metabolism, 577

Striatum, kainate lesions, benzo-diazepine receptor changes

after, substantia nigra, gb-bus pallidus and entopedun-cular nucleus (rats), 768

Strong, H. A., Oates, J., Sembi, J.,Renwick, A. G. and George,C. F.: Role of the gut flora in

the reduction of sulfinpyra-zone in humans, 726

Structure-activity relationship,guanidine alkyl derivativesand norepinephrine release(rats), 710

Suarez-Kurtz, G., de Costa, M. J.B. and Coutinho, S.: Inhibi-tory effects of salicylate oncontractility in skeletal mus-dc, 478

Substance Pcapsaicin and bradykinin ef-

fects, iris sphincter muscle(rabbits), 469

1984 Index 785

receptors, salivary gland (rats),116

Substantia nigra pars reticulata,benzodiazepine receptor

changes, lesions and (rats),768

Suckow, R. F., see Barkai, A. I.,330

Sulfide, sulfinpyrazone reduction,gut flora effects (humans),726

Sulfinpyrazone, microbial reduc-tion, intestine (humans), 726

Sulfoconjugation, dose-depend-ent, salicylamide (dogs), 89

Sv#{228}rd,H., see Hartvig, P., 250

Tachycardia, supraventricular,KB-944 and (dogs), 632

Takahashi, K., see Maleque, M.A., 619

Tang, J., see Chou, J., 349Taylor, C. J., see Slizgi, G. R., 641

Temperature, cold exposure, betaadrenoceptors and, atria(rats), 450

Terbutaline, norepinephrine and,antibody response (mice),183

2,3,7,8-Tetrachborodibenzo-p- di-oxin, edema response to car-rageenan and dextran (rats),670

Theobald, H. M., see Katz, L. B.,670

i-Thiocarbamoyl-2-imidazoli-none, niridazole and, Schis-tosoma japonicum infection(humans), 133

Thompson, D. M., see Moersch-baecher, J. M., 541

Thurman, R. G., see Belinsky,S. A., 755

Thyroid hormone, nervous sys-tern catecholaminergic neu-ron development, propyl-thiouracil (rats), 53

Toluene, anticonvulsant and an-tipunishment effects, penty-lenetetrazol and (rats), 407

Tomography, position emission,“C-labeled opiate kinetics,brain (monkeys), 250

Toxicity, desipramine, bicarbon-ate and (rats), 12

Toxin, Clostridium botulinum

type C2, molecular pharma-cobogy (mice), 665

Trachea, antigen challenged(guinea pigs), 534

Tran, M.-A., Lac, D. T., Berban,M. and Lafontan, M.: Inter-play of alpha-2 and beta

Lt� adrenoceptors in the control� � of free fatty acid release from

bone marrow adipose tissue,228

Transcapillary exchange, urea

distribution kinetics (dogs),

269Triggle, D. J. see Luchowski, E.

M.,607Trypan blue, uptake, hepatotox-

icity investigation (rats), 755L-Tryptophan, blood pressure ef-

fects (rats), 324Tumor, xenograft, human, mono-

cbonal antibody-coated nan-oparticles (mice), 733

U-50,488, renal effects (dogs), 641Ueda, N., Muramatsu, I. and Fu-

jiwara, M.: Capsaicin andbradykinin-induced sub-stance P-ergic responses inthe iris sphincter muscle ofthe rabbit, 469

Umemura, S., see Smyth, D. D.,387

U’Prichard, D. C., see Stolk, J. M.,577

Urea, distribution kinetics, trans-capillary exchange effects(dogs), 269

Urthaber, F. and Walker, A. A.:Indirect stimulatory action ofthe calcium channel blockerAQA-39, 336

Uterus, contractility, parathyroidhormone effects (rats), 1

Valencia, C. I., Catto, B. A., Fair-child, E. H., Wilson, S. B.,Maramba, N. C. and Web-ster, L. T., Jr.: Concentra-tion-tirne course of niridazoleand six metabolites in the se-rum of four Filipinos withSchistosomajaponicum infec-tion, 133

Valproate, ionic channel effects

(squid), 75

Valproic acid, learning, effects on(pigeons), 307

Vanhoutte, P. M., see Flavahan,N. A., 699

Vantini, G., see Stolk, J. M., 577Vasculature, dermal, permeabil-

ity, histamine, leukotrienesand A23187 (guinea pigs),550

Vas deferens, receptor selectivityof dynorphin fragments(mice), 200

Vasodilator, 2-nicotinamidoethylnitrate, excitation-contrac-tion coupling, vascularsmooth muscle (rabbits), 462

