immediate pre-operative decolonization therapy reduces surgical site infections: a multidisciplinary...
TRANSCRIPT
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Immediate Pre-operative Decolonization Therapy
Reduces Surgical Site Infections:
A multidisciplinary quality improvement project
Dr. Elizabeth Bryce Dr. Titus Wong on behalf of the VGH decolonization team
Surgery and Orthopaedics Combined Grand Rounds12 December, 2012
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The TeamSurgery: Bas Masri Gary Redekop
Perioperative Services: Debbie Jeske Claire JohnstonKelly Barr Shelly Errico
Anna-Marie MacDonald Tammy Thandi,Lorraine Haas Pauline GoundarLucia Allocca Dawn BreedveldSteve Kabanuk
Infection Control: Elizabeth Bryce Chandi PandithaLeslie Forrester Diane LoukeTracey Woznow
Medical Microbiology: Diane RoscoeTitus Wong
Patient Safety: Linda Dempster
Ondine Biomedical: Shelagh Weatherill et al
Special Thanks: microbiology technologists, and perioperative staff
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Overview
• VGH SSI infection reduction decolonization quality improvement project
• Findings from the project: microbiologic efficacy, safety, outcomes, program impact
• Final thoughts / discussion
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SSIs, Patient Flora and Decolonization Strategies
• Most SSIs arise from the patient’s own flora including skin and head/neck distant from wound
• Decreasing the bacterial load prior to surgery can decrease risk of SSIs
• Traditional decolonization strategies consist of chlorhexidine (CHG) +/- intranasal mupirocin
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VGH SSI reduction decolonization QI project
Wanted: • Consistent pre-operative decolonization
program in high risk surgeries• High degree of compliance with program• Minimal risk of antibiotic resistance• Must be effective
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Our Novel Approach
• Nasal Photodisinfection using MRSAid
• Chlorhexidine impregnated washcloths
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Treatment Site
Tissue Colonized with Pathogenic
Bacteria
Irrigation
Apply Photosensitizer
that binds to bacterial surfaces
Illumination
Illuminate the Treatment Site
Using Non-Thermal Light
Energy
Eradication
“Activated” Photosensitizer creates reactive oxygen species, killing bacteria
How Photodisinfection works
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MRSAid™ Treatment Protocol
1. Connect nasal illuminator tips to laser cable port via fiber-optic connector2. Illuminate for 2 minutes with tips placed as shown above (directed into inner tip of nose for 1st cycle and posterior for 2nd cycle)
1st Illumination Cycle 2nd Illumination Cycle
1 2
3 4
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Chlorhexidine Washcloths
• Alcohol-free washcloth impregnated
with CHG
• FDA and Health Canada approved
• Used below the neck day of or night
prior to surgery
• Left on the skin (not rinsed off)
• Equivalent to 4% CHG on skin http://www.sageproducts.com/lit/20778C.pdf
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Advantages of this Approach
• Horizontal infection control strategy• Eradicate antibiotic resistant bacterial strains• No generation of bacterial resistance• No/minimal effect on human tissues• Rapid action – maximally effective in minutes• Increased compliance
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VGH SSI reduction decolonization QI project
Objectives:1. To determine if immediate preoperative decolonization
using nasal photodisinfection therapy + CHG wipes reduces SSI rates in elective non-general surgeries.
2. To assess the feasibility of integration of a decolonization program in the pre-operative area
Target Population: all elective surgical procedures that were normally followed for SSI as part of the Infection Prevention and Control surveillance program
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Decolonization ProtocolSurgeries included: • cardiac, thoracic, ortho-recon,
ortho-trauma, vascular, neuro/spine, and breast cases.