Vasodilator fiber, ouabain effects,

kidney (dogs), 275Vasopressin, prostaglandins and,

divalent ion excretion (rats),295

renal adenylate cyclase (rats),

387

Vaupel, D. B., McCoun, D. andCone, E. J.: Phencyclidineanalogs and precursors: Re-tarod and lethal dose studiesin the mouse, 20

Venom, hypotensive and hemo-static properties (dogs), 393

Ventricle, refractoriness, dl-so-talol effects (dogs), 519

Verapamil, cardiovascular actions(rats, rabbits), 103

Voltage clamp, ethosuximide andvalproate testing (squid), 75

Vizi, E. S., Ono, K., Adam-Vizi,V., Duncalf, D. and F#{246}ldes,F.F.: Presynaptic inhibitory ef-fect of Met-enkephalin on[‘4C]acetylcholine releasefrom the myenteric plexusand its interaction with mus-carinic negative feedback in-hibition, 493

Vodicnik, M. J., see Spindler-

Vornachka, M., 263

[3H]W-7, calmodulin antagonisticactivity of bepridil (cows,chickens, rabbits), 737

Walker, A. A., see Urthaler, F.,336

Wallace, A. A., see Winquist, R.J., 103

Ward, S., see KOpfer, A., 28Warltier, D. C., Zyvoboski, M. G.,

Gross, G. J. and Brooks,H. L.: Comparative actions ofdihydropyridine slow chan-nd calcium blocking agentsin conscious dogs: Altera-tions in baroreflex sensitiv-ity, 376

Warltier, D. C., Zyvoloski, M. G.,Gross, G. J. and Brooks,H. L.: Comparative actions ofdihydropyridine slow chan-nd calcium blocking agentsin conscious dogs: Systemicand coronary hemodynamicswith and without combinedbeta adrenergic blockade, 367

Waschek, J. A., Rubin, G. M.,Tozer, T. N., Fielding, R. M.,Couet, W. R., Effeney, D. J.and Pond, S. M.: Dose-dc-pendent bioavailabiity andmetabolism of salicylamidein dogs, 89

Webb, P., see Miska, S. P., 419Webster, L. T., Jr., see Valencia,

C. I., 133White, W. J., see McCormick,

G.Y.,353Willette, R N., Barcas, P. P.

Krieger, A. J. and Sapru, H.N.: Endogenous GABAergicmechanisms in the medulla

and the regulation of bloodpressure, 34

Williams, G. E., see Martin, G. E.,

569Wilson, S. B., see Valencia, C. I.,

133Winquist, R. J., Siegl, P. K. S.,

Baskin, E. P., Bohn, D. L.,Morgan, G. and Wallace, A.A.: Calcium entry blocker ac-tivity of cyproheptadine inisolated cardiovascular prep-arations, 103

Winsauer, J. P., see Moersch-

baecher, J. M., 541

Winters, W. D., Petit, J. P.,Lakin, M. L. and Miller, C.H.: Effects ofamine pretreat-ment on ketamine catatoniain pinealectomized or hy-pophysectomized animals, 69

Witkop, B., see Maleque, M. A.,619

Wolf, W. A. and Kuhn, D. M.:Effects of L-tryptophan onblood pressure in normoten-sive and hypertensive rats,324

Wood, R W., Coleman, J. B.,Schuler, R. and Cox, C.: An-ticonvulsant and antipunish-ment effects of toluene, 407

Woods, J. H., see France, C. P.,652

Woolverton, W. L., Goldberg, L.

I. and Ginos, J. Z.: Intrave-nous self-administration ofdopamine receptor agonistsby rhesus monkeys, 678

Woolverton, W. L., see Slifer,B. L., 399

WUster, M., see Schulz, P., 200

m-Xylene, anticonvulsant activ-ity, pentylenetetrazol and(rats), 407

Yamamoto, see Hori, R, 742Yang, H.-Y. T., see Chou, J., 349Yarbrough, G. G., see Martin,

G. E., 569Yee, J. A., see Shew, R. L., 1Yeh, J. Z., see Morelbo, R. S., 156Yohimbine, chronic, brain cate-

cholamine metabolism and(rats), 577

Young, A. B., see Pan, H. S., 768

Yousif, F., see Luchowski, E. M.,607

Zagon, I. S., see McCormick,G. Y., 353

Zidichouski, J., see Smith, P. A.,221

Zyvoloski, M. G., see Warltier,D. C., 367, 376