Surgeries excluded: • open fractures, dirty/contaminated
cases, duplicate cases, cases in 6 week introductory period
CHG within 24h Nasal Culture
Document Compliance, AE
Perform SurgerySSI Surveillance
Photodisinfection Therapy (MRSAid)
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Microbiological Efficacy, Safety and Compliance
• Microbiological EfficacyRecords during
study period N=6090
PDT treatedN= 5691
PDT not treatedN= 399
Not ColonizedMRSA: (98.72%)MSSA: (76.63%)
Colonized with MSSA
N = 1315/5627 (23.37%)
Baseline Colonization:
MRSA: 1.28%
MSSA: 23.37%
Colonized with MRSA
N = 56/4370 (1.28%)
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Microbiological Efficacy, Safety, and Compliance
• Microbiological EfficacyGrowth MSSA reduction
n = 1286 (%)MRSA reduction
n=51 (%)
Heavy 105/109 (96.3%) 8 /10(80%)
Moderate 348/383 (90.9%) 13/16 (81.3%)
Scant 598/794 (75.3%) 18/25 (72%)
Total 1051/1286 (81.7%) 39/51 (76.4%)
*unpaired data was excluded ** reduction defined as complete or partial bioburden reduction
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SSI Data - ExtractionCases during study period and study
hours N=5176
Total Eligible for SSI surveillance
N= 3264
Not eligible for SSI surveillance
N = 1912
Cases not treated N = 196
Cases treated preop with PDT
N = 3068
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Comparing SSI rates: Treated and Historical*
Treated 4 year Historical Specialty SSI Procedures SSI
RateSSI (Avg) Procedures SSI
RateP-value Odds
Ratio
Cardiovascular1 18 628 0.029 21 833.5 0.025 0.5830 0.8652
Neuro2 2 502 0.004 7.75 538 0.014 0.0764 3.6539
Orthopedics3 5 892 0.006 12.5 711 0.018 0.0141 3.1747
Spine 19 475 0.04 34 201.5 0.085 0.0015 2.2204
Thoracic 2 431 0.005 3.5 1357 0.010 0.2884 2.2360
Vascular 4 140 0.029 6.25 1273.5 0.023 0.6747 0.7951
Total 50 3068 0.016 85 3097 0.027 0.0005 1.6984
(1) CHG/mupirocin program in place previously (2) CHG bathing program in place previously (3) CHG/mupirocin used variably* Statistics done on the four year total numbers rather than the average
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Impact: SSI Case Reduction
Parameter SSI
SSIs/total treated patients (rate) 50/3068 (0.016)
Projected number of SSIs if all eligible patients (n=3264) treated
0.0016 x 3264 = 52
Four year historical average number of SSIs 85
Potential cases avoided if all patients treated
33 (39% reduction)
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Impact: FinancialService Cases Avoided Case Cost* Cost Avoidance
Neurosurgery 6 $25,000 $150,000
Cardiovascular 3 $30,000 $90,000
Orthopedics 8 $33,000 $ 264,000
Spine 15 $30,000 $450,000
Vascular 2 $20,000 $ 40,000
Thoracic 1 $10,000 $ 10,000
Total 35** $1,040,000
*Case Cost provided by A. Karpa Financial Planning and Business Support**Cases are rounded up for Neuro and Orthopedics
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Impact: ReadmissionsParameter April 1/2012
to Sept 2012Average 09/10
and 10/11Avg number of
readmissions/Fiscal period
1.25/pd 4.04/pd
Average days stay 16.5 16.5 days
Projected Readmissions for this fiscal year
15 48.5
Days Stay x Cost/dy 15 x 16.5 x $500/dy =$123,750
48.5 x 16.5 x $500/dy = $400,125
Cost Avoidance $276,375
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Impact: Cost Avoidance
1. LPNs able to treat 5176 patients/yr2. 3608 were cases routinely followed for SSI outcomes3. If remaining 1912 cases had a similar SSI rate
reduction (0.016) , 31 additional infections prevented.4. $20,000/SSI x 31 = $ 611,840 avoided costs
Total Cost Avoidance: $1,040,000 + $276,375 + $611,840 = $1,928,215
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Education and Knowledge Dissemination
• Within VCH– rounds / in-services: surgical subspecialties, peri-
operative services, PAR, infection control, medical microbiology
– newsletter / electronic media• Beyond VCH
– Conference presentations:• AMMI 2012 (Vancouver), IDWEEK 2012 (San Diego), Knee
Society Summer Meeting (Garden City)• upcoming: AAOS 2013 (Chicago)
– Publications: pending
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Conclusions• Nasal photodisinfection therapy is microbiologically
effective
• Decolonization therapy reduces surgical site infections
• Decolonization programs can be integrated into perioperative work flow
• Nasal and skin decolonization have high degree of compliance when performed (98.8%)
• Decreases patient morbidity and is cost effective
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From: Photodynamic therapy for localized infections—State of the art Tianhong Daia, b, Ying-Ying Huanga, b,
c, Michael R. Hamblin, PhDa, b, d, , Photodiagnosis and photodynamic Therapy 2009;6:170=188
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Other uses of PDT
• Treatment of infections: periodontitis, sinusitis, ventilator associated pneumonia, catheter related urinary tract infections
• Treatment of skin conditions: psoriasis, eczema, fungal infections
• Cancer therapy
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Further study required
• Accurate doses of photosensitizer and light• Appropriate illumination device(s)• Type of delivery system e.g. topical, interstitial,
injection, aerosolization• Stability and ease of application• Patient acceptibility• Safety profile of light/photosensitizer combinations• Role of PDT in stimulating the host immune system
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Thank you!The Patients
Surgery Perioperative Services
Infection Control Medical Microbiology
Patient SafetyOperations and Senior Leaders
Ondine Biomedical
Special Thanks: Study LPNs, data clerks, data analysts, microbiology technologists, and perioperative staffSpecial Thanks: UBC- VGH Hospital Foundation Team Awards:
AMMI 2012 Innovation Academy
Award
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Discussion / Questions?
